Papain-induced in vitro disc degeneration model for the study of injectable nucleus pulposus therapy

Spine Journal

Volumn 13, Issue 3, 2013, Pages 273-283

  Chan, Samantha C W ^a   Bürki, Alexander ^a   Bonél, Harald M ^a   Benneker, Lorin M ^a   Gantenbein Ritter, Benjamin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Chemonucleolysis; Disc degeneration; In vitro; Mesenchymal stem cells; Papain

Indexed keywords

GLYCOSAMINOGLYCAN; PAPAIN; PHOSPHATE BUFFERED SALINE; PROTEINASE; TISSUE SCAFFOLD;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MATRIX; CELL ASSAY; CELL LABELING; CELL MEMBRANE; CELL NUCLEUS; CELL SURVIVAL; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; COW; DISEASE MODEL; DISEASE SEVERITY; EXPLANT; FEMALE; FLUORESCENCE ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERVERTEBRAL DISK DEGENERATION; MALE; MESENCHYMAL STEM CELL; MUSCULOSKELETAL STIFFNESS; NERVE ENDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS PULPOSUS; PRIORITY JOURNAL; SIMULATION; STAINING; TISSUE ENGINEERING; TORSION; WATER LOSS;

ANIMALS; CATTLE; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; GLYCOSAMINOGLYCANS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; PAPAIN; SEVERITY OF ILLNESS INDEX; TISSUE ENGINEERING;

EID: 84875521643     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2012.12.007     Document Type: Article

References (69)

1. P.P. Raj Intervertebral disc: anatomy-physiology-pathophysiology- treatment Pain Pract 8 2008 18 44
2. G. Leone, P. Torricelli, and A. Chiumiento Amidic alginate hydrogel for nucleus pulposus replacement J Biomed Mater Res A 84 2008 391 401
3. A. Bertolo, M. Mehr, and N. Aebli Influence of different commercial scaffolds on the in vitro differentiation of human mesenchymal stem cells to nucleus pulposus-like cells Eur Spine J 21 2012 S826 S838
4. E.C. Collin, S. Grad, and D.I. Zeugolis An injectable vehicle for nucleus pulposus cell-based therapy Biomaterials 32 2011 2862 2870
5. M. Alini, S.M. Eisenstein, and K. Ito Are animal models useful for studying human disc disorders/degeneration? Eur Spine J 17 2008 2 19
6. L. Haglund, J. Moir, and L. Beckman Development of a bioreactor for axially loaded intervertebral disc organ culture Tissue Eng Part C Methods 17 2011 1011 1019
7. H. Zhang, F. La Marca, and S.J. Hollister Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture J Neurosurg Spine 10 2009 522 530
8. K.S. Kim, S.T. Yoon, and J. Li Disc degeneration in the rabbit: a biochemical and radiological comparison between four disc injury models Spine 30 2005 33 37
9. K. Singh, K. Masuda, and H.S. An Animal models for human disc degeneration Spine J 5 6 Suppl 2005 267S 279S
10. S.C. Chan, S.J. Ferguson, and B. Gantenbein-Ritter The effects of dynamic loading on the intervertebral disc Eur Spine J 20 2011 1796 1812
11. S. Jünger, B. Gantenbein-Ritter, and P. Lezuo Effect of limited nutrition on in situ intervertebral disc cells under simulated-physiological loading Spine 34 2009 1264 1271
12. R. Felder-Puig, M. Gyimesi, T. Mittermayr, and S. Geiger-Gritsch Chemonucleolysis and intradiscal electrothermal therapy: what is the current evidence? Rofo 181 2009 936 944
13. J.W. Simmons, E.J. Nordby, and A.G. Hadjipavlou Chemonucleolysis: the state of the art Eur Spine J 10 2001 192 202
14. M.D. Brown Update on chemonucleolysis Spine 21 24 Suppl 1996 62S 68S
15. S. Patt, M. Brock, and H.M. Mayer Nucleus pulposus regeneration after chemonucleolysis with chymopapain? Spine 18 1993 227 231
16. A. Hedtmann, H. Fett, R. Steffen, and J. Kramer Chemonucleolysis using chymopapain and collagenase. 3-year results of a prospective randomized study Z Orthop Ihre Grenzgeb 130 1992 36 44
17. G.D. Tregonning, E.E. Transfeldt, and J.A. McCulloch Chymopapain versus conventional surgery for lumbar disc herniation. 10-year results of treatment J Bone Joint Surg Br 73 1991 481 486
18. M.D. Brown, and J.S. Tompkins Pain response post-chemonucleolysis or disc excision Spine 14 1989 321 326
19. A.L. Nachemson, and B. Rydevik Chemonucleolysis for sciatica. A critical review Acta Orthop Scand 59 1988 56 62
20. J.P. Valat, M.C. Eveleigh, and B. Fouquet Chemonucleolysis in the treatment of disk lumbo-radiculalgia. Cooperative study of 333 cases Rev Rhum Mal Osteoartic 53 1986 467 471
21. D.S. Bradford, T.R. Oegema, and K.M. Cooper Chymopapain, chemonucleolysis, and nucleus pulposus regeneration. A biochemical and biomechanical study Spine 9 1984 135 147
22. A. Ejeskar, A. Nachemson, and P. Herberts Surgery versus chemonucleolysis for herniated lumbar discs. A prospective study with random assignment Clin Orthop Relat Res 174 1983 236 242
23. D.S. Bradford, K.M. Cooper, and T.R. Oegema Chymopapain, chemonucleolysis, and nucleus pulposus regeneration J Bone Joint Surg Am 65 1983 1220 1231
24. K. Takegami, H.S. An, and F. Kumano Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis Spine J 5 2005 231 238
25. K. Yamada, S. Tanabe, and H. Ueno Investigation of the short-term effect of chemonucleolysis with chondroitinase ABC J Vet Med Sci 63 2001 521 525
26. M. Sasaki, T. Takahashi, K. Miyahara, and AT. Hirose Effects of chondroitinase ABC on intradiscal pressure in sheep: an in vivo study Spine 26 2001 463 468
27. A. Ono, S. Harata, K. Takagaki, and M. Endo Proteoglycans in the nucleus pulposus of canine intervertebral discs after chondroitinase ABC treatment J Spinal Disord 11 1998 253 260
28. D.S. Lü, Y. Shono, and I. Oda Effects of chondroitinase ABC and chymopapain on spinal motion segment biomechanics. An in vivo biomechanical, radiologic, and histologic canine study Spine 22 1997 1828 1834 discussion 1834-5
29. T. Sugimura, F. Kato, and K. Mimatsu Experimental chemonucleolysis with chondroitinase ABC in monkeys Spine 21 1996 161 165
30. T. Ando, F. Kato, K. Mimatsu, and H. Iwata Effects of chondroitinase ABC on degenerative intervertebral discs Clin Orthop Relat Res 318 1995 214 221
31. T.R. Fry, J.C. Eurell, and A.L. Johnson Radiographic and histologic effects of chondroitinase ABC on normal canine lumbar intervertebral disc Spine 16 1991 816 819
32. F. Kato, H. Iwata, K. Mimatsu, and T. Miura Experimental chemonucleolysis with chondroitinase ABC Clin Orthop Relat Res 253 1990 301 308
33. K. Chiba, K. Masuda, and G.B. Andersson Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain Spine J 7 2007 694 700
34. J. Melrose, T.K. Taylor, and P. Ghosh Intervertebral disc reconstitution after chemonucleolysis with chymopapain is dependent on dosage Spine 21 1996 9 17
35. J.I. Boxberger, J.D. Auerbach, S. Sen, and D.M. Elliott An in vivo model of reduced nucleus pulposus glycosaminoglycan content in the rat lumbar intervertebral disc Spine 33 2008 146 154
36. R.J. Hoogendoorn, M.N. Helder, and R.J. Kroeze Reproducible long-term disc degeneration in a large animal model Spine 33 2008 949 954
37. R.J. Hoogendoorn, P.I. Wuisman, and T.H. Smit Experimental intervertebral disc degeneration induced by chondroitinase ABC in the goat Spine 32 2007 1816 1825
38. Y. Imai, M. Okuma, and H.S. An Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC Spine 32 2007 1197 1205
39. J.P. Norcross, G.E. Lester, P. Weinhold, and L.E. Dahners An in vivo model of degenerative disc disease J Orthop Res 21 2003 183 188
40. S. Roberts, J. Menage, S. Sivan, and J.P. Urban Bovine explant model of degeneration of the intervertebral disc BMC Musculoskelet Disord 9 2008 24
41. W.H. Chen, H.Y. Liu, and W.C. Lo Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma Biomaterials 30 2009 5523 5533
42. B. Jim, T. Steffen, and J. Moir Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential Eur Spine J 20 2011 1244 1254
43. K. Masuda, Y. Aota, and C. Muehleman A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration Spine 30 2005 5 14
44. S.C. Chan, S.J. Ferguson, K. Wuertz, and B. Gantenbein-Ritter Biological response of the intervertebral disc to repetitive short term cyclic torsion Spine 36 2011 2021 2030
45. B. Gantenbein, T. Grünhagen, and C.R. Lee An in vitro organ culturing system for intervertebral disc explants with vertebral endplates: a feasibility study with ovine caudal discs Spine 31 2006 2665 2673
46. S.C. Chan, and B. Gantenbein-Ritter Preparation of intact bovine tail intervertebral discs for organ culture J Vis Exp 60 2012 e3490
47. B. Gantenbein-Ritter, E. Potier, and S. Zeiter Accuracy of three techniques to determine cell viability in 3D tissues or scaffolds Tissue Eng Part C Methods 14 2008 353 358
48. R.W. Farndale, D.J. Buttle, and A.J. Barrett Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue Biochim Biophys Acta 883 1986 173 177
49. A. Watanabe, L.M. Benneker, and C. Boesch Classification of intervertebral disk degeneration with axial T2 mapping AJR Am J Roentgenol 189 2007 936 942
50. S.C.W. Chan, B. Gantenbein-Ritter, and V.Y. Leung Cryopreserved intervertebral disc with injected bone marrow-derived stromal cells: a feasibility study using organ culture Spine J 10 2010 486 496
51. R. Sztrolovics, M. Alini, P.J. Roughley, and J.S. Mort Aggrecan degradation in human intervertebral disc and articular cartilage Biochem J 326 pt 1 1997 235 241
52. P. Goupille, M.I. Jayson, J.P. Valat, and A.J. Freemont Matrix metalloproteinases: the clue to intervertebral disc degeneration? Spine 23 1998 1612 1626
53. S. Roberts, B. Caterson, and J. Menage Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc Spine 25 2000 3005 3013
54. G. Crevensten, A.J. Walsh, and D. Ananthakrishnan Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs Ann Biomed Eng 32 2004 430 434
55. H.E. Gruber, K. Leslie, and J. Ingram Cell-based tissue engineering for the intervertebral disc: in vitro studies of human disc cell gene expression and matrix production within selected cell carriers Spine J 4 2004 44 55
56. H.E. Gruber, and E.N. Hanley Biologic strategies for the therapy of intervertebral disc degeneration Expert Opin Biol Ther 3 2003 1209 1214
57. I.L. Moss, L. Gordon, and K.A. Woodhouse A novel thiol-modified hyaluronan and elastin-like polypetide composite material for tissue engineering of the nucleus pulposus of the intervertebral disc Spine 36 2011 1022 1029
58. S.H. Park, E.S. Gil, and H. Cho Intervertebral disc tissue engineering using biphasic silk composite scaffolds Tissue Eng Part A 18 2011 447 458
59. A.T. Reza, and S.B. Nicoll Characterization of novel photocrosslinked carboxymethylcellulose hydrogels for encapsulation of nucleus pulposus cells Acta Biomater 6 2010 179 186
60. C. Mauth, E. Bono, and S. Haas Cell-seeded polyurethane-fibrin structures-a possible system for intervertebral disc regeneration Eur Cell Mater 18 2009 27 38 discussion 38-9
61. L.J. Nesti, W.J. Li, and R.M. Shanti Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam Tissue Eng Part A 14 2008 1527 1537
62. S.M. Richardson, J.A. Hoyland, and R. Mobasheri Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering J Cell Physiol 222 2010 23 32
63. J. Clouet, C. Vinatier, and C. Merceron The intervertebral disc: from pathophysiology to tissue engineering Joint Bone Spine 76 2009 614 618
64. X. Yang, and X. Li Nucleus pulposus tissue engineering: a brief review Eur Spine J 18 2009 1 9
65. J.V. Stoyanov, B. Gantenbein-Ritter, and A. Bertolo Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells Eur Cell Mater 21 2011 533 547
66. B. Gantenbein-Ritter, L.M. Benneker, M. Alini, and S. Grad Differential response of human bone marrow stromal cells to either TGF-β(1) or rhGDF-5 Eur Spine J 20 2011 962 971
67. C.L. Korecki, J.M. Taboas, R.S. Tuan, and J.C. Iatridis Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype Stem Cell Res Ther 1 2010 18
68. S. Stephan, W.E. Johnson, and S. Roberts The influence of nutrient supply and cell density on the growth and survival of intervertebral disc cells in 3D culture Eur Cell Mater 22 2011 97 108
69. K. Serigano, D. Sakai, and A. Hiyama Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model J Orthop Res 28 2010 1267 1275