Nicotine content in tobacco and tobacco smoke

Tobacco: Science, Policy and Public Health

Volumn , Issue , 2010, Pages

  Djordjevic, Mirjana V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cigarettes; Nicotine content; Tobacco; Tobacco addiction; Tobacco smoke

Indexed keywords

EID: 84875631267     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1093/acprof:oso/9780199566655.003.0010     Document Type: Chapter

References (134)

1. Adam, T., Mitschke, S., Streibel, T., Baker, R.R., and Zimmermann, R. (2006) Puff-by-puff resolved characterization of cigarette mainstream smoke by single photon ionization (SPI)-time-of-flight mass spectrometry (TOFMS): comparison of the 2R4F research cigarette and pure Burley, Virginia, Oriental and Maryland tobacco cigarettes. Anal Chimica Acta, 572:219-229.
2. Alpert, H.R., Koh, H., and Connolly, G.N. (2008) Free nicotine content and strategic marketing of moist snuff tobacco products in the United States: 2000-2006. Tob Control, 18:332-338.
3. Appel, B.R., Guirguis, G., Kim, I.S., Garbin, O., Fracchia, M., Flessel, C.P. et al. (1990) Benzene, benzo(a)pyrene, and lead in smoke from tobacco products other than cigarettes. Am J Public Health, 80:560-564.
4. Armitage, A.K., Dixon, M., Fros, B.E., Mariner, D.C., and Sinclair, N.M. (2004) The effect of tobacco blend additives on the retention of nicotine and solanesol in the human respiratory tract and on subsequent plasma nicotine concentrations during cigarette smoking. Chem Res Toxicol, 17(4):537-544.
5. Ashley, D.L., Pankow, J.F., Tavakoli, A.D., and Watson, C.H. (2009) Approaches, challenges, and experience in assessing free nicotine. Handb Exp Pharmacology, 192:437-456.
6. Ayo-Yusuf, O.A., Swart, T.J., and Pickworth, W.B. (2004) Nicotine delivery capabilities of smokeless tobacco products and implications for control of tobacco dependence in South Africa. Tob Control, 13:186-189.
7. Benowitz, N.L. and Henningfield, J.E. (1994) Establishing a nicotine threshold for addiction. The implication of tobacco regulation. New England J Med, 331:123-125.
8. Benowitz, N.L., Hall, S.M., Stewart, S., Wilson, M., Dempsay, D., and Jacob, P. III (2007) Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Cancer Epi Biomark Prev, 16:2479-2485.
9. Benowitz, N.L., Dains, K.M., Hall, S.M., Stewart, S., Wilson, M., Dempsey, D. et al. (2009) Progressive commercial cigarette yield reduction: biochemical exposure and behavioral assessment. Cancer Epi Biomark Prev, 18(3):876-883.
10. Bhide, S.V., Nair, J., Maru, G.B., Nair, U.J., Kameshwar Rao, B.V., Chakraborty, M.K. et al. (1987) Tobacco-specific N-nitrosamines (TNSA) in green mature and processed tobacco leaves from India. Beitr Tabakforsch, 14:29-32.
11. Bradford, J.A., Harlan, W.R., and Hanmer, H.R. (1936) Nature of cigarette smoke: technic of experimental smoking. Industrial Engineering Chem, 29:836-839.
12. Breland, A.B., Evans, S.E., Buchhalter, A.R., and Eissenberg, T. (2002) Acute effects of Advance™: a potential reduced exposure product for smokers. Tob Control, 11:376-378.
13. Breland, A.B., Acosta, M.C., and Eissenberg, T. (2008) Tobacco-specific nitrosamines and potential reduced exposure products for smokers: a preliminary evaluation of Advance ™. Tob Control, 12:317-321.
14. Borgerding, M., Klus, H. (2005) Analysis of complex mixtures -cigarette smoke. Experimental Toxicologic Pathology, 57:43-73.
15. Burns, D.M., Dybing, E., Gray, N., Hecht, S., Anderson, C., Sanner, T. et al. (2008) Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal. Tob Control, 17:132-141.
16. Burton, H.R., Bush, L.P., and Hamilton, J.L. (1983) Effect of curing on the chemical composition of burley tobacco. Recent Adv Tob Sci, 9:91-153.
17. Burton, H.R., Bush, L.P., Djordjevic, M.V. (1989a) Influence of temperature and humidity on the accumulation of tobacco-specific nitrosamines in stored burley tobacco. J Agric Food Chem, 37:1372-1377.
18. Burton, H.R., Childs, G.H. Jr, Andersen, R.A., and Fleming, P.D. (1989b) Changes in chemical composition of burley tobacco during senescence and curing. 3. Tobacco-specific nitrosamines. J Agric Food Chem, 37:426-430.
19. Burton, H.R., Dye, N.K., and Bush, L.P. (1992) Distribution of tobacco constituents in tobacco leaf tissue. 1. Tobacco-specific nitrosamines, nitrate, nitrite and alkaloids. J Agric Food Chem, 40:1050-1055.
20. Burton, H.R., Dye, N.K., and Bush, L.P. (1994) Relationship between tobacco-specific nitrosamines and nitrite from different air cured tobacco varieties. J Agric Food Chem, 42:2007-2011.
21. Calafat, A.M., Polzin, G.M., Saylor, J., Richter, P., Ashley, D.L., and Watson, C.H. (2004) Determination of tar, nicotine, and carbon monoxide yields in the mainstream smoke of selected international cigarettes. Tob Control, 13:45-51.
22. Callicutt, C.H., Cox, R.H., Farthing, D., Hsu, F.S., Johnson, L., Laffoon, S. et al. (2006) The ability of the FTC method to quantify nicotine as a function of ammonia in mainstream smoke. Beitr Tabakforsch, 22(2):71-78.
23. Carmella, S.G., Borukhova, A., Desai, D., and Hecht, S.S. (1997) Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrate. Carcinogenesis, 18(3):587-592.
24. Chamberlain, W.J. and Chortyk, O.T. (1992) Effects of curing and fertilization on nitrosamine formation in bright and burley tobacco. Chemical composition of nonsmoking tobacco products. Beitr Tabakforsch, 15:87-92.
25. Chen, J., Higby, R., Tian, D., Tan, D., Johnson, M.D., Xiao, Y. et al. (2008) Toxicological analysis of low-nicotine and nicotine free-cigarettes. Toxicology, 249:194-203.
26. Chen, C. and Pankow, J.F. (2009) Gas/particle partitioning of two acid-base active compounds in mainstream tobacco smoke: nicotine and ammonia. J Agric Food Cgem, 57(7):2678-2690.
27. Connolly, G.N., Alpert, H.R., Wayne, G.F., and Koh, H. (2007) Trends in nicotine yield in smoke and its relationship with design characteristics among popular US cigarette brands, 1997-2005. Tob Control, 16:e5,1-8.
28. Connolly, G.N. and Alpert, H.R. (2008) Trends in the use of cigarettes and other tobacco products, 2000-2007. JAMA, 299:2629-2630.
29. Counts, M.E., Morton, M.J., Lafoon, S.W., Cox, R.H., and Lipowicz, P.J. (2005) Smoke composition and potential relationship for international commercial cigarettes smoked with three machine-smoking conditions. Regulatory Toxicol Pharmacol, 41:185-227.
30. DeRoton, C., Wiernik, A., Wahlberg, I., and Vidal B (2005) Factors influencing the formation of tobacco-specific nitrosamines in french air-cured tobaccos in trials and at the farm level. Beitr Tabakforsch, 21:305-320.
31. Djordjevic, M.V., Gay, S.L., Bush, L.P., and Chaplin, J.F. (1989) Tobacco-specific nitrosamine accumulation and distribution in flue-cured tobacco isolines. J Agric Food Chem, 37:752-756.
32. Djordjevic, M.V., Bush, L.P., Gay, S.L., and Burton, H.R. (1990a) Accumulation and distribution of acylated nornicotine derivatives in flue-cured tobacco alkaloid isolines. J Agric Food Chem, 38:347-350.
33. Djordjevic, M.V., Sigountos, C.W., Brunnemann, K.D., and Hoffmann, D. (1990b) Tobaccospecific nitrosamine delivery in the mainstream smoke of high-and low-yield cigarettes smoked with varying puff volume. In: CORESTA Information Bulletin. Symposium 1990, Oct. 7-11 Hellas, p. 209.
34. Djordjevic, M.V., Sigountos, C.W., Hoffmann, D., Brunnemann, K.D., Kagan, M., Bush, L.P.et al. (1991) Assessment of major carcinogens and alkaloids in the tobacco and mainstream smoke of USSR cigarettes. Int J Cancer, 47:348-351.
35. Djordjevic, M.V., Hoffmann, D., Glynn, T., Connolly, G.N. (1995) US commercial brands of moist snuff, 1994. I. Assessment of nicotine, moisture, and pH. Tob Control, 4:62-66.
36. Djordjevic, M.V., Eixarch, L., and Hoffmann, D. (1997) Self-administered and effective dose of cigar smoke constituents. The 51st Tobacco Chemists' Research Conference, Abstr. # 9, Winston-Salem, NC, September 14-17.
37. Djordjevic, M.V., Stellman, S.D., and Zang, E. (2000) Dosages of nicotine and lung carcinogens delivered to cigarette smokers. J Natl Cancer Inst, 92:106-111.
38. Eissenberg, T., Ward, K.D., Smith-Simone, S., and Maziak, W. (2008) Waterpipe tobacco smoking on a US College campus: prevalence and correlates. J Adolesc Health, 42(5):526-529.
39. Fant, R.V., Henningfield, J.E., Nelson, R.A., and Pickworth, W.B. (1999) Pharmacokinetcs and pharmcodynamics of moist snuff in humans. Tob Control, 8:387-392.
40. Farrelly, M.C., Loomis, B.R., and Mann, N.H. (2007) Do increases in cigarette prices lead to increases in sales of cigarettes with hightar and nicotine yields? Nicotine Tob Res, 9(10):1015-1020.
41. FTC, Federal Trade Commission (2000) 'Tar', nicotine, and carbon monoxide of the smoke of 1294 varieties of domestic cigarettes for the year 1998. Federal Trade Commission Report p. 9.
42. Funk-Brentano, C., Raphaël, M., Lafontaine, M., Arnould, J.-P., Verstuyft, C., Lebot, M. et al. (2006) Effects of type of smoking (pipe, cigars or cigarettes) on biological indices of tobacco exposure and toxicity. Lung Cancer, 54:11-18.
43. Geiss, O. and Kotzais, D. (2003) Determination of ammonium, urea, and chlorinated pesticides in cigarette tobacco. Fresenius Env. Bull, 12(12):1562-1565 PSP 1018-4619.
44. Green, C.R., Schumacher, J.N., Lloyd, R.A., and Rodgman, A. (2007a) Comparison of the composition of tobacco smoke and the smokes from various tobacco substitutes. Beitrage Tabakforsch, 22(4): 258-289.
45. Green, C.R., Scumacher, J.N., and Rodgman, A. (2007b) The expansion of tobacco and its effect on cigarette mainstream smoke properties. Beitrage Tabakforsch, 22(5):317-345.
46. Greg, E., Hill, C., Hollywood, M., Kearney, M., McAdam, K., Mclaughlin, D. et al. (2004) The UK smoke constituents testing study. Summary of results and comparison with other studies. Beitr Tabakforsch, 21:117-138.
47. Gupta, P. (2004) Laboratory Testing of Smokeless Tobacco Products. Final Report to the India Office of the WHO (allotment No. SE IND TOB 001.RB.02). New Delhi.
48. Hammond, D., Fong, G.T., Cummings, K.M., O'Connor, R.J., Giovino, G.A., and McNeill, A. (2006) Cigarette yields and human exposure: a comparison of alternative testing regimens. Cancer Epidemiol Biomarkers Prev, 15(8):1495-1501.
49. Harris, J.E. (2001) Smoke yields of tobacco-specific nitrosamines in relation to FTC tar level and cigarette manufacturer: analysis of the Massachusetts Benchmark Study. Public Health Reports, 116:336-343.
50. Hatsukami, D.K., Slade, J., Benowitz, N.L., Giovino, G.A., Gritz, E.R., Leischow, S. et al. (2002) Reducing tobacco harm: research challenges and issues. Nicotine Tob Res, (Suppl 2):S89-S101.
51. Hatsukami, D.K., Giovino, G.A., Eissenberg, T., Clark, P.I., Lawrence, D., and Leischow, S. (2005) Methods to asses potential reduced exposure products. Nicotine Tob Res, 7:827-844.
52. Hecht, S.S., Murphy, S.E., Carmella, S.G., Li, S., Jensen, J., Le, C. et al. (2005) Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes. Cancer Epidemiol Biomar Prev, 14:693-698.
53. Henningfield, J.E., Radzius, A., and Cone, E.J. (1995) Estimation of available nicotine content in six smokeless tobacco products. Tob Control, 4:57-61.
54. Henningfield, J.E., Benowitz, N.L., Slade, J., Houston, T.P., Davis, R.M., and Deitchman, S.D. (1998) Reducing the addictiveness of cigarettes. Tob Control, 7:281-293.
55. Henningfield, J.E., Fant, R.V., Radzius, A., and Frost, S. (1999) Nicotine concentrations, smoke pH and whole tobacco aqueous pH of some cigar brands and types popular in the United States. Nicotine Tob Res, 1:163-168.
56. Henningfield, J.E., Pankow, J., and Garrett, B. (2004) Ammonia and other chemical base tobacco additives and cigarette nicotine delivery: issues and research needs. Nicotine Tob Res, 6:199-205.
57. Henningfield, J.E., Stolerman, I.P., Miczek, K.A. (2006) Nicotine psychopharmacology research: advancing science, public health, and global policy. Psychopharmacology, 184:263-265.
58. Hoffmann, D., Brunnemann, K.D., Prokopczyk, B., and Djordjevic, M.V. (1994) Tobaccospecific N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans. J Toxicol Env Health, 41:1-52.
59. Hoffmann, D., Djordjevic, M.V., Fan, J., Zang, E., Glynn, T., and Connolly, G.N. (1995) Five leading US commercial brands in moist snuff in 1994: Assessment of carcinogenic Nnitrosamines. J Natl Cancer Inst, 87:1862-1869.
60. Hoffmann, D. and Hoffmann, I. (1997) The changing cigarette, 1950-1995. J Toxicol Environ Health, 50:307-364.
61. Hoffmann, D. and Hoffmann, I. (1998) Chemistry and Toxicology. In: Smoking and Tobacco Control Monograph No. 9. Cigars. Health Effects and Trends. Washington, DC, USA: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute.
62. Hoffmann, D., Hoffmann, I., and El-Bayoumy, K. (2001) The less harmful cigarette: A controversial Issue. A tribute to Ernst L. Wynder. Chem Res Toxicol, 14:767-790.
63. Idris, A.M., Nair, J., Oshima, H., Friesen, M., Bronet, I., Faustman, E.M. et al. (1991) Unusually high levels of carcinogenic tobacco-specific nitrosamines in Sudan snuff (toombak). Carcinogenesis, 12:1115-1118.
64. Idris, A.M., Ibrahim, S.O., Vasstrand, E.N., Johannessen, A.C., Lillehaug, J.R., Magnusson, B. et al. (1998) The Swedish snus and the Sudanese toombak: are they different? Oral Oncol, 34:558-566.
65. IARC, International Agency for Research on Cancer (1986) Tobacco Smoking. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 38, p. 61. IARC, Lyon, France.
66. IARC, International Agency for Research on Cancer (2004) Tobacco Smoke and Involuntary Smoking. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 83, IARC, Lyon, France.
67. IARC, International Agency for Research on Cancer (2007) Smokeless Tobacco and Some Tobacco-specific N-nitrosamines In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 89, IARC, Lyon, France.
68. Jack, A., Fennin, N., and Bush, L.P. (2007) Implications of reducing nornicotine accumulation in burley tobacco. Recent Adv Tob Sci, 33:39-92.
69. Jacob, III P., Yu, L., Shulgin, A.T., and Benowitz, N.L. (1999) Minor tobacco alkaloids as biomarkers for tobacco use: comparison of users of cigarettes, smokeless tobacco, cigars and pipes. Am J Pub Health, 89:731-736.
70. Kaiserman, M.J. and Rickert, W.S. (1992a) Carcinogens in tobacco smoke: benzo[a]pyrene from Canadian cigarettes and cigarette tobacco. Am J Pub Health, 82:1023-1026.
71. Kaiserman, M.J. and Rickert, W.S. (1992b) Handmade cigarettes: it's the tube that counts. Am J Pub Health, 82:107-109.
72. Kozlowski, L.T., Mehta, N.Y., Sweeney, C.T., Schwartz, S.S., Vogler, G.P., Jarvis, M.J. et al. (1998) Filter ventilation and nicotine content of tobacco of cigarettes from Canada, the United Kingdom, and the United States. Tob Control, 7:369-375.
73. Laugesen, M. (2003) Tobacco Manufacturers' returns for calendar year 2002. Report to the Ministry of Health, New Zealand, Health New Zealand.
74. Laugesen, M. and Fowles, J. (2006) Marlboro UltraSmooth: a potentially reduced exposure cigarette? Tob Control, 15:430-435.
75. Laugesen, M., Epton, M., Frampton, C.M.A., Glower, M., and Lea, R.A. (2009) Hand-rolled cigarette smoking patterns compared with factory-made cigarette smoking in New Zealand men. BMC Public health, 9(194):1-6.
76. Lee, E.M., Malson, J.L., Moolchan, E.T., and Pickworth, W.B. (2004) Quantitative comparison between a nicotine delivery device (Eclipse) and conventional cigarette smoking. Nicotine Tob Res, 6:95-102.
77. MacKown, C.T., Douglas, B., Djordjevic, M.V., and Bush, L.P. (1988) Tobacco-specific nitrosamines: formation during processing of midvein and lamina fines. J Agric Food Chem, 36:1031-1035.
78. McNeill, A., Bedi, R., Islam, S., Alkhatib, M.N., and West, R. (2006) Levels of toxins in oral tobacco products in the UK. Tob Control, 15:64-67.
79. Malik, S.K. and Behera, D. (1985) Chemistry of tobacco and tobacco smoke in chutta -a home made cigar; a preliminary study. Int J Clin Pharmacol Ther Toxicol, 23(11):604-605.
80. Malson, J.L., Sims, K., Murty, R., and Pickworth, W.B. (2001) Comparison of the nicotine content of tobacco used in bidis and conventional cigarettes. Tob Control, 10:181-183.
81. Malson, J.L., Lee, E.M., Moolchan, E.T., and Pickworth, W.B. (2002) Nicotine delivery from smoking bidis and additive-free cigarette. Nicotin Tob Res, 4:485-490.
82. Malson, J.L., Lee, E.M., Murty, R., Moolchan, E.T., and Pickworth, W.B. (2003) Clove cigarette smoking: biochemical, physiological, and subjective effects. Pharmacol Biochem Behavior, 74:739-745.
83. Maziak, W., Ward, K.D., Afifi Soweid, R.A., and Eissenberg, T. (2004) Tobacco smoking using a waterpipe: a re-emerging strain in a global epidemic. Tob Control, 13:327-333.
84. Maziak, W., Eissenberg, T., and Ward, K.D. (2005) Patterns of waterpipe use and dependence: implications for intervention development. Pharmacol Biochem Behavior, 80:173-179.
85. Melikian, A.A., Djordjevic, M.V., Chen, S., Richie, J.P. Jr, and Stellman, S.D. (2007a) Impact of delivered dosage of cigarette smoke toxins on the levels of urinary biomarkers of exposure. Cancer Epi Biomarkers Prev, 16:1408-1415.
86. Melikian, A.A., Djordjevic, M.V., Hosey, J., Zhang, J., Chen, S., Zang, E. et al. (2007b) Gender differences relative to smoking behavior and emission of toxins from mainstream cigarette smoke. Nicotine Tob Res, 9(3):377-387.
87. Mitacek, E.J., Brunnemann, K.D., Polednak, A.P., Hoffmann, D., and Suttajit, M. (1991) Composition of popular tobacco products in Thailand and its relevance to disease prevention. Prev Med, 20:764-773.
88. Moldoveanu, S.C., Borgerding, M. (2008) Formation of tobacco specific nitrosamines in mainstream cigarette smoke; Part 1, FTC smoking. Beitrage Tabakforsch, 23(1):19-31.
89. Monzer, B., Sepetdjian, E., Saliba, N., and Shihadeh, A. (2008) Charcoal emissions as a source of CO and carcinogenic PAH in mainstream narghile WP smoke. Food Chem Toxicol, 46(9):2992-2995.
90. National Cancer Institute (2001) Risk associated with smoking cigarettes with low machine-measured yields of tar and nicotine. In: Smoking and Tobacco Control Monograph No.13. Washington, DC, USA: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute.
91. Neergaard, J., Singh, P., Job, J., and Montgomery, S. (2007) Waterpipe smoking and nicotine exposure: E review of the current evidence. Nicotine Tob Res, 9:987-994.
92. O'Connor, R.J., Giovino, G.A., Kozlowski, L.T., Shiffman, S., Hyland, A., Bernert, J.T. et al. (2006) Changes in nicotine intake and cigarette use over time in two nationally representative cross-sectional samples of smokers. Am J Epidemiol, 164:750-759.
93. O'Connor, R.J. and Hurley, P.J. (2008) Existing technologies to reduce specific toxicant emissions in cigarette smoke. Tob Control Suppl, 1:i39-48.
94. Official Journal of European Communities (2001) Directive 2001/37/EC of the European Parliament and of the Council of 5 June.
95. Pakhale, S.S. and Maru,G.B. (1998) Distribution of major and minor alkaloids in tobacco, mainstream, and sidestream smoke of popular Indian smoking products. Food Chem Toxicol, 36:1131-1138.
96. Pakhale, S.S., Jayant, K., and Bhide, S.V. (1989) Total particulate matter and nicotine in Indian bidis and cigarettes: a comparative study of standard machine estimates and exposure levels in smokers in Bombay. Indian J Cancer, 26(4):227-232.
97. Pankow, J.F. (2001) A consideration of the role of gas/particle partitioning in the deposition of nicotine and other tobacco smoke compounds in the respiratory tract. Perspective. Chem Res Toxicol, 14(11):1465-1481.
98. Pankow, J.F., Barsanti, K.C., and Peyton, D.H. (2003a) Fraction of free-base nicotine in fresh smoke particulate matter from the Eclipse 'cigarette' by 1H NMR spectroscopy. Chem Res Toxicol, 16:1014-1018.
99. Pankow, J.F., Tavakoli, A.D., Luo, W., and Isabelle, L.M. (2003b) Percent free base nicotine in the tobacco smoke particulate matter of selected commercial and reference cigarettes. Chem Res Toxicol, 16:23-27.
100. Peele, D.M., Danehower, D.A., and Goins, G.D. (1995) Chemical and biochemical changes during flue curing. Recent Adv Tob Sci, 21:81-133.
101. Pillsbury, H.C. (1996) Review of the Federal Trade Commission Method for determining cigarette tar and nicotine yield. In: The FTC Cigarette Test Method for Determining Tar, Nicotine, and Carbon Monoxide Yields of US Cigarettes. Report of the NCI Expert Committee. Smoking and Tobacco Control Monograph No.7, Bethesda (MD): US Department of Health and Human Services. National Institutes of Health, National Cancer Institute, NIH Publication No. 96-4028.
102. Primack, B.A., Sidani, J., Agarwal, A.A., Shadel, W.G., Donny, E.C., and Eissenberg, T.E. (2008) Prevalence and associations with waterpipe tobacco smoking among US university students. Ann Behav Med, 36(1):81-86.
103. Primack, B.A., Walsh, M., Bryce, C., and Eissenberg, T. (2009) Water-pipe tobacco smoking among middle and high school students in Arizona. Pwediatrics, 123(2):e282-288.
104. Rees, V.W., Wayne, J.F., Thomas, B.F., and Connolly, G.N. (2007) Physical design analysis and mainstream smoke constituent yields of new potential reduced exposure product, Marlboro UltraSmooth. Nicotine Tob Res, 9(11):1197-1206.
105. Richter, P. and Watson, C. (2008) Chemistry and Toxicology. In: P.C. Gupta and S. Asma (eds), Bidi Smoking and Public Health. New Delhi: Ministry of Health and Family Welfare. Government of India.
106. Rodgman, A. and Perfetti, T.A. (2009) The chemical components of tobacco and tobacco smoke. CRS Press, Taylor & Francis Group, LLC.
107. SCENIHR, Scientific Committee on Emerging and Newly Identified Health Risks (2008) Opinion on Health Effects of Smokeless Tobacco. Opinion adopted by SCENIHR at the 22nd plenary on 6 February. Available at:
108. Shihadeh, A. (2003) Investigation of mainstream aerosol of the argileh waterpipe. Food Chem Toxicol, 41:143-152.
109. Shihadeh, A. and Saleh, R. (2005) Polycyclic aromatic hydrocarbons, carbon monoxide, 'tar', and nicotine in the mainstream smoke aerosol of the narghile water pipe. Food Chem Toxicol, 43:655-661.
110. Siminszky, B., Gavilano, L.B., and Chakrabarti, M. (2007) Evolution of nicotine Ndemethylaze genes and their use in reducing nornicotine levels in tobacco. Recent Adv Tob Sci, 33:27-38.
111. Sisson, V.A. and Severson, R.F. (1990) Alkaloid composition of the Nicotiana species. Beitr Takforsch, 14:327-340.
112. Smith et al. (2006)
113. Stanfill, S.B., Brown, C.R., Yan, X., Watson, C.H., and Ashley, D.L. (2006) Quantification of flavor-related compounds in the unburned contents of bidi and clove cigarettes. J Agric Food Chem, 54:8580-8588.
114. Stedman, R.L. (1968) The chemical composition of tobacco and tobacco smoke. Chem Rev, 68:153-207.
115. Stepanov, I., Carmella, S.G., Hecht, S.S., and Duca, G. (2002) Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco. J Agric Food Chem, 50:2793-2797.
116. Stepanov, I., Jensen, J., Hatsukami, D., and Hecht, S.S. (2008) New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels. Nicotine Tob Res, 10(12):1773-1782.
117. Stepanov, I., Carmella, S.G., Han, S., Pinto, A., Strasser, A., Lerman, C. et al. (2009) Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users. Nicotine Tob Res, 11(1):99-105.
118. Strasser, A.A., Lerman, C., and Capella, J.N. (2006) Lower nicotine cigarettes may not lower harm. LDI Issue brief, 12(2):1-4.
119. Strasser, A.A., Lerman, C., Sanborn, P.M., Pickworth, W.B., and Feldman, E.A. (2007) New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Drug Alcohol Depend, 86:294-300.
120. Stratton, K., Shetty, P., Wallace, R., and Bondurant, S. (2001) Clearing the smoke. Assessing the science base for tobacco harm reduction. Washington DC, USA: National Academy Press.
121. Tamim, H., Terro, A., Kassem, H., Ghazi, A., Khamis, T.A., Hay, M.M. et al. (2003) Tobacco use by university students, Lebanon 2001. Addictions, 98(7):933-939.
122. Tamim et al. (2007)
123. Tso, T.C. (1990) Organic metabolism-alkaloids. In: T.C.Tso (ed.) Production, Physiology and Biochemistry of Tobacco Plant. IDEALS, Inc., Beltsville, MD, pp 427-486.
124. US DHHS (Department of Health and Human Services) (2004). The Health Consequences of Smoking: A Report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health.
125. Varsano, S., Ganz, I., Eldor, N., and Garenkin, M. (2003) [Water-pipe tobacco smoking among school children in Israel: frequencies, habits, and attitudes]. Harefuah, 142(11):736-741.
126. Walton, L.R., Burton, H.R., and Swetnam, L.D. (1995) Effect of mechanization on the physical appearance and chemical composition of burley tobacco. Recent Adv Tob Sci, 21:3-38.
127. Wangan, K.R. and Biørn, E. (2001) Prevalence and substitution effects in tobacco consumption: a discrete choice analysis of panel data. No. 312. Statistics Norway, Research Department.
128. Watson, C.H., Polzin, G.M., Calafat, A.M., and Ashley, D.L. (2003) Determination of tar, nicotine, and carbonmonoxide yields in the smoke of bidi cigarettes. Nicotine Tob Res, 5:747-753.
129. Watson, C.H., Trommel, J.S., and Ashley, D.L. (2004) Solid-phase microextraction-based approach to determine free-base nicotine in trapped mainstream cigarette smoke total particulate matter. J Agric Food Chem, 52:7240-7245.
130. Wu, W., Song, S., Ashley, D.L., and Watson, C.H. (2004) Assessment of tobacco-specific nitrosamines in the tobacco and mainstream smoke of Bidi cigarettes. Carcinogenesis, 25(2):283-287.
131. WHO, World Health Organization (2008) Mandated lowering of toxicants in cigarette smoke: tobacco-specific nitrosamines and selected other constituents. Technical Report Series, 951:45-260.
132. Young, D., Borland, R., Hammond, D., Cummings, K.M., Devlin, E., Yong, H.-H. et al. (2006) Prevalence and attributes of roll-your-own smokers in the International Tobacco Control (ITC) four country survey. Tob Control, 15(Suppl III): iii76-iii82.
133. Young, D., Yong, H.-H., Borland, R., Ross, H., Sirirassamee, B., Kin, F. et al. (2008) Prevalence and correlates of roll-your-own smoking in Thailand and Malaysia: Findings of the ITC-South East Asia survey. Nicotine Tob Res, 10:907-915.
134. Yu, J., Taylor, L.T., Aref, S., Bodnar, J.A., and Borgerding. M.F. (2006) Influence of puffing parameters and filter vent blocking condition on nicotine fate in a burning cigarette. Part 1. Full flavor cigarette. Beitr Takforsch, 144:185-195.