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Volumn 228, Issue 7, 2013, Pages 1423-1427

Evolution of the tissue selective estrogen complex (TSEC)

Author keywords

[No Author keywords available]

Indexed keywords

BAZEDOXIFENE; CONJUGATED ESTROGEN; ESTROGEN RECEPTOR; LASOFOXIFENE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STEROID HORMONE RECEPTOR BLOCKING AGENT; TISSUE SELECTIVE ESTROGEN COMPLEX; UNCLASSIFIED DRUG;

EID: 84875517862     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24324     Document Type: Review
Times cited : (31)

References (65)
  • 1
    • 84865798770 scopus 로고    scopus 로고
    • Safety and tolerability of bazedoxifene/conjugated estrogens in postmenopausal women: Findings from a 1-year, randomized, placebo- and active-controlled, phase 3 trial
    • abstract P-25
    • Archer DF, Lobo RA, Pan K, Chines AA, Mirkin S. 2011. Safety and tolerability of bazedoxifene/conjugated estrogens in postmenopausal women: Findings from a 1-year, randomized, placebo- and active-controlled, phase 3 trial. Menopause 18: 1355-1356; abstract P-25.
    • (2011) Menopause , vol.18 , pp. 1355-1356
    • Archer, D.F.1    Lobo, R.A.2    Pan, K.3    Chines, A.A.4    Mirkin, S.5
  • 3
    • 58149218461 scopus 로고    scopus 로고
    • Differential biochemical and cellular actions of premarin estrogens: Distinct pharmacology of bazedoxifene-conjugated estrogens combination
    • Berrodin TJ, Chang KC, Komm BS, Freedman LP, Nagpal S. 2009. Differential biochemical and cellular actions of premarin estrogens: Distinct pharmacology of bazedoxifene-conjugated estrogens combination. Mol Endocrinol 23: 75-85.
    • (2009) Mol Endocrinol , vol.23 , pp. 75-85
    • Berrodin, T.J.1    Chang, K.C.2    Komm, B.S.3    Freedman, L.P.4    Nagpal, S.5
  • 5
    • 72649104020 scopus 로고    scopus 로고
    • Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: Insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens
    • Chang KCN, Wang Y, Bodine PV, Nagpal S, Komm BS. 2010. Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: Insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens. J Steroid Biochem Mol Biol 118: 117-124.
    • (2010) J Steroid Biochem Mol Biol , vol.118 , pp. 117-124
    • Chang, K.C.N.1    Wang, Y.2    Bodine, P.V.3    Nagpal, S.4    Komm, B.S.5
  • 6
    • 0033305454 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators: Clinical spectrum
    • Cosman F, Lindsay R. 1999. Selective estrogen receptor modulators: Clinical spectrum. Endocr Rev 20: 418-434.
    • (1999) Endocr Rev , vol.20 , pp. 418-434
    • Cosman, F.1    Lindsay, R.2
  • 7
    • 43549101923 scopus 로고    scopus 로고
    • Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland
    • Crabtree JS, Peano BJ, Zhang X, Komm BS, Winneker RC, Harris HA. 2008. Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland. Mol Cell Endocrinol 287: 40-46.
    • (2008) Mol Cell Endocrinol , vol.287 , pp. 40-46
    • Crabtree, J.S.1    Peano, B.J.2    Zhang, X.3    Komm, B.S.4    Winneker, R.C.5    Harris, H.A.6
  • 8
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • Deroo BJ, Korach KS. 2006. Estrogen receptors and human disease. J Clin Invest 116: 561-570.
    • (2006) J Clin Invest , vol.116 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 9
    • 85027917933 scopus 로고    scopus 로고
    • Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys
    • Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB. 2012. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause 19: 1242-1252.
    • (2012) Menopause , vol.19 , pp. 1242-1252
    • Ethun, K.F.1    Wood, C.E.2    Register, T.C.3    Cline, J.M.4    Appt, S.E.5    Clarkson, T.B.6
  • 10
    • 0029759978 scopus 로고    scopus 로고
    • Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia
    • Evans GL, Bryant HU, Magee DE, Turner RT. 1996. Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia. Endocrinology 137: 4139-4144.
    • (1996) Endocrinology , vol.137 , pp. 4139-4144
    • Evans, G.L.1    Bryant, H.U.2    Magee, D.E.3    Turner, R.T.4
  • 11
    • 84865764554 scopus 로고    scopus 로고
    • Effects of bazedoxifene/conjugated estrogens on bone mineral density and bone turnover markers in postmenopausal women: A double-blind, randomized, placebo- and active-controlled phase 3 study
    • abstract 1133
    • Gallagher JC, Lindsay R, Pan K, Mirkin S, Chines A. 2011. Effects of bazedoxifene/conjugated estrogens on bone mineral density and bone turnover markers in postmenopausal women: A double-blind, randomized, placebo- and active-controlled phase 3 study. J Bone Miner Res 26: S46; abstract 1133.
    • (2011) J Bone Miner Res , vol.26
    • Gallagher, J.C.1    Lindsay, R.2    Pan, K.3    Mirkin, S.4    Chines, A.5
  • 12
    • 0034728659 scopus 로고    scopus 로고
    • Distribution of estrogen receptor beta (ERbeta) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: Continued expression with hormone replacement
    • Gundlah C, Kohama SG, Mirkes SJ, Garyfallou VT, Urbanski HF, Bethea CL. 2000. Distribution of estrogen receptor beta (ERbeta) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: Continued expression with hormone replacement. Brain Res Mol Brain Res 76: 191-204.
    • (2000) Brain Res Mol Brain Res , vol.76 , pp. 191-204
    • Gundlah, C.1    Kohama, S.G.2    Mirkes, S.J.3    Garyfallou, V.T.4    Urbanski, H.F.5    Bethea, C.L.6
  • 13
    • 0033304993 scopus 로고    scopus 로고
    • The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
    • Hall JM, McDonnell DP. 1999. The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140: 5566-5578.
    • (1999) Endocrinology , vol.140 , pp. 5566-5578
    • Hall, J.M.1    McDonnell, D.P.2
  • 14
    • 84865729785 scopus 로고    scopus 로고
    • The effects of bazedoxifene/conjugated estrogens on breast density in postmenopausal women
    • abstract S-1
    • Harvey JA, Pinkerton JV, Pan K, Thompson JR, Ryan KA, Mirkin S, Chines AA. 2011. The effects of bazedoxifene/conjugated estrogens on breast density in postmenopausal women. Menopause 18: 1342; abstract S-1.
    • (2011) Menopause , vol.18 , pp. 1342
    • Harvey, J.A.1    Pinkerton, J.V.2    Pan, K.3    Thompson, J.R.4    Ryan, K.A.5    Mirkin, S.6    Chines, A.A.7
  • 16
    • 0033304703 scopus 로고    scopus 로고
    • Tamoxifen, raloxifene, and the prevention of breast cancer
    • Jordan VC, Morrow M. 1999. Tamoxifen, raloxifene, and the prevention of breast cancer. Endocr Rev 20: 253-278.
    • (1999) Endocr Rev , vol.20 , pp. 253-278
    • Jordan, V.C.1    Morrow, M.2
  • 17
    • 37649007431 scopus 로고    scopus 로고
    • Selective estrogen-receptor modulators and antihormonal resistance in breast cancer
    • Jordan VC, O'Malley BW. 2007. Selective estrogen-receptor modulators and antihormonal resistance in breast cancer. J Clin Oncol 25: 5815-5824.
    • (2007) J Clin Oncol , vol.25 , pp. 5815-5824
    • Jordan, V.C.1    O'Malley, B.W.2
  • 18
    • 0023547257 scopus 로고
    • Effects of anti-estrogens on bone in castrated and intact female rats
    • Jordan VC, Phelps E, Lindgren JU. 1987. Effects of anti-estrogens on bone in castrated and intact female rats. Breast Cancer Res Treat 10: 31-35.
    • (1987) Breast Cancer Res Treat , vol.10 , pp. 31-35
    • Jordan, V.C.1    Phelps, E.2    Lindgren, J.U.3
  • 20
    • 4243901882 scopus 로고    scopus 로고
    • Co-treatment of lasofoxifene (CP-336,156) and estrogen inhibits estrogen's effect in the uterus but maintains the bone protective effects in ovariectomized rats [abstract]
    • Ke HZ, Chidsey-Frink KL, Simmons A, Thompson DD. 2000. Co-treatment of lasofoxifene (CP-336, 156) and estrogen inhibits estrogen's effect in the uterus but maintains the bone protective effects in ovariectomized rats [abstract]. J Bone Miner Res 15: S310.
    • (2000) J Bone Miner Res , vol.15
    • Ke, H.Z.1    Chidsey-Frink, K.L.2    Simmons, A.3    Thompson, D.D.4
  • 21
    • 0036556843 scopus 로고    scopus 로고
    • Lasofoxifene (CP-336, 156), a novel selective estrogen receptor modulator, in preclinical studies
    • Ke HZ, Brown TA, Thompson DD. 2002. Lasofoxifene (CP-336, 156), a novel selective estrogen receptor modulator, in preclinical studies. J Am Aging Assoc 25: 87-100.
    • (2002) J Am Aging Assoc , vol.25 , pp. 87-100
    • Ke, H.Z.1    Brown, T.A.2    Thompson, D.D.3
  • 22
    • 1642489155 scopus 로고    scopus 로고
    • Long-term treatment of lasofoxifene preserves bone mass and bone strength and does not adversely affect the uterus in ovariectomized rats
    • Ke HZ, Foley GL, Simmons HA, Shen V, Thompson DD. 2004. Long-term treatment of lasofoxifene preserves bone mass and bone strength and does not adversely affect the uterus in ovariectomized rats. Endocrinology 145: 1996-2005.
    • (2004) Endocrinology , vol.145 , pp. 1996-2005
    • Ke, H.Z.1    Foley, G.L.2    Simmons, H.A.3    Shen, V.4    Thompson, D.D.5
  • 23
    • 56549102911 scopus 로고    scopus 로고
    • The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention
    • Kharode Y, Bodine PV, Miller CP, Lyttle CR, Komm BS. 2008. The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention. Endocrinology 149: 6084-6091.
    • (2008) Endocrinology , vol.149 , pp. 6084-6091
    • Kharode, Y.1    Bodine, P.V.2    Miller, C.P.3    Lyttle, C.R.4    Komm, B.S.5
  • 24
    • 57849153536 scopus 로고    scopus 로고
    • A new approach to menopausal therapy: The tissue selective estrogen complex
    • Komm BS. 2008. A new approach to menopausal therapy: The tissue selective estrogen complex. Reprod Sci 15: 984-992.
    • (2008) Reprod Sci , vol.15 , pp. 984-992
    • Komm, B.S.1
  • 26
    • 79960580689 scopus 로고    scopus 로고
    • Skeletal effects of bazedoxifene paired with conjugated estrogens in ovariectomized rats
    • Komm BS, Vlasseros F, Samadfam R, Chouinard L, Smith SY. 2011. Skeletal effects of bazedoxifene paired with conjugated estrogens in ovariectomized rats. Bone 49: 376-386.
    • (2011) Bone , vol.49 , pp. 376-386
    • Komm, B.S.1    Vlasseros, F.2    Samadfam, R.3    Chouinard, L.4    Smith, S.Y.5
  • 27
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    • Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA. 1997. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138: 863-870.
    • (1997) Endocrinology , vol.138 , pp. 863-870
    • Kuiper, G.G.1    Carlsson, B.2    Grandien, K.3    Enmark, E.4    Haggblad, J.5    Nilsson, S.6    Gustafsson, J.A.7
  • 28
    • 79960713351 scopus 로고    scopus 로고
    • Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model
    • Kulak J, Jr., Fischer C, Komm B, Taylor HS. 2011. Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model. Endocrinology 152: 3226-3232.
    • (2011) Endocrinology , vol.152 , pp. 3226-3232
    • Kulak Jr, J.1    Fischer, C.2    Komm, B.3    Taylor, H.S.4
  • 30
    • 0025338591 scopus 로고
    • Development of antiestrogens and their use in breast cancer: Eighth Cain memorial award lecture
    • Lerner LJ, Jordan VC. 1990. Development of antiestrogens and their use in breast cancer: Eighth Cain memorial award lecture. Cancer Res 50: 4177-4189.
    • (1990) Cancer Res , vol.50 , pp. 4177-4189
    • Lerner, L.J.1    Jordan, V.C.2
  • 32
    • 80053199540 scopus 로고    scopus 로고
    • The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor alpha and cyclin D1
    • Lewis-Wambi JS, Kim H, Curpan R, Grigg R, Sarker MA, Jordan VC. 2011. The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor alpha and cyclin D1. Mol Pharmacol 80: 610-620.
    • (2011) Mol Pharmacol , vol.80 , pp. 610-620
    • Lewis-Wambi, J.S.1    Kim, H.2    Curpan, R.3    Grigg, R.4    Sarker, M.A.5    Jordan, V.C.6
  • 33
    • 84861998607 scopus 로고    scopus 로고
    • Inhibitory effects of ERbeta on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells-prognostication for the use of ERbeta-selective therapy
    • Li H, Tu Z, An L, Qian Z, Achilefu S, Gu Y. 2012. Inhibitory effects of ERbeta on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells-prognostication for the use of ERbeta-selective therapy. Pharm Biol 50: 839-849.
    • (2012) Pharm Biol , vol.50 , pp. 839-849
    • Li, H.1    Tu, Z.2    An, L.3    Qian, Z.4    Achilefu, S.5    Gu, Y.6
  • 34
    • 69049083661 scopus 로고    scopus 로고
    • Efficacy of tissue-selective estrogen complex of bazedoxifene/conjugated estrogens for osteoporosis prevention in at-risk postmenopausal women
    • Lindsay R, Gallagher JC, Kagan R, Pickar JH, Constantine G. 2009. Efficacy of tissue-selective estrogen complex of bazedoxifene/conjugated estrogens for osteoporosis prevention in at-risk postmenopausal women. Fertil Steril 92: 1045-1052.
    • (2009) Fertil Steril , vol.92 , pp. 1045-1052
    • Lindsay, R.1    Gallagher, J.C.2    Kagan, R.3    Pickar, J.H.4    Constantine, G.5
  • 35
    • 69049120132 scopus 로고    scopus 로고
    • Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile
    • Lobo RA, Pinkerton JV, Gass ML, Dorin MH, Ronkin S, Pickar JH, Constantine G. 2009. Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile. Fertil Steril 92: 1025-1038.
    • (2009) Fertil Steril , vol.92 , pp. 1025-1038
    • Lobo, R.A.1    Pinkerton, J.V.2    Gass, M.L.3    Dorin, M.H.4    Ronkin, S.5    Pickar, J.H.6    Constantine, G.7
  • 38
    • 1642332240 scopus 로고    scopus 로고
    • Estrogen signaling: A subtle balance between ER alpha and ER beta
    • Matthews J, Gustafsson JA. 2003. Estrogen signaling: A subtle balance between ER alpha and ER beta. Mol Interv 3: 281-292.
    • (2003) Mol Interv , vol.3 , pp. 281-292
    • Matthews, J.1    Gustafsson, J.A.2
  • 39
    • 33644550627 scopus 로고    scopus 로고
    • Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters
    • Matthews J, Wihlen B, Tujague M, Wan J, Strom A, Gustafsson JA. 2006. Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. Mol Endocrinol 20: 534-543.
    • (2006) Mol Endocrinol , vol.20 , pp. 534-543
    • Matthews, J.1    Wihlen, B.2    Tujague, M.3    Wan, J.4    Strom, A.5    Gustafsson, J.A.6
  • 40
    • 78149501152 scopus 로고    scopus 로고
    • The molecular mechanisms underlying the pharmacological actions of ER modulators: Implications for new drug discovery in breast cancer
    • McDonnell DP, Wardell SE. 2010. The molecular mechanisms underlying the pharmacological actions of ER modulators: Implications for new drug discovery in breast cancer. Curr Opin Pharmacol 10: 620-628.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 620-628
    • McDonnell, D.P.1    Wardell, S.E.2
  • 41
    • 0033542402 scopus 로고    scopus 로고
    • The protective effects of estrogen on the cardiovascular system
    • Mendelsohn ME, Karas RH. 1999. The protective effects of estrogen on the cardiovascular system. N Engl J Med 340: 1801-1811.
    • (1999) N Engl J Med , vol.340 , pp. 1801-1811
    • Mendelsohn, M.E.1    Karas, R.H.2
  • 42
    • 84875503848 scopus 로고    scopus 로고
    • Effects of bazedoxifene/conjugated estrogens on endometrial safety and bone in postmenopausal women
    • DOI: 10.3109/13697137.2012.717994
    • Mirkin S, Komm BS, Pan K, Chines AA. 2012a. Effects of bazedoxifene/conjugated estrogens on endometrial safety and bone in postmenopausal women. Climacteric DOI: 10.3109/13697137.2012.717994
    • (2012) Climacteric
    • Mirkin, S.1    Komm, B.S.2    Pan, K.3    Chines, A.A.4
  • 43
    • 84932108214 scopus 로고    scopus 로고
    • A pooled analysis of the effects of bazedoxifene/conjugated estrogens on lipid parameters from the selective estrogens, menopause, and response to therapy trials
    • abstract SAT-30)
    • Mirkin S, Ryan KA, Pan K, Chines AA, Lobo RA. 2012b. A pooled analysis of the effects of bazedoxifene/conjugated estrogens on lipid parameters from the selective estrogens, menopause, and response to therapy trials. Endocr Rev 33 (abstract SAT-30).
    • (2012) Endocr Rev , vol.33
    • Mirkin, S.1    Ryan, K.A.2    Pan, K.3    Chines, A.A.4    Lobo, R.A.5
  • 45
    • 84857508749 scopus 로고    scopus 로고
    • The 2012 hormone therapy position statement of The North American Menopause Society
    • North American Menopause Society. . : -
    • North American Menopause Society. 2012. The 2012 hormone therapy position statement of The North American Menopause Society. Menopause 19: 257-271.
    • (2012) Menopause , vol.19 , pp. 257-271
  • 47
    • 1342302106 scopus 로고    scopus 로고
    • Estrogen receptor gene expression in relation to neuropsychiatric disorders
    • Ostlund H, Keller E, Hurd YL. 2003. Estrogen receptor gene expression in relation to neuropsychiatric disorders. Ann N Y Acad Sci 1007: 54-63.
    • (2003) Ann N Y Acad Sci , vol.1007 , pp. 54-63
    • Ostlund, H.1    Keller, E.2    Hurd, Y.L.3
  • 49
    • 0034795943 scopus 로고    scopus 로고
    • Estrogen receptors in rat bone: Their interaction with estrogen receptor modulators
    • Pal R, Chaturvedi R, Kamboj KK, Chowdhury SR, Dwivedi A. 2001. Estrogen receptors in rat bone: Their interaction with estrogen receptor modulators. Endocr Res 27: 283-291.
    • (2001) Endocr Res , vol.27 , pp. 283-291
    • Pal, R.1    Chaturvedi, R.2    Kamboj, K.K.3    Chowdhury, S.R.4    Dwivedi, A.5
  • 50
    • 39149088369 scopus 로고    scopus 로고
    • Controversies in the management of patients with breast cancer: Adjuvant endocrine therapy in premenopausal women
    • Parton M, Smith IE. 2008. Controversies in the management of patients with breast cancer: Adjuvant endocrine therapy in premenopausal women. J Clin Oncol 26: 745-752.
    • (2008) J Clin Oncol , vol.26 , pp. 745-752
    • Parton, M.1    Smith, I.E.2
  • 51
    • 1642535535 scopus 로고    scopus 로고
    • Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest
    • Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL, Leitman DC. 2004. Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res 64: 423-428.
    • (2004) Cancer Res , vol.64 , pp. 423-428
    • Paruthiyil, S.1    Parmar, H.2    Kerekatte, V.3    Cunha, G.R.4    Firestone, G.L.5    Leitman, D.C.6
  • 52
    • 63849224133 scopus 로고    scopus 로고
    • Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland
    • Peano BJ, Crabtree JS, Komm BS, Winneker RC, Harris HA. 2009. Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland. Endocrinology 150: 1897-1903.
    • (2009) Endocrinology , vol.150 , pp. 1897-1903
    • Peano, B.J.1    Crabtree, J.S.2    Komm, B.S.3    Winneker, R.C.4    Harris, H.A.5
  • 53
    • 0034486848 scopus 로고    scopus 로고
    • Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs
    • Pelletier G, El-Alfy M. 2000. Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs. J Clin Endocrinol Metab 85: 4835-4840.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4835-4840
    • Pelletier, G.1    El-Alfy, M.2
  • 54
    • 69049085452 scopus 로고    scopus 로고
    • Endometrial effects of a tissue selective estrogen complex containing bazedoxifene/conjugated estrogens as a menopausal therapy
    • Pickar JH, Yeh I-T, Bachmann G, Speroff L. 2009. Endometrial effects of a tissue selective estrogen complex containing bazedoxifene/conjugated estrogens as a menopausal therapy. Fertil Steril 92: 1018-1024.
    • (2009) Fertil Steril , vol.92 , pp. 1018-1024
    • Pickar, J.H.1    Yeh, I.-T.2    Bachmann, G.3    Speroff, L.4
  • 55
    • 77956652851 scopus 로고    scopus 로고
    • SERMs: Progress and future perspectives
    • Pickar JH, MacNeil T, Ohleth K. 2010. SERMs: Progress and future perspectives. Maturitas 67: 129-138.
    • (2010) Maturitas , vol.67 , pp. 129-138
    • Pickar, J.H.1    MacNeil, T.2    Ohleth, K.3
  • 56
    • 77952228433 scopus 로고    scopus 로고
    • Endometrial safety: A key hurdle for selective estrogen receptor modulators in development
    • Pinkerton JV, Goldstein SR. 2010. Endometrial safety: A key hurdle for selective estrogen receptor modulators in development. Menopause 17: 642-653.
    • (2010) Menopause , vol.17 , pp. 642-653
    • Pinkerton, J.V.1    Goldstein, S.R.2
  • 57
    • 68349129906 scopus 로고    scopus 로고
    • Relief of vasomotor symptoms with the tissue-selective estrogen complex containing bazedoxifene/conjugated estrogens: A randomized, controlled trial
    • Pinkerton JV, Utian WH, Constantine GD, Olivier S, Pickar JH. 2009. Relief of vasomotor symptoms with the tissue-selective estrogen complex containing bazedoxifene/conjugated estrogens: A randomized, controlled trial. Menopause 16: 1116-1124.
    • (2009) Menopause , vol.16 , pp. 1116-1124
    • Pinkerton, J.V.1    Utian, W.H.2    Constantine, G.D.3    Olivier, S.4    Pickar, J.H.5
  • 58
    • 84863066879 scopus 로고    scopus 로고
    • Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERalpha and ERbeta
    • Powell E, Shanle E, Brinkman A, Li J, Keles S, Wisinski KB, Huang W, Xu W. 2012. Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERalpha and ERbeta. PLoS ONE 7: e30993.
    • (2012) PLoS ONE , vol.7
    • Powell, E.1    Shanle, E.2    Brinkman, A.3    Li, J.4    Keles, S.5    Wisinski, K.B.6    Huang, W.7    Xu, W.8
  • 59
    • 84870152953 scopus 로고    scopus 로고
    • Effects of the conjugated equine estrogen/bazedoxifene tissue-selective estrogen complex (TSEC) on mammary gland and breast cancer in mice
    • Song Y, Santen RJ, Wang JP, Yue W. 2012. Effects of the conjugated equine estrogen/bazedoxifene tissue-selective estrogen complex (TSEC) on mammary gland and breast cancer in mice. Endocrinology 153: 5706-5715.
    • (2012) Endocrinology , vol.153 , pp. 5706-5715
    • Song, Y.1    Santen, R.J.2    Wang, J.P.3    Yue, W.4
  • 60
    • 3042681155 scopus 로고    scopus 로고
    • Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: Distinct and common target genes for these receptors
    • Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS. 2004. Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: Distinct and common target genes for these receptors. Endocrinology 145: 3473-3486.
    • (2004) Endocrinology , vol.145 , pp. 3473-3486
    • Stossi, F.1    Barnett, D.H.2    Frasor, J.3    Komm, B.4    Lyttle, C.R.5    Katzenellenbogen, B.S.6
  • 61
    • 1242300083 scopus 로고    scopus 로고
    • Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D
    • Strom A, Hartman J, Foster JS, Kietz S, Wimalasena J, Gustafsson JA. 2004. Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci USA 101: 1566-1571.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1566-1571
    • Strom, A.1    Hartman, J.2    Foster, J.S.3    Kietz, S.4    Wimalasena, J.5    Gustafsson, J.A.6
  • 62
    • 0033517107 scopus 로고    scopus 로고
    • Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta
    • Vanacker JM, Pettersson K, Gustafsson JA, Laudet V. 1999. Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta. EMBO J 18: 4270-4279.
    • (1999) EMBO J , vol.18 , pp. 4270-4279
    • Vanacker, J.M.1    Pettersson, K.2    Gustafsson, J.A.3    Laudet, V.4
  • 63
    • 1542410452 scopus 로고    scopus 로고
    • Hormone replacement therapy, selective estrogen receptor modulators, and tissue-specific compounds: Cardiovascular effects and clinical implications
    • Vogelvang TE, van der Mooren MJ, Mijatovic V. 2004. Hormone replacement therapy, selective estrogen receptor modulators, and tissue-specific compounds: Cardiovascular effects and clinical implications. Treat Endocrinol 3: 105-115.
    • (2004) Treat Endocrinol , vol.3 , pp. 105-115
    • Vogelvang, T.E.1    van der Mooren, M.J.2    Mijatovic, V.3
  • 64
    • 84863309104 scopus 로고    scopus 로고
    • Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes
    • Wardell SE, Kazmin D, McDonnell DP. 2012. Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. Mol Endocrinol 26: 1235-1248.
    • (2012) Mol Endocrinol , vol.26 , pp. 1235-1248
    • Wardell, S.E.1    Kazmin, D.2    McDonnell, D.P.3
  • 65
    • 77957126077 scopus 로고
    • Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The postmenopausal estrogen/progestin interventions (PEPI) trial
    • Writing Group for the PEPI Trial. . : -
    • Writing Group for the PEPI Trial. 1995. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The postmenopausal estrogen/progestin interventions (PEPI) trial. JAMA 273: 199-208.
    • (1995) JAMA , vol.273 , pp. 199-208


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