Cytoplasmic p21WAF1/CIP1 expression in human hepatocellular carcinomas

Liver International

Volumn 26, Issue 8, 2006, Pages 1018-1019

  Shiraki, Katsuya ^a   Wagayama, Hidetaka ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; TUMOR SUPPRESSOR PROTEIN;

ACTIN POLYMERIZATION; APOPTOSIS; CANCER GROWTH; CANCER INVASION; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; CHRONIC HEPATITIS; CYTOPLASM; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HEPATITIS C; HUMAN; IMMUNOHISTOCHEMISTRY; LETTER; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NECROSIS; METASTASIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

CARCINOMA, HEPATOCELLULAR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOPLASM; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER DISEASES; LIVER NEOPLASMS;

EID: 33748310810     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01320.x     Document Type: Letter

References (6)

1. Moran D M, Mayes N, Koniaris L G, Cahill P A, McKillop I H. Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. Liver Int 2005; 25: 445-57.
2. Schoniger-Hekele M, Hanel S, Wrba F, Muller C. Hepatocellular carcinoma - survival and clinical characteristics in relation to various histologic molecular markers in Western patients. Liver Int 2005; 25: 62-9.
3. Wagayama H, Shiraki K, Sugimoto K, et al. High expression of p21WAF1/ CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases. Hum Pathol 2002; 33: 429-34.
4. Asada M, Yamada T, Ichijo H, et al. Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J 1999; 18: 1223-34.
5. Tanaka H, Yamashita T, Asada M, Mizutani S, Yoshikawa H, Tohyama M. Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J Cell Biol 2002; 158: 321-9.
6. Lee S, Helfman DM. Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J Biol Chem 2004; 279: 1885-91.