Platycodi Radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2-mediated antioxidant enzymes

Food and Chemical Toxicology

Volumn 56, Issue , 2013, Pages 231-239

  Choi, Jae Ho ^a   Jin, Sun Woo ^a   Kim, Hyung Gyun ^a   Khanal, Tilak ^a   Hwang, Yong Pil ^a,b   Lee, Kyung Jin ^c   Choi, Chul Yung ^d   Chung, Young Chul ^b   Lee, Young Chun ^b,e   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b International University of Korea   (South Korea)

^c Asan Medical Center   (South Korea)

^d Jeollanamdo Institute of Natural Resources Research   (South Korea)

^e JangSaeng Doraji Co Ltd   (South Korea)

Author keywords

Antioxidant enzymes; COX 2; Liver fibrosis; Nrf2; Platycodi Radix

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; BETA ACTIN; COLLAGEN TYPE 1; COLLAGENASE 3; CYCLOOXYGENASE 2; DIMETHYLNITROSAMINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; MALONALDEHYDE; MESSENGER RNA; NAD(P)H QUINONE OXIDOREDUCTASE 1; PLATYCODON GRANDIFLORUM EXTRACT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WATER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BETA ACTIN GENE; BODY WEIGHT; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER PROTECTION; LIVER TOXICITY; LIVER WEIGHT; MALE; MATRIX METALLOPROTEINASE 13 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT ROOT; PLATYCODON; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE 1 GENE; TUMOR NECROSIS FACTOR ALPHA GENE; WESTERN BLOTTING;

ACTINS; ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; COLLAGEN TYPE I; CYCLOOXYGENASE 2; DIMETHYLNITROSAMINE; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE (DECYCLIZING); HEP G2 CELLS; HUMANS; LIPID PEROXIDATION; LIVER; LIVER CIRRHOSIS; MALE; MALONDIALDEHYDE; MATRIX METALLOPROTEINASE 13; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; NF-KAPPA B; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875310738     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.02.033     Document Type: Article

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