Matrix metalloproteinases: The clue to intervertebral disc degeneration?

Spine

Volumn 23, Issue 14, 1998, Pages 1612-1626

  Goupille, Philippe ^a,b   Jayson, Malcom I V ^a   Valat, Jean Pierre ^a   Freemont, Anthony J ^a  

^a Department of Rheumatology ^*

^b SERVICE DE DERMATOLOGIE   (France)

Author keywords

Degeneration; Intervertebral disc; Metalloproteinases

Indexed keywords

COLLAGENASE; CYTOKINE; GROWTH FACTOR; MATRIX METALLOPROTEINASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK DISEASE; PRIORITY JOURNAL; REVIEW;

EXTRACELLULAR MATRIX; HUMANS; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; METALLOENDOPEPTIDASES;

EID: 0032527482     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199807150-00021     Document Type: Review

References (165)

1. Abramson SR, Conner GE, Nagase H, Neuhaus I, Woessner JF. Characterization of rat uterine matrilysin and its cDNA. J Biol Chem 1995;270:16016-22.
2. Adams MA, Hutton WC. Prolapsed intervertebral disc: A hyperflexion injury. Spine 1982;7:184-91.
3. Ahrens D, Koch AE, Pope RM, Stein-Picarella M, Niedbala MJ. Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis. Arthritis Rheum 1996;39:1576-87.
4. Arend WP, Welgus HG, Thompson RC, Eisenberg SP. Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist. J Clin Invest 1990;85: 1694-7.
5. Arend WP. Interleukin-1 receptor antagonist. Adv Immunol 1993;54:167-227.
6. Basset P, Bellocq JP, Wolf C, et al. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature 1990;348:699-704.
7. Bayliss MT, Johnstone B. Biochemistry of the intervertebral disc. In: Jayson MIV, ed. The Lumbar Spine and Back Pain. 4th ed. Edinburgh: Churchill Livingstone, 1992:111-31.
8. Boone TC, Johnson MJ, De Clerck YA, Langley KE. cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases. Proc Natl Acad Sci USA 1990;87:2800-4.
9. Bunning RAD, Crawford A, Richardson HJ, Opdenakker G, Damme JV, Russel RGG. Interleukin 1 preferentially stimulates the production of tissue-type plasminogen activator by human articular chondrocytes. Biochim Biophys Acta 1987; 924:472-82.
10. Cacesse RG, Dijoseph JF, Scotnicki JS, Borella LE, Adam LM. Inhibition of interleukin-1 (IL-1) induced neutral proteases from rabbit articular chondrocytes by WY-46,135 and WY-48,989. Agents Actions 1991;34:223-5.
11. Caron JP, Fernandes JC, Martel-Pelletier J, et al. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Arthritis Rheum 1996;39:1535-44.
12. Cawston TE, Curry VA, Clark IM, Hazleman BL. Identification of a new metalloproteinase inhibitor that forms tight-binding complexes with collagenase. Biochem J 1990;269: 183-7.
13. Cawston TE, Billington C. Metalloproteinases in the rheumatic diseases. J Pathol 1996;180:115-7.
14. Chandrasekhar S, Harvey AK, Dell CP, Ambler SJ, Smith CW. Identification of a novel chemical series that blocks interleukin-1-stimulated metalloprotease activity in chondrocytes. J Pharmacol Exp Ther 1995;273:1519-28.
15. Chedid M, Yoza BK, Brooks JW, Mizel SB. Activation of AP-1 by IL-1 and phorbol esters in T cells. J Immunol 1991; 147:867-73.
16. Chin JR, Murphy G, Werb Z. Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. J Biol Chem 1985;260:12367-76.
17. Chubinskaya S, Huch K, Mikecz K, et al. Neutrophil collagenase expression in cartilage of normal human ankle and knee visualized by in situ hybridization. Trans Orthop Res Soc 1995;20:342.
18. Clark IM, Cawston TE. Fragments of human fibroblast collagenase. Purification and characterization. Biochem J 1989;263:201-6.
19. Clark SD, Kobayashi DK, Welgus HG. Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts. J Clin Invest 1987;80:1280-8.
20. Cole AA, Kuettner KE. MMP-8 (neutrophil collagenase) mRNA and aggrecanase cleavage products are present in normal and osteoarthritic cartilage. Acta Orthop Scand Suppl 1995;66:98-102.
21. Cole TC, Melrose J, Ghosh P. Cysteine proteinase inhibitors of the canine intervertebral disc. Biochim Biophys Acta 1988;952:201-7.
22. Cole TC, Melrose J, Ghosh P. Isolation and characterisation of a neutral proteinase from the canine intervertebral disc. Biochim Biophys Acta 1989;990:254-62.
23. Collier IE, Wilhelm SM, Eisen AZ, et al. H-ras oncogene transformed human bronchial epithelial cells (TBE-1) secrete a single metalloproteinase capable of degrading basement membrane collagen. J Biol Chem 1988;263:6579-87.
24. Collier S, Ghosh P. The role of plasminogen in interleukin-1 mediated cartilage degradation. J Rheumatol 1988;15: 1129-37.
25. Curry VA, Clark IM, Bigg H, Cawston TE. Large inhibitor of metalloproteinase (LIMP) contains tissue inhibitor of metalloproteases (TIMP)-2 bound to 72,000-Mr progelatinase. Biochem J 1992;285:143-7.
26. 2 production by human synovial cells. J Clin Invest 1986;77:645-8.
27. Dean DD, Martel-Pelletier J, Pelletier JP, Howell DS, Woessner JF. Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage. J Clin Invest 1989;84:678-85.
28. Deshmukh K, Kline WG. Characterisation of collagen and its precursors synthesized by rabbit articular cartilage cells in various culture systems. Eur J Biochem 1976;69:117-23.
29. Deyo RA, Tsui-Wu YJ. Descriptive epidemiology of low back pain and its related medical care in the United States. Spine 1987;12:264-8.
30. 1 inhibit cytokine-induced metalloprotease expression in human synovial fibroblasts. Lab Invest 1994;71:270-8.
31. DiMartino MJ, Wolff CE, High W, Crimmin MJ, Galloway WA. Antiinflammatory and chondroprotective activities of a potent metalloproteinase inhibitor. J Cell Biochem 1991; 19(Suppl E):179.
32. DiPasquale G, Cacesse R, Paternak R, Contay J, Hubbs S, Perry K. Proteoglycan- and collagen-degrading enzymes from human interleukin-1 stimulated chondrocytes from several species: Proteoglycanase and collagenase inhibitors as potentially new disease-modifying antiartritis agents (42416). Proc Soc Exp Biol Med 1986;183:262-7.
33. Docherty AJ, Murphy G. The tissue metalloproteinase family and inhibitor TIMP: A study using cDNAs and recombinant proteins. Ann Rheum Dis 1990;49:469-79.
34. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJ. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 1987;6:1899-904.
35. Evans CH, Robbins PD. The interleukin-1 receptor antagonist and its delivery by gene transfer. Receptor 1994;4:9-15.
36. Eyre DR, Muir H. Types I and II collagens in intervertebral disc. Interchanging radical distribution in annulus fibrosus. Biochem J 1976;157:267-70.
37. Eyre DR, Muir H. Quantitative analysis of type I and II collagens in human intervertebral discs at various ages. Biochim Biophys Acta 1977;492:29-42.
38. Eyre DR, Wu JJ, Apone S. A growing family of collagens in articular cartilage: Identification of 5 genetically distinct types. J Rheumatol 1987;14:25-7.
39. Eyre DR. Collagens of the disc. In: Gosh P, ed. The Biology of the Intervertebral Disc. Boca Raton, FL: CRC Press Inc. 1988:171-88.
40. Fessler LI, Duncan KG, Fessler JH, Salo T, Tryggvason K. Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase. J Biol Chem 1984;259: 9783-9.
41. Fosang AJ, Neame PJ, Last K, Hardingham TE, Murphy G, Hamilton JA. The intcrglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases and cathepsin B. J Biol Chem 1992;267:19470-4.
42. Fosang AJ, Last K, Neame PJ, et al. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan. Biochem J 1994; 304:347-51.
43. Freije JMP, Diez-Itza I, Balbin M, et al. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem 1994;269:16766-73.
44. Fujimoto N, Mouri N, Iwata K, Ohuchi E, Okada Y, Hayakawa T. A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies. Clin Chim Acta 1993;221:91-103.
45. Fujita K, Nakagawa T, Hirabayashi K, Nagai Y. Neutral proteinases in human intervertebral disc. Role in degeneration and probable origin. Spine 1993;18:1766-73.
46. Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ. Human fibroblast collagenase. J Biol Chem 1986;261:6600-5.
47. Goldberg GI, Marmer BL, Grant GA, Eisen AZ, Wilhelm S, He C. Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteinase designated TIMP-2. Proc Natl Acad Sci USA 1989;86:8207-11.
48. Golub L, Ramamurthy NS, MacNamara TF, Greenwald RA. Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991;2:297-322.
49. Gordon JL, Drummond AH, Galloway WA. Metalloproteinase inhibitors as therapeutics. Clin Exp Rheumatol 1993; 11(Suppl 8):S91-4.
50. Greenwald RA, Golub LM, Lavietes B, et al. Tetracyclines inhibit human synovial collagenase in vitro and in vivo. J Rheumatol 1987;14:28-32.
51. Grönblad M, Virri J, Tolonen J, Kankare J, Seitsalo S, Karaharju EO. Stromelysin expression in disc herniation cells. International Society for the Study of the Lumbar Spine, Seattle, 1994.
52. Harris ED Jr, Welgus HG, Krane SM. Regulation of the mammalian collagenases. Collagen Relat Res 1984;4: 493-512.
53. Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG. The collagen substrate specificity of human neutrophil collagenase. J Biol Chem 1987;262:1048-52.
54. Hasty KA, Pourmotabbed TF, Goldberg GI, et al. Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J Biol Chem 1990;265: 11421-4.
55. Henderson B, Docherty AJP, Beeley NRA. Design of inhibitors of articular cartilage destruction. Drugs Future 1990; 15:495-508.
56. Herbert CM, Lindberg KA, Jayson MIV, Bailey AJ. Changes in the collagen of the human intervertebral disc during ageing and degenerative disc disease. J Mol Med 1975; 1:79-81.
57. Hibbs MS, Hasty KA, Kang AH, Mainardi CL. Biochemical and immunologic characterization of the secreted forms of human neutrophil gelatinase. J Biol Chem 1984;260: 2493-500.
58. Hirose T, Patterson C, Pourmotabbed T, Mainardi CL, Hasty KA. Structure-function relationship of human neutrophil collagenase: Identification of regions responsible for substrate specificity and general proteinase activity. Proc Natl Acad Sci USA 1993;90:2569-73.
59. Horowitz AL, Hance AJ, Crystal RG. Granulocyte collagenase: Selective digestion of type I relative to type III collagen. Proc Natl Acad Sci USA 1977;74:897-901.
60. Howard EW, Bullen EC, Banda MJ. Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinase-2. J Biol Chem 1991;266:13064-9.
61. Hubbard JR, Steinberg JJ, Bednar MS, Sledge CB. Effect of purified human interleukin-1 on cartilage degradation. J Orthop Res 1988;6:180-7.
62. Huch K, Chubinskaya S, Harris AI, Mikecz K, Kuettner KL, Cole AA. Human osteoarthritic chondrocytes express message for neutrophil collagenase and stromelysin. Trans Orthop Res Soc 1995;20:338.
63. Ito A, Goshowaki H, Sato T, Mori Y, Yamashita K, Hayakawa T. Human recombinant interleukin-1 alpha-mediated stimulation of procollagenase production and suppression of biosynthesis of tissue inhibitor of metalloproteinases in rabbit uterine cervical fibroblasts. FEBS Lett 1988;234:326-30.
64. Jacoby AS, Melrose J, Robinson BG, Hyland VJ, Ghosh P. Secretory leucocyte proteinase inhibitor is produced by human articular cartilage chondrocytes and intervertebral disc fibrochondrocytes. Eur J Biochem 1993;218:951-7.
65. Jayson MIV, Herbert CM, Barks JS. Intervertebral discs: Nuclear morphology and bursting pressures. Ann Rheum Dis 1973;32:308-15.
66. Johnson WH, Roberts NA, Borkakoti N. Collagenase inhibitors: Their design and potential therapeutic use. J Enzyme Inhib 1987;2:1-22.
67. Kääpä E, Wei W, Ervasti-Koivisto H, Konttinen Y, Poussa M, Vanharanta H. Collagen chemistry in normal and degenerate human annulus fibrosus. International Society for the Study of the Lumbar Spine, Seattle, 1994.
68. Kääpä E, Han X, Holm S, Peltonen J, Takala T, Vanharanta H. Collagen synthesis and types I, III, IV and VI collagens in an animal model of disc degeneration. Spine 1995;20: 59-67.
69. Kandel RA, Petelycky M, Dinarello CA, Minden M, Pritzker KPH, Cruz TF. Comparison of the effect of interleukin 6 and interleukin 1 on collagenase and proteoglycan production by chondrocytes. J Rheumatol 1990;17:953-7.
70. Kanemoto M, Hukuda S, Komiya Y, Katsuura A, Nishioka J. Immunohistochemical study of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in human intervertebral discs. Spine 1996;21:1-8.
71. 2. Spine 1996;21:271-7.
72. Khokher MA, Crock HV, Brown MF, Shiraishi T, Batten JJ, Hughes SPF. Measurement of proliferative and degradative activity of chondrocytes and osteoblasts isolated from the endplate of patients with disc disease. International Society for the Study of the Lumbar Spine, Seattle, 1994.
73. Knäuper V, Wilhelm SM, Seperack PK, et al. Direct evaluation of human neutrophil procollagenase by recombinant stromelysin. Biochem J 1993;295:581-6.
74. Knauper V, Osthues A, DeClerck YA, Langley KE, Bläser T, Tschesche H. Fragmentation of human polymorphonuclearleucocyte collagenase. Biochem J 1993;291:847-54.
75. Knäuper V, Lopez-Otin C, Smith B, Knight G, Murphy G. Biochemical characterization of human collagenase-3. J Biol Chem 1996;271:1544-50.
76. Knight JA, Stephens RW, Bushell GR, Ghosh P, Taylor TKF. Neutral protease inhibitors from human intervertebral disc and femoral head articular cartilage. Biochem Biophys Acta 1979;584:304-10.
77. Kolkenbrock H, Orgel D, Hecker-Kia A, Noack W, Ulbrich N. The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor. Eur J Biochem 1991;198:775-81.
78. Laiho M, Keski-Oja J. Growth factors in the regulation of pericellular proteolysis: A review. Cancer Res 1989;49: 2533-53.
79. Lee E, Vaughan DE, Parikh SH, et al. Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells. Circ Res 1996;78:44-9.
80. Lefebvre V, Peeters-Joris C, Vaes G. Modulation by interleukin 1 and tumor necrosis factor alpha of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes. Biochim Biophys Acta 1990;1052:366-78.
81. Liu J, Roughley PJ, Mort JS. Identification of human intervertebral disc stromelysin and its involvement in matrix degradation. J Orthop Res 1991;9:568-75.
82. Lotz M, Guerne PA. Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/Erythroid potentiating activity (TIMP-1/EPA). J Biol Chem 1991;266:2017-20.
83. MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson NI. Discoordinate expression of stromelysin, collagenase, and TIMP-1 in rheumatoid human synovial fibroblasts: Synergistic effects of interleukin-1 and tumor necrosis factor-α on stromelysin expression. J Biol Chem 1990;265:17238-45.
84. Mainardi CL, Pourmotabbed TF, Hasty KA. Inflammatory phagocytes and connective tissue degrading metalloproteinases. Am J Med Sci 1991;302:171-5.
85. Maroudas A, Stockwell RA, Nachemson A, Urban J. Factors involved in the nutrition of the human intervertebral disc: Cellularity and diffusion of glucose in vitro. J Anat 1975;120: 113-30.
86. Martel-Pelletier J, Pelletier JP, Cloutier JM, Howell DS, Ghandur-Mnaymneh L, Woessner JF. Neutral proteases capable of proteoglycan digesting activity in osteoarthritic and normal human articular cartilage. Arthritis Rheum 1984;27: 305-12.
87. Martel-Pelletier J, Cloutier JM, Howell DS, Pelletier JP. Human rheumatoid arthritic cartilage and its neutral proteoglycan-degrading proteases. The effects of antirheumatic drugs. Arthritis Rheum 1985;28:405-12.
88. Martel-Pelletier J, Zafarullah M, Kodama S, Pelletier JP. In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage. J Rheumatol 1991;18:80-4.
89. Martel-Pelletier J, McCollum R, DiBattista J, Faure MP, Chin JA, Fournier S. The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 1992;35:530-40.
90. Martel-Pelletier J, McCollum R, Fujimoto N, Obata K, Cloutier JM, Pelletier JP. Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. Lab Invest 1994;70:807-15.
91. Matrisian LM. Metalloproteinases and their inhibitor in matrix remodeling. Trends Genet 1990;6:121-5.
92. Meachim G, Cornah MS. Fine structure of juvenile human nucleus pulposus. J Anat 1970;107:337-50.
93. Melrose J, Ghosh P. Low molecular weight serine proteinase inhibitors of the human intervertebral disc. Biochem Int 1987;15:117-25.
94. Melrose J, Ghosh P, Taylor TK. Neutral proteinases of the intervertebral disc. Biochim Biophys Acta 1987;923:483-95.
95. Melrose J, Ghosh P, Tailor TK, Andrews JL. The serine proteinase inhibitory proteins of the human intervertebral disc: Their isolation, characterization and variation with ageing and degeneration. Matrix 1992;12:456-70.
96. Mignon C, Okada A, Mattei MG, Basset P. Assignment of the human membrano-type matrix metalloproteinase (MMP 14) gene to 14q11-q12 by in situ hybridization. Genomics 1995;28:360-1.
97. Mitchell PG, Magna HA, Reeves LM, et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996;97:761-8.
98. Mohtai M, Smith RL, Schuman DJ, et al. Expression of 92-kd type IV collagenase-gelatinase (gelatinase b) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1. J Clin Invest 1993;92:179-85.
99. Mort JS, Dodge GR, Roughley PJ, et al. Direct evidence for active metalloproteinases mediating matrix degradation in interleukin-1-stimulated human articular cartilage. Matrix 1993;13:95-102.
100. Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R. The collagenase gene family in human consists of at least four members. Biochem J 1988;253: 187-92.
101. Murphy G, Reynolds JJ, Werb Z. Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. J Biol Chem 1985;260:3079-83.
102. Murphy G, Cockett MI, Stephens PE, Smith BJ, Docherty AJP. Stromelysin is an activator of procollagenase: A study with natural and recombinant enzymes. Biochem J 1987;248: 265-8.
103. Murphy GJP, Murphy G, Reynolds JJ. The origin of matrix metalloproteinases and their family relationships. FEBS Lett 1991;289:4-7.
104. Murphy G, Cockett MI, Ward RV, Docherty AJP. Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP). Biochem J 1991;277:277-9.
105. Murphy G, Allan JA, Willenbrock F, Cockett MI, O'Connel JP, Docherty AJP. The role of the C-terminal domain in collagenase and stromelysin specificity. J Biol Chem 1992; 267:9612-8.
106. Nagano T, Yonenobu K, Miyamoto S, Tohyama M, Ono K. Distribution of the basic fibroblast growth factor and its receptor gene expression in normal and degenerated rat intervertebral disc. Spine 1995;20:1972-8.
107. Nagase H, Ogata Y, Suzuki K, Enghild JJ, Salvesen G. Substrate specificities and activation mechanisms of matrix metalloproteinases. Biochem Soc Trans 1991;19:715-8.
108. Nemoto H, Yamagishi M, Kikuchi T, Ozeki Y, Shinmei M. Effect of IL-1 and IL-6 on MMP-3 and TIMP-1 production in human degenerated disc tissue. Rinsho Seikei Geka 1994;29: 369-76.
109. Ng SCS, Weiss JB, Quennel R, Jayson MIV. Abnormal connective tissue degrading enzyme patterns in prolapsed intervertebral discs. Spine 1986;11:695-701.
110. Ogata Y, Enghild JJ, Nagase H. Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. J Biol Chem 1992;267:3581-4.
111. Okada Y, Nagase H, Harris ED. A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components: Purification and characterization. J Biol Chem 1986;261:14245-55.
112. Okada Y, Watanabe S, Nakanishi I, et al. Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases. FEBS Lett 1988;29:157-60.
113. Okada Y, Morodomi T, Enghild JJ, Suzuki K, Yasui A, Nakanishi I. Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. Eur J Biochem 1990;194: 721-30.
114. Overall CM, Wrana JL, Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 1989;264:1860-9.
115. Pavloff N, Staskus PW, Kishnani NS, Hawkes SP. A new inhibitor of metalloproteinases from chicken: CHIMP-3 a third member of the TIMP family. Proc Nad Acad Sci USA 1992; 267:17321-6.
116. Pearce RH, Mathieson JM, Mort JS, Roughley PJ. The effect of age on abundance and fragmentation of link protein of the human intervertebral disc. J Orthop Res 1989;7:861-7.
117. Pelletier JP, Martel-Pelletier J, Howell DS, Ghandur-Mnaymneh L, Enis JE, Woessner JF. Collagenase and collagenolytic activity in human osteoarthritic cartilage. Arthritis Rheum 1983;26:63-8.
118. Pelletier JP, Mineau F, Faure MP, Martel-Pelletier J. Imbalance between the mechanisms of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritis. Arthritis Rheum 1990;33:1466-76.
119. Pendas AM, Knauper V, Puente XS, et al. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. J Biol Chem 1997;272:4281-6.
120. Pritzker KPH. Aging and degeneration in the lumbar intervertebral disc. Orthop Clin North Am 1977;8:65-77.
121. Quantin B, Murphy G, Breathnach R. Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members. Biochemistry 1989;28: 5327-34.
122. Ratcliffe A, Tyler JA, Hardingham TE. Articular cartilage cultured with interleukin 1: Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments. Biochem J 1986;238:571-80.
123. Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier J. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes: A role in osteoarthritis. J Clin Invest 1996;97:2011-19.
124. Roaf R. A study of the mechanical spinal injuries. J Bone Joint Surg [Br] 1960;42:810-5.
125. Roberts S, Menage J, Duance V, Wotton S, Ayad S. Collagen types around the cells of the intervertebral disc and cartilage end plate: An immunolocalization study. Spine 1991;16: 1030-8.
126. Saksela O, Rifkin DB. Cell-associated plasminogen activation. Regulation and physiological functions. Annu Rev Cell Biol 1988;4:93-126.
127. Sanchez-Lopez R, Nicholson R, Gesnel MC, Matrisian LM, Breathnach R. Structure-function relationships in the collagenase family member transin. J Biol Chem 1988;263: 11892-9.
128. Sanchez-Lopez R, Alexander CM, Behrendtsen O, Breathnach R, Werb Z. Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins. J Biol Chem 1993;268:7238-47.
129. Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 1994;370:61-5.
130. Schnyder J, Payne T, Dinarello CA. Human monocyte or recombinant interleukin 1 are specific for the secretion of a metalloproteinase from chondrocytes. J Immunol 1987;138:496-503.
131. Sedowofia KA, Tomlinson IW, Weiss JB, Hilton RC, Jayson MIV. Collagenolytic enzyme systems in human intervertebral disc. Their control, mechanism, and their possible role in the initiation of biochemical failure. Spine 1982;7:213-22.
132. Sellers A, Woessner JF. The extraction of a neutral metalloproteinase from the involuting rat uterus, and its action on cartilage proteoglycan. Biochem J 1980;189:521-31.
133. Senior RM, Griffin GL, Fliszar CJ, Shapiro SD, Goldberg GI, Welgus HG. Human 92- and 72-kilodalton type IV collagenases are elastases. J Biol Chem 1991;266:7870-5.
134. Shapiro SD, Griffin GL, Gilbert DJ, et al. Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. J Biol Chem 1992;267: 4664-71.
135. Shapiro SD, Kobayashi DK, Ley TJ. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J Biol Chem 1993;268: 23824-9.
136. Shapiro SD, Fliszar CJ, Broekelmann TJ, Mecham RP, Senior RM, Welgus HG. Activation of the 92-kDa gelatinase by stromelysin and 4-aminophenylmercuric acetate. Differential processing and stabilization of the carboxyl-terminal domain by tissue inhibitor of metalloproteinases (TIMP). J Biol Chem 1995;270:6351-6.
137. Shinmei M, Kikuchi T, Yamagishi M, Shimomura Y. The role of interleukin-1 on proteoglycan metabolism of rabbit anulus fibrosus cells cultured in vitro. Spine 1988;13:1284-90.
138. Smith FP. Experimental biomechanics of intervertebral disc rupture through a vertebral body. J Neurosurg 1969;30:134-9.
139. Smith RJ, Chin JE, Sam LM, Justen JM. Biologic effects of an interleukin-1 receptor antagonist protein on interleukin-1 stimulated cartilage erosion and chondrocytes responsiveness. Arthritis Rheum 1991;34:78-83.
140. Springman EB, Angleton EL, Birkedal-Hansen H, Van Wart HE. Multiples modes of activation of latent human fibroblast collagenase: Evidence for the role of a Cys 73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation. Proc Natl Acad Sci USA 1990;87:364-8.
141. Stetler-Stevenson WG, Krutzsch HC, Liotta LA. Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. J Biol Chem 1989;264: 17374-8.
142. Stetler-Stevenson WG, Brown PD, Onisto M, Levy AT, Liotta LA. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. J Biol Chem 1990;265:13933-8.
143. Suzuki K, Enghild JJ, Morodomi T, Salvesen G, Nagase H. Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry 1990;29: 10261-70.
144. Takahashi H, Suguro T, Okazima Y, Motegi M, Okada Y, Kakiuchi T. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine 1996;21:218-24.
145. Tengblad A, Pearce RH, Grimmer BJ. Demonstration of link protein in proteoglycan aggregates from human intervertebral disc. Biochem J 1984;222:85-92.
146. Unemori EN, Werb Z. Collagenase expression and endogenous activation in rabbit synovial fibroblasts stimulated by the calcium ionophore A23187. J Biol Chem 1988;263:16252-9.
147. Van der Rest M, Garrone R. Collagen family of proteins. FASEB J 1991;5:2814-23.
148. Van Wart HE, Birkedal-Hansen H. The cysteine switch: A principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl Acad Sci USA 1990;87:5578-82.
149. Vincenti MP, Clark IM, Brinckerhoff CE. Using inhibitors of metalloproteinases to treat arthritis. Arthritis Rheum 1994; 37:1115-26.
150. Von der Mark H, Von der Mark K, Gay S. Study of differential collagen synthesis during development of the chick embryo by immunofluorescence. Dev Biol 1976;8:237-49.
151. Welgus HG, Jeffrey JJ, Eisen AZ. The collagen substrate specificity of human skin fibroblast collagenase. J Biol Chem 1981;256:9511-5.
152. Welgus HG, Kobayashi DK, Jeffrey JJ. The collagen substrate specificity of rat uterus collagenase. J Biol Chem 1983; 258:14162-5.
153. Welgus HG, Jeffrey JJ, Eisen AZ, Roswit WT, Stricklin GP. Human skin fibroblast collagenase: Interaction with substrate and inhibitor. Collagen Relat Res 1985;5:167-79.
154. Werb Z, Mainardi CL, Vater CA, Harris ED. Endogenous activation of latent collagenase by rheumatoid synovial cells. N Engl J Med 1977;296:1017-23.
155. Whitham SE, Murphy G, Angei P, et al. Comparisons of human stromelysin and collagenase by cloning and sequence analysis. Biochem J 1986;240:913-6.
156. Wilhelm SM, Collier IE, Kronberger A, et al. Human skin fibroblast stromelysin: Structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells. Proc Natl Acad Sci USA 1987;84:6725-9.
157. Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI. SV-40 transformed human lung fibroblasts secrete a 92-kda type IV collagenase which is identical to that secreted by normal human macrophages. J Biol Chem 1989; 264:17213-21.
158. Woessner JF. Separation of collagenase and a metal-dependent endopeptidase of rat uterus that hydrolyses a heptapeptide related to collagen. Biochim Biophys Acta 1979;571: 313-20.
159. Woessner JF. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991;5: 2145-54.
160. Wu JJ, Lark MW, Chun LE, Eyre DR. Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage. J Biol Chem 1991;266:5625-8.
161. Wu JJ, Eyre DR. Identification of hydroxypyridinium cross-linking sites in type II collagen of bovine articular cartilage. Biochemistry 1984;123:1033-9.
162. Yamada H, Stephens RW, Nakagawa T, McNicol D. Human articular cartilage contains an inhibitor of plasminogen activator. J Rheumatol 1988;15:1138-43.
163. Yamagishi M, Nemoto H, Kikuchi T, Shinmei M. Ruptured human disc tissues produce matrix metalloproteinase-3 and interleukin-1. Trans Orthop Res Soc 1992;16:438.
164. Yu LP, Smith GN, Brandt KD, Myers SL, O'Connor BL, Brandt DA. Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthritis Rheum 1992;35:1150-9.
165. Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP. Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte. FEBS Lett 1992;306:169-72.