Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism

Journal of Biological Chemistry

Volumn 288, Issue 12, 2013, Pages 8209-8221

  Streich, Frederick C ^a,b   Ronchi, Virginia P ^a   Connick, J Patrick ^a   Haas, Arthur L ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; ENZYMES; OLIGOMERIZATION; OLIGOMERS;

ALLOSTERIC MECHANISMS; CATALYSE; CHAIN FORMATION; CONJUGATED PROTEINS; LIGASES; OLIGOMERIZATIONS; POLYUBIQUITIN; POST-TRANSLATIONAL MODIFICATIONS; THIOESTERS; TRIPARTITE MOTIFS;

CHAINS;

LIGASE; NUCLEAR PROTEIN; POLYUBIQUITIN; PROTEIN UBC5; TRIPARTITE MOTIF LIGASE; TRIPARTITE MOTIF PROTEIN 25; TRIPARTITE MOTIF PROTEIN 32; TRIPARTITE MOTIF PROTEIN 5; UBIQUITIN CONJUGATING ENZYME E2; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONCENTRATION (PARAMETERS); CONJUGATION; CONTROLLED STUDY; CROSS LINKING; DIMERIZATION; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; OLIGOMERIZATION; PRIORITY JOURNAL;

EID: 84875443220     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.451567     Document Type: Article

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