Analytical chemistry, toxicology, epidemiology and health impact assessment of melamine in infant formula: Recent progress and developments

Food and Chemical Toxicology

Volumn 56, Issue , 2013, Pages 325-335

  Wu, Yongning ^a   Zhang, Yu ^b  

^a CHINA NATIONAL CENTER FOR FOOD SAFETY RISK ASSESSMENT   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Analysis; Health risks; Infant formula; Melamine; Nephrotoxicity

Indexed keywords

CYANURIC ACID; MELAMINE; URIC ACID;

ARTIFICIAL MILK; CAPILLARY ELECTROPHORESIS; CARCINOGENICITY; CHINA; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDEMIC; EXTRACELLULAR FLUID; FOOD ANALYSIS; FOOD CONTAMINATION; FOOD SAFETY; GENOTOXICITY; HEALTH HAZARD; HEALTH IMPACT ASSESSMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HUMAN; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MAXIMUM ALLOWABLE CONCENTRATION; NEPHROLITHIASIS; NEPHROTOXICITY; NONHUMAN; QUALITY CONTROL; RELIABILITY; REVIEW; RISK ASSESSMENT; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; TOLERABLE DAILY INTAKE; TOXICOKINETICS; TOXICOLOGICAL PARAMETERS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DNA DAMAGE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INFANT; INFANT FORMULA; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TANDEM MASS SPECTROMETRY; TRIAZINES; URIC ACID; URINARY TRACT; UROLITHIASIS;

EID: 84875610402     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.02.044     Document Type: Review

References (81)

1. Baynes R.E., Smith G., Mason S.E., Barrett E., Barlow B.M., Riviere J.E. Pharmacokinetics of melamine in pigs following intravenous administration. Food Chem. Toxicol. 2008, 46:1196-1200.
2. Baynes R.E., Barlow B., Mason S.E., Riviere J.E. Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine. Food Chem. Toxicol. 2010, 48:2542-2546.
3. Bhalla V., Grimm P.C., Chertow G.M., Pao A.C. Melamine nephrotoxicity: an emerging epidemic in an era of globalization. Kidney Int. 2009, 75:774-779.
4. Bingham, E., Cohrssen, B., Powell, C.H., 2001. Patty's Toxicology, vols. 1-9, fifth ed. John Wiley & Sons, New York.
5. Braekevelt E., Lau B.P.Y., Feng S., Ménard C., Tittlemier S.A. Determination of melamine, ammeline, ammelide and cyanuric acid in infant formula purchased in Canada by liquid chromatography-tandem mass spectrometry. Food Addit. Contam. Part A-Chem. 2011, 28:698-704.
6. Breidbach A., Bouten K., Kröger K., Ulberth F. Capabilities of laboratories to determine melamine in food-results of an international proficiency test. Anal. Bioanal. Chem. 2010, 396:503-510.
7. Chan M., Lo C.K., Cheng L.S., Cheung T.C., Wong Y.C. Evaluation of testing capabilities for the determination of melamine in milk through an interlaboratory proficiency test programme during the melamine crisis. Food Addit. Contam. Part A-Chem. 2009, 26:1450-1458.
8. Chang H., Shi X.F., Shen W., Wang W., Yue Z.J. Characterization of melamine-associated urinary stones in children with consumption of melamine-contaminated infant formula. Clin. Chim. Acta 2012, 413:985-991.
9. Chen J.S. A worldwide food safety concern in 2008-melamine-contaminated infant formula in China caused urinary tract stone in 290000 children in China. Chin. Med. J. 2009, 122:243-244.
10. Chen J.S. What can we learn from the 2008 melamine crisis in China?. Biomed. Environ. Sci. 2009, 22:109-111.
11. Chu P.W.S., Chan K.M., Cheung S.T.C., Wong Y.C. Review of analytical techniques used in proficiency-testing programs for melamine in animal feed and milk. Trends Anal. Chem. 2010, 29:1014-1026.
12. Codex Alimentarius Commission (CAC), 2010. Joint FAO/WHO Standards Programme. Codex Committee on Contaminants in Foods. Proposed Draft Maximum Levels of Melamine in Food and Feed (March). http://ftp://ftp.fao.org/codex/meetings/CCCF/CCCF4/cf04_05e.pdf.
13. Codex Alimentarius Commission (CAC), 2012. Joint FAO/WHO Standards Programme. Codex Alimentarius Commission 35th Session. July 2012. Report of the Sixth Session of the Codex Committee on Contaminants in Foods (March). http://www.codexalimentarius.net/input/download/report/770/REP12_FHe.pdf.
14. Cremonezzi D.C., Díaz M.P., Valentich M.A., Eynard A.R. Neoplastic and preneoplastic lesions induced by melamine in rat urothelium are modulated by dietary polyunsaturated fatty acids. Food Chem. Toxicol. 2004, 42:1999-2007.
15. Dalal R.P., Goldfarb D.S. Melamine-related kidney stones and renal toxicity. Nat. Rev. Nephrol. 2011, 7:267-274.
16. Desmarchelier A., Cuadra M.G., Delatour T., Mottier P. Simultaneous quantitative determination of melamine and cyanuric acid in cow's milk and milk-based infant formula by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Agric. Food Chem. 2009, 57:7186-7193.
17. Duan H.J., Guan N., Wu Y.N., Zhang J., Ding J., Shao B. Identification of biomarkers for melamine-induced nephrolithiasis in young children based on ultra high performance liquid chromatography coupled to time-of-flight mass spectrometry (U-HPLC-Q-TOF/MS). J. Chromatogr. B 2011, 879:3544-3550.
18. Ehling S., Tefera S., Ho I.P. High-performance liquid chromatographic method for the simultaneous detection of the adulteration of cereal flours with melamine and related triazine by-products ammeline, ammelide, and cyanuric acid. Food Addit. Contam. 2007, 24:1319-1325.
19. FDA, 2008. GC-MS Screen for the Presence of Melamine, Ammeline, Ammelide and Cyanuric Acid. http://www.fda.gov/cvm/GCMSMelamine.htm.
20. Gao J., Xu H., Kuang X.Y., Huang W.Y., Zhao N.Q., Rao J., Qian Q.Y., Cheng X.Y., Feng Z.M., Xu J., Zhang X., Wang X. Follow-up results of children with melamine induced urolithiasis: a prospective observational cohort study. World J. Pediatr. 2011, 7:232-239.
21. Garber E.A.E. Detection of melamine using commercial enzyme-linked immunosorbent assay technology. J. Food Prot. 2008, 71:590-594.
22. General Administration of Quality Supervision, 2008. Inspection and Quarantine of the People's Republic of China. With Regard to the Results of the Special Inspection of the National Infant Milk Formula (16 September). http://www.aqsiq.gov.cn/zjxw/zjxw/zjftpxw/200809/t20080916_89958.htm.
23. Goscinny S., Hanot V., Halbardier J.F., Michelet J.Y., Van Loco J. Rapid analysis of melamine residue in milk, milk products, bakery goods and flour by ultra-performance liquid chromatography/tandem mass spectrometry: from food crisis to accreditation. Food Control 2011, 22:226-230.
24. Guan N., Fan Q.F., Ding J., Zhao Y.M., Lu J.Q., Ai Y., Xu G.B., Zhu S.N., Yao C., Jiang L.N., Miao J., Zhang H., Zhao D., Liu X.Y., Yao Y. Melamine-contaminated powdered formula and urolithiasis in young children. N. Engl. J. Med. 2009, 360:1067-1074.
25. Hard G.C., Flake G.P., Sills R.C. Re-evaluation of kidney histopathology from 13-week toxicity and two-year carcinogenicity studies of melamine in the F344 rat: morphologic evidence of retrograde nephropathy. Vet. Pathol. 2009, 46:1248-1257.
26. He Y., Jiang G.P., Zhao L., Qian J.J., Yang X.Z., Li X.Y., Du L.Z., Shu Q. Ultrasonographic characteristics of urolithiasis in children exposed to melamine-tainted powdered formula. World J. Pediatr. 2009, 5:118-121.
27. Heller D.N., Nochetto C.B. Simultaneous determination and confirmation of melamine and cyanuric acid in animal feed by zwitterionic hydrophilic interaction chromatography and tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2008, 22:3624-3632.
28. Hsieh D.P.H., Chiang C.F., Chiang P.H., Wen C.P. Toxicological analysis points to a lower tolerable daily intake of melamine in food. Regul. Toxicol. Pharmacol. 2009, 55:13-16.
29. Hu P., Lu L., Hu B., Zhang C.R. The size of melamine-induced stones is dependent on the melamine content of the formula fed, but not on duration of exposure. Pediatr. Nephrol. 2010, 25:565-566.
30. Ibáñez M., Sancho J.V., Hernández F. Determination of melamine in milk-based products and other food and beverage products by ion-pair liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta 2009, 649:91-97.
31. International Agency for Research on Cancer (IARC), 2008. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, V73 (17 September). http://monographs.iarc.fr/ENG/Monographs/vol73/mono73-17.pdf.
32. International Organization for Standardization, 2005. ISO/IEC 17025:2005, General Requirement and Operation of Laboratory Proficiency Testing. ISO, Geneva, Switzerland.
33. International Uniform Chemical Information Database (IUCLID), 2000. Datasheet on Melamine (24 September). http://ecb.jrc.ec.europa.eu/esis/.
34. Jacob C.C., Von Tungeln L.S., Vanlandingham M., Beland F.A., da Costa G.G. Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats. Toxicol. Sci. 2012, 126:317-324.
35. Jia X.D., Li N., Wang Z.T., Zhao Y.F., Wu Y.N., Yan W.X. Assessment on dietary melamine exposure from tainted infant formula. Biomed. Environ. Sci. 2009, 22:100-103.
36. Jia B., Ouyang Y.Z., Sodhi R.N.S., Hu B., Zhang T.T., Li J.Q., Chen H.W. Differentiation of human kidney stones induced bymlamine and uric acid using surface desorption atmospheric pressure chemical ionization mass spectrometry. J. Mass Spectrom. 2011, 46:313-319.
37. Koh G., Chia R.S.C., Lin Q., Cheow P.S., Teo T.L., Lee T.K. Determination of melamine in milk powder using gas chromatography-high-resolution isotope dilution mass spectrometry. J. Sep. Sci. 2011, 34:3043-3052.
38. Kong A.P.S., Choi K.C., Ho C.S., Chan M.H.M., Wong C.K., Liu E.K.H., Chu W.C.W., Chow V.C.Y., Lau J.T.F., Chan J.C.N. Hong Kong Chinese school children with elevated urine melamine levels: a prospective follow up study. BMC Public Health 2011, 11:354.
39. Lam C.W., Lan L., Che X.Y., Tam S., Wong S.S.Y., Chen Y., Jin J., Tao S.H., Tang X.M., Yuen K.Y., Tam P.K.H. Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans. Clin. Chim. Acta 2009, 402:150-155.
40. Lau H.Y., Wong C.S., Ma J.K.F., Kan E., Siu K.L. US findings of melamine-related renal disorders in Hong Kong children. Pediatr. Radiol. 2009, 39:1188-1193.
41. Li J., Qi H.Y., Shi Y.P. Determination of melamine residues in milk products by zirconia hollow fiber sorptive microextraction and gas chromatography-mass spectrometry. J. Chromatogr. A 2009, 1216:5467-5471.
42. Li G., Jiang S.F., Yin X.J., Deng Y., Pang X.H., Wang Y. The risk of melamine-induced nephrolithiasis in young children starts at a lower intake level than recommended by the WHO. Pediatr. Nephrol. 2010, 25:135-141.
43. Li M., Zhang L.Y., Meng Z.H., Wang Z.Y., Wu H. Molecularly-imprinted microspheres for selective extraction and determination of melamine in milk and feed using gas chromatography-mass spectrometry. J. Chromatogr. B 2010, 878:2333-2338.
44. Liu G., Li S., Jia J., Yu C., He J., Yu C., Zhu J. Pharmacokinetic study of melamine in rhesus monkey after a single oral administration of a tolerable daily intake dose. Regul. Toxicol. Pharmacol. 2010, 56:193-196.
45. Lutter P., Savoy-Perroud M.C., Campos-Gimenez E., Meyer L., Goldmann T., Bertholet M.C., Mottier P., Desmarchelier A., Monard F., Perrin C., Robert F., Delatour T. Screening and confirmatory methods for the determination of melamine in cow's milk and milk-based powdered infant formula: validation and proficiency-tests of ELISA, HPLC-UV, GC-MS and LC-MS/MS. Food Control 2011, 22:903-913.
46. 14C]melamine in male Fischer 344 rats. Food Chem. Toxicol. 1983, 21:807-810.
47. Melnick R.L., Boorman G.A., Haseman J.K., Montali R.J., Huff J. Urolithiasis and bladder carcinogenicity of melamine in rodents. Toxicol. Appl. Pharmacol. 1984, 72:292-303.
48. Miao H., Fan S., Wu Y.N., Zhang L., Zhou P.P., Li J.G., Chen H.J., Zhao Y.F. Simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography-tandem mass spectrometry. Biomed. Environ. Sci. 2009, 22:87-94.
49. Miao H., Fan S., Zhou P.P., Zhang L., Zhao Y.F., Wu Y.N. Determination of melamine and its analogues in egg by gas chromatography-tandem mass spectrometry using an isotope dilution technique. Food Addit. Contam. Part A-Chem. 2010, 27:1497-1506.
50. Ministry of Health P.R. China, 2009. The Special Topic of Infant Formula Powder Case on Sanlu (24 January). http://www.moh.gov.cn/publicfiles/business/htmlfiles/wsb/pmtxwbd/200901/38923.htm.
51. National Toxicology Program (NTP), 1983. Carcinogenesis Bioassay of Melamine in F344/N Rats and B6C3F1 Mice (Feed Study). NTP Tech. Rep. Ser. No. 245.
52. Ogasawara H., Imaida K., Ishiwata H., Toyoda K., Kawanishi T., Uneyama C., Hayashi S., Takahashi M., Hayashi Y. Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis 1995, 16:2773-2777.
53. Organisation for Economic Co-operation and Development (OECD), 1999. Screening Information Data set for Isocyanuric Acid, CAS No. #108-80-5 (17 September 2008). http://www.chem.unep.ch/irptc/sids/OECDSIDS/108805.pdf.
54. Organisation for Economic Co-operation and Development (OECD), 1998. Screening Information Data Set for Melamine, CAS No. #108-78-1 (17 September 2008). http://www.chem.unep.ch/irptc/sids/OECDSIDS/108781.pdf.
55. Pei X.F., Tandon A., Alldrick A., Giorgi L., Huang W., Yang R.J. The China melamine milk scandal and its implications for food safety regulation. Food Policy 2011, 36:412-420.
56. Shen Y., Liu X.R., Zhang G.J., Zhou N. Blood purification therapy in treatment of acute renal failure in infants with melamine-induced stones. Chin. Med. J. 2009, 122:257-261.
57. Shen Y., Sun Q., Gao J., Jia L.Q., Sun N., Pan Y.S., Liu X.M., Liu X.R., Wang Y., Wu D.X., Jiang Y.P. One year follow up of the outcomes of child patients with melamine-related kidney stones in Beijing and surrounding provinces in China. Nephrology 2011, 16:433-439.
58. Skinner C.G., Thomas J.D., Osterloh J.D. Melamine toxicity. J. Med. Toxicol. 2010, 6:50-55.
59. Sun N., Shen Y., He L.J. Histopathological features of the kidney after acute renal failure from melamine. N. Engl. J. Med. 2010, 362:662-664.
60. Sun Q., Shen Y., Sun N., Zhang G.J., Chen Z., Fan J.F., Jia L.Q., Xiao H.Z., Li X.R., Puschner B. Diagnosis, treatment and follow-up of 25 patients with melamine-induced kidney stones complicated by acute obstructive renal failure in Beijing Children's Hospital. Eur. J. Pediatr. 2010, 169:483-489.
61. Sun X.Z., Shen L.M., Cong X.M., Zhu H.J., Lv J.L., He L. Infrared spectroscopic analysis of urinary stones (including stones induced by melamine-contaminated milk powder) in 189 Chinese children. J. Pediatr. Surg. 2011, 46:723-728.
62. Tittlemier S.A. Methods for the analysis of melamine and related compounds in foods: a review. Food Addit. Contam. Part A-Chem. 2010, 27:129-145.
63. Venkatasami G., Sowa J.R. A rapid, acetonitrile-free, HPLC method for determination of melamine in infant formula. Anal. Chim. Acta 2010, 665:227-230.
64. Wang L., Ding X.M., Zhang K.Y., Bai S.P., Wu C.M. Toxicity of cyanuric acid to broilers on hepatic and renal health with and without melamine. Hum. Exp. Toxicol. 2011, 31:166-173.
65. Wen J.G., Chang Q.L., Lou A.F., Li Z.Z., Lu S., Wang Y., Wang Y.L., Hu J.H., Mao S.P., Zhang Y., Xue R., Ren C.C., Xing L., Zhang G.X., Zhang S.J., Djurhuus J.C., Frøkiaer J. Melamine-related urinary stones in 195 infants and young children: clinical features within 2 years of follow-up. Urol. Int. 2011, 87:429-433.
66. World Health Organization (WHO), 2004. IPCS Risk Assessment Terminology: Internationally Harmonized Terms in Relation to Chemicals. http://www.who.int/entity/ipcs/methods/harmonization/areas/ipcsterminologyparts1and2.pdf.
67. World Health Organization (WHO), 2008a. Melamine and Cyanuric Acid: Toxicity, Preliminary Risk Assessment and Guidance on Levels in Food (25 September 2008). http://www.who.int/foodsafety/fs_management/conclusions_recommendations.pdf.
68. World Health Organization (WHO), 2008b. Expert Meeting to Review Toxicological Aspects of Melamine and Cyanuric Acid, Ottawa, Canada (1-4 December 8, 2008). Executive Summary. http://www.who.int/foodsafety/fs_management/Exec_Summary_melamine.pdf.
69. Wu, Y.N., Zhao, Y.F., Li, J.G., Melamine Analysis Group, 2009. A survey on occurrence of melamine and its analogues in tainted infant formula in China. Biomed. Environ. Sci. 22, 95-99.
70. Xia J.G., Zhou N.Y., Liu Y.J., Chen B., Wu Y.N., Yao S.Z. Simultaneous determination of melamine and related compounds by capillary zone electrophoresis. Food Control 2010, 21:912-918.
71. Xia J.G., Zhou N.Y., Zhou C., Chen B., Wu Y.N., Yao S.Z. Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatography-electrospray mass spectrometry. J. Sep. Sci. 2010, 33:2688-2697.
72. Xie G.X., Zheng X.J., Qi X., Cao Y., Chi Y., Su M.M., Ni Y., Qiu Y.P., Liu Y.M., Li H.K., Zhao A.H., Jia W. Metabonomic evaluation of melamine-induced acute renal toxicity in rats. J. Proteome Res. 2010, 9:125-133.
73. Xin H., Stone R. TAINTED MILK SCANDAL Chinese probe unmasks high-tech adulteration with melamine. Science 2008, 322:1310-1311.
74. Xu X.M., Ren Y.P., Zhu Y., Cai Z.X., Han J.L., Huang B.F., Zhu Y. Direct determination of melamine in dairy products by gas chromatography/mass spectrometry with coupled column separation. Anal. Chim. Acta 2009, 650:39-43.
75. Xu C.F., Gao X.L., Du Y.X., Ren S.T. The rapid establishment and implications of a melamine-induced standardized bladder stone model in mice. Food Chem. Toxicol. 2011, 49:3013-3017.
76. Yan N., Zhou L., Zhu Z.F., Chen X.G. Determination of melamine in dairy products, fish feed, and fish by capillary zone electrophoresis with diode array detection. J. Agric. Food Chem. 2009, 57:807-811.
77. Yang F., Mao Y., Zhang X.D., Ma Z.Q., Zhang X.R. LC-MS/MS method for the determination of melamine in rat plasma: toxicokinetic study in Sprague-Dawley rats. J. Sep. Sci. 2009, 32:2974-2978.
78. Yoon Y.S., Kim D.H., Kim S.K., Song S.B., Uh Y., Jin D., Qi X.F., Teng Y.C., Lee K.J. The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice. Food Chem. Toxicol. 2011, 49:1814-1819.
79. Zhang Q.X., Yang G.Y., Li J.T., Li W.X., Zhang B., Zhu W. Melamine induces sperm DNA damage and abnormality, but not genetic toxicity. Regul. Toxicol. Pharmacol. 2011, 60:144-150.
80. Zhou J.H., Zhao J., Xue X.F., Chen F., Zhang J.Z., Li Y., Wu L.M., Chen L.Z. Determination of melamine in royal jelly and lyophilized powder using ultrasonically assisted extraction by ion-pair HPLC with UV detection. J. Sep. Sci. 2010, 33:167-173.
81. Zhu M.D., Peng T., Xiao L., Li S.J., Chen D.D., Li X.J., Li W.L., Tang Y.Z. Proficiency test of melamine in milk powder. Chin. J. Health Lab. Technol. 2009, 19:1457-1460.