Bis-N-norgliovictin, a small-molecule compound from marine fungus, inhibits LPS-induced inflammation in macrophages and improves survival in sepsis

European Journal of Pharmacology

Volumn 705, Issue 1-3, 2013, Pages 49-60

  Song, Yuxian ^a   Dou, Huan ^a   Gong, Wei ^a   Liu, Xianqin ^a   Yu, Zhiguo ^a   Li, Erguang ^a   Tan, Renxiang ^a   Hou, Yayi ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Bis N norgliovictin; Macrophage polarization; MyD88; Sepsis; Toll like receptor 4; TRIF

Indexed keywords

BETA INTERFERON; BIS N NORGLIOVICTIN; GLIOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG MEGADOSE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIVER INJURY; LUNG INJURY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEPSIS; SURVIVAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DIKETOPIPERAZINES; FUNGI; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; SEPSIS; SULFIDES; TOLL-LIKE RECEPTOR 4;

EID: 84875319095     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.02.008     Document Type: Article

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