Mitochondrial superoxide mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination

Biochemical Pharmacology

Volumn 83, Issue 12, 2012, Pages 1643-1654

  Luanpitpong, Sudjit ^a,b   Chanvorachote, Pithi ^b   Nimmannit, Ubonthip ^c   Leonard, Stephen S ^d   Stehlik, Christian ^e   Wang, Liying ^d   Rojanasakul, Yon ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^d NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Apoptosis; Bcl 2; Doxorubicin; ERK; Keratinocytes; Reactive oxygen species

Indexed keywords

DOXORUBICIN; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME INACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KERATINOCYTE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN MODIFICATION; UBIQUITINATION;

APOPTOSIS; CELL LINE; DOXORUBICIN; ELECTRON SPIN RESONANCE SPECTROSCOPY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; HUMANS; KERATINOCYTES; MITOCHONDRIA; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SUPEROXIDES; UBIQUITINATION;

EID: 84860195676     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.010     Document Type: Article

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