메뉴 건너뛰기




Volumn 25, Issue 2, 2002, Pages 87-99

Lasofoxifene (CP-336,156), a novel selective estrogen receptor modulator, in preclinical studies

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; CHOLESTEROL; ESTRADIOL; ESTROGEN; GROWTH HORMONE; LASOFOXIFENE; PARATHYROID HORMONE; PROSTAGLANDIN E2; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

EID: 0036556843     PISSN: 01619152     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11357-002-0007-y     Document Type: Article
Times cited : (12)

References (67)
  • 3
    • 0012917151 scopus 로고    scopus 로고
    • The pathophysiology of osteoporosis
    • edited by Rosen, C.J., Humana Press Inc., Totowa, New Jersey
    • Kessenich, C.R., and Rosen, C.J.: The pathophysiology of osteoporosis, in Osteoporosis: Diagnostic and Therapeutic Principles, edited by Rosen, C.J., Humana Press Inc., Totowa, New Jersey, 1996, pp.47-63.
    • (1996) Osteoporosis: Diagnostic and Therapeutic Principles , pp. 47-63
    • Kessenich, C.R.1    Rosen, C.J.2
  • 6
    • 0030685090 scopus 로고    scopus 로고
    • Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo study
    • Greendale, G.A., Edelstein, S., and Barrett-Connor, E.: Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo study. J. Bone Miner. Res., 12:1833-1843, 1997.
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 1833-1843
    • Greendale, G.A.1    Edelstein, S.2    Barrett-Connor, E.3
  • 7
    • 0031756218 scopus 로고    scopus 로고
    • Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen
    • Khosla, S., Melton, L.J. III, Atkinson, E.J., O'Fallon, W.M., Klee, G.G., and Riggs, B.L.: Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J. Clin. Endocronol. Metab., 83:2266-2274, 1998.
    • (1998) J. Clin. Endocronol. Metab. , vol.83 , pp. 2266-2274
    • Khosla, S.1    Melton L.J. III2    Atkinson, E.J.3    O'Fallon, W.M.4    Klee, G.G.5    Riggs, B.L.6
  • 8
    • 0031955217 scopus 로고    scopus 로고
    • A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men
    • Riggs, B.L., Khosla, S., and Melton, L.J. III: A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J. Bone Miner. Res., 13:763-773, 1998.
    • (1998) J. Bone Miner. Res. , vol.13 , pp. 763-773
    • Riggs, B.L.1    Khosla, S.2    Melton L.J. III3
  • 10
    • 0026732689 scopus 로고
    • The prevention and treatment of osteoporosis
    • Riggs, B.L., and Melton, III L.J.: The prevention and treatment of osteoporosis. N. Engl. J. Med., 327:620-627, 1992.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 620-627
    • Riggs, B.L.1    Melton L.J. III2
  • 12
    • 0029120477 scopus 로고
    • Benefits and risks of estrogen replacement therapy
    • Lobo, A.: Benefits and risks of estrogen replacement therapy. Am. J. Obstet. Gynecol., 173:982-990, 1995.
    • (1995) Am. J. Obstet. Gynecol. , vol.173 , pp. 982-990
    • Lobo, A.1
  • 13
    • 0028885330 scopus 로고
    • Fracture protection provided by long-term estrogen treatment
    • Maxim, P., Ettinger, B., and Spitalny, G.M.: Fracture protection provided by long-term estrogen treatment. Osteoporosis Int., 5:23-29, 1995.
    • (1995) Osteoporosis Int. , vol.5 , pp. 23-29
    • Maxim, P.1    Ettinger, B.2    Spitalny, G.M.3
  • 14
    • 0023203768 scopus 로고
    • Controversies concerning the safety of estrogen replacement therapy
    • Whitehead, M.I. and Fraser, D.: Controversies concerning the safety of estrogen replacement therapy. Am. J. Ob. Gyn., 156:1313-1322, 1987.
    • (1987) Am. J. Ob. Gyn. , vol.156 , pp. 1313-1322
    • Whitehead, M.I.1    Fraser, D.2
  • 16
    • 0028033883 scopus 로고
    • Effects of tamoxifen on lumbar spine bone mineral density in postmenopausal women after 5 years
    • Love, R.R., Bardon, H.S., Mazess, R.B., Epstein, S., and Chappell, R.J.: Effects of tamoxifen on lumbar spine bone mineral density in postmenopausal women after 5 years. Arch. Int. Med., 154:2585-2588, 1994.
    • (1994) Arch. Int. Med. , vol.154 , pp. 2585-2588
    • Love, R.R.1    Bardon, H.S.2    Mazess, R.B.3    Epstein, S.4    Chappell, R.J.5
  • 19
    • 0029016173 scopus 로고
    • Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats
    • Ke, H.Z., Simmons, H.A., Pirie, C.M., Crawford, D.T., and Thompson, D.D.: Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats. Endocrinology, 136:2435-2441, 1995.
    • (1995) Endocrinology , vol.136 , pp. 2435-2441
    • Ke, H.Z.1    Simmons, H.A.2    Pirie, C.M.3    Crawford, D.T.4    Thompson, D.D.5
  • 20
    • 0031013929 scopus 로고    scopus 로고
    • Comparative effects of droloxifene, tamoxifen, and estrogen on bone, serum cholesterol, and uterine histology in the ovariectomized rat model
    • Ke, H.Z., Chen, H.K., Simmons, H.A., Qi, H., Crawford, D.T., Pirie, C.M., Chidsey-Frink, K.L., Ma, Y.F., Jee, W.S.S., and Thompson, D.D.: Comparative effects of droloxifene, tamoxifen, and estrogen on bone, serum cholesterol, and uterine histology in the ovariectomized rat model. Bone, 20:31-39, 1997.
    • (1997) Bone , vol.20 , pp. 31-39
    • Ke, H.Z.1    Chen, H.K.2    Simmons, H.A.3    Qi, H.4    Crawford, D.T.5    Pirie, C.M.6    Chidsey-Frink, K.L.7    Ma, Y.F.8    Jee, W.S.S.9    Thompson, D.D.10
  • 21
    • 0031973426 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators: An alternative to hormone replacement therapy
    • Bryant, H.U., and Dere, W.H.: Selective estrogen receptor modulators: an alternative to hormone replacement therapy. Proce. Society Exp. Biol. Medicine, 217:45-52, 1998.
    • (1998) Proce. Society Exp. Biol. Medicine , vol.217 , pp. 45-52
    • Bryant, H.U.1    Dere, W.H.2
  • 26
    • 0002366905 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen
    • McDonnell, D.P.: Selective estrogen receptor modulators (SERMs): a first step in the development of perfect hormone replacement therapy regimen. J. Soc. Gynecol. Investig., 7:S10-S15, 2000.
    • (2000) J. Soc. Gynecol. Investig. , vol.7
    • McDonnell, D.P.1
  • 28
    • 0034457008 scopus 로고    scopus 로고
    • Lasofoxifene (CP-336,156), a selective estrogen receptor modulator, prevents bone loss induced by aging and orchidectomy in the adult rat
    • Ke, H.Z., Qi, H., Crawford, D.T., Chidsey-Frink, K.L., Simmons, H.A., and Thompson, D.D.: Lasofoxifene (CP-336,156), a selective estrogen receptor modulator, prevents bone loss induced by aging and orchidectomy in the adult rat. Endocrinology, 141:1338-1344, 2000.
    • (2000) Endocrinology , vol.141 , pp. 1338-1344
    • Ke, H.Z.1    Qi, H.2    Crawford, D.T.3    Chidsey-Frink, K.L.4    Simmons, H.A.5    Thompson, D.D.6
  • 29
    • 0035082747 scopus 로고    scopus 로고
    • Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats
    • Ke, H.Z., Qi, H., Chidsey-Frink, K.L., Crawford, D.T., and Thompson, D.D.: Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats. J. Bone Miner. Res., 16:765-773, 2001.
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 765-773
    • Ke, H.Z.1    Qi, H.2    Chidsey-Frink, K.L.3    Crawford, D.T.4    Thompson, D.D.5
  • 30
    • 0035893734 scopus 로고    scopus 로고
    • LAS, a novel selective estrogen receptor modulator with chemopreventive and therapeutic activity in the N-methylurea-induced rat mammary tumor model
    • Cohen, L.A., Pittman, B., Wang, C.-X., Aliaga, C., Yu, L., and Moyer, J.D.: LAS, a novel selective estrogen receptor modulator with chemopreventive and therapeutic activity in the N-methylurea-induced rat mammary tumor model. Cancer Research, 61:8683-8688, 2001.
    • (2001) Cancer Research , vol.61 , pp. 8683-8688
    • Cohen, L.A.1    Pittman, B.2    Wang, C.-X.3    Aliaga, C.4    Yu, L.5    Moyer, J.D.6
  • 31
    • 0031791153 scopus 로고    scopus 로고
    • Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues
    • Petersen, D.N., Tkalcevic, G.T., Koza-Taylor, P.H., Turi, T.G., and Brown, T.A.: Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues. Endocrinology, 139:1082-92, 1998.
    • (1998) Endocrinology , vol.139 , pp. 1082-1092
    • Petersen, D.N.1    Tkalcevic, G.T.2    Koza-Taylor, P.H.3    Turi, T.G.4    Brown, T.A.5
  • 32
    • 0002231014 scopus 로고
    • Steroid hormone receptors: Assay and characterization
    • Green, B. and Leake, R.E. (eds), Oxford, IRL Press Ltd.
    • Leake, R.E., and Habib, F.: Steroid hormone receptors: assay and characterization. In Steroid Hormones: A Practical Approach. Green, B. and Leake, R.E. (eds), Oxford, IRL Press Ltd., 1987, pp. 67-92.
    • (1987) Steroid Hormones: A Practical Approach , pp. 67-92
    • Leake, R.E.1    Habib, F.2
  • 34
    • 84995870933 scopus 로고
    • Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
    • Tzukerman, M.T., Esty, A., Santiso-Mere, D., Danielian, P., Parker, M.G., Stein, R.B., Pike, J.W., and McDonnell, D.P.: Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Molecular Endocrinology, 8:21-30, 1994.
    • (1994) Molecular Endocrinology , vol.8 , pp. 21-30
    • Tzukerman, M.T.1    Esty, A.2    Santiso-Mere, D.3    Danielian, P.4    Parker, M.G.5    Stein, R.B.6    Pike, J.W.7    McDonnell, D.P.8
  • 35
    • 0029038986 scopus 로고
    • Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens
    • McDonnell, D.P., Clemm, D.L., Hermann, T., Goldman, M.E., and Pike, J.W.: Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Molecular Endocrinology, 9:659-69, 1995.
    • (1995) Molecular Endocrinology , vol.9 , pp. 659-669
    • McDonnell, D.P.1    Clemm, D.L.2    Hermann, T.3    Goldman, M.E.4    Pike, J.W.5
  • 36
    • 0033305654 scopus 로고    scopus 로고
    • Characterization of estrogen receptor-beta (ERbeta) messenger ribonucleic acid and protein expression in rat granulosa cells
    • O'Brien, M.L., Park, K., In, Y., and Park-Sarge, O.K.: Characterization of estrogen receptor-beta (ERbeta) messenger ribonucleic acid and protein expression in rat granulosa cells. Endocrinology, 140:4530-41, 1999.
    • (1999) Endocrinology , vol.140 , pp. 4530-4541
    • O'Brien, M.L.1    Park, K.2    In, Y.3    Park-Sarge, O.K.4
  • 37
    • 0026068145 scopus 로고
    • The ovariectomized rat model of post-menopausal bone loss
    • Kalu, D.N.: The ovariectomized rat model of post-menopausal bone loss. Bone and Mineral, 15:175-192, 1991.
    • (1991) Bone and Mineral , vol.15 , pp. 175-192
    • Kalu, D.N.1
  • 38
    • 0002081094 scopus 로고
    • The ovariectomized rat model as an animal model for postmenopausal bone loss
    • Wronski, T.J., and Yen, C.-F.: The ovariectomized rat model as an animal model for postmenopausal bone loss. Cells Materials, suppl. 1:69-74; 1991.
    • (1991) Cells Materials , vol.1 , Issue.SUPPL. , pp. 69-74
    • Wronski, T.J.1    Yen, C.-F.2
  • 39
    • 0026733404 scopus 로고
    • On the rat model of human osteopenias and osteoporosis
    • Frost, H.M. and Jee, W.S.S.: On the rat model of human osteopenias and osteoporosis. Bone and Mineral, 18:227-236, 1992.
    • (1992) Bone and Mineral , vol.18 , pp. 227-236
    • Frost, H.M.1    Jee, W.S.S.2
  • 40
    • 0001590928 scopus 로고    scopus 로고
    • Overview: Animal models of osteopenia and osteoporosis
    • Jee, W.S.S. and Yao, W.: Overview: animal models of osteopenia and osteoporosis. J. Musculoskel. Neuron. Interact., 1:193-207;2001.
    • (2001) J. Musculoskel. Neuron. Interact. , vol.1 , pp. 193-207
    • Jee, W.S.S.1    Yao, W.2
  • 42
    • 0028857870 scopus 로고
    • Effects of Droloxifene on prevention of can cellous bone loss and bone turnover of the axial skeleton of aged, ovariectomized rats
    • Ke, H.Z., Chen, H.K., Qi, H., Pirie, C.M., Simmons, H.A., Ma, Y.F., Jee, W.S.S., and Thompson, D.D.: Effects of Droloxifene on prevention of cancellous bone loss and bone turnover of the axial skeleton of aged, ovariectomized rats. Bone, 17:491-496, 1995.
    • (1995) Bone , vol.17 , pp. 491-496
    • Ke, H.Z.1    Chen, H.K.2    Qi, H.3    Pirie, C.M.4    Simmons, H.A.5    Ma, Y.F.6    Jee, W.S.S.7    Thompson, D.D.8
  • 43
    • 0029163115 scopus 로고
    • Droloxifene Prevents ovariectomy-induced bone loss in tibiae and femora of aged female rats: A dual-energy x-ray absorptiometric and histomorphometric study
    • Chen, H.K., Ke, H.Z., Jee, W.S.S., Ma, Y.F., Pirie, C.M., Simmons, H.A., and Thompson, D.D.: Droloxifene Prevents ovariectomy-induced bone loss in tibiae and femora of aged female rats: a dual-energy x-ray absorptiometric and histomorphometric study. J. Bone and Miner. Res., 10:1256-1262, 1995.
    • (1995) J. Bone and Miner. Res. , vol.10 , pp. 1256-1262
    • Chen, H.K.1    Ke, H.Z.2    Jee, W.S.S.3    Ma, Y.F.4    Pirie, C.M.5    Simmons, H.A.6    Thompson, D.D.7
  • 45
    • 0028785711 scopus 로고
    • FDA guidelines and animal models for osteoporosis
    • Thompson, D.D., Simmons, H.A., Pirie, C.M., and Ke, H.Z.: FDA guidelines and animal models for osteoporosis. Bone, 17(suppl. 4):125S-133S, 1995.
    • (1995) Bone , vol.17 , Issue.SUPPL. 4
    • Thompson, D.D.1    Simmons, H.A.2    Pirie, C.M.3    Ke, H.Z.4
  • 47
    • 0030696015 scopus 로고    scopus 로고
    • The in vivo anabolic actions of prostaglandins in bone
    • Jee, W.S.S. and Ma, Y.F.: The in vivo anabolic actions of prostaglandins in bone. Bone, 21:297-304; 1997.
    • (1997) Bone , vol.21 , pp. 297-304
    • Jee, W.S.S.1    Ma, Y.F.2
  • 49
    • 0032889707 scopus 로고    scopus 로고
    • Droloxifene does not blunt the bone anabolic effects of prostaglandin E2 but maintains the prostaglandin E2-restored bone in aged, ovariectomized rats
    • Ke, H.Z., Crawford, D.T., Qi, H., Pirie, C.M., Simmons, H.A., Chidsey-Frink, K.L., Chen, H.K., Jee, W.S.S. and Thompson, D.D.: Droloxifene does not blunt the bone anabolic effects of prostaglandin E2 but maintains the prostaglandin E2-restored bone in aged, ovariectomized rats. Bone, 24:41-47; 1999.
    • (1999) Bone , vol.24 , pp. 41-47
    • Ke, H.Z.1    Crawford, D.T.2    Qi, H.3    Pirie, C.M.4    Simmons, H.A.5    Chidsey-Frink, K.L.6    Chen, H.K.7    Jee, W.S.S.8    Thompson, D.D.9
  • 50
    • 4243901882 scopus 로고    scopus 로고
    • Co-treatment of lasofoxifene (CP-336,156) and estrogen inhibits estrogen's effect in the uterus but maintains the bone protective effects in ovariectomized rats
    • Ke, H.Z., Chidsey-Frink, K.L., Crawford, D.T., Qi, H., Simmons, H.A., and Thompson, D.D.: Co-treatment of lasofoxifene (CP-336,156) and estrogen inhibits estrogen's effect in the uterus but maintains the bone protective effects in ovariectomized rats. J. Bone and Mineral Res., 15 (suppl. 1) S310, 2000.
    • (2000) J. Bone and Mineral Res. , vol.15 , Issue.SUPPL. 1
    • Ke, H.Z.1    Chidsey-Frink, K.L.2    Crawford, D.T.3    Qi, H.4    Simmons, H.A.5    Thompson, D.D.6
  • 51
    • 25544473755 scopus 로고    scopus 로고
    • CP-336,156, A New Selective Estrogen Receptor Modulator (SERM), Enhances the Effects of Parathyroid Hormone in Restoring Bone Mass and Strength in Ovariectomized Rats
    • Ke, H.Z., Chidsey-Frink, K.L., Simmons, H.A., Crawford, D.T., Qi, H., Pirie, C.M., Shen, V. and Thompson, D.D.: CP-336,156, A New Selective Estrogen Receptor Modulator (SERM), Enhances the Effects of Parathyroid Hormone in Restoring Bone Mass and Strength in Ovariectomized Rats. J. Bone and Mineral Res., 13 (suppl. 1) S495, 1998.
    • (1998) J. Bone and Mineral Res. , vol.13 , Issue.SUPPL. 1
    • Ke, H.Z.1    Chidsey-Frink, K.L.2    Simmons, H.A.3    Crawford, D.T.4    Qi, H.5    Pirie, C.M.6    Shen, V.7    Thompson, D.D.8
  • 55
    • 4243424326 scopus 로고    scopus 로고
    • Combined administration of a growth hormone secretagogue (GHS) and a new selective estrogen receptor modulator (SERM) increases bone and muscle mass and decreases total serum cholesterol in ovariectomized rats
    • Ke, H.Z., Li, M., Pan, L.C., Yu, L., MacLean, D.B., and Thompson, D.D.: Combined administration of a growth hormone secretagogue (GHS) and a new selective estrogen receptor modulator (SERM) increases bone and muscle mass and decreases total serum cholesterol in ovariectomized rats. J. Bone and Mineral Res., 13 (suppl. 1) S390, 1998.
    • (1998) J. Bone and Mineral Res. , vol.13 , Issue.SUPPL. 1
    • Ke, H.Z.1    Li, M.2    Pan, L.C.3    Yu, L.4    MacLean, D.B.5    Thompson, D.D.6
  • 56
    • 0026536013 scopus 로고
    • Epidemiology of osteoporosis
    • Kanis, J.A., and Pitt, F.A.: Epidemiology of osteoporosis. Bone, 13:S7-S15, 1992.
    • (1992) Bone , vol.13
    • Kanis, J.A.1    Pitt, F.A.2
  • 57
    • 0026446492 scopus 로고
    • Hip fractures in the elderly: A world-wide projection
    • Cooper, C., Campion, G., and Melton, L.J.: Hip fractures in the elderly: a world-wide projection. Osteoporosis Int., 2:285-289, 1992.
    • (1992) Osteoporosis Int. , vol.2 , pp. 285-289
    • Cooper, C.1    Campion, G.2    Melton, L.J.3
  • 59
    • 0030685090 scopus 로고    scopus 로고
    • Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo study
    • Greendale, G.A., Edelstein, S., and Barrett-Connor, E.: Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo study. J. Bone Miner. Res., 12:1833-1843, 1997.
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 1833-1843
    • Greendale, G.A.1    Edelstein, S.2    Barrett-Connor, E.3
  • 60
    • 0031756218 scopus 로고    scopus 로고
    • Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen
    • Khosla, S., Melton, L.J. III, Atkinson, E.J., O'Fallon, W.M., Klee, G.G., and Riggs, B.L.: Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J. Clin. Endocronol. Metab., 83:2266-2274, 1998.
    • (1998) J. Clin. Endocronol. Metab. , vol.83 , pp. 2266-2274
    • Khosla, S.1    Melton L.J. III2    Atkinson, E.J.3    O'Fallon, W.M.4    Klee, G.G.5    Riggs, B.L.6
  • 61
    • 0031955217 scopus 로고    scopus 로고
    • A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postemenopausal women and contributes to bone loss in aging men
    • Riggs, B.L., Khosla, S., and Melton, L.J. III: A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postemenopausal women and contributes to bone loss in aging men. J. Bone Mineral Res., 13:763-773, 1998.
    • (1998) J. Bone Mineral Res. , vol.13 , pp. 763-773
    • Riggs, B.L.1    Khosla, S.2    Melton L.J. III3
  • 63
    • 0034088513 scopus 로고    scopus 로고
    • Androgen deficiency induces high turnover osteopenia in aged male rats: A sequential histomorphometric study
    • Erben, R.G., Eberle, J., Stahr, K., and Goldberg, M.: Androgen deficiency induces high turnover osteopenia in aged male rats: a sequential histomorphometric study. J. Bone Miner. Res., 15:1085-1098, 2000.
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 1085-1098
    • Erben, R.G.1    Eberle, J.2    Stahr, K.3    Goldberg, M.4
  • 64
    • 0025884279 scopus 로고
    • Androgen treatment prevents loss of cancellous bone in the orchidectomized rats
    • Wakley, G.K., Schutt, H.D., Hannon, K.S., and Turner, R.T.: Androgen treatment prevents loss of cancellous bone in the orchidectomized rats. J. Bone Miner. Res., 6:325-330, 1991.
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 325-330
    • Wakley, G.K.1    Schutt, H.D.2    Hannon, K.S.3    Turner, R.T.4
  • 65


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.