Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G 2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway

Journal of Ethnopharmacology

Volumn 139, Issue 3, 2012, Pages 829-837

  Pan, Tai Long ^a   Wang, Pei Wen ^a   Leu, Yann Lii ^a   Wu, Tung Ho ^b   Wu, Tian Shung ^c,d  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bax; Caspase; ERK; Hepatic stellate cells; Scutellaria baicalensis Georgi

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CASPASE; CASPASE 3; COLLAGEN; CYCLIN B1; CYTOCHROME C; DIMETHYLNITROSAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; SCUTELLARIA BAICALENSIS EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DOWN REGULATION; FIBROGENESIS; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; IMMUNOBLOTTING; LIVER FIBROSIS; M PHASE CELL CYCLE CHECKPOINT; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION;

ACTINS; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL DEATH; COLLAGEN; DIMETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROSIS; HEPATIC STELLATE CELLS; LIVER; LIVER DISEASES; MUSCLE, SMOOTH; PHYTOTHERAPY; PLANT EXTRACTS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; SCUTELLARIA BAICALENSIS;

RATTUS; SCUTELLARIA BAICALENSIS;

EID: 84856220504     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.12.028     Document Type: Article

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