The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies

Free Radical Biology and Medicine

Volumn 60, Issue , 2013, Pages 157-167

  Lee, Kristy ^a   Briehl, Margaret M ^a   Mazar, Andrew P ^b   Batinic Haberle, Ines ^c   Reboucas, Julio S ^d   Glinsmann Gibson, Betty ^a   Rimsza, Lisa M ^a   Tome, Margaret E ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Bcl 2; CcOX; Free radicals; Leukemia; Lymphoma; Peroxynitrite; Porphyrins; SOD1

Indexed keywords

CASPASE 3; CHOLINE TETRATHIOMOLYBDATE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C OXIDASE; DOXORUBICIN; PEROXYNITRITE; PROTEIN BCL 2;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CELL DEATH; CELL VIABILITY; CONCENTRATION (PARAMETERS); DRUG POTENTIATION; HEMATOLOGIC MALIGNANCY; HISTIOCYTIC LYMPHOMA; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NITRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; B-LYMPHOCYTES; CELL DEATH; CELL SURVIVAL; CHELATING AGENTS; COPPER; HEMATOLOGIC NEOPLASMS; HUMANS; MICE; MOLYBDENUM; OXIDATIVE STRESS; PEROXYNITROUS ACID; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-BCL-2; STRESS, PHYSIOLOGICAL; SUPEROXIDE DISMUTASE; U937 CELLS;

EID: 84875322993     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.02.003     Document Type: Article

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