Changes in gene expression in the rat hippocampus following exposure to 56Fe particles and protection by berry diets

Central Nervous System Agents in Medicinal Chemistry

Volumn 13, Issue 1, 2013, Pages 36-42

  Shukitt Hale, Barbara ^a   Lau, Francis C ^b   Cheng, Vivian ^a   Luskin, Katharine ^a   Carey, Amanda N ^a   Carrihill Knoll, Kirsty ^c   Rabin, Bernard M ^c   Joseph, James A ^a  

^a TUFTS UNIVERSITY   (United States)

^b InterHealth Nutraceuticals Inc   (United States)

^c UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

Berry; Gene expression; High energy particles; Hippocampus; Irradiation; Nuclear factor kappa B

Indexed keywords

COMPLEMENTARY RNA; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMOLUMINESCENCE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSIMETRY; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENE FUNCTION; HIPPOCAMPUS; HYBRIDIZATION; IRRADIATION; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPTICAL DENSITY; PROTECTION; RAT; UPREGULATION; X RAY;

ANIMALS; ANTIOXIDANTS; BLUEBERRY PLANT; FRAGARIA; FRUIT; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IRON COMPOUNDS; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84875349390     PISSN: 18715249     EISSN: 18756166     Source Type: Journal    
DOI: 10.2174/1871524911313010006     Document Type: Article

References (58)

1. Townsend, L.W.; Cucinotta, F.A.; Wilson, J.W. Interplanetary crew exposure estimates for galactic cosmic rays. Radiat. Res., 1992, 129, 48-52.
2. Letaw, J.R.; Silberberg, R.; Tsao, C.H. Radiation hazards on space missions outside the magnetosphere, Adv. Space Res., 1989, 9, 285-291.
3. Ball, J.R.; Evans, C.H., Jr., (Eds.) Safe Passage: Astronaut Care for Exploratory Missions, National Academy Press, Washington, D.C. 2001.
4. Rabin, B.M.; Joseph, J.A.; Shukitt-Hale, B. Heavy particle irradiation, neurochemistry and behavior: thresholds, dose-response curves and recovery of function. Adv. Space Res., 2004, 33, 1330-1333.
5. Joseph, J.A.; Hunt, W.A.; Rabin, B.M.; Dalton, T.K. Possible accelerated striatal aging induced by 56Fe heavy-particle irradiation: implications for manned space flights. Radiat. Res., 1992, 130, 88-93.
6. Rabin, B.M.; Joseph, J.A.; Erat, S. Effects of exposure to different types of radiation on behaviors mediated by peripheral or central systems. Adv. Space Res., 1998, 22, 217-225.
7. Rabin, B.M.; Joseph, J.A.; Shukitt-Hale, B.; McEwen, J. Effects of exposure to heavy particles on a behavior mediated by the dopaminergic system. Adv. Space Res., 2000, 25, 2065-2074.
8. Rabin, B.M.; Shukitt-Hale, B.; Joseph, J.A.; Denissova, N. Effects of exposure to 56Fe particles on the acquisition of a conditioned place preference in rats. Phys. Med., 2001, 17(Suppl 1), 196-197.
9. Rabin, B.M.; Shukitt-Hale, B.; Szprengiel, A.; Joseph, J.A. Effects of heavy particle irradiation and diet on amphetamine- and lithium chloride-induced taste avoidance learning in rats. Brain Res., 2002, 953, 31-36.
10. Rabin, B.M.; Buhler, L.L.; Joseph, J.A.; Shukitt-Hale, B.; Jenkins, D.G. Effects of exposure to 56Fe particles or protons on fixed-ratio operant responding in rats. J. Radiat. Res. (Tokyo), 2002, 43, S225-S228.
11. Rabin, B.M.; Joseph, J.A.; Shukitt-Hale, B. Long-term changes in amphetamine-induced reinforcement and aversion in rats following exposure to 56Fe particle. Adv. Space Res., 2003, 31, 127-133.
12. Rabin, B.M.; Carrihill-Knoll, K.L.; Carey, A.N.; Shukitt-Hale, B.; Joseph, J.A.; Foster, B.C. Elevated plus-maze performance of Fischer-344 rats as a function of age and of exposure to 56Fe particles. Adv. Space Res., 2007, 39, 981-986.
13. Shukitt-Hale, B.; Casadesus, G.; McEwen, J.J.; Rabin, B.M.; Joseph, J.A. Spatial learning and memory deficits induced by exposure to iron-56-particle radiation. Radiat. Res., 2000, 154, 28-33.
14. Shukitt-Hale, B.; Szprengiel, A.; Pluhar, J.; Rabin, B.M.; Joseph, J.A. The effects of proton exposure on neurochemistry and behavior. Adv. Space Res., 2004, 33, 1334-1339.
15. Rabin, B.M.; Carrihill-Knoll, K.; Hinchman, M.; Shukitt-Hale, B.; Joseph, J.A.; Foster, B.C. Effects of heavy particle irradiation and diet on object recognition memory in rats. Adv. Space Res. 2009, 43, 1193-1199.
16. Joseph, J.A.; Hunt, W.A.; Rabin, B.M.; Dalton, T.K.; Harris, A.H. Deficits in the sensitivity of striatal muscarinic receptors induced by 56Fe heavy-particle irradiation: further age-radiation parallels. Radiat. Res., 1993, 135, 257-261.
17. Joseph, J.A.; Erat, S.; Rabin, B.M. CNS effects of heavy particle irradiation in space: behavioral implications. Adv. Space Res., 1998, 22, 209-216.
18. Joseph, J.A.; Shukitt-Hale, B.; McEwen, J.; Rabin, B.M. CNS-induced deficits of heavy particle irradiation in space: the aging connection. Adv. Space Res., 2000, 25, 2057-2064.
19. Manda, K.; Ueno, M.; Anzai, K. Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid. Behav. Brain Res., 2008, 187, 387-395.
20. Shukitt-Hale, B.; Casadesus, G.; Carey, A.N.; Rabin, B.M.; Joseph, J.A. Exposure to 56Fe irradiation accelerates normal brain aging and produces deficits in spatial learning and memory. Adv. Space Res., 2007, 39, 1087-1092.
21. Rabin, B.M.; Shukitt-Hale, B.; Joseph, J.A.; Carrihill-Knoll, K.L.; Carey, A.N.; Cheng, V. Relative effectiveness of different particles and energies in disrupting behavioral performance. Radiat. Environ. Biophys., 2007, 46, 173-177.
22. Casadesus, G.; Shukitt-Hale, B.; Cantuti-Castelvetri, I.; Rabin, B.M.; Joseph, J.A. The effects of heavy particle irradiation on exploration and response to environmental change, Adv. Space Res., 2004, 33, 1340-1346.
23. Denisova, N.A.; Shukitt-Hale, B.; Rabin, B.M.; Joseph, J.A. Brain signaling and behavioral responses induced by exposure to (56)Fe-particle radiation. Radiat. Res., 2002, 158, 725-734.
24. Shukitt-Hale, B.; Casadesus, G.; Cantuti-Castelvetri, I.; Rabin, B.M.; Joseph, J.A. Cognitive deficits induced by 56Fe radiation exposure. Adv. Space Res., 2003, 31, 119-126.
25. Shukitt-Hale, B.; Carey, A.N.; Jenkins, D.; Rabin, B.M.; Joseph, J.A. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol. Aging, 2007, 28, 1187-1194.
26. Vlkolinsky, R.; Krucker, T.; Nelson, G.A.; Obenaus, A. (56)Fe-particle radiation reduces neuronal output and attenuates lipopolysaccharide-induced inhibition of long-term potentiation in the mouse hippocampus. Radiat. Res., 2008, 169, 523-530.
27. Vlkolinsky, R.; Krucker, T.; Smith, A.L.; Lamp, T.C.; Nelson, G.A.; Obenaus, A. Effects of lipopolysaccharide on 56Fe-particle radiation-induced impairment of synaptic plasticity in the mouse hippocampus. Radiat. Res., 2007, 168, 462-470.
28. Casadesus, G.; Shukitt-Hale, B.; Stellwagen, H.M.; Smith, M.A.; Rabin, B.M.; Joseph, J.A. Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats. Exp. Gerontol., 2005, 40, 249-254.
29. Andres-Mach, M.; Rola, R.; Fike, J.R. Radiation effects on neural precursor cells in the dentate gyrus. Cell Tissue Res., 2008, 331, 251-262.
30. Rola, R.; Otsuka, S.; Obenaus, A.; Nelson, G.A.; Limoli, C.L.; VandenBerg, S.R.; Fike, J.R. Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dose-dependent manner. Radiat. Res., 2004, 162, 442-446.
31. Rola, R.; Raber, J.; Rizk, A.; Otsuka, S.; VandenBerg, S.R.; Morhardt, D.R.; Fike, J.R. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp. Neurol., 2004, 188, 316-330.
32. Rola, R.; Sarkissian, V.; Obenaus, A.; Nelson, G.A.; Otsuka, S.; Limoli, C.L.; Fike, J.R. High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesis. Radiat. Res., 2005, 164, 556-560.
33. Rola, R.; Fishman, K.; Baure, J.; Rosi, S.; Lamborn, K.R.; Obenaus, A.; Nelson, G.A.; Fike, J.R. Hippocampal neurogenesis and neuroinflammation after cranial irradiation with (56)Fe particles. Radiat. Res., 2008, 169, 626-632.
34. Philpott, D.E.; Sapp, W.; Miquel, J.; Kato, K.; Corbett, R.; Stevenson, J.; Black, S.; Lindseth, K.A.; Benton, E.V. The effect of high energy (HZE) particle radiation (40Ar) on aging parameters of mouse hippocampus and retina. Scan. Electron Microsc., 1985, 1177-1182.
35. Higuchi, Y.; Nelson, G.A.; Vazquez, M.; Laskowitz, D.T.; Slater, J.M.; Pearlstein, R.D. Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. J. Radiat. Res. (Tokyo), 2002, 43, S219-S224.
36. Villasana, L.; Rosenberg, J.; Raber, J. Sex-dependent effects of (56)Fe irradiation on contextual fear conditioning in C57BL/6J mice. Hippocampus, 2010, 20(1), 19-23.
37. Villasana, L.; Acevedo, S.; Poage, C.; Raber, J. Sex- and APOE isoform-dependent effects of radiation on cognitive function. Radiat. Res., 2006, 166, 883-891.
38. Joseph, J.A.; Shukitt-Hale, B.; Denisova, N.A.; Bielinski, D.; Martin, A.; McEwen, J.J.; Bickford, P.C. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci., 1999, 19, 8114-8121.
39. Youdim, K.A.; Shukitt-Hale, B.; Martin, A.; Wang, H.; Denisova, N.; Bickford, P.C.; Joseph, J.A. Short-term dietary supplementation of blueberry polyphenolics: beneficial effects on aging brain performance and peripheral tissue function. Nutr. Neurosci., 2000, 3, 383-397.
40. Goyarzu, P.; Malin, D.H.; Lau, F.C.; Taglialatela, G.; Moon, W.D.; Jennings, R.; Moy, E.; Moy, D.; Lippold, S.; Shukitt-Hale, B.; Joseph, J.A. Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr. Neurosci., 2004, 7, 75-83.
41. Shukitt-Hale, B., Galli, R., Meterko, V., Carey, A., Bielinski, D., McGhie, T., Joseph, J.A. Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. AGE, 2005, 27, 49-57.
42. Williams, C.M.; El Mohsen, M.A.; Vauzour, D.; Rendeiro, C.; Butler, L.T.; Ellis, J.A.; Whiteman, M.; Spencer, J.P. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic. Biol. Med., 2008, 45, 295-305.
43. Rabin, B.M.; Shukitt-Hale, B.; Joseph, J.A. Effects of berry fruits on neurocognitive deficits produced by exposure to space radiation, in Herbal Radiomodulators: Applications in Medicine, Homeland Defence & Space; Arora, R. Ed.; CABI Publishing: Wallingford: United Kingdom, 2008; pp 151-161.
44. 56Fe particles. AGE, 2005, 27, 69-73.
45. Rabin, B.M.; Joseph, J.A.; Shukitt-Hale, B. Effects of age and diet on the heavy particle-induced disruption of operant responding produced by a ground-based model for exposure to cosmic rays. Brain Res., 2005, 1036, 122-129.
46. 56Fe particles. Adv. Space Res., 2007, 40, 576-580.
47. Rabin, B.M.; Shukitt-Hale, B.; Joseph, J.; Todd, P. Diet as a factor in behavioral radiation protection following exposure to heavy particles. Gravit. Space Biol. Bull., 2005, 18, 71-77.
48. Yin, E.; Nelson, D.O.; Coleman, M.A.; Peterson, L.E.; Wyrobek, A.J. Gene expression changes in mouse brain after exposure to low-dose ionizing radiation. Int. J. Radiat. Biol., 2003, 79, 759-775.
49. Akerman, G.S.; Rosenzweig, B.A.; Domon, O.E.; Tsai, C.A.; Bishop, M.E.; McGarrity, L.J.; Macgregor, J.T.; Sistare, F.D.; Chen, J.J.; Morris, S.M. Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells. Environ. Mol. Mutagen, 2005, 45, 188-205.
50. Monje, M.L.; Palmer, T. Radiation injury and neurogenesis. Curr. Opin. Neurol., 2003, 16, 129-134.
51. Monje, M.L.; Toda, H.; Palmer, T.D. Inflammatory blockade restores adult hippocampal neurogenesis. Science, 2003, 302, 1760-1765.
52. Monje, M.L.; Mizumatsu, S.; Fike, J.R.; Palmer, T.D. Irradiation induces neural precursor-cell dysfunction. Nat. Med., 2002, 8, 955-962.
53. Limoli, C.L.; Giedzinski, E.; Baure, J.; Rola, R.; Fike, J.R. Redox changes induced in hippocampal precursor cells by heavy ion irradiation. Radiat. Environ. Biophys., 2007, 46, 167-172.
54. Manda, K.; Ueno, M.; Anzai, K. Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: ameliorative potential of the melatonin metabolite, AFMK. J. Pineal. Res., 2008, 45, 430-438.
55. Mahmoud-Ahmed, A.S.; Atkinson, S.; Wong, C.S. Early gene expression profile in mouse brain after exposure to ionizing radiation. Radiat. Res., 2006, 165, 142-154.
56. Kalm, M.; Fukuda, A.; Fukuda, H.; Ohrfelt, A.; Lannering, B.; Bjork-Eriksson, T.; Blennow, K.; Marky, I.; Blomgren, K. Transient inflammation in neurogenic regions after irradiation of the developing brain. Radiat. Res., 2009, 171, 66-76.
57. Lau, F.C.; Bielinski, D.F.; Joseph, J.A. Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J. Neurosci. Res., 2007, 85, 1010-1017.
58. Joseph, J.A.; Carey, A.; Brewer, G.J.; Lau, F.C.; Fisher, D.R. Dopamine and abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract. J. Alzheimers Dis., 2007, 11, 433-446.