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Volumn 8, Issue 3, 2013, Pages

HCMV Activates the IL-6-JAK-STAT3 Axis in HepG2 Cells and Primary Human Hepatocytes

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN 1; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; JANUS KINASE; KI 67 ANTIGEN; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; PROTEIN P72; STAT3 PROTEIN; SURVIVIN; UNCLASSIFIED DRUG;

EID: 84875440552     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059591     Document Type: Article
Times cited : (62)

References (62)
  • 1
    • 58149376548 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocellular carcinoma
    • Aravalli RN, Steer CJ, Cressman EN, (2008) Molecular mechanisms of hepatocellular carcinoma. Hepatology 48: 2047-2063.
    • (2008) Hepatology , vol.48 , pp. 2047-2063
    • Aravalli, R.N.1    Steer, C.J.2    Cressman, E.N.3
  • 2
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, et al. (2007) Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317: 121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5
  • 3
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY, He G, Ali SR, et al. (2010) Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140: 197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5
  • 4
    • 70349849505 scopus 로고    scopus 로고
    • Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences
    • Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, et al. (2009) Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences. Int J Cancer 125: 2264-2269.
    • (2009) Int J Cancer , vol.125 , pp. 2264-2269
    • Nakagawa, H.1    Maeda, S.2    Yoshida, H.3    Tateishi, R.4    Masuzaki, R.5
  • 5
    • 65649111667 scopus 로고    scopus 로고
    • High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
    • Wong VW, Yu J, Cheng AS, Wong GL, Chan HY, et al. (2009) High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B. Int J Cancer 124: 2766-2770.
    • (2009) Int J Cancer , vol.124 , pp. 2766-2770
    • Wong, V.W.1    Yu, J.2    Cheng, A.S.3    Wong, G.L.4    Chan, H.Y.5
  • 6
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: from basic science to medicine-40 years in immunology
    • Kishimoto T, (2005) Interleukin-6: from basic science to medicine-40 years in immunology. Annu Rev Immunol 23: 1-21.
    • (2005) Annu Rev Immunol , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 8
    • 78650859531 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 - key players in liver inflammation and cancer
    • He G, Karin M, (2011) NF-kappaB and STAT3- key players in liver inflammation and cancer. Cell Res 21: 159-168.
    • (2011) Cell Res , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 9
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H, Pardoll D, Jove R, (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9: 798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 10
    • 69149098253 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?
    • Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, et al. (2009) Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann N Y Acad Sci 1171: 59-76.
    • (2009) Ann N Y Acad Sci , vol.1171 , pp. 59-76
    • Aggarwal, B.B.1    Kunnumakkara, A.B.2    Harikumar, K.B.3    Gupta, S.R.4    Tharakan, S.T.5
  • 11
    • 3242808001 scopus 로고    scopus 로고
    • Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients
    • Coaquette A, Bourgeois A, Dirand C, Varin A, Chen W, et al. (2004) Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients. Clin Infect Dis 39: 155-161.
    • (2004) Clin Infect Dis , vol.39 , pp. 155-161
    • Coaquette, A.1    Bourgeois, A.2    Dirand, C.3    Varin, A.4    Chen, W.5
  • 12
    • 0037096733 scopus 로고    scopus 로고
    • Human cytomegalovirus infection and expression in human malignant glioma
    • Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, et al. (2002) Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res 62: 3347-3350.
    • (2002) Cancer Res , vol.62 , pp. 3347-3350
    • Cobbs, C.S.1    Harkins, L.2    Samanta, M.3    Gillespie, G.Y.4    Bharara, S.5
  • 13
    • 0037121233 scopus 로고    scopus 로고
    • Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer
    • Harkins L, Volk AL, Samanta M, Mikolaenko I, Britt WJ, et al. (2002) Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 360: 1557-1563.
    • (2002) Lancet , vol.360 , pp. 1557-1563
    • Harkins, L.1    Volk, A.L.2    Samanta, M.3    Mikolaenko, I.4    Britt, W.J.5
  • 14
    • 79954502340 scopus 로고    scopus 로고
    • Detection of human cytomegalovirus in normal and neoplastic breast epithelium
    • Harkins LE, Matlaf LA, Soroceanu L, Klemm K, Britt WJ, et al. (2010) Detection of human cytomegalovirus in normal and neoplastic breast epithelium. Herpesviridae 1: 8.
    • (2010) Herpesviridae , vol.1 , pp. 8
    • Harkins, L.E.1    Matlaf, L.A.2    Soroceanu, L.3    Klemm, K.4    Britt, W.J.5
  • 15
    • 0042236661 scopus 로고    scopus 로고
    • High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma
    • Samanta M, Harkins L, Klemm K, Britt WJ, Cobbs CS, (2003) High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma. J Urol 170: 998-1002.
    • (2003) J Urol , vol.170 , pp. 998-1002
    • Samanta, M.1    Harkins, L.2    Klemm, K.3    Britt, W.J.4    Cobbs, C.S.5
  • 17
    • 80053390591 scopus 로고    scopus 로고
    • Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target
    • Baryawno N, Rahbar A, Wolmer-Solberg N, Taher C, Odeberg J, et al. (2011) Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. J Clin Invest 121: 4043-4055.
    • (2011) J Clin Invest , vol.121 , pp. 4043-4055
    • Baryawno, N.1    Rahbar, A.2    Wolmer-Solberg, N.3    Taher, C.4    Odeberg, J.5
  • 18
    • 82255169334 scopus 로고    scopus 로고
    • Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship
    • Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T, (2012) Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol 92: 118-125.
    • (2012) Exp Mol Pathol , vol.92 , pp. 118-125
    • Melnick, M.1    Sedghizadeh, P.P.2    Allen, C.M.3    Jaskoll, T.4
  • 19
    • 79954991007 scopus 로고    scopus 로고
    • Is HCMV a tumor promoter?
    • Soroceanu L, Cobbs CS, (2010) Is HCMV a tumor promoter? Virus Res 157: 193-203.
    • (2010) Virus Res , vol.157 , pp. 193-203
    • Soroceanu, L.1    Cobbs, C.S.2
  • 20
    • 85056067718 scopus 로고    scopus 로고
    • Cytomegalovirus and tumors: two players for one goal-immune escape
    • Lepiller Q, Aziz Khan K, Di Martino V, Herbein G, (2011) Cytomegalovirus and tumors: two players for one goal-immune escape. Open Virol J 5: 60-69.
    • (2011) Open Virol J , vol.5 , pp. 60-69
    • Lepiller, Q.1    Aziz Khan, K.2    Di Martino, V.3    Herbein, G.4
  • 21
    • 67649201751 scopus 로고    scopus 로고
    • Bcl-3-regulated transcription from major immediate-early promoter of human cytomegalovirus in monocyte-derived macrophages
    • Khan KA, Coaquette A, Davrinche C, Herbein G, (2009) Bcl-3-regulated transcription from major immediate-early promoter of human cytomegalovirus in monocyte-derived macrophages. J Immunol 182: 7784-7794.
    • (2009) J Immunol , vol.182 , pp. 7784-7794
    • Khan, K.A.1    Coaquette, A.2    Davrinche, C.3    Herbein, G.4
  • 22
    • 10744225986 scopus 로고    scopus 로고
    • Coding potential of laboratory and clinical strains of human cytomegalovirus
    • Murphy E, Yu D, Grimwood J, Schmutz J, Dickson M, et al. (2003) Coding potential of laboratory and clinical strains of human cytomegalovirus. Proc Natl Acad Sci U S A 100: 14976-14981.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14976-14981
    • Murphy, E.1    Yu, D.2    Grimwood, J.3    Schmutz, J.4    Dickson, M.5
  • 23
    • 84255197298 scopus 로고    scopus 로고
    • Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells
    • Carlier J, Martin H, Mariame B, Rauwel B, Mengelle C, et al. (2011) Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells. Blood 118: 6783-6792.
    • (2011) Blood , vol.118 , pp. 6783-6792
    • Carlier, J.1    Martin, H.2    Mariame, B.3    Rauwel, B.4    Mengelle, C.5
  • 24
    • 0025159174 scopus 로고
    • Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and Ki-67 antigen: a new view of the cell cycle
    • Landberg G, Tan EM, Roos G, (1990) Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and Ki-67 antigen: a new view of the cell cycle. Exp Cell Res 187: 111-118.
    • (1990) Exp Cell Res , vol.187 , pp. 111-118
    • Landberg, G.1    Tan, E.M.2    Roos, G.3
  • 25
    • 0033005556 scopus 로고    scopus 로고
    • Cytomegalovirus induction of interleukin-6 in lung fibroblasts occurs independently of active infection and involves a G protein and the transcription factor, NF-kappaB
    • Carlquist JF, Edelman L, Bennion DW, Anderson JL, (1999) Cytomegalovirus induction of interleukin-6 in lung fibroblasts occurs independently of active infection and involves a G protein and the transcription factor, NF-kappaB. J Infect Dis 179: 1094-1100.
    • (1999) J Infect Dis , vol.179 , pp. 1094-1100
    • Carlquist, J.F.1    Edelman, L.2    Bennion, D.W.3    Anderson, J.L.4
  • 26
    • 0031114133 scopus 로고    scopus 로고
    • Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression
    • Iwamoto GK, Konicek SA, (1997) Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression. J Investig Med 45: 175-182.
    • (1997) J Investig Med , vol.45 , pp. 175-182
    • Iwamoto, G.K.1    Konicek, S.A.2
  • 27
    • 0025929101 scopus 로고
    • Cellular oncogene activation by human cytomegalovirus. Lack of correlation with virus infectivity and immediate early gene expression
    • Boldogh I, AbuBakar S, Millinoff D, Deng CZ, Albrecht T, (1991) Cellular oncogene activation by human cytomegalovirus. Lack of correlation with virus infectivity and immediate early gene expression. Arch Virol 118: 163-177.
    • (1991) Arch Virol , vol.118 , pp. 163-177
    • Boldogh, I.1    AbuBakar, S.2    Millinoff, D.3    Deng, C.Z.4    Albrecht, T.5
  • 28
    • 0042265526 scopus 로고    scopus 로고
    • Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus
    • Wang X, Huong SM, Chiu ML, Raab-Traub N, Huang ES, (2003) Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus. Nature 424: 456-461.
    • (2003) Nature , vol.424 , pp. 456-461
    • Wang, X.1    Huong, S.M.2    Chiu, M.L.3    Raab-Traub, N.4    Huang, E.S.5
  • 29
    • 0034007745 scopus 로고    scopus 로고
    • Liver regeneration
    • Fausto N, (2000) Liver regeneration. J Hepatol 32: 19-31.
    • (2000) J Hepatol , vol.32 , pp. 19-31
    • Fausto, N.1
  • 30
    • 0035038252 scopus 로고    scopus 로고
    • Cyclin D1 overexpression in hepatocellular carcinoma
    • Joo M, Kang YK, Kim MR, Lee HK, Jang JJ, (2001) Cyclin D1 overexpression in hepatocellular carcinoma. Liver 21: 89-95.
    • (2001) Liver , vol.21 , pp. 89-95
    • Joo, M.1    Kang, Y.K.2    Kim, M.R.3    Lee, H.K.4    Jang, J.J.5
  • 31
    • 77950530704 scopus 로고    scopus 로고
    • CADPE suppresses cyclin D1 expression in hepatocellular carcinoma by blocking IL-6-induced STAT3 activation
    • Won C, Lee CS, Lee JK, Kim TJ, Lee KH, et al. (2010) CADPE suppresses cyclin D1 expression in hepatocellular carcinoma by blocking IL-6-induced STAT3 activation. Anticancer Res 30: 481-488.
    • (2010) Anticancer Res , vol.30 , pp. 481-488
    • Won, C.1    Lee, C.S.2    Lee, J.K.3    Kim, T.J.4    Lee, K.H.5
  • 32
    • 0037267333 scopus 로고    scopus 로고
    • Validating survivin as a cancer therapeutic target
    • Altieri DC, (2003) Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3: 46-54.
    • (2003) Nat Rev Cancer , vol.3 , pp. 46-54
    • Altieri, D.C.1
  • 34
    • 84864465226 scopus 로고    scopus 로고
    • Clinical implications of cancer stem cell biology in hepatocellular carcinoma
    • Ji J, Wang XW, (2012) Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Semin Oncol 39: 461-472.
    • (2012) Semin Oncol , vol.39 , pp. 461-472
    • Ji, J.1    Wang, X.W.2
  • 35
    • 79958271033 scopus 로고    scopus 로고
    • Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines
    • Cao L, Zhou Y, Zhai B, Liao J, Xu W, et al. (2011) Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterology 11: 71.
    • (2011) BMC Gastroenterology , vol.11 , pp. 71
    • Cao, L.1    Zhou, Y.2    Zhai, B.3    Liao, J.4    Xu, W.5
  • 37
    • 58149326854 scopus 로고    scopus 로고
    • Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, et al. (2009) Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 457: 200-204.
    • (2009) Nature , vol.457 , pp. 200-204
    • Rebouissou, S.1    Amessou, M.2    Couchy, G.3    Poussin, K.4    Imbeaud, S.5
  • 38
    • 40649087829 scopus 로고    scopus 로고
    • Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN
    • Sun X, Zhang J, Wang L, Tian Z, (2008) Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN. Cancer Lett 262: 201-213.
    • (2008) Cancer Lett , vol.262 , pp. 201-213
    • Sun, X.1    Zhang, J.2    Wang, L.3    Tian, Z.4
  • 39
    • 83455162844 scopus 로고    scopus 로고
    • IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
    • Gu FM, Li QL, Gao Q, Jiang JH, Zhu K, et al. (2011) IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma. Mol Cancer 10: 150.
    • (2011) Mol Cancer , vol.10 , pp. 150
    • Gu, F.M.1    Li, Q.L.2    Gao, Q.3    Jiang, J.H.4    Zhu, K.5
  • 40
    • 77956635499 scopus 로고    scopus 로고
    • HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis
    • Slinger E, Maussang D, Schreiber A, Siderius M, Rahbar A, et al. (2010) HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis. Sci Signal 3: ra58.
    • (2010) Sci Signal , vol.3
    • Slinger, E.1    Maussang, D.2    Schreiber, A.3    Siderius, M.4    Rahbar, A.5
  • 41
    • 78049430384 scopus 로고    scopus 로고
    • The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice
    • Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, et al. (2010) The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. J Clin Invest 120: 3969-3978.
    • (2010) J Clin Invest , vol.120 , pp. 3969-3978
    • Bongers, G.1    Maussang, D.2    Muniz, L.R.3    Noriega, V.M.4    Fraile-Ramos, A.5
  • 42
    • 34147096292 scopus 로고    scopus 로고
    • Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression
    • Tashiro E, Tsuchiya A, Imoto M, (2007) Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. Cancer Sci 98: 629-635.
    • (2007) Cancer Sci , vol.98 , pp. 629-635
    • Tashiro, E.1    Tsuchiya, A.2    Imoto, M.3
  • 43
    • 34250800462 scopus 로고    scopus 로고
    • Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver
    • Takahashi Y, Kawate S, Watanabe M, Fukushima J, Mori S, et al. (2007) Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver. Pathol Int. Australia. pp. 437-442.
    • (2007) Pathol Int. Australia , pp. 437-442
    • Takahashi, Y.1    Kawate, S.2    Watanabe, M.3    Fukushima, J.4    Mori, S.5
  • 44
    • 0031278624 scopus 로고    scopus 로고
    • Cyclin D1 antisense RNA destabilizes pRb and retards lung cancer cell growth
    • Driscoll B, Wu L, Buckley S, Hall FL, Anderson KD, et al. (1997) Cyclin D1 antisense RNA destabilizes pRb and retards lung cancer cell growth. Am J Physiol 273: L941-949.
    • (1997) Am J Physiol , vol.273
    • Driscoll, B.1    Wu, L.2    Buckley, S.3    Hall, F.L.4    Anderson, K.D.5
  • 45
    • 77749342725 scopus 로고    scopus 로고
    • Survivin overexpression in HCC and liver cirrhosis differentially correlates with p-STAT3 and E-cadherin
    • Peroukides S, Bravou V, Alexopoulos A, Varakis J, Kalofonos H, et al. (2010) Survivin overexpression in HCC and liver cirrhosis differentially correlates with p-STAT3 and E-cadherin. Histol Histopathol 25: 299-307.
    • (2010) Histol Histopathol , vol.25 , pp. 299-307
    • Peroukides, S.1    Bravou, V.2    Alexopoulos, A.3    Varakis, J.4    Kalofonos, H.5
  • 46
    • 78650973200 scopus 로고    scopus 로고
    • IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin
    • Botto S, Streblow DN, DeFilippis V, White L, Kreklywich CN, et al. (2011) IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin. Blood 117: 352-361.
    • (2011) Blood , vol.117 , pp. 352-361
    • Botto, S.1    Streblow, D.N.2    DeFilippis, V.3    White, L.4    Kreklywich, C.N.5
  • 47
    • 65549120715 scopus 로고    scopus 로고
    • Modes of p53 regulation
    • Kruse JP, Gu W, (2009) Modes of p53 regulation. Cell 137: 609-622.
    • (2009) Cell , vol.137 , pp. 609-622
    • Kruse, J.P.1    Gu, W.2
  • 48
    • 0029957281 scopus 로고    scopus 로고
    • Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells
    • Kovacs A, Weber ML, Burns LJ, Jacob HS, Vercellotti GM, (1996) Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells. Am J Pathol 149: 1531-1539.
    • (1996) Am J Pathol , vol.149 , pp. 1531-1539
    • Kovacs, A.1    Weber, M.L.2    Burns, L.J.3    Jacob, H.S.4    Vercellotti, G.M.5
  • 49
    • 0027967730 scopus 로고
    • Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts
    • Muganda P, Mendoza O, Hernandez J, Qian Q, (1994) Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts. J Virol 68: 8028-8034.
    • (1994) J Virol , vol.68 , pp. 8028-8034
    • Muganda, P.1    Mendoza, O.2    Hernandez, J.3    Qian, Q.4
  • 50
    • 0028033418 scopus 로고
    • Potential role of human cytomegalovirus and p53 interaction in coronary restenosis
    • Speir E, Modali R, Huang ES, Leon MB, Shawl F, et al. (1994) Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 265: 391-394.
    • (1994) Science , vol.265 , pp. 391-394
    • Speir, E.1    Modali, R.2    Huang, E.S.3    Leon, M.B.4    Shawl, F.5
  • 51
    • 35748977117 scopus 로고    scopus 로고
    • Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination
    • Chen Z, Knutson E, Wang S, Martinez LA, Albrecht T, (2007) Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination. J Biol Chem 282: 29284-29295.
    • (2007) J Biol Chem , vol.282 , pp. 29284-29295
    • Chen, Z.1    Knutson, E.2    Wang, S.3    Martinez, L.A.4    Albrecht, T.5
  • 52
    • 3042600724 scopus 로고    scopus 로고
    • HCMV IE2-mediated inhibition of HAT activity downregulates p53 function
    • Hsu CH, Chang MD, Tai KY, Yang YT, Wang PS, et al. (2004) HCMV IE2-mediated inhibition of HAT activity downregulates p53 function. Embo J 23: 2269-2280.
    • (2004) Embo J , vol.23 , pp. 2269-2280
    • Hsu, C.H.1    Chang, M.D.2    Tai, K.Y.3    Yang, Y.T.4    Wang, P.S.5
  • 53
    • 67649424560 scopus 로고    scopus 로고
    • p21 in cancer: intricate networks and multiple activities
    • Abbas T, Dutta A, (2009) p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 9: 400-414.
    • (2009) Nat Rev Cancer , vol.9 , pp. 400-414
    • Abbas, T.1    Dutta, A.2
  • 54
    • 0036017536 scopus 로고    scopus 로고
    • High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases
    • Wagayama H, Shiraki K, Sugimoto K, Ito T, Fujikawa K, et al. (2002) High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases. Hum Pathol 33: 429-434.
    • (2002) Hum Pathol , vol.33 , pp. 429-434
    • Wagayama, H.1    Shiraki, K.2    Sugimoto, K.3    Ito, T.4    Fujikawa, K.5
  • 55
    • 33748310810 scopus 로고    scopus 로고
    • Cytoplasmic p21(WAF1/CIP1) expression in human hepatocellular carcinomas
    • Shiraki K, Wagayama H, (2006) Cytoplasmic p21(WAF1/CIP1) expression in human hepatocellular carcinomas. Liver Int 26: 1018-1019.
    • (2006) Liver Int , vol.26 , pp. 1018-1019
    • Shiraki, K.1    Wagayama, H.2
  • 56
    • 84866447416 scopus 로고    scopus 로고
    • The evolving concept of cancer and metastasis stem cells
    • Baccelli I, Trumpp A, (2012) The evolving concept of cancer and metastasis stem cells. J Cell Biol 198: 281-293.
    • (2012) J Cell Biol , vol.198 , pp. 281-293
    • Baccelli, I.1    Trumpp, A.2
  • 57
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • Iliopoulos D, Hirsch HA, Wang G, Struhl K, (2011) Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci USA 108: 1397-1402.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.3    Struhl, K.4
  • 58
    • 84855876635 scopus 로고    scopus 로고
    • STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+/CD133+ stem cell-like human colon cancer cells
    • Lin L, Fuchs J, Li C, Olson V, Bekaii-Saab T, et al. (2011) STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+/CD133+ stem cell-like human colon cancer cells. Biochem Biophys Res Commun 416: 246-251.
    • (2011) Biochem Biophys Res Commun , vol.416 , pp. 246-251
    • Lin, L.1    Fuchs, J.2    Li, C.3    Olson, V.4    Bekaii-Saab, T.5
  • 59
    • 70350212976 scopus 로고    scopus 로고
    • STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
    • Sherry MM, Reeves A, Wu JK, Cochran BH, (2009) STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 27: 2383-2392.
    • (2009) Stem Cells , vol.27 , pp. 2383-2392
    • Sherry, M.M.1    Reeves, A.2    Wu, J.K.3    Cochran, B.H.4
  • 60
    • 79953691412 scopus 로고    scopus 로고
    • The multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication
    • Michaelis M, Paulus C, Loschmann N, Dauth S, Stange E, et al. (2011) The multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication. Cell Mol Life Sci 68: 1079-1090.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1079-1090
    • Michaelis, M.1    Paulus, C.2    Loschmann, N.3    Dauth, S.4    Stange, E.5
  • 61
    • 84984559474 scopus 로고    scopus 로고
    • Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
    • Chen KF, Tai WT, Liu TH, Huang HP, Lin YC, et al. (2010) Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3. Clin Cancer Res 16: 5189-5199.
    • (2010) Clin Cancer Res , vol.16 , pp. 5189-5199
    • Chen, K.F.1    Tai, W.T.2    Liu, T.H.3    Huang, H.P.4    Lin, Y.C.5
  • 62
    • 79955022151 scopus 로고    scopus 로고
    • Complete histologic response induced by sorafenib in advanced hepatocellular carcinoma: a case report
    • Curtit E, Thiery-Vuillemin A, Nguyen T, Heyd B, Pivot X, et al. (2011) Complete histologic response induced by sorafenib in advanced hepatocellular carcinoma: a case report. J Clin Oncol 29: e330-332.
    • (2011) J Clin Oncol , vol.29
    • Curtit, E.1    Thiery-Vuillemin, A.2    Nguyen, T.3    Heyd, B.4    Pivot, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.