Susceptibility to diet-induced obesity and glucose intolerance in the APPSWE/PSEN1A246E mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

Diabetologia

Volumn 54, Issue 8, 2011, Pages 2143-2151

  Mody, N ^a   Agouni, A ^a   Mcilroy, G D ^a   Platt, B ^b   Delibegovic, M ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Alzheimer's disease; Diet induced obesity; Glucose intolerance; Human mutations; Insulin resistance; Transgenes; Type 2 diabetes

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PRESENILIN 1; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; RETINOL BINDING PROTEIN 4; S6 KINASE;

AGE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APP SWE GENE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DIET; DIET RESTRICTION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE MUTATION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HYPERGLYCEMIA; INSULIN RESISTANCE; LIPID DIET; LOW FAT DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PSEN1 A246E GENE; RISK FACTOR; SIGNAL TRANSDUCTION; TRANSGENE; WEIGHT GAIN;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BODY WEIGHT; BRAIN; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUCOSE INTOLERANCE; HUMANS; IMMUNOBLOTTING; MICE; MICE, TRANSGENIC; OBESITY; PHOSPHORYLATION; PRESENILIN-1; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RETINOL-BINDING PROTEINS, PLASMA; RIBOSOMAL PROTEIN S6;

EID: 79960902137     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2160-2     Document Type: Article

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