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Volumn 36, Issue 3, 2013, Pages 152-162

Brainstem respiratory networks: Building blocks and microcircuits

Author keywords

Brainstem; Breathing; Breathing disorders; Respiratory central pattern generator

Indexed keywords

BRAIN STEM; BREATHING PATTERN; CENTRAL PATTERN GENERATOR; CONGENITAL CENTRAL HYPOVENTILATION SYNDROME; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PONTINE NUCLEUS; PRIORITY JOURNAL; RESPIRATION DEPRESSION; RETT SYNDROME; REVIEW; SLEEP DISORDERED BREATHING; SOLITARY TRACT NUCLEUS; SUDDEN INFANT DEATH SYNDROME; SYNAPTIC INHIBITION;

EID: 84875261242     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2012.11.004     Document Type: Review
Times cited : (312)

References (114)
  • 1
    • 72549088712 scopus 로고    scopus 로고
    • Measured motion: searching for simplicity in spinal locomotor networks
    • Grillner S., Jessell T.M. Measured motion: searching for simplicity in spinal locomotor networks. Curr. Opin. Neurobiol. 2009, 19:572-586.
    • (2009) Curr. Opin. Neurobiol. , vol.19 , pp. 572-586
    • Grillner, S.1    Jessell, T.M.2
  • 3
    • 20044395619 scopus 로고    scopus 로고
    • The cortex as a central pattern generator
    • Yuste R., et al. The cortex as a central pattern generator. Nat. Rev. Neurosci. 2005, 6:477-483.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 477-483
    • Yuste, R.1
  • 4
    • 33947189354 scopus 로고    scopus 로고
    • Biological pattern generation: the cellular and computational logic of networks in motion
    • Grillner S. Biological pattern generation: the cellular and computational logic of networks in motion. Neuron 2006, 52:751-766.
    • (2006) Neuron , vol.52 , pp. 751-766
    • Grillner, S.1
  • 7
    • 69949091248 scopus 로고    scopus 로고
    • Structural and functional architecture of respiratory networks in the mammalian brainstem
    • Smith J.C., et al. Structural and functional architecture of respiratory networks in the mammalian brainstem. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2577-2587.
    • (2009) Philos. Trans. R. Soc. Lond. B: Biol. Sci. , vol.364 , pp. 2577-2587
    • Smith, J.C.1
  • 8
    • 68949196307 scopus 로고    scopus 로고
    • Multiple pontomedullary mechanisms of respiratory rhythmogenesis
    • Abdala A.P.L., et al. Multiple pontomedullary mechanisms of respiratory rhythmogenesis. Respir. Physiol. Neurobiol. 2009, 168:19-25.
    • (2009) Respir. Physiol. Neurobiol. , vol.168 , pp. 19-25
    • Abdala, A.P.L.1
  • 9
    • 84875256403 scopus 로고    scopus 로고
    • Respiratory central pattern generator
    • Oxford University Press, G.M. Shepherd, S. Grillner (Eds.)
    • Feldman J.L. Respiratory central pattern generator. Handbook of Brain Microcircuits 2010, 377-386. Oxford University Press. G.M. Shepherd, S. Grillner (Eds.).
    • (2010) Handbook of Brain Microcircuits , pp. 377-386
    • Feldman, J.L.1
  • 10
    • 80051600351 scopus 로고    scopus 로고
    • Caudal nuclei of the rat nucleus of the solitary tract differentially innervate respiratory compartments within the ventrolateral medulla
    • Alheid G.F., et al. Caudal nuclei of the rat nucleus of the solitary tract differentially innervate respiratory compartments within the ventrolateral medulla. Neuroscience 2011, 190:207-227.
    • (2011) Neuroscience , vol.190 , pp. 207-227
    • Alheid, G.F.1
  • 11
    • 67649379064 scopus 로고    scopus 로고
    • Opioids depress cortical centers responsible for the volitional control of respiration
    • Pattinson K.T., et al. Opioids depress cortical centers responsible for the volitional control of respiration. J. Neurosci. 2009, 29:8177-8186.
    • (2009) J. Neurosci. , vol.29 , pp. 8177-8186
    • Pattinson, K.T.1
  • 12
    • 56349100157 scopus 로고    scopus 로고
    • Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging
    • Pattinson K.T., et al. Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging. Neuroimage 2009, 44:295-305.
    • (2009) Neuroimage , vol.44 , pp. 295-305
    • Pattinson, K.T.1
  • 13
    • 37549055001 scopus 로고    scopus 로고
    • Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms
    • Smith J.C., et al. Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms. J. Neurophysiol. 2007, 98:3370-3387.
    • (2007) J. Neurophysiol. , vol.98 , pp. 3370-3387
    • Smith, J.C.1
  • 14
    • 57349135773 scopus 로고    scopus 로고
    • Functional connectivity in the pontomedullary respiratory network
    • Segers L.S., et al. Functional connectivity in the pontomedullary respiratory network. J. Neurophysiol. 2008, 100:1749-1769.
    • (2008) J. Neurophysiol. , vol.100 , pp. 1749-1769
    • Segers, L.S.1
  • 15
    • 69949097411 scopus 로고    scopus 로고
    • Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator
    • Champagnat J., et al. Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2469-2476.
    • (2009) Philos. Trans. R. Soc. Lond. B: Biol. Sci. , vol.364 , pp. 2469-2476
    • Champagnat, J.1
  • 17
    • 78049513914 scopus 로고    scopus 로고
    • Developmental origin of pre-Bötzinger complex respiratory neurons
    • Gray P.A., et al. Developmental origin of pre-Bötzinger complex respiratory neurons. J. Neurosci. 2010, 30:14883-14895.
    • (2010) J. Neurosci. , vol.30 , pp. 14883-14895
    • Gray, P.A.1
  • 18
    • 77956185848 scopus 로고    scopus 로고
    • Hindbrain interneurons and axon guidance signaling critical for breathing
    • Bouvier J., et al. Hindbrain interneurons and axon guidance signaling critical for breathing. Nat. Neurosci. 2010, 13:1066-1074.
    • (2010) Nat. Neurosci. , vol.13 , pp. 1066-1074
    • Bouvier, J.1
  • 19
    • 59149092855 scopus 로고    scopus 로고
    • Galanin is a selective marker of the retrotrapezoid nucleus in rats
    • Stornetta R.L., et al. Galanin is a selective marker of the retrotrapezoid nucleus in rats. J. Comp. Neurol. 2009, 512:373-383.
    • (2009) J. Comp. Neurol. , vol.512 , pp. 373-383
    • Stornetta, R.L.1
  • 20
    • 77950863314 scopus 로고    scopus 로고
    • Projections of preBotzinger complex neurons in adult rats
    • Tan W., et al. Projections of preBotzinger complex neurons in adult rats. J. Comp. Neurol. 2010, 518:1862-1878.
    • (2010) J. Comp. Neurol. , vol.518 , pp. 1862-1878
    • Tan, W.1
  • 21
    • 27744538719 scopus 로고    scopus 로고
    • Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons
    • McKay L.C., et al. Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons. Nat. Neurosci. 2005, 8:1142-1144.
    • (2005) Nat. Neurosci. , vol.8 , pp. 1142-1144
    • McKay, L.C.1
  • 22
    • 33644559872 scopus 로고    scopus 로고
    • Distinct rhythm generators for inspiration and expiration in the juvenile rat
    • Janczewski W.A., Feldman J.L. Distinct rhythm generators for inspiration and expiration in the juvenile rat. J. Physiol. 2006, 570:407-420.
    • (2006) J. Physiol. , vol.570 , pp. 407-420
    • Janczewski, W.A.1    Feldman, J.L.2
  • 23
    • 42649112394 scopus 로고    scopus 로고
    • Silencing preBotzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat
    • Tan W., et al. Silencing preBotzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat. Neurosci. 2008, 11:538-540.
    • (2008) Nat. Neurosci. , vol.11 , pp. 538-540
    • Tan, W.1
  • 24
    • 77956843436 scopus 로고    scopus 로고
    • Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration
    • Marina N., et al. Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration. J. Neurosci. 2010, 30:12466-12473.
    • (2010) J. Neurosci. , vol.30 , pp. 12466-12473
    • Marina, N.1
  • 25
    • 65949119125 scopus 로고    scopus 로고
    • Photostimulation of retrotrapezoid nucleus Phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats
    • Abbott S.B., et al. Photostimulation of retrotrapezoid nucleus Phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats. J. Neurosci. 2009, 29:5806-5819.
    • (2009) J. Neurosci. , vol.29 , pp. 5806-5819
    • Abbott, S.B.1
  • 26
    • 79951648674 scopus 로고    scopus 로고
    • Active expiration induced by excitation of ventral medulla in adult anesthetized rats
    • Pagliardini S., et al. Active expiration induced by excitation of ventral medulla in adult anesthetized rats. J. Neurosci. 2011, 31:2895-2905.
    • (2011) J. Neurosci. , vol.31 , pp. 2895-2905
    • Pagliardini, S.1
  • 27
    • 0035426390 scopus 로고    scopus 로고
    • Studying rhythmogenensis of breathing: comparison of in vivo and in vitro models
    • Richter D.W., Spyer K.M. Studying rhythmogenensis of breathing: comparison of in vivo and in vitro models. Trend Neurosci. 2001, 24:464-472.
    • (2001) Trend Neurosci. , vol.24 , pp. 464-472
    • Richter, D.W.1    Spyer, K.M.2
  • 28
    • 0028986056 scopus 로고
    • Pre-Botzinger complex in the cat
    • Schwarzacher S.W., et al. Pre-Botzinger complex in the cat. J. Neurophysiol. 1995, 73:1452-1461.
    • (1995) J. Neurophysiol. , vol.73 , pp. 1452-1461
    • Schwarzacher, S.W.1
  • 29
    • 84859508072 scopus 로고    scopus 로고
    • Computational models and emergent properties of respiratory neural networks
    • Lindsey B., et al. Computational models and emergent properties of respiratory neural networks. Compr. Physiol. 2012, 2:1619-1670.
    • (2012) Compr. Physiol. , vol.2 , pp. 1619-1670
    • Lindsey, B.1
  • 30
    • 34848893279 scopus 로고    scopus 로고
    • Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation
    • Rybak I.A., et al. Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation. Prog. Brain Res. 2007, 165:201-220.
    • (2007) Prog. Brain Res. , vol.165 , pp. 201-220
    • Rybak, I.A.1
  • 31
    • 0026360052 scopus 로고
    • Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals
    • Smith J.C., et al. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 1991, 254:726-729.
    • (1991) Science , vol.254 , pp. 726-729
    • Smith, J.C.1
  • 32
    • 7044235331 scopus 로고    scopus 로고
    • The rhombencephalon and breathing: a view from the pons
    • McCrimmon D.R., et al. The rhombencephalon and breathing: a view from the pons. Respir. Physiol. Neurobiol. 2004, 143:103-104.
    • (2004) Respir. Physiol. Neurobiol. , vol.143 , pp. 103-104
    • McCrimmon, D.R.1
  • 33
    • 69949092071 scopus 로고    scopus 로고
    • Noeud vital for breathing in the brainstem: gasping - yes, eupnoea - doubtful
    • St John W.M. Noeud vital for breathing in the brainstem: gasping - yes, eupnoea - doubtful. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2625-2633.
    • (2009) Philos. Trans. R. Soc. Lond. B: Biol. Sci. , vol.364 , pp. 2625-2633
    • St John, W.M.1
  • 34
    • 65949112240 scopus 로고    scopus 로고
    • Multiple rhythmic states in a model of the respiratory central pattern generator
    • Rubin J.E., et al. Multiple rhythmic states in a model of the respiratory central pattern generator. J. Neurophysiol. 2009, 101:2146-2165.
    • (2009) J. Neurophysiol. , vol.101 , pp. 2146-2165
    • Rubin, J.E.1
  • 35
    • 0037454571 scopus 로고    scopus 로고
    • A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Botzinger complex
    • Stornetta R.L., et al. A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Botzinger complex. J. Comp. Neurol. 2003, 455:499-512.
    • (2003) J. Comp. Neurol. , vol.455 , pp. 499-512
    • Stornetta, R.L.1
  • 36
    • 39549122203 scopus 로고    scopus 로고
    • +-dominated leak currents contribute to respiratory rhythm generation in the pre-Bötzinger complex in vitro
    • +-dominated leak currents contribute to respiratory rhythm generation in the pre-Bötzinger complex in vitro. J. Neurosci. 2008, 28:1773-1785.
    • (2008) J. Neurosci. , vol.28 , pp. 1773-1785
    • Koizumi, H.1    Smith, J.C.2
  • 37
    • 67650400716 scopus 로고    scopus 로고
    • Location and properties of respiratory neurones with putative intrinsic bursting properties in the rat in situ
    • St-John W.M., et al. Location and properties of respiratory neurones with putative intrinsic bursting properties in the rat in situ. J. Physiol. 2009, 587:3175-3188.
    • (2009) J. Physiol. , vol.587 , pp. 3175-3188
    • St-John, W.M.1
  • 38
    • 33644558047 scopus 로고    scopus 로고
    • Looking for inspiration: new perspectives on respiratory rhythm
    • Feldman J.L., Del Negro C.A. Looking for inspiration: new perspectives on respiratory rhythm. Nat. Rev. Neurosci. 2006, 7:232-241.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 232-241
    • Feldman, J.L.1    Del Negro, C.A.2
  • 40
    • 84967560751 scopus 로고    scopus 로고
    • Oscillatory bursting mechanisms in respiratory pacemaker neurons and networks
    • World Scientific Press, S. Coombes, P.C. Bresloff (Eds.)
    • Butera R.J., et al. Oscillatory bursting mechanisms in respiratory pacemaker neurons and networks. Bursting: The Genesis of Rhythm in the Nervous System 2005, 303-347. World Scientific Press. S. Coombes, P.C. Bresloff (Eds.).
    • (2005) Bursting: The Genesis of Rhythm in the Nervous System , pp. 303-347
    • Butera, R.J.1
  • 41
    • 40449083844 scopus 로고    scopus 로고
    • Functional imaging, spatial reconstruction, and biophysical analysis of a respiratory motor circuit isolated in vitro
    • Koizumi H., et al. Functional imaging, spatial reconstruction, and biophysical analysis of a respiratory motor circuit isolated in vitro. J. Neurosci. 2008, 28:2353-2365.
    • (2008) J. Neurosci. , vol.28 , pp. 2353-2365
    • Koizumi, H.1
  • 42
    • 77949823263 scopus 로고    scopus 로고
    • +-dominated leak current regulating respiratory rhythm generation in vitro
    • +-dominated leak current regulating respiratory rhythm generation in vitro. J. Neurosci. 2010, 30:4273-4284.
    • (2010) J. Neurosci. , vol.30 , pp. 4273-4284
    • Koizumi, H.1
  • 43
    • 33846902039 scopus 로고    scopus 로고
    • Intrinsic bursters increase the robustness of rhythm generation in an excitatory network
    • Purvis L.K., et al. Intrinsic bursters increase the robustness of rhythm generation in an excitatory network. J. Neurophysiol. 2007, 97:1515-1526.
    • (2007) J. Neurophysiol. , vol.97 , pp. 1515-1526
    • Purvis, L.K.1
  • 44
    • 34147160256 scopus 로고    scopus 로고
    • Role of persistent sodium current in mouse pre-Bötzinger complex neurons and respiratory rhythm generation
    • Pace R.W., et al. Role of persistent sodium current in mouse pre-Bötzinger complex neurons and respiratory rhythm generation. J. Physiol. 2007, 580:485-496.
    • (2007) J. Physiol. , vol.580 , pp. 485-496
    • Pace, R.W.1
  • 45
    • 78649481571 scopus 로고    scopus 로고
    • Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals
    • Del Negro C.A., et al. Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals. Prog. Brain Res. 2010, 187:111-136.
    • (2010) Prog. Brain Res. , vol.187 , pp. 111-136
    • Del Negro, C.A.1
  • 46
    • 33644820352 scopus 로고    scopus 로고
    • 2A receptors
    • 2A receptors. J. Neurosci. 2006, 26:2623-2634.
    • (2006) J. Neurosci. , vol.26 , pp. 2623-2634
    • Tryba, A.K.1
  • 47
    • 33344479424 scopus 로고    scopus 로고
    • Respiratory rhythm generation during gasping depends on persistent sodium current
    • Paton J.F.R., et al. Respiratory rhythm generation during gasping depends on persistent sodium current. Nat. Neurosci. 2006, 9:311-313.
    • (2006) Nat. Neurosci. , vol.9 , pp. 311-313
    • Paton, J.F.R.1
  • 48
    • 9644294519 scopus 로고    scopus 로고
    • Pacemaker neurons and neuronal networks: an integrative view
    • Ramirez J.M., et al. Pacemaker neurons and neuronal networks: an integrative view. Curr. Opin. Neurobiol. 2004, 14:665-674.
    • (2004) Curr. Opin. Neurobiol. , vol.14 , pp. 665-674
    • Ramirez, J.M.1
  • 49
    • 34347267663 scopus 로고    scopus 로고
    • Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice
    • Pace R.W., et al. Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice. J. Physiol. 2007, 582:113-125.
    • (2007) J. Physiol. , vol.582 , pp. 113-125
    • Pace, R.W.1
  • 50
    • 47549104755 scopus 로고    scopus 로고
    • Differential modulation of neural network and pacemaker activity underlying eupnea and sigh-breathing activities
    • Tryba A.K., et al. Differential modulation of neural network and pacemaker activity underlying eupnea and sigh-breathing activities. J. Neurophysiol. 2008, 99:2114-2125.
    • (2008) J. Neurophysiol. , vol.99 , pp. 2114-2125
    • Tryba, A.K.1
  • 51
    • 42949154681 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice
    • Mironov S.L. Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice. J. Physiol. 2008, 586:2277-2291.
    • (2008) J. Physiol. , vol.586 , pp. 2277-2291
    • Mironov, S.L.1
  • 52
    • 84861917831 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Botzinger complex in mice
    • Ben-Mabrouk F., et al. Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Botzinger complex in mice. Eur. J. Neurosci. 2012, 35:1725-1737.
    • (2012) Eur. J. Neurosci. , vol.35 , pp. 1725-1737
    • Ben-Mabrouk, F.1
  • 53
    • 79960094811 scopus 로고    scopus 로고
    • Two types of independent bursting mechanisms in inspiratory neurons: an integrative model
    • Toporikova N., Butera R. Two types of independent bursting mechanisms in inspiratory neurons: an integrative model. J. Comput. Neurosci. 2011, 30:515-528.
    • (2011) J. Comput. Neurosci. , vol.30 , pp. 515-528
    • Toporikova, N.1    Butera, R.2
  • 54
    • 0034946418 scopus 로고    scopus 로고
    • Identification of two types of inspiratory pacemaker neurons in the isolated respiratory neural network of mice
    • Thoby-Brisson M., Ramirez J.M. Identification of two types of inspiratory pacemaker neurons in the isolated respiratory neural network of mice. J. Neurophysiol. 2001, 86:104-112.
    • (2001) J. Neurophysiol. , vol.86 , pp. 104-112
    • Thoby-Brisson, M.1    Ramirez, J.M.2
  • 55
    • 34547096726 scopus 로고    scopus 로고
    • Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBotzinger complex
    • Crowder E.A., et al. Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBotzinger complex. J. Physiol. 2007, 582:1047-1058.
    • (2007) J. Physiol. , vol.582 , pp. 1047-1058
    • Crowder, E.A.1
  • 56
    • 78751557840 scopus 로고    scopus 로고
    • Dendritic calcium activity precedes inspiratory bursts in preBotzinger complex neurons
    • Del Negro C.A., et al. Dendritic calcium activity precedes inspiratory bursts in preBotzinger complex neurons. J. Neurosci. 2011, 31:1017-1022.
    • (2011) J. Neurosci. , vol.31 , pp. 1017-1022
    • Del Negro, C.A.1
  • 57
    • 62449244294 scopus 로고    scopus 로고
    • Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations
    • Rubin J.E., et al. Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2939-2944.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 2939-2944
    • Rubin, J.E.1
  • 58
    • 67649557436 scopus 로고    scopus 로고
    • Glycinergic interneurons are functionally integrated into the inspiratory network of mouse medullary slices
    • Winter S., et al. Glycinergic interneurons are functionally integrated into the inspiratory network of mouse medullary slices. Pflügers Arch. 2009, 458:459-469.
    • (2009) Pflügers Arch. , vol.458 , pp. 459-469
    • Winter, S.1
  • 59
    • 77949355865 scopus 로고    scopus 로고
    • Glycinergic pacemaker neurons in preBotzinger complex of neonatal mouse
    • Morgado-Valle C., et al. Glycinergic pacemaker neurons in preBotzinger complex of neonatal mouse. J. Neurosci. 2010, 30:3634-3639.
    • (2010) J. Neurosci. , vol.30 , pp. 3634-3639
    • Morgado-Valle, C.1
  • 60
    • 33644963061 scopus 로고    scopus 로고
    • Electrophysiological and morphological characteristics of GABAergic respiratory neurons in the mouse pre-Bötzinger complex
    • Kuwana S., et al. Electrophysiological and morphological characteristics of GABAergic respiratory neurons in the mouse pre-Bötzinger complex. Eur. J. Neurosci. 2006, 23:667-674.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 667-674
    • Kuwana, S.1
  • 61
    • 0033577685 scopus 로고    scopus 로고
    • Evidence for glycinergic respiratory neurons: Botzinger neurons express mRNA for glycinergic transporter 2
    • Schreihofer A.M., et al. Evidence for glycinergic respiratory neurons: Botzinger neurons express mRNA for glycinergic transporter 2. J. Comp. Neurol. 1999, 407:583-597.
    • (1999) J. Comp. Neurol. , vol.407 , pp. 583-597
    • Schreihofer, A.M.1
  • 62
    • 0032588020 scopus 로고    scopus 로고
    • Mutual inhibition between Botzinger-complex bulbospinal expiratory neurons detected with cross-correlation in the decerebrate rat
    • Tian G.F., et al. Mutual inhibition between Botzinger-complex bulbospinal expiratory neurons detected with cross-correlation in the decerebrate rat. Exp. Brain Res. 1999, 125:440-446.
    • (1999) Exp. Brain Res. , vol.125 , pp. 440-446
    • Tian, G.F.1
  • 63
    • 79960084124 scopus 로고    scopus 로고
    • Interacting oscillations in neural control of breathing: modeling and qualitative analysis
    • Rubin J., et al. Interacting oscillations in neural control of breathing: modeling and qualitative analysis. J. Comput. Neurosci. 2011, 30:607-632.
    • (2011) J. Comput. Neurosci. , vol.30 , pp. 607-632
    • Rubin, J.1
  • 64
    • 80054683531 scopus 로고    scopus 로고
    • Computational modelling of 5-HT receptor-mediated reorganization of the brainstem respiratory network
    • Shevtsova N.A., et al. Computational modelling of 5-HT receptor-mediated reorganization of the brainstem respiratory network. Eur. J. Neurosci. 2011, 34:1276-1291.
    • (2011) Eur. J. Neurosci. , vol.34 , pp. 1276-1291
    • Shevtsova, N.A.1
  • 65
    • 25644441731 scopus 로고    scopus 로고
    • Regulation of ventral surface chemoreceptors by the central respiratory pattern generator
    • Guyenet P.G., et al. Regulation of ventral surface chemoreceptors by the central respiratory pattern generator. J. Neurosci. 2005, 25:8938-8947.
    • (2005) J. Neurosci. , vol.25 , pp. 8938-8947
    • Guyenet, P.G.1
  • 66
    • 79951522470 scopus 로고    scopus 로고
    • Control of breathing by raphé obscurus serotonergic neurons in mice
    • DePuy S.D., et al. Control of breathing by raphé obscurus serotonergic neurons in mice. J. Neurosci. 2011, 31:1981-1990.
    • (2011) J. Neurosci. , vol.31 , pp. 1981-1990
    • DePuy, S.D.1
  • 67
    • 64849101288 scopus 로고    scopus 로고
    • Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P
    • Ptak K., et al. Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J. Neurosci. 2009, 29:3720-3737.
    • (2009) J. Neurosci. , vol.29 , pp. 3720-3737
    • Ptak, K.1
  • 68
    • 69949102053 scopus 로고    scopus 로고
    • Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphe-pontomedullary respiratory network
    • Nuding S.C., et al. Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphe-pontomedullary respiratory network. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2501-2516.
    • (2009) Philos. Trans. R. Soc. Lond. B: Biol. Sci. , vol.364 , pp. 2501-2516
    • Nuding, S.C.1
  • 69
    • 80755127200 scopus 로고    scopus 로고
    • Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats
    • Abbott S.B., et al. Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats. J. Neurosci. 2011, 31:16410-16422.
    • (2011) J. Neurosci. , vol.31 , pp. 16410-16422
    • Abbott, S.B.1
  • 70
    • 0037442811 scopus 로고    scopus 로고
    • A novel functional neuron group for respiratory rhythm generation in the ventral medulla
    • Onimaru H., Homma I. A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J. Neurosci. 2003, 23:1478-1486.
    • (2003) J. Neurosci. , vol.23 , pp. 1478-1486
    • Onimaru, H.1    Homma, I.2
  • 71
    • 68149100811 scopus 로고    scopus 로고
    • Genetic identification of an embryonic parafacial oscillator coupling to the preBotzinger complex
    • Thoby-Brisson M., et al. Genetic identification of an embryonic parafacial oscillator coupling to the preBotzinger complex. Nat. Neurosci. 2009, 12:1028-1035.
    • (2009) Nat. Neurosci. , vol.12 , pp. 1028-1035
    • Thoby-Brisson, M.1
  • 72
    • 58149393861 scopus 로고    scopus 로고
    • 2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat
    • 2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat. J. Neurosci. 2008, 28:12845-12850.
    • (2008) J. Neurosci. , vol.28 , pp. 12845-12850
    • Onimaru, H.1
  • 73
    • 84859258295 scopus 로고    scopus 로고
    • 2 responses in parafacial respiratory neurons of newborn rats
    • 2 responses in parafacial respiratory neurons of newborn rats. J. Physiol. 2012, 590:1615-1624.
    • (2012) J. Physiol. , vol.590 , pp. 1615-1624
    • Onimaru, H.1
  • 74
    • 67651114060 scopus 로고    scopus 로고
    • Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation
    • Abdala A.P.L., et al. Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation. J. Physiol. 2009, 587:3539-3559.
    • (2009) J. Physiol. , vol.587 , pp. 3539-3559
    • Abdala, A.P.L.1
  • 75
    • 78049507151 scopus 로고    scopus 로고
    • Late-expiratory activity: emergence and interactions with the respiratory CPG
    • Molkov Y.I., et al. Late-expiratory activity: emergence and interactions with the respiratory CPG. J. Neurophysiol. 2010, 104:2713-2729.
    • (2010) J. Neurophysiol. , vol.104 , pp. 2713-2729
    • Molkov, Y.I.1
  • 76
    • 56649102271 scopus 로고    scopus 로고
    • Pacemakers handshake synchronization mechanism of mammalian respiratory rhythmogenesis
    • Wittmeier S., et al. Pacemakers handshake synchronization mechanism of mammalian respiratory rhythmogenesis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:18000-18005.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 18000-18005
    • Wittmeier, S.1
  • 77
    • 77954726334 scopus 로고    scopus 로고
    • Retrotrapezoid nucleus and parafacial respiratory group
    • Guyenet P.G., Mulkey D.K. Retrotrapezoid nucleus and parafacial respiratory group. Respir. Physiol. Neurobiol. 2010, 173:244-255.
    • (2010) Respir. Physiol. Neurobiol. , vol.173 , pp. 244-255
    • Guyenet, P.G.1    Mulkey, D.K.2
  • 78
    • 38449118278 scopus 로고    scopus 로고
    • Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism
    • Mulkey D.K., et al. Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism. J. Neurosci. 2007, 27:14128-14138.
    • (2007) J. Neurosci. , vol.27 , pp. 14128-14138
    • Mulkey, D.K.1
  • 79
    • 33747604351 scopus 로고    scopus 로고
    • The Kolliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat
    • Dutschmann M., Herbert H. The Kolliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat. Eur. J. Neurosci. 2006, 24:1071-1084.
    • (2006) Eur. J. Neurosci. , vol.24 , pp. 1071-1084
    • Dutschmann, M.1    Herbert, H.2
  • 80
    • 33749509940 scopus 로고    scopus 로고
    • Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat
    • Stornetta R.L., et al. Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat. J. Neurosci. 2006, 26:10305-10314.
    • (2006) J. Neurosci. , vol.26 , pp. 10305-10314
    • Stornetta, R.L.1
  • 81
    • 13744250748 scopus 로고    scopus 로고
    • Respiratory control by ventral surface chemoreceptor neurons in rats
    • Mulkey D., et al. Respiratory control by ventral surface chemoreceptor neurons in rats. Nat. Neurosci. 2004, 7:1360-1369.
    • (2004) Nat. Neurosci. , vol.7 , pp. 1360-1369
    • Mulkey, D.1
  • 82
    • 33645523011 scopus 로고    scopus 로고
    • 2-sensitive neurons in rats
    • 2-sensitive neurons in rats. J. Physiol. 2006, 572:503-523.
    • (2006) J. Physiol. , vol.572 , pp. 503-523
    • Takakura, A.C.1
  • 83
    • 53449094254 scopus 로고    scopus 로고
    • 2 homeostasis, and breathing automaticity
    • 2 homeostasis, and breathing automaticity. J. Appl. Physiol. 2008, 105:404-416.
    • (2008) J. Appl. Physiol. , vol.105 , pp. 404-416
    • Guyenet, P.G.1
  • 84
    • 77955696717 scopus 로고    scopus 로고
    • Central respiratory chemoreception
    • Guyenet P.G., et al. Central respiratory chemoreception. J. Comp. Neurol. 2010, 518:3883-3906.
    • (2010) J. Comp. Neurol. , vol.518 , pp. 3883-3906
    • Guyenet, P.G.1
  • 85
    • 77950862515 scopus 로고    scopus 로고
    • Somatostatin selectively ablates post-inspiratory activity after injection into the Botzinger complex
    • Burke P.G., et al. Somatostatin selectively ablates post-inspiratory activity after injection into the Botzinger complex. Neuroscience 2010, 167:528-539.
    • (2010) Neuroscience , vol.167 , pp. 528-539
    • Burke, P.G.1
  • 86
    • 0141641041 scopus 로고    scopus 로고
    • Glycine is used as a transmitter by decrementing expiratory neurons of the ventrolateral medulla in the rat
    • Ezure K., et al. Glycine is used as a transmitter by decrementing expiratory neurons of the ventrolateral medulla in the rat. J. Neurosci. 2003, 23:8941-8948.
    • (2003) J. Neurosci. , vol.23 , pp. 8941-8948
    • Ezure, K.1
  • 87
    • 78650709726 scopus 로고    scopus 로고
    • Neuroanatomical characteristics of the human pre-Botzinger complex and its involvement in neurodegenerative brainstem diseases
    • Schwarzacher S.W., et al. Neuroanatomical characteristics of the human pre-Botzinger complex and its involvement in neurodegenerative brainstem diseases. Brain 2011, 134:24-35.
    • (2011) Brain , vol.134 , pp. 24-35
    • Schwarzacher, S.W.1
  • 88
    • 2642547405 scopus 로고    scopus 로고
    • Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis
    • Richerson G.B. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat. Rev. Neurosci. 2004, 5:449-461.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 449-461
    • Richerson, G.B.1
  • 89
    • 79960937702 scopus 로고    scopus 로고
    • Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition
    • Ray R.S., et al. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science 2011, 333:637-642.
    • (2011) Science , vol.333 , pp. 637-642
    • Ray, R.S.1
  • 90
    • 0346363231 scopus 로고    scopus 로고
    • Serotonin receptors: guardians of stable breathing
    • Richter D.W., et al. Serotonin receptors: guardians of stable breathing. Trend Mol. Med. 2003, 9:542-548.
    • (2003) Trend Mol. Med. , vol.9 , pp. 542-548
    • Richter, D.W.1
  • 91
    • 69049111812 scopus 로고    scopus 로고
    • Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development
    • Hodges M.R., et al. Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development. J. Neurosci. 2009, 29:10341-10349.
    • (2009) J. Neurosci. , vol.29 , pp. 10341-10349
    • Hodges, M.R.1
  • 92
    • 66149091961 scopus 로고    scopus 로고
    • The brainstem and serotonin in the sudden infant death syndrome
    • Kinney H.C., et al. The brainstem and serotonin in the sudden infant death syndrome. Annu. Rev. Pathol. 2009, 4:517-550.
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 517-550
    • Kinney, H.C.1
  • 93
    • 33750518186 scopus 로고    scopus 로고
    • Multiple serotonergic brainstem abnormalities in sudden infant death syndrome
    • Paterson D., et al. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. J. Am. Med. Assoc. 2006, 296:2124-2132.
    • (2006) J. Am. Med. Assoc. , vol.296 , pp. 2124-2132
    • Paterson, D.1
  • 94
    • 26044432811 scopus 로고    scopus 로고
    • In pursuit (and discovery) of a genetic basis for congenital central hypoventilation syndrome
    • Weese-Mayer D.E., et al. In pursuit (and discovery) of a genetic basis for congenital central hypoventilation syndrome. Respir. Physiol. Neurobiol. 2005, 149:73-82.
    • (2005) Respir. Physiol. Neurobiol. , vol.149 , pp. 73-82
    • Weese-Mayer, D.E.1
  • 95
    • 38349040023 scopus 로고    scopus 로고
    • Congenital central hypoventilation syndrome: PHOX2B genotype determines risk for sudden death
    • Gronli J.O., et al. Congenital central hypoventilation syndrome: PHOX2B genotype determines risk for sudden death. Pediatr. Pulmonol. 2008, 43:77-86.
    • (2008) Pediatr. Pulmonol. , vol.43 , pp. 77-86
    • Gronli, J.O.1
  • 96
    • 69949094303 scopus 로고    scopus 로고
    • Emerging principles and neural substrates underlying tonic sleep-state-dependent influences on respiratory motor activity
    • Horner R.L. Emerging principles and neural substrates underlying tonic sleep-state-dependent influences on respiratory motor activity. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2553-2564.
    • (2009) Philos. Trans. R. Soc. Lond. B: Biol. Sci. , vol.364 , pp. 2553-2564
    • Horner, R.L.1
  • 97
    • 79956224544 scopus 로고    scopus 로고
    • Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension
    • Zoccal D.B., Machado B.H. Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. Curr. Hypertens. Rep. 2011, 13:229-236.
    • (2011) Curr. Hypertens. Rep. , vol.13 , pp. 229-236
    • Zoccal, D.B.1    Machado, B.H.2
  • 98
    • 35648978121 scopus 로고    scopus 로고
    • The story of Rett syndrome: from clinic to neurobiology
    • Chahrour M., Zoghbi H.Y. The story of Rett syndrome: from clinic to neurobiology. Neuron 2007, 56:422-437.
    • (2007) Neuron , vol.56 , pp. 422-437
    • Chahrour, M.1    Zoghbi, H.Y.2
  • 99
    • 78149259999 scopus 로고    scopus 로고
    • Correction of respiratory disorders in a mouse model of Rett syndrome
    • Abdala A.P., et al. Correction of respiratory disorders in a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:18208-18213.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 18208-18213
    • Abdala, A.P.1
  • 100
    • 33947145165 scopus 로고    scopus 로고
    • -/y knockout mice
    • -/y knockout mice. J. Physiol. 2007, 579:863-876.
    • (2007) J. Physiol. , vol.579 , pp. 863-876
    • Stettner, G.M.1
  • 101
    • 0037477467 scopus 로고    scopus 로고
    • 4(a) receptors avert opioid-induced breathing depression without loss of analgesia
    • 4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Science 2003, 301:226-229.
    • (2003) Science , vol.301 , pp. 226-229
    • Manzke, T.1
  • 102
    • 69949103707 scopus 로고    scopus 로고
    • Serotonin targets inhibitory synapses to induce modulation of network functions
    • Manzke T., et al. Serotonin targets inhibitory synapses to induce modulation of network functions. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2589-2602.
    • (2009) Philos. Trans. R. Soc. Lond. B: Biol. Sci. , vol.364 , pp. 2589-2602
    • Manzke, T.1
  • 103
    • 67049125704 scopus 로고    scopus 로고
    • Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats
    • Ren J., et al. Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats. Anesthesiology 2009, 110:1364-1370.
    • (2009) Anesthesiology , vol.110 , pp. 1364-1370
    • Ren, J.1
  • 104
    • 70350784143 scopus 로고    scopus 로고
    • Math1 is essential for the development of hindbrain neurons critical for perinatal breathing
    • Rose M.F., et al. Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron 2009, 64:341-354.
    • (2009) Neuron , vol.64 , pp. 341-354
    • Rose, M.F.1
  • 105
    • 58149149969 scopus 로고    scopus 로고
    • Central respiratory rhythmogenesis is abnormal in Lbx1-deficient mice
    • Pagliardini S., et al. Central respiratory rhythmogenesis is abnormal in Lbx1-deficient mice. J. Neurosci. 2008, 28:11030-11041.
    • (2008) J. Neurosci. , vol.28 , pp. 11030-11041
    • Pagliardini, S.1
  • 106
    • 57349097234 scopus 로고    scopus 로고
    • Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments
    • Rybak I.A., et al. Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments. J. Neurophysiol. 2008, 100:1770-1799.
    • (2008) J. Neurophysiol. , vol.100 , pp. 1770-1799
    • Rybak, I.A.1
  • 107
    • 65149104199 scopus 로고    scopus 로고
    • Transneuronal circuit tracing with neurotropic viruses
    • Callaway E.M. Transneuronal circuit tracing with neurotropic viruses. Curr. Opin. Neurobiol. 2008, 18:617-623.
    • (2008) Curr. Opin. Neurobiol. , vol.18 , pp. 617-623
    • Callaway, E.M.1
  • 108
    • 78049303968 scopus 로고    scopus 로고
    • Monosynaptic rabies virus reveals premotor network organization and synaptic specificity of cholinergic partition cells
    • Stepien A.E., et al. Monosynaptic rabies virus reveals premotor network organization and synaptic specificity of cholinergic partition cells. Neuron 2010, 68:456-472.
    • (2010) Neuron , vol.68 , pp. 456-472
    • Stepien, A.E.1
  • 109
  • 110
    • 33644849342 scopus 로고    scopus 로고
    • Catecholamine neurons in rats modulate sleep, breathing, central chemoreception and breathing variability
    • Li A., Nattie E. Catecholamine neurons in rats modulate sleep, breathing, central chemoreception and breathing variability. J. Physiol. 2006, 570:385-396.
    • (2006) J. Physiol. , vol.570 , pp. 385-396
    • Li, A.1    Nattie, E.2
  • 111
    • 77953740018 scopus 로고    scopus 로고
    • State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing
    • Doi A., Ramirez J.M. State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing. J. Neurosci. 2010, 30:8251-8262.
    • (2010) J. Neurosci. , vol.30 , pp. 8251-8262
    • Doi, A.1    Ramirez, J.M.2
  • 112
    • 7044228168 scopus 로고    scopus 로고
    • Pontine and basal forebrain cholinergic interaction: implications for sleep and breathing
    • Douglas C.L., et al. Pontine and basal forebrain cholinergic interaction: implications for sleep and breathing. Respir. Physiol. Neurobiol. 2004, 143:251-262.
    • (2004) Respir. Physiol. Neurobiol. , vol.143 , pp. 251-262
    • Douglas, C.L.1
  • 113
    • 53849145356 scopus 로고    scopus 로고
    • Hypothalamic orexins/hypocretins as regulators of breathing
    • Williams R.H., Burdakov D. Hypothalamic orexins/hypocretins as regulators of breathing. Expert Rev. Mol. Med. 2008, 10:e28.
    • (2008) Expert Rev. Mol. Med. , vol.10
    • Williams, R.H.1    Burdakov, D.2
  • 114
    • 41649118388 scopus 로고    scopus 로고
    • A bilateral cortico-bulbar network associated with breath holding in humans, determined by functional magnetic resonance imaging
    • McKay L., et al. A bilateral cortico-bulbar network associated with breath holding in humans, determined by functional magnetic resonance imaging. Neuroimage 2008, 40:1824-1832.
    • (2008) Neuroimage , vol.40 , pp. 1824-1832
    • McKay, L.1


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