Reproducible long-term disc degeneration in a large animal model

Spine

Volumn 33, Issue 9, 2008, Pages 949-954

  Hoogendoorn, Roel J W ^a,b   Helder, Marco N ^a,b   Kroeze, Robert Jan ^a,b   Bank, Ruud A ^b,c   Smit, Theo H ^a,b   Wuisman, Paul I J M ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Skeletal Tissue Engineering Group Amsterdam   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Animal model; Goat; Intervertebral disc degeneration; Long term; Reproducible

Indexed keywords

CHONDROITIN ABC LYASE; GLYCOSAMINOGLYCAN; HYDROXYPROLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; DISEASE SEVERITY; FEMALE; GOAT; HISTOLOGY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RADIOGRAPHY; ANIMAL; CHEMICALLY INDUCED DISORDER; CHRONIC DISEASE; DISEASE MODEL; HOSPITALIZATION; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; OSTEOPHYTE; PATHOLOGY; REPRODUCIBILITY; SPINE DISEASE; TIME;

ANIMALS; CHONDROITIN ABC LYASE; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FEMALE; GLYCOSAMINOGLYCANS; GOATS; HYDROXYPROLINE; INJECTIONS, SPINAL; INTERVERTEBRAL DISK; MAGNETIC RESONANCE IMAGING; OSTEOPHYTE; REPRODUCIBILITY OF RESULTS; SEVERITY OF ILLNESS INDEX; SPINAL DISEASES; TIME FACTORS;

EID: 42449117238     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31816c90f0     Document Type: Article

References (33)

1. Lotz JC. Animal models of intervertebral disc degeneration: lessons learned. Spine 2004;29:2742-50.
2. Singh K, Masuda K, An HS. Animal models for human disc degeneration. Spine J 2005;5:S267S-S2679.
3. Urban JP, Holm S, Maroudas A. Diffusion of small solutes into the intervertebral disc: as in vivo study. Biorheology 1978;15:203-21.
4. Urban JP, Smith S, Fairbank JC. Nutrition of the intervertebral disc. Spine 2004;29:2700-9.
5. Peacock A. Observations on the prenatal development of the intervertebral disc in man. J Anat 1951;85:260-74.
6. Peacock A. Observations on the postnatal structure of the intervertebral disc in man. J Anat 1952;86:162-79.
7. Hunter CJ, Matyas JR, Duncan NA. Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison. J Anat 2004;205:357-62.
8. Aguiar DJ, Johnson SL, Oegema TR. Notochordal cells interact with nucleus pulposus cells: regulation of proteoglycan synthesis. Exp Cell Res 1999;246:129-37.
9. Erwin WM, Inman RD. Notochord cells regulate intervertebral disc chondrocyte proteoglycan production and cell proliferation. Spine 2006;31:1094-9.
10. Hunter CJ, Matyas JR, Duncan NA. The three-dimensional architecture of the notochordal nucleus pulposus: novel observations on cell structures in the canine intervertebral disc. J Anat 2003;202:279-91.
11. Krijnen MR, Mensch D, van Dieen JH, et al. Primary spinal segment stability with a stand-alone cage: in vitro evaluation of a successful goat model. Acta Orthop 2006;77:454-61.
12. Smit TH. The use of a quadruped as an in vivo model for the study of the spine - biomechanical considerations. Eur Spine J 2002;11:137-44.
13. Smit TH, van Dijk M, Arnoe MF, et al. The mechanics of absorbable spinal cages perforating the endplates: an in vitro study. Trans Orthop Res Soc 2000;349.
14. Hoogendoorn RJ, Helder MN, Smit TH, et al. Notochordal cells in mature caprine intervertebral discs. Eur Cells Mater 2005;10:59.
15. Hoogendoorn RJ, Wuisman P, Smit TH, et al. Experimental intervertebral disc degeneration induced by chondroitinase ABC in the Goat. Spine 2007;32:1816-25.
16. Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine 1995;20:1307-14.
17. Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine 2006;31:2151-61.
18. Shao Z, Rompe G, Schiltenwolf M. Radiographic changes in the lumbar intervertebral discs and lumbar vertebrae with age. Spine 2002;27:263-8.
19. Battie MC, Videman T. Lumbar disc degeneration: epidemiology and genetics. J Bone Joint Surg Am 2006;88 2:3-9.
20. Thompson JP, Pearce RH, Schechter MT, et al. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 1990;15:411-5.
21. Boos N, Weissbach S, Rohrbach H, et al. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 2002;27:2631-44.
22. Mwale F, Roughley P, Antoniou J. Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc. Eur Cell Mater 2004;8:58-63.
23. Le Maitre CL, Freemont AJ, Hoyland JA. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 2004;204:47-54.
24. Sive JI, Baird P, Jeziorsk M, et al. Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol Pathol 2002;55:91-7.
25. Sugimura T, Kato F, Mimatsu K, et al. Experimental chemonucleolysis with chondroitinase ABC in monkeys. Spine 1996;21:161-5.
26. Lu DS, Shono Y, Oda I, et al. Effects of chondroitinase ABC and chymopapain on spinal motion segment biomechanics. An in vivo biomechanical, radiologic, and histologic canine study. Spine 1997;22:1828-34.
27. Sobajima S, Kompel JF, Kim JS, et al. A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology. Spine 2005;30:15-24.
28. Burleigh MC, Barrett AJ, Lazarus GS. Cathepsin B1. A lysosomal enzyme that degrades native collagen. Biochem J 1974;137:387-98.
29. Lipson SJ, Muir H. 1980 Volvo award in basic science. Proteoglycans in experimental intervertebral disc degeneration. Spine 1981;6:194-210.
30. Masuda K, Aota Y, Muehleman C, et al. A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine 2005;30:5-14.
31. Nimni ME. Collagen: structure, function, and metabolism in normal and fibrotic tissues. Semin Arthritis Rheum 1983;13:1-86.
32. Roughley PJ. Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine 2004;29:2691-9.
33. Anderson DG, Tannoury C. Molecular pathogenic factors in symptomatic disc degeneration. Spine J 2005;5:S260-S266.