HRD1 levels increased by zonisamide prevented cell death and caspase-3 activation caused by endoplasmic reticulum stress in SH-SY5Y cells

Journal of Molecular Neuroscience

Volumn 46, Issue 3, 2012, Pages 527-535

  Omura, Tomohiro ^a   Asari, Masaru ^a   Yamamoto, Joe ^a   Kamiyama, Naoya ^a   Oka, Kumiko ^a   Hoshina, Chisato ^a   Maseda, Chikatoshi ^a   Awaya, Toshio ^a   Tasaki, Yoshikazu ^a   Shiono, Hiroshi ^a   Shimizu, Keiko ^a   Matsubara, Kazuo ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

6 OHDA; Er stress; ERAD; HRD1; Parkinson's disease; SEL1L

Indexed keywords

CASPASE 3; OXIDOPAMINE; TUNICAMYCIN; UBIQUITIN LIGASE HRD1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ZONISAMIDE;

ARTICLE; CELL DEATH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; PARKINSON DISEASE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; RECEPTOR UPREGULATION;

ANTICONVULSANTS; CASPASE 3; CASPASE INHIBITORS; CELL DEATH; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HUMANS; ISOXAZOLES; NEUROBLASTOMA; UBIQUITIN-PROTEIN LIGASES;

PARKINSONIA;

EID: 84859158190     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9638-8     Document Type: Article

References (38)

1. Asanuma M, Miyazaki I, Diaz-Corrales FJ et al (2010) Neuroprotective effects of zonisamide target astrocyte. Ann Neurol 67:239-249
2. Bouman L, Schlierf A, Lutz AK et al (2011) Parkin istranscriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ 18:769-782
3. Damier P, Hirsch EC, Agid Y, Graybiel AM (1999) The substantia nigra of the human brain. II. Patterns of loss of dopaminecontaining neurons in Parkinson's disease. Brain 122:1437-1448
4. Ding X, Goldberg MS (2009) Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. PLoS One 4:e5949
5. Fonseca SG, Ishigaki S, Oslowski CM et al (2010) Wolfram syndrome 1gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest 120:744-755
6. Gardner RG, Swarbrick GM, Bays NW et al (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151:69-82
7. Gilbert JJ, Kish SJ, Chang LJ, Morito C, Shannak K, Hornykiewicz O (1988) Dementia, parkinsonism, and motor neuron disease: neurochemical and neuropathological correlates. Ann Neurol 24:688-691 (Pubitemid 18262675)
8. Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D (2000) Perk isessential for translational regulation and cell survival during the unfolded protein response. Mol Cell 5:897-904
9. Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425-479 (Pubitemid 28411135)
10. Iida Y, Fujimori T, Okawa K, Nagata K, Wada I, Hosokawa N (2011) SEL1L critically determines the stability of the HRD1-SEL1L ERAD complex to optimize the degradation kinetics of ERAD substrates. J Biol Chem 286:16929-16939
11. Imai Y, Soda M, Takahashi R (2000) Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem 275:35661-35664
12. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (2001) An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105:891-902 (Pubitemid 32635090)
13. Kaneko M, Ishiguro M, Niinuma Y, Uesugi M, Nomura Y (2002) Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. FEBS Lett 532:147-152 (Pubitemid 35375880)
14. Kaneko M, Yasui S, Niinuma Yet al (2007) A different pathway inthe endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes. FEBS Lett 581:5355-5360 (Pubitemid 350101515)
15. Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, Nomura Y (2010) Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. J Neurosci 30:3924-3932
16. Kawajiri S, Machida Y, Saiki S, Sato S, Hattori N (2010) Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. Neurosci Lett 481:88-91
17. Kitada T, Asakawa S, Hattori N et al (1998) Mutations inthe parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605-608 (Pubitemid 28207717)
18. Ko HS, Bailey R, Smith WWet al (2009) CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc Natl Acad Sci USA 106:2897-2902
19. Lawrence AD, Evans AH, Lees AJ (2003) Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry? Lancet Neurol 2:595-604 (Pubitemid 37162568)
20. Lindholm D, Wootz H, Korhonen L (2006) ER stress and neurodegenerative diseases. Cell Death Differ 13:385-392
21. Mei J, Niu C (2010) Alterations of Hrd1 expression in various encephalic regional neurons in 6-OHDA model of Parkinson's disease. Neurosci Lett 474:63-68
22. Mizuno Y, Hattori N, Matsumine H (1998) Neurochemical and neurogenetic correlates of Parkinson's disease. J Neurochem 71:893-902 (Pubitemid 28390243)
23. Murata M, Horiuchi E, Kanazawa I (2001) Zonisamide has beneficial effects on Parkinson's disease patients. Neurosci Res 41:397-399 (Pubitemid 33733759)
24. Murata M, Hasegawa K, Kanazawa I, Japan Zonisamide on PD Study Group (2007) Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study. Neurology 68:45-50 (Pubitemid 46058551)
25. Omura T, Kaneko M, Okuma Y et al (2006) A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J Neurochem 99:1456-1469 (Pubitemid 44924225)
26. Omura T, Kaneko M, Onoguchi M et al (2008a) Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains. J Pharmacol Sci 106:512-519 (Pubitemid 351468605)
27. Omura T, Kaneko M, Tabei N, Okuma Y, Nomura Y (2008b) Immunohistochemical localization of aubiquitin ligase HRD1 in murine brain. J Neurosci Res 86:1577-1587 (Pubitemid 351642451)
28. Saito R, Kaneko M, Okuma Y, Nomura Y (2010) Correlation between decrease inprotein levels of ubiquitin ligase HRD1 and amyloidbeta production. J Pharmacol Sci 113:285-288
29. SatakeW, NakabayashiY, Mizuta I et al (2009) Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet 41:1303-1307
30. Shimura H, Schlossmacher MG, Hattori N et al (2001) Ubiquitination of anew form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science 293:263-269 (Pubitemid 32694735)
31. Simón-Sánchez J, Schulte C, Bras JM et al (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet 41:1308-1312
32. Tiong CX, Lu M, Bian JS (2010) Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathway. Br J Pharmacol 161:467-480
33. Yamada T, Ishihara H, Tamura A et al (2006) WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. Hum Mol Genet 15:1600-1609 (Pubitemid 43904826)
34. Yamamuro A, Yoshioka Y, Ogita K, Maeda S (2006) Involvement of endoplasmic reticulum stress on the cell death induced by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells. Neurochem Res 31:657-664 (Pubitemid 43886413)
35. Yang H, Zhong X, Ballar P et al (2007) Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin. Exp Cell Res 313:538-550 (Pubitemid 46188633)
36. Yoshida H (2007) ER stress and diseases. FEBS J 274:630-658
37. Yoshida H, Matsui T,YamamotoA,Okada T,MoriK(2001) XBP1mRNA isinduced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107:881-891 (Pubitemid 34084979)
38. Zheng N, Wang P, Jeffrey PD, Pavletich NP (2000) Structure of ac-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell 102:533-539