Inhibitory effects of ERβ on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells-prognostication for the use of ERβ-selective therapy

Pharmaceutical Biology

Volumn 50, Issue 7, 2012, Pages 839-849

  Li, Hui ^a   Tu, Zhenzhen ^a   An, Lianxiao ^a   Qian, Zhiyu ^b   Achilefu, Samuel ^c   Gu, Yueqing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF AERONAUTICS AND ASTRONAUTICS   (China)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

breast cancer; Estrogen receptor ; GFP; stable transfection; xenograft

Indexed keywords

CATHEPSIN D; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENISTEIN; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; RALOXIFENE; TRICHOSTATIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CELL ASSAY; CELL INVASION; CELL MOTILITY; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOPLASM; DRUG SELECTIVITY; DRUG TARGETING; FEMALE; GENETIC TRANSFECTION; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TUMOR XENOGRAFT; WOUND HEALING;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ESTROGEN RECEPTOR BETA; EVIDENCE-BASED MEDICINE; FEMALE; GROWTH INHIBITORS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; PROGNOSIS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; MUS;

EID: 84861998607     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.637506     Document Type: Article

References (37)

1. Ali S, Coombes RC. (2002). Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer, 2, 101-112. (Pubitemid 37328797)
2. Allred CD, Allred KF, Ju YH, Virant SM, Helferich WG. (2001). Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res, 61, 5045-5050. (Pubitemid 32681533)
3. Bardin A, Boulle N, Lazennec G, Vignon F, Pujol P. (2004). Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer, 11, 537-551. (Pubitemid 39331282)
4. Behrens D, Gill JH, Fichtner I. (2007). Loss of tumourigenicity of stably ERbeta-transfected MCF-7 breast cancer cells. Mol Cell Endocrinol, 274, 19-29. (Pubitemid 47161102)
5. Deroo BJ, Korach KS. (2006). Estrogen receptors and human disease. J Clin Invest, 116, 561-570. (Pubitemid 43326860)
6. Duong V, Licznar A, Margueron R, Boulle N, Busson M, Lacroix M, Katzenellenbogen BS, Cavaillès V, Lazennec G. (2006). ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors. Oncogene, 25, 1799-1806.
7. Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA. (1997). Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab, 82, 4258-4265. (Pubitemid 27525550)
8. Gottardis MM, Robinson SP, Jordan VC. (1988). Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic action of tamoxifen. J Steroid Biochem, 30, 311-314.
9. Gruvberger-Saal SK, Bendahl PO, Saal LH, Laakso M, Hegardt C, Edén P, Peterson C, Malmström P, Isola J, Borg A, Fernö M. (2007). Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res, 13, 1987-1994. (Pubitemid 46649864)
10. Hartman J, Lindberg K, Morani A, Inzunza J, Ström A, Gustafsson JA. (2006). Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. Cancer Res, 66, 11207-11213. (Pubitemid 46009948)
11. Hartman J, Ström A, Gustafsson JA. (2009). Estrogen receptor beta in breast cancer-diagnostic and therapeutic implications. Steroids, 74, 635-641.
12. Henderson BE, Ross R, Bernstein L. (1988). Estrogens as a cause of human cancer: The Richard and Hinda Rosenthal Foundation award lecture. Cancer Res, 48, 246-253. (Pubitemid 18045752)
13. Hodges-Gallagher L, Valentine CD, El Bader S, Kushner PJ. (2008). Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells. Breast Cancer Res Treat, 109, 241-250. (Pubitemid 351644839)
14. Honma N, Horii R, Iwase T, Saji S, Younes M, Takubo K, Matsuura M, Ito Y, Akiyama F, Sakamoto G. (2008). Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. J Clin Oncol, 26, 3727-3734.
15. Hsieh CY, Santell RC, Haslam SZ, Helferich WG. (1998). Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res, 58, 3833-3838. (Pubitemid 28405638)
16. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. (1996). Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA, 93, 5925-5930. (Pubitemid 26190778)
17. Kumagai Y, Fujita T, Ozaki M, Yokota S, Maeda M, Shida M, Otani Y, Yamaya H, Tsuruta H. (2009). Safety, tolerability and pharmacokinetics of TAS-108, a novel anti-oestrogen, in healthy post-menopausal Japanese women: A phase I single oral dose study. Basic Clin Pharmacol Toxicol, 104, 352-359.
18. Lazennec G, Bresson D, Lucas A, Chauveau C, Vignon F. (2001). ER beta inhibits proliferation and invasion of breast cancer cells. Endocrinology, 142, 4120-4130. (Pubitemid 32802685)
19. Levy N, Tatomer D, Herber CB, Zhao X, Tang H, Sargeant T, Ball LJ, Summers J, Speed TP, Leitman DC. (2008). Differential regulation of native estrogen receptor-regulatory elements by estradiol, tamoxifen, and raloxifene. Mol Endocrinol, 22, 287-303. (Pubitemid 351185932)
20. Leygue E, Dotzlaw H, Watson PH, Murphy LC. (1998). Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesis. Cancer Res, 58, 3197-3201. (Pubitemid 28371051)
21. Lindberg K, Ström A, Lock JG, Gustafsson JA, Haldosén LA, Helguero LA. (2010). Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer cells. J Cell Physiol, 222, 156-167.
22. Messina M, Barnes S. (1991). The role of soy products in reducing risk of cancer. J Natl Cancer Inst, 83, 541-546.
23. Moore JT, McKee DD, Slentz-Kesler K, Moore LB, Jones SA, Horne EL, Su JL, Kliewer SA, Lehmann JM, Willson TM. (1998). Cloning and characterization of human estrogen receptor beta isoforms. Biochem Biophys Res Commun, 247, 75-78. (Pubitemid 28412528)
24. Mosselman S, Polman J, Dijkema R. (1996). ER beta: Identification and characterization of a novel human estrogen receptor. FEBS Lett, 392, 49-53. (Pubitemid 26268330)
25. Novelli F, Milella M, Melucci E, Di Benedetto A, Sperduti I, Perrone- Donnorso R, Perracchio L, Venturo I, Nisticò C, Fabi A, Buglioni S, Natali PG, Mottolese M. (2008). A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: An observational prospective study. Breast Cancer Res, 10, R74.
26. Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL, Leitman DC. (2004). Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res, 64, 423-428. (Pubitemid 38114127)
27. Peng J, Sengupta S, Jordan VC. (2009). Potential of selective estrogen receptor modulators as treatments and preventives of breast cancer. Anticancer Agents Med Chem, 9, 481-499.
28. Pettersson K, Gustafsson JA. (2001). Role of estrogen receptor beta in estrogen action. Annu Rev Physiol, 63, 165-192. (Pubitemid 32318327)
29. Rochefort H, Platet N, Hayashido Y, Derocq D, Lucas A, Cunat S, Garcia M. (1998). Estrogen receptor mediated inhibition of cancer cell invasion and motility: An overview. J Steroid Biochem Mol Biol, 65, 163-168. (Pubitemid 28335602)
30. Rody A, Holtrich U, Solbach C, Kourtis K, von Minckwitz G, Engels K, Kissler S, Gätje R, Karn T, Kaufmann M. (2005). Methylation of estrogen receptor beta promoter correlates with loss of ER-beta expression in mammary carcinoma and is an early indication marker in premalignant lesions. Endocr Relat Cancer, 12, 903-916. (Pubitemid 41815784)
31. Roger P, Sahla ME, Mäkelä S, Gustafsson JA, Baldet P, Rochefort H. (2001). Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res, 61, 2537-2541. (Pubitemid 32685835)
32. Shaaban AM, Green AR, Karthik S, Alizadeh Y, Hughes TA, Harkins L, Ellis IO, Robertson JF, Paish EC, Saunders PT, Groome NP, Speirs V. (2008). Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients. Clin Cancer Res, 14, 5228-5235.
33. Skliris GP, Leygue E, Curtis-Snell L, Watson PH, Murphy LC. (2006). Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. Br J Cancer, 95, 616-626. (Pubitemid 44325902)
34. Williams C, Edvardsson K, Lewandowski SA, Ström A, Gustafsson JA. (2008). A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells. Oncogene, 27, 1019-1032. (Pubitemid 351225390)
35. Xing W, Archer TK. (1998). Upstream stimulatory factors mediate estrogen receptor activation of the cathepsin D promoter. Mol Endocrinol, 12, 1310-1321. (Pubitemid 128496193)
36. Zhao C, Dahlman-Wright K, Gustafsson JA. (2008). Estrogen receptor beta: An overview and update. Nucl Recept Signal, 6, e003.
37. Zhao C, Lam EW, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA, Dahlman-Wright K. (2003). Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: Regulation by methylation. Oncogene, 22, 7600-7606. (Pubitemid 37464093)