Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia

Endocrinology

Volumn 137, Issue 10, 1996, Pages 4139-4144

  Evans, Glenda L ^a   Bryant, Henry U ^b   Magee, David E ^b   Turner, Russell T ^a  

^a MAYO CLINIC   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RALOXIFENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BONE ATROPHY; BONE TURNOVER; CANCELLOUS BONE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; ESTROGEN THERAPY; HORMONAL REGULATION; HORMONE ACTION; MENOPAUSE; MORPHOMETRICS; NONHUMAN; OSTEOPENIA; PRIORITY JOURNAL; RAT; SUBSTITUTION THERAPY;

EID: 0029759978     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.10.8828469     Document Type: Article

References (43)

1. Richelson LS, Wahner HW, Melton LJ, Riggs BL 1984 Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. N Engl J Med 311:1273-1275
2. Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton III LJ 1981 Differential changes in bone mineral density of the appendicular skeleton with aging: relationship to spinal osteoporosis. J Clin Invest 67:328-335
3. Parfitt AM, Mathews CHE, Villaneuva AR, Kleerekoper M, Frame B, Rao DS 1983 Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 72:1396-1409
4. Genant HK, Cann CE, Ettinger B, Gordan GS 1982 Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 97:699-705
5. Riggs BL, Wahner NW, Dunn WL, Mazess RB, Offord KP, Melton LJ 1981 Differential changes in bone mineral density of the appendicular and axial skeleton with aging. J Clin Invest 67:328-335
6. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson KB, Clarke AC 1976 Long-term prevention of postmenopausal osteoporosis by estrogen. Lancet 1:1038-1041
7. Quigley ME, Martin PL, Burnier AM, Brooks P 1987 Estrogen therapy arrests bone loss in elderly women. Am J Obstet Gynecol 156:1516-1523
8. Weiss NS, Ure CL, Ballard JH, Williams AR, Daling JR 1980 Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N Engl J Med 303:1195-1198
9. Hutchinson TA, Polansky SM, Feinstein AR 1979 Postmenopausal oestrogens protect against fractures of hip and distal radius. Lancet 2:705-709
10. Ettinger B, Genant HK, Cann CE 1985 Long-term estrogen replacement therapy prevents bone loss and fractures. Ann Intern Med 102:319-324
11. Henderson BE 1989 The cancer question: an overview of recent epidemiologic and retrospective data. Am J Obstet Gynecol 161:1859-1864
12. Mack TM, Ross RK 1989 Risks and benefits of long-term treatment with estrogens. Schweiz Med Wocheschr [Suppl] 119:1811-1820
13. Key TJA, Pike MC 1988 The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer. Eur J Cancer 24:29-43
14. Steinberg KK, Thacker SB, Smith SJ, Stroup DE, Zack MM, Flanders WD, Berkelman RL 1991 A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. JAMA 265:1985-1990
15. Draper NW, Flowers DE, Huster WJ, Effects of raloxifene (LY139481 HCI) on biochemical markers of bone and lipid metabolism in healthy post-menopausal women. In: Christiansen K, Riis B (eds) Proceedings of the Fourth International Symposia on Osteoporosis. J Bone Miner Res, in press
16. Jordan VC, Phelps E, Lindgren JV 1987 Effects of antiestrogens on bone in castrated, and intact female rats. Breast Cancer Res Treat 10:31-35
17. Turner RT, Wakley GK, Hannon KS, Bell NH 1987 Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats. J Bone Miner Res 2:449-456
18. Turner RT, Wakley GK, Hannon KS, Bell NH 1988 Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone deficient rats. Endocrinology 122:1146-1150
19. Fentiman CM, Rodin A, Murby A, Fogelman I 1989 Bone mineral content of women receiving tamoxifen for mastalgia. Br J Cancer 60:262-264
20. Love RR, Mazess RB, Barden HS, Epstein S, Newcomb PA, Jordan VC, Carbone PP, DeMets DL 1992 Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N Engl J Med 326:852-856
21. Sibonga JD, Evans GL, Hauck ER, Turner RT, Long-term treatment with tamoxifen (TAM) alters cancellous bone architecture in adult ovary-intact rats. Breast Cancer Res Treat, in press
22. Black LJ, Sato M, Rowley ER, Magee DE, Bekele A, Williams DC, Cullinan GJ, Bendele R, Kauffman FG, Bensch WR, Frolik CA, Termine JD, Bryant HU 1994 Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest 93:63-69
23. Evans GL, Bryant HU, Magee D, Sato M, Turner RT 1994 The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology 134:2283-2288
24. Turner RT 1994 Cancellous bone turnover in growing rats: Time-dependent changes in association between calcein label and osteoblasts. J Bone Miner Res 9:1419-1424
25. Jones CD, Suarez T, Massey EH, Black LJ, Tinsley FC 1979 Synthesis and anti-estrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-napthalenyl] [4-(2-pyrrolidinyl)ethyoxy]-phenyl] methanone, methane sulfonic acid salt. J Med Chem 22:962-966
26. Black LJ, Jones CD, Falcone JF 1983 Antagonism of estrogen action with a new benzothiophene derived anti-estrogen. Life Sci 32:1031-1036
27. Westerlind KC, Wakley GK, Evans GL, Turner RT 1993 Estrogen does not increase bone formation in growing rats. Endocrinology 133:2924-2934
28. Schmidt IU, Dobnig H, Turner RT 1995 Intermittent parathyroid hormone treatment increases osteoblast number, steady state messenger ribonucleic acid levels for osteocalcin. Endocrinology 136:5127-5134
29. Parfitt AM, Mathews CHE, Villanueva AR, Kleesekoper M, Frame B, Rao DS 1983 Relationship between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72:1396-1409
30. Dempster DW, Birchman R, Xu R, Lindsay R, Shen V 1995 Temporal changes in cancellous bone structure of rats immediately after ovariectomy. Bone 16:157-161
31. Jordan VC, Murphy CS 1990 Endocrine pharmacology of antiestrogen as antitumor agents. Endocr Rev 11:578-610
32. Stenström A, Hansson LI, Thorngren KG 1982 Effect of ovariectomy on longitudinal bone growth. Anat Embryol 164:9-18
33. Wronski TJ, Lowry PL, Walsh CC, Ignaszewski LA 1985 Skeletal alterations in ovariectomized rats. Calcif Tissue Int 37:324-328
34. Wronski TJ, Walsh CC, Ignaszewski LA 1986 Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats. Bone 7:119-123
35. Turner RT, Evans GL, Wakley GK 1994 Reduced chondroclast differentiation results in increased cancellous bone volume in estrogen-treated growing rats. Endocrinology 134:461-466
36. Wronski TJ, Yen C-F, Dann LM 1993 Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats. Endocrinology 132:823-831
37. Abe T, Chow JWM, Lean JM, Chambers TJ 1993 Estrogen does not restore bone lost after ovariectomy in the rat. J Bone Miner Res 7:831-838
38. Staels B, Auwerx J, Chan L 1989 Influence of development, estrogens and food intake on apo-lipoproteins AI, AII, and E mRNA in rat liver and intestine. J Lipid Research 30:1137-1145
39. Ke HZ, Simmons HA, Pirie CM, Crawford DT, Thompson DD 1995 Droloxifene, a new estrogen antagonist/agonist, prevent bone loss in ovariectomized rats. Endocrinology 136:2435-2441
40. Turner RT 1996 Effects on bone and mineral metabolism: basic aspects. In: Dempster DW, Lindsay R, Jordan VC (eds) Estrogens and Antiestrogens. Lippincott-Raven Publishers, Philadelphia, in press
41. Wronski TJ, Cintron M, Dann LM 1988 Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Int 43:179-183
42. Westerlind KC, Wronski TJ, Evans GL, Turner RT 1994 Evidence that increased bone turnover is insufficient to result in bone loss in ovariectomized rats. J Bone Miner Res 9:S198 (Abstract A282)
43. Chow J, Lean JM, Chambers TJ 1992 17β-Estradiol stimulates cancellous bone formation in female rats. Endocrinology 130:3025-3032