Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain

Spine Journal

Volumn 7, Issue 6, 2007, Pages 694-700

  Chiba, Kazuhiro ^a   Masuda, Koichi ^a   Andersson, Gunnar B J ^a   Momohara, Shigeki ^a   Thonar, Eugene J ^a  

^a RUSH MEDICAL COLLEGE   (United States)

Author keywords

Alginate beads; Anulus fibrosus; Chondroitinase ABC; Chymopapain; Collagen; Intervertebral disc; Nucleus pulposus; Proteoglycan

Indexed keywords

ALGINIC ACID; CHONDROITIN ABC LYASE; CHYMOPAPAIN; COLLAGEN; DNA; PROTEOGLYCAN;

ANIMAL CELL; ANIMAL CELL CULTURE; CHEMONUCLEOLYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; EXTRACELLULAR MATRIX; IN VITRO STUDY; INTERVERTEBRAL DISK; MONITORING; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; RABBIT; REVIEW;

ALGINATES; ANIMALS; CELLS, CULTURED; CHONDROITIN ABC LYASE; CHYMOPAPAIN; COLLAGEN; DNA; EXTRACELLULAR MATRIX; GLUCURONIC ACID; HEXURONIC ACIDS; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK CHEMOLYSIS; MICROSPHERES; PROTEOGLYCANS; RABBITS; REGENERATION; SULFATES;

EID: 35848950742     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2006.09.005     Document Type: Review

References (46)

1. Atlas S.J., Deyo R.A., Keller R.B., et al. The Maine lumbar spine study, part ii. 1-year outcomes of surgical and nonsurgical management of sciatica. Spine 21 (1996) 1777-1786
2. Fisher C., Noonan V., Bishop P., et al. Outcome evaluation of the operative management of lumbar disc herniation causing sciatica. J Neurosurg 100 (2004) 317-324
3. Lu W.W., Luk K.D., Ruan D.K., Fei Z.Q., and Leong J.C. Stability of the whole lumbar spine after multilevel fenestration and discectomy. Spine 24 (1999) 1277-1282
4. Brown M.D. Intradiscal therapy: chymopapain or collagenase (1983), Year Book Medical Publisher, Chicago
5. Smith L., Garvin P.J., Gesler R.M., and Jennings R.B. Enzyme dissolution of the nucleus pulposus. Nature 198 (1963) 1311-1312
6. Smith L. Enzyme dissolution of the nucleus pulposus in humans. JAMA 187 (1964) 137-140
7. Eguro H. Transverse myelitis following chemonucleolysis. Report of a case. J Bone Joint Surg Am 65 (1983) 1328-1330
8. Hall B.B., and McCulloch J.A. Anaphylactic reactions following the intradiscal injection of chymopapain under local anesthesia. J Bone Joint Surg Am 65 (1983) 1215-1219
9. Smith S., Leibrock L.G., Gelber B.R., and Pierson E.W. Acute herniated nucleus pulposus with cauda equina compression syndrome following chemonucleolysis. Report of three cases. J Neurosurg 66 (1987) 614-617
10. Weitz E.M. Paraplegia following chymopapain injection. A case report. J Bone Joint Surg Am 66 (1984) 1131-1135
11. Watts C. Complications of chemonucleolysis for lumbar disc disease. Neurosurgery 1 (1977) 2-5
12. Tsuchida T. A pathological study of experimental chemonucleolysis with collagenase. J Orthop Sci 61 (1987) 1237-1249
13. Mayne R., and Brewton R.G. Extracellular matrix of cartilage collagen. In: Woessner J.F., and Howell D.S. (Eds). Joint cartilage degradation basic and clinical aspects (1993), Marcel Dekker, New York 81-108
14. Artigas J., Brock M., and Mayer H.M. Complications following chemonucleolysis with collagenase. J Neurosurg 61 (1984) 679-685
15. Garvin P.J. Toxicity of collagenase: The relation to enzyme therapy of disk herniation. Clin Orthop 101 (1974) 286-291
16. Olmarker K., Rydevik B., Dahlin L.B., Danielsen N., and Nordborg C. Effects of epidural and intrathecal application of collagenase in the lumbar spine: an experimental study in rabbits. Spine 12 (1987) 477-482
17. Rydevik B., Brown M.D., Ehira T., and Nordberg C. Effects of collagenase on nerve tissue: an experimental study on acute and long-term effects in rabbits. Spine 10 (1985) 562-566
18. Ando T., Kato F., Mimatsu K., and Iwata H. Effects of chondroitinase abc on degenerative intervertebral discs. Clin Orthop (1995) 214-221
19. Eurell J.A.C., Brown M.D., and Ramos M. The effects of chondroitinase abc on the rabbit intervertebral disc. A roentgenographic and histological study. Clin Orthop 256 (1990) 238-243
20. Fry T.R., Eurell J.C., Johnson A.L., Brown M.D., Losonsky J.M., and Schaeffer D.J. Radiographic and histologic effects of chondroitinase abc on normal canine lumbar intervertebral disc. Spine 16 (1991) 816-819
21. Henderson N., Stanescu V., and Cauchoix J. Nucleolysis of the rabbit intervertebral disc using chondroitinase abc. Spine 16 (1991) 203-208
22. Kato F., Iwata H., Mimatsu K., and Miura T. Experimental chemonucleolysis with chondroitinase abc. Clin Orthop 253 (1990) 301-308
23. Kato F., Mimatsu K., Iwata H., and Miura T. Comparison of tissue reaction with chondroitinase abc and chymopapain in rabbits as the basis of clinical application in chemonucleolysis. Clin Orthop 288 (1993) 294-302
24. Olmarker K., Danielsen N., Nannmark U., Sennerby L., and Rydevik B. Microvascular effects of chondroitinase abc and chymopapain. An in vivo experimental study on hamsters and rabbits. Clin Orthop 257 (1990) 274-279
25. Olmarker K., Danielsen N., Nordborg C., and Rydevik B. Effects of chondroitinase abc on intrathecal and peripheral nerve tissue. An in vivo experimental study on rabbits. Spine 16 (1991) 43-45
26. Olmarker K., Stromberg J., Blomquist J., et al. Chondroitinase abc (pharmaceutical grade) for chemonucleolysis. Functional and structural evaluation after local application on intraspinal nerve structures and blood vessels. Spine 21 (1996) 1952-1956
27. Park J.S., and Ahn J.I. The effect of chondroitinase ABC on rabbit intervertebral disc. Radiological, histological and electron microscopic findings. Int Orthop 19 (1995) 103-109
28. Sugimura T., Kato F., Mimatsu K., Takenaka O., and Iwata H. Experimental chemonucleolysis with chondroitinase abc in monkeys. Spine 21 (1996) 161-165
29. Takahashi T., Kurihara H., Nakajima S., et al. Chemonucleolytic effects of chondroitinase abc on normal rabbit intervertebral discs. Course of action up to 10 days postinjection and minimum effective dose. Spine 21 (1996) 2405-2411
30. Suguro T., Oegema Jr. T.R., and Bradford D.S. Ultrastructural study of the short-term effects of chymopapain on the intervertebral disc. J Orthop Res 4 (1986) 281-287
31. Bradford D.S., Oegema T.J., Cooper K.M., Wakano K., and Chao E.Y. Chymopapain, chemonucleolysis, and nucleus pulposus regeneration. A biochemical and biomechanical study. Spine 9 (1984) 135-147
32. Chiba K., Andersson G.B.J., Masuda K., and Thonar E.J.-M.A. Metabolism of the extracellular matrix formed by intervertebral disc cells cultured in alginate. Spine 22 (1997) 2885-2893
33. Maldonado B.A., and Oegema T.J. Initial characterization of the metabolism of intervertebral disc cells encapsulated in microspheres. J Orthop Res 10 (1992) 677-690
34. Mok S.S., Masuda K., Hauselmann H.J., Aydelotte M.B., and Thonar E.J. Aggrecan synthesized by mature bovine chondrocytes suspended in alginate. Identification of two distinct metabolic matrix pools. J Biol Chem 269 (1994) 33021-33027
35. Hamai A., Hashimoto N., Mochizuki H., et al. Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides. J Biol Chem 272 (1997) 9123-9130
36. Hauselmann H.J., Aydelotte M.B., Schumacher B.L., Kuettner K.E., Gitelis S.H., and Thonar E.J. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads. Matrix 12 (1992) 116-129
37. Kim Y.J., Sah R.L., Doong J.Y., and Grodzinsky A.J. Fluorometric assay of DNA in cartilage explants using hoechst 33258. Anal Biochem 174 (1988) 168-176
38. Chandrasekhar S., Esterman M.A., and Hoffman H.A. Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Anal Biochem 161 (1987) 103-108
39. Petit B., Masuda K., D'Souza A.L., et al. Characterization of crosslinked collagens synthesized by mature articular chondrocytes cultured in alginate beads: Comparison of two distinct matrix compartments. Exp Cell Res 225 (1996) 151-161
40. Masuda K., Shirota H., and Thonar E.J. Quantification of 35s-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates. Anal Biochem 217 (1994) 167-175
41. Chiba K., Andersson G.B., Masuda K., Momohara S., Williams J.M., and Thonar E.J. A new culture system to study the metabolism of the intervertebral disc in vitro. Spine 23 (1998) 1821-1827
42. Takegami K., Thonar E.J., An H.S., Kamada H., and Masuda K. Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1. Spine 27 (2002) 1318-1325
43. Takegami K., An H.S., Kumano F., et al. Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis. Spine J 5 (2005) 231-238
44. Gruber H.E., and Hanley Jr. E.N. Human disc cells in monolayer vs 3d culture: cell shape, division and matrix formation. BMC Musculoskelet Disord 1 (2000) 1
45. Gruber H.E., Leslie K., Ingram J., Norton H.J., and Hanley E.N. Cell-based tissue engineering for the intervertebral disc: in vitro studies of human disc cell gene expression and matrix production within selected cell carriers. Spine J 4 (2004) 44-55
46. Horner H.A., Roberts S., Bielby R.C., Menage J., Evans H., and Urban J.P. Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype. Spine 27 (2002) 1018-1028