-
1
-
-
79960202841
-
Type 2 diabetes across generations: From pathophysiology to prevention and management
-
Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 2011;378:169-181
-
(2011)
Lancet
, vol.378
, pp. 169-181
-
-
Nolan, C.J.1
Damm, P.2
Prentki, M.3
-
2
-
-
34248581989
-
Disordered lipid metabolism and the pathogenesis of insulin resistance
-
Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev 2007;87:507-520
-
(2007)
Physiol Rev
, vol.87
, pp. 507-520
-
-
Savage, D.B.1
Petersen, K.F.2
Shulman, G.I.3
-
3
-
-
0346887187
-
Putting the brakes on insulin signaling
-
Saltiel AR. Putting the brakes on insulin signaling. N Engl J Med 2003;349: 2560-2562
-
(2003)
N Engl J Med
, vol.349
, pp. 2560-2562
-
-
Saltiel, A.R.1
-
4
-
-
15444339756
-
Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
-
Frölich L, Blum-Degen D, Bernstein HG, et al. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm 1998;105:423-438
-
(1998)
J Neural Transm
, vol.105
, pp. 423-438
-
-
Frölich, L.1
Blum-Degen, D.2
Bernstein, H.G.3
-
5
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes?
-
Steen E, Terry BM, Rivera EJ, et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes? J Alzheimers Dis 2005;7:63-80
-
(2005)
J Alzheimers Dis
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
-
6
-
-
0026597107
-
Glucose and memory in mild senile dementia of the Alzheimer type
-
Craft S, Zallen G, Baker LD. Glucose and memory in mild senile dementia of the Alzheimer type. J Clin Exp Neuropsychol 1992;14:253-267
-
(1992)
J Clin Exp Neuropsychol
, vol.14
, pp. 253-267
-
-
Craft, S.1
Zallen, G.2
Baker, L.D.3
-
7
-
-
0031907459
-
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein e genotype
-
Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, Porte D Jr. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology 1998;50:164-168
-
(1998)
Neurology
, vol.50
, pp. 164-168
-
-
Craft, S.1
Peskind, E.2
Schwartz, M.W.3
Schellenberg, G.D.4
Raskind, M.5
Porte Jr., D.6
-
8
-
-
0842309993
-
Increased risk of type 2 diabetes in Alzheimer disease
-
Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 2004;53:474-481
-
(2004)
Diabetes
, vol.53
, pp. 474-481
-
-
Janson, J.1
Laedtke, T.2
Parisi, J.E.3
O'Brien, P.4
Petersen, R.C.5
Butler, P.C.6
-
9
-
-
79960902137
-
Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinolbinding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein
-
Mody N, Agouni A, McIlroy GD, Platt B, Delibegovic M. Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinolbinding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein. Diabetologia 2011;54:2143-2151
-
(2011)
Diabetologia
, vol.54
, pp. 2143-2151
-
-
Mody, N.1
Agouni, A.2
McIlroy, G.D.3
Platt, B.4
Delibegovic, M.5
-
10
-
-
84861877424
-
Amyloid-b induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway
-
Zhang Y, Zhou B, Zhang F, et al. Amyloid-b induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway. Diabetes 2012;61:1434-1443
-
(2012)
Diabetes
, vol.61
, pp. 1434-1443
-
-
Zhang, Y.1
Zhou, B.2
Zhang, F.3
-
12
-
-
77951776829
-
Alzheimer's disease: Strategies for disease modification
-
Citron M. Alzheimer's disease: strategies for disease modification. Nat Rev Drug Discov 2010;9:387-398
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 387-398
-
-
Citron, M.1
-
13
-
-
38049110692
-
Amyloid beta oligomers induce impairment of neuronal insulin receptors
-
Zhao WQ, De Felice FG, Fernandez S, et al. Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J 2008;22:246-260
-
(2008)
FASEB J
, vol.22
, pp. 246-260
-
-
Zhao, W.Q.1
De Felice, F.G.2
Fernandez, S.3
-
14
-
-
36348935683
-
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
-
Townsend M, Mehta T, Selkoe DJ. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 2007;282:33305-33312
-
(2007)
J Biol Chem
, vol.282
, pp. 33305-33312
-
-
Townsend, M.1
Mehta, T.2
Selkoe, D.J.3
-
15
-
-
60549084867
-
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Abeta oligomers
-
De Felice FG, Vieira MN, Bomfim TR, et al. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A 2009;106:1971-1976
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1971-1976
-
-
De Felice, F.G.1
Vieira, M.N.2
Bomfim, T.R.3
-
16
-
-
18744438248
-
Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
-
Xie L, Helmerhorst E, Taddei K, Plewright B, Van Bronswijk W, Martins R. Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci 2002;22:RC221
-
(2002)
J Neurosci
, vol.22
-
-
Xie, L.1
Helmerhorst, E.2
Taddei, K.3
Plewright, B.4
Van Bronswijk, W.5
Martins, R.6
-
17
-
-
0036319503
-
Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Parsadanian M, et al. Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease. J Neurochem 2002;81:229-236
-
(2002)
J Neurochem
, vol.81
, pp. 229-236
-
-
Demattos, R.B.1
Bales, K.R.2
Parsadanian, M.3
-
18
-
-
0037703255
-
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
-
Deane R, Du Yan S, Submamaryan RK, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 2003;9:907-913
-
(2003)
Nat Med
, vol.9
, pp. 907-913
-
-
Deane, R.1
Du Yan, S.2
Submamaryan, R.K.3
-
19
-
-
0024451476
-
Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease
-
Joachim CL, Mori H, Selkoe DJ. Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease. Nature 1989;341:226-230
-
(1989)
Nature
, vol.341
, pp. 226-230
-
-
Joachim, C.L.1
Mori, H.2
Selkoe, D.J.3
-
20
-
-
77951028451
-
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes
-
Takeda S, Sato N, Uchio-Yamada K, et al. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A 2010;107: 7036-7041
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 7036-7041
-
-
Takeda, S.1
Sato, N.2
Uchio-Yamada, K.3
-
21
-
-
9644252796
-
Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice
-
Liu L, Herukka SK, Minkeviciene R, van Groen T, Tanila H. Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice. Neurobiol Dis 2004;17: 516-523
-
(2004)
Neurobiol Dis
, vol.17
, pp. 516-523
-
-
Liu, L.1
Herukka, S.K.2
Minkeviciene, R.3
Van Groen, T.4
Tanila, H.5
-
22
-
-
33749020837
-
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
-
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 2006;313:1781-1784
-
(2006)
Science
, vol.313
, pp. 1781-1784
-
-
Meyer-Luehmann, M.1
Coomaraswamy, J.2
Bolmont, T.3
-
23
-
-
0031737373
-
Correct homeostasis model assessment (HOMA) evaluation uses the computer program
-
Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998; 21:2191-2192
-
(1998)
Diabetes Care
, vol.21
, pp. 2191-2192
-
-
Levy, J.C.1
Matthews, D.R.2
Hermans, M.P.3
-
24
-
-
57749109116
-
JAK2/STAT2/STAT3 are required for myogenic differentiation
-
Wang K, Wang C, Xiao F, Wang H, Wu Z. JAK2/STAT2/STAT3 are required for myogenic differentiation. J Biol Chem 2008;283:34029-34036
-
(2008)
J Biol Chem
, vol.283
, pp. 34029-34036
-
-
Wang, K.1
Wang, C.2
Xiao, F.3
Wang, H.4
Wu, Z.5
-
25
-
-
34948904815
-
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
-
Matsuzaka T, Shimano H, Yahagi N, et al. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat Med 2007; 13:1193-1202
-
(2007)
Nat Med
, vol.13
, pp. 1193-1202
-
-
Matsuzaka, T.1
Shimano, H.2
Yahagi, N.3
-
26
-
-
82755197062
-
Functional links between Ab toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast
-
Treusch S, Hamamichi S, Goodman JL, et al. Functional links between Ab toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science 2011;334:1241-1245
-
(2011)
Science
, vol.334
, pp. 1241-1245
-
-
Treusch, S.1
Hamamichi, S.2
Goodman, J.L.3
-
27
-
-
8544240891
-
Systemic catabolism of Alzheimer's Abeta40 and Abeta42
-
Ghiso J, Shayo M, Calero M, et al. Systemic catabolism of Alzheimer's Abeta40 and Abeta42. J Biol Chem 2004;279:45897-45908
-
(2004)
J Biol Chem
, vol.279
, pp. 45897-45908
-
-
Ghiso, J.1
Shayo, M.2
Calero, M.3
-
28
-
-
33847043503
-
Diabetes and suppressors of cytokine signaling proteins
-
Rønn SG, Billestrup N, Mandrup-Poulsen T. Diabetes and suppressors of cytokine signaling proteins. Diabetes 2007;56:541-548
-
(2007)
Diabetes
, vol.56
, pp. 541-548
-
-
Rønn, S.G.1
Billestrup, N.2
Mandrup-Poulsen, T.3
-
29
-
-
58549096688
-
Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons
-
Chiba T, Yamada M, Sasabe J, et al. Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Mol Psychiatry 2009;14:206-222
-
(2009)
Mol Psychiatry
, vol.14
, pp. 206-222
-
-
Chiba, T.1
Yamada, M.2
Sasabe, J.3
-
30
-
-
77952604395
-
Tyk2/STAT3 signaling mediates beta-amyloidinduced neuronal cell death: Implications in Alzheimer's disease
-
Wan J, Fu AK, Ip FC, et al. Tyk2/STAT3 signaling mediates beta-amyloidinduced neuronal cell death: implications in Alzheimer's disease. J Neurosci 2010;30:6873-6881
-
(2010)
J Neurosci
, vol.30
, pp. 6873-6881
-
-
Wan, J.1
Fu, A.K.2
Ip, F.C.3
-
31
-
-
84055223593
-
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
-
Meakin PJ, Harper AJ, Hamilton DL, et al. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. Biochem J 2012;441:285-296
-
(2012)
Biochem J
, vol.441
, pp. 285-296
-
-
Meakin, P.J.1
Harper, A.J.2
Hamilton, D.L.3
-
32
-
-
79952734461
-
Signaling by vitamin A and retinolbinding protein regulates gene expression to inhibit insulin responses
-
Berry DC, Jin H, Majumdar A, Noy N. Signaling by vitamin A and retinolbinding protein regulates gene expression to inhibit insulin responses. Proc Natl Acad Sci U S A 2011;108:4340-4345
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4340-4345
-
-
Berry, D.C.1
Jin, H.2
Majumdar, A.3
Noy, N.4
-
33
-
-
33745293071
-
Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: Possible target to ameliorate insulin resistance
-
Thirone AC, JeBailey L, Bilan PJ, Klip A. Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance. Diabetes 2006;55:942-951
-
(2006)
Diabetes
, vol.55
, pp. 942-951
-
-
Thirone, A.C.1
Jebailey, L.2
Bilan, P.J.3
Klip, A.4
-
34
-
-
84858952949
-
Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance
-
Shi SY, Martin RG, Duncan RE, et al. Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance. J Biol Chem 2012;287:10277-10288
-
(2012)
J Biol Chem
, vol.287
, pp. 10277-10288
-
-
Shi, S.Y.1
Martin, R.G.2
Duncan, R.E.3
-
36
-
-
37549035051
-
Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
-
Cao D, Lu H, Lewis TL, Li L. Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 2007;282: 36275-36282
-
(2007)
J Biol Chem
, vol.282
, pp. 36275-36282
-
-
Cao, D.1
Lu, H.2
Lewis, T.L.3
Li, L.4
-
37
-
-
4644286910
-
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
-
Ho L, Qin W, Pompl PN, et al. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 2004;18:902-904
-
(2004)
FASEB J
, vol.18
, pp. 902-904
-
-
Ho, L.1
Qin, W.2
Pompl, P.N.3
-
38
-
-
29844432266
-
Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: Review and hypothesis
-
Qiu WQ, Folstein MF. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol Aging 2006;27:190-198
-
(2006)
Neurobiol Aging
, vol.27
, pp. 190-198
-
-
Qiu, W.Q.1
Folstein, M.F.2
-
39
-
-
79956158458
-
Molecular mechanisms linking diabetes mellitus and Alzheimer disease: Beta-amyloid peptide, insulin signaling, and neuronal function
-
Takeda S, Sato N, Rakugi H, Morishita R. Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. Mol Biosyst 2011;7: 1822-1827
-
(2011)
Mol Biosyst
, vol.7
, pp. 1822-1827
-
-
Takeda, S.1
Sato, N.2
Rakugi, H.3
Morishita, R.4
-
40
-
-
4644267911
-
Plasma levels of amyloid betaprotein 42 are increased in women with mild cognitive impairment
-
Assini A, Cammarata S, Vitali A, et al. Plasma levels of amyloid betaprotein 42 are increased in women with mild cognitive impairment. Neurology 2004;63:828-831
-
(2004)
Neurology
, vol.63
, pp. 828-831
-
-
Assini, A.1
Cammarata, S.2
Vitali, A.3
-
41
-
-
0037699792
-
Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels
-
Fukumoto H, Tennis M, Locascio JJ, Hyman BT, Growdon JH, Irizarry MC. Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. Arch Neurol 2003;60:958-964
-
(2003)
Arch Neurol
, vol.60
, pp. 958-964
-
-
Fukumoto, H.1
Tennis, M.2
Locascio, J.J.3
Hyman, B.T.4
Growdon, J.H.5
Irizarry, M.C.6
-
42
-
-
45449085687
-
Amyloid precursor protein expression is upregulated in adipocytes in obesity
-
Lee YH, Tharp WG, Maple RL, Nair S, Permana PA, Pratley RE. Amyloid precursor protein expression is upregulated in adipocytes in obesity. Obesity (Silver Spring) 2008;16:1493-1500
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 1493-1500
-
-
Lee, Y.H.1
Tharp, W.G.2
Maple, R.L.3
Nair, S.4
Permana, P.A.5
Pratley, R.E.6
-
43
-
-
33644592540
-
Plasma Abeta42 correlates positively with increased body fat in healthy individuals
-
Balakrishnan K, Verdile G, Mehta PD, et al. Plasma Abeta42 correlates positively with increased body fat in healthy individuals. J Alzheimers Dis 2005;8:269-282
-
(2005)
J Alzheimers Dis
, vol.8
, pp. 269-282
-
-
Balakrishnan, K.1
Verdile, G.2
Mehta, P.D.3
-
44
-
-
67349112388
-
Common features between diabetes mellitus and Alzheimer's disease
-
Götz J, Ittner LM, Lim YA. Common features between diabetes mellitus and Alzheimer's disease. Cell Mol Life Sci 2009;66:1321-1325
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 1321-1325
-
-
Götz, J.1
Ittner, L.M.2
Lim, Y.A.3
-
45
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006;444:840-846
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
46
-
-
2342466734
-
Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
-
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27:1047-1053
-
(2004)
Diabetes Care
, vol.27
, pp. 1047-1053
-
-
Wild, S.1
Roglic, G.2
Green, A.3
Sicree, R.4
King, H.5
|