Spontaneous insertion of a B2 element in the Ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans

American Journal of Pathology

Volumn 178, Issue 4, 2011, Pages 1701-1714

  Nesterovitch, Andrew B ^a   Szanto, Sandor ^a   Gonda, Andrea ^a   Bardos, Tamas ^a   Kis Toth, Katalin ^a   Adarichev, Vyacheslav A ^a   Olasz, Katalin ^a   Ghassemi Najad, Sheida ^a   Hoffman, Mark D ^a   Tharp, Michael D ^a   Mikecz, Katalin ^a   Glant, Tibor T ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BIOMOL; CEFAZOLIN; GAMMA INTERFERON; GLIOTOXIN; HYDROCODONE; I KAPPA B ALPHA; I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY IM7; PARACETAMOL; PREDNISONE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SULFAMETHOXAZOLE; TRIMETHOPRIM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE FEBRILE NEUTROPHILIC DERMATOSIS; ADAPTIVE IMMUNITY; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOINFLAMMATORY DISEASE; BLOOD; BONE MARROW; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CHROMOSOME 6; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; EXON; GENE INSERTION; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; GRANULOCYTE PRECURSOR; HISTOPATHOLOGY; INNATE IMMUNITY; LYMPHOCYTE COUNT; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PYODERMA GANGRENOSUM; SKIN DISEASE; SKIN ULCER;

EID: 79953667487     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.12.053     Document Type: Article

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