Putting the Brakes on Insulin Signaling

New England Journal of Medicine

Volumn 349, Issue 26, 2003, Pages 2560-2562

  Saltiel, Alan R ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOCORTICOID; GLUCOSE; INSULIN; INSULIN RECEPTOR; LIPID; METFORMIN; MUTANT PROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL; PROTEIN; PROTEIN KINASE B; PROTEIN TRB3; UNCLASSIFIED DRUG;

ARTICLE; DRUG TARGETING; EPIDEMIC; GASTROINTESTINAL SYMPTOM; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRESS;

ANIMALS; BLOOD GLUCOSE; CELL CYCLE PROTEINS; FASTING; GENE EXPRESSION REGULATION; HUMANS; INSULIN; INSULIN RESISTANCE; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, INSULIN; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 0346887187     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMcibr031668     Document Type: Article

References (5)

1. Du K, Herzig S, Kulkarni RN, Montiminy M. TKB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 2003;300:1574-7.
2. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799-806.
3. Puigserver P, Rhee J, Donovan J, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003;423:550-5.
4. Saltiel AR, Pessin JE. Insulin signaling pathways in time and space. Trends Cell Biol 2002;12:65-71.
5. Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002;420:333-6.