Contribution of tubular injury to loss of remnant kidney function

Kidney International

Volumn 54, Issue 4, 1998, Pages 1157-1165

  Gandhi, Mehul ^a   Olson, Jean L ^c   Meyer, Timothy W ^b  

^a NATIONAL KIDNEY FOUNDATION   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c NONE

Author keywords

Atrophy; Glomerulus; Interstitium; Progression of renal disease; Proteinuria; Tubule

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; INTERSTITIUM; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; TISSUE SECTION;

EID: 0031708154     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00107.x     Document Type: Article

References (31)

1. MARCUSSEN N: Atubular glomeruli and the structural basis for chronic renal failure. Lab Invest 66:265-284, 1992
2. MARCUSSEN N, OTTOSEN P, CHRISTENSEN S, OLSEN T: Atubular glomeruli in lithium induced chronic nephropathy in rats. Lab Invest 61:295-302, 1989
3. MARCUSSEN N: Atubular glomeruli in cisplatin induced chronic interstitial nephropathy: An experimental stereologic investigation. APMIS 98:1087-1997, 1992
4. PAGTALUNAN ME, OBERBAUER R, HAAS M, BARLAN M, MAYER G, OLSON JL, MEYER TW: Atubular glomeruli in patients with chronic allograft rejection. Transplantation 61:1166-1171, 1996
5. LANE PH, STEFFES MW, MAUER SM: Estimation of glomerular volume: A comparison of four methods. Kidney Int 41:1085-1089, 1992
6. COHEN EP, ROBBINS MEC, WHITEHOUSE E, HOPEWELL JW: Stenosis of the tubular neck: A possible mechanism for progressive renal failure. J Lab Clin Med 129:567-573, 1997
7. GRETZ N, WALDHERR R, STAUCH M: The remnant kidney model, in Rat Models of Chronic Renal Failure, edited by GRETZ N, STRAUCH M, Basel, Karger, 1992, pp 1-28
8. PICHLER RH, HUGO C, SHANKLAND SJ, REED MJ, BASSUK JA, ANDOH TF, LOMBARDI DM, SCHWARTZ SM, BENNETT WM, ALPERS CE, SAGE EH, JOHNSON RJ, COUSER WJ: SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Kidney Int 50:1978-1989, 1996
9. JOHNSON TS, GRIFFIN M, THOMAS GL, SKILL J, COX A, YANG B, NICHOLAS B, BIRCKBICHLER PJ, MUCHANETA-KUBARA C, EL NAHAS AM: The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis. J Clin Invest 99:2950-2960, 1997
10. SCHAINUCK LI, STRIKER GE, CUTLER RE, BENDITT EP: Structural-functional correlations in renal disease. Hum Pathol 1:631-641, 1970
11. RISDON RA, SLOPER JAC, DE WARDENER H: Relations between renal function and histological changes found in renal biopsy specimens from patients with persistent glomerular nephritis. Lancet ii:363-366, 1968
12. MACKENSEN-HAEN S, BADER R, GRUND K, BOHLE A: Correlations between renal cortical interstitial fibrosis, atrophy of proximal tubules and impairment of glomerular nitration rate. Clin Nephrol 15:167-171, 1981
13. BOHLE A, GISE H, MACKENSEN-HAEN S, STARK-JACOB B: The obliteration of the postglomerular capillaries and its influence upon the function of both glomeruli and tuhuli. Klin Wschwr 59:1043-1051, 1981
14. BOHLE A, MACKENSEN-HAEN S, GISE H: Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: A morphometric contribution. Am J Nephrol 7:421-433, 1987
15. LAFAYETTE RA, MAYER G, PARK SK, MEYER TW: Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. J Clin Invest 90:766-771, 1992
16. FRIES JWU, SANDSTROM DJ, MEYER TW, RENNKE HG: Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat. Lab Invest 60:205-218, 1989
17. MILLER PL, SCHOLEY JW, RENNKE HG, MEYER TW: Glomerular hypertrophy aggravates epithelial cell injury in nephrotic rats. J Clin Invest 85:1119-1126, 1990
18. BENIGNI A, REMUZZI G: Glomerular protein trafficking and progression of renal disease to terminal uremia. Semin Nephrol 16:151-159, 1996
19. EDDY AA: Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions. J Am Soc Nephrol 5:1273-1287, 1994
20. GRIFFIN KA, PICKEN M, BIDANI AK: Method of renal mass reduction is a critical modulator of subsequent hypertension and glomerular injury. J Am Soc Nephrol 4:2023-2031, 1994
21. BIDANI AK, MITCHELL KD, SCHWARTZ MM, NAVAR LG, LEWIS EJ: Absence of glomerular injury or nephron loss in a normotensive rat remnant kidney model. Kidney Int 38:28-38, 1990
22. GROND J, BEUKERS JYB, SCHILTHUIS MS, WEENING JJ, ELEMA JD: Analysis of renal structural and functional features in two rat strains with a different susceptibility to glomerular sclerosis. Lab Invest 54:77-85, 1986
23. TANNER GA, EVAN AP: Glomerular and proximal tubular morphology after single nephron obstruction. Am J Physiol 36:1050-1060, 1989
24. HARRIS DC, TAY YC, CHEN J, CHEN L, NANKIVELL BJ: Mechanisms of iron-induced proximal tubule injury in rat remnant kidney. Am J Physiol 269:F218-F224, 1995
25. KEES-FOLTS D, SADOW JL, SCHREINER GF: Tubular catabolism of albumin is associated with the release of an inflammatory lipid. Kidney Int 45:1697-1709, 1994
26. AGARWAL A, NATH KA: Effect of proteinuria on renal interstitium: Effect of products of nitrogen metabolism. Am J Nephrol 13:376-384, 1993
27. FUJIHARA CK, LIMONGI DM, FALZONE R, GRAUDENZ MS, ZATZ R: Pathogenesis of glomerular sclerosis in subtotally nephrectomized analbuminemic rats. Am J Physiol 261:F256-F264, 1991
28. NATH KA, HOSTETTER MK, HOSTETTER TH: Increased ammoniagenesis as a determinant of progressive renal injury. Am J Kidney Dis 17:654-657, 1991
29. HARRIS DCH, CHAN L, SCHRIER RW: Remnant kidney hypermetabolism and progression of chronic renal failure. Am J Physiol 254:F267-F276, 1988
30. NATH KA, CROAT AJ, HOSTETTER TH: Oxygen consumption and oxidant stress in surviving nephrons. Am J Physiol 258:F1354-F1362, 1990
31. EDDY AA: Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 7:2495-2508, 1996