Multivalent fusion protein vaccine for lymphatic filariasis

Vaccine

Volumn 31, Issue 12, 2013, Pages 1616-1622

  Dakshinamoorthy, Gajalakshmi ^a   Samykutty, Abhilash Kumble ^a   Munirathinam, Gnanasekar ^a   Reddy, Maryada Venkatarami ^b   Kalyanasundaram, Ramaswamy ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b MAHATMA GANDHI INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Abundant Larval transcript 2; Antibody dependent cellular cytotoxicty; Lymphatic filariasis; Multivalent vaccine; Small heat shock proteins; Tetraspanin

Indexed keywords

ANTIPARASITIC AGENT; HEAT SHOCK PROTEIN 12.6-ABUNDANT LARVAL TRANSCRIPT 2; HEAT SHOCK PROTEIN 12.6-ABUNDANT LARVAL TRANSCRIPT 2-TETRASPANIN LARGE EXTRA CELLULAR LOOP; HEAT SHOCK PROTEIN 12.6-TETRASPANIN LARGE EXTRA CELLULAR LOOP; TETRASPANIN LARGE EXTRA CELLULAR LOOP-ABUNDANT LARVAL TRANSCRIPT 2; UNCLASSIFIED DRUG; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; BAGG ALBINO MOUSE; BRUGIA MALAYI; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; LYMPHATIC FILARIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, HELMINTH; ANTIBODY FORMATION; ANTIGENS, HELMINTH; BRUGIA MALAYI; ELEPHANTIASIS, FILARIAL; HEAT-SHOCK PROTEINS; HUMANS; IMMUNITY, CELLULAR; MICE; MICE, INBRED BALB C; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; TETRASPANINS; TH1 CELLS; TH2 CELLS; VACCINES; VACCINES, DNA;

EID: 84875259696     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.09.055     Document Type: Article

References (34)

1. Michel E., Bundy D.A. Global mapping of lymphatic filariasis. Parasitol Today 1997, 13(12):472-476.
2. Day K.P. The endemic normal in lymphatic filariasis: a static concept. Parasitol Today 1991, 7(12):341-343.
3. Veerapathran A., Dakshinamoorthy G., Gnanasekar M., Reddy M.V., Kalyanasundaram R. Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis. PLoS Negl Trop Dis 2009, 3(6):e457.
4. Dakshinamoorthy G., Samykutty A.K., Munirathinam G., Shinde G.B., Nutman T., Reddy M.V., et al. Biochemical characterization and evaluation of a Brugia malayi small heat shock protein as a vaccine against lymphatic filariasis. PLoS One 2012, 7(3):e34077.
5. Gnanasekar M., Rao K.V., He Y.X., Mishra P.K., Nutman T.B., Kaliraj P., et al. Novel phage display-based subtractive screening to identify vaccine candidates of Brugia malayi. Infect Immun 2004, 72(8):4707-4715.
6. Gnanasekar M., Anandharaman V., Anand S.B., Nutman T.B., Ramaswamy K. A novel small heat shock protein 12.6 (HSP12.6) from Brugia malayi functions as a human IL-10 receptor binding protein. Mol Biochem Parasitol 2008, 159(2):98-103.
7. Gnanasekar M., Anand S.B., Ramaswamy K. Identification and cloning of a novel tetraspanin (TSP) homologue from Brugia malayi. DNA Seq 2008, 19(2):151-156.
8. Kalyanasundaram R., Balumuri P. Multivalent vaccine formulation with BmVAL-1 and BmALT-2 confer significant protection against challenge infections with Brugia malayi in mice and jirds. Res Rep Trop Med 2011, 2011(2):45-56.
9. Thirugnanam S., Pandiaraja P., Ramaswamy K., Murugan V., Gnanasekar M., Nandakumar K., et al. Brugia malayi: comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model. Exp Parasitol 2007, 116(4):483-491.
10. Madhumathi J., Prince P.R., Anugraha G., Kiran P., Rao D.N., Reddy M.V., et al. Identification and characterization of nematode specific protective epitopes of Brugia malayi TRX towards development of synthetic vaccine construct for lymphatic filariasis. Vaccine 2010, 28(31):5038-5048.
11. Murray J., Gregory W.F., Gomez-Escobar N., Atmadja A.K., Maizels R.M. Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins. Mol Biochem Parasitol 2001, 118(1):89-96.
12. Pokharel D.R., Rai R., Nandakumar Kodumudi K., Reddy M.V., Rathaur S. Vaccination with Setaria cervi 175kDa collagenase induces high level of protection against Brugia malayi infection in jirds. Vaccine 2006, 24(37-39):6208-6215.
13. Sahoo M.K., Sisodia B.S., Dixit S., Joseph S.K., Gaur R.L., Verma S.K., et al. Immunization with inflammatory proteome of Brugia malayi adult worm induces a Th1/Th2-immune response and confers protection against the filarial infection. Vaccine 2009, 27(32):4263-4271.
14. Vedi S., Dangi A., Hajela K., Misra-Bhattacharya S. Vaccination with 73kDa recombinant heavy chain myosin generates high level of protection against Brugia malayi challenge in jird and mastomys models. Vaccine 2008, 26(47):5997-6005.
15. Devaney E., Osborne J. The third-stage larva (L3) of Brugia: its role in immune modulation and protective immunity. Microbes Infect 2000, 2:1363-1371.
16. Hoerauf A., Satoguina J., Saeftel M., Specht S. Immunomodulation by filarial nematodes. Parasite Immunol 2005, 27(10-11):417-429.
17. Samykutty A., Dakshinamoorthy G., Kalyanasundaram R. Multivalent vaccine for lymphatic filariasis. Proc Vaccinol 2010, 3:12-18.
18. Apt D., Raviprakash K., Brinkman A., Semyonov A., Yang S., Skinner C., et al. Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen. Vaccine 2006, 24(3):335-344.
19. Jiang G., Charoenvit Y., Moreno A., Baraceros M.F., Banania G., Richie N., et al. Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization. Malar J 2007, 6:135.
20. Wang X., Zhang L., Chi Y., Hoellwarth J., Zhou S., Wen X., et al. The nature and combination of subunits used in epitope-based Schistosoma japonicum vaccine formulations affect their efficacy. Parasites Vectors 2010, 3:109.
21. Spier R.E. Multivalent vaccines: prospects and challenges. Folia Microbiol (Praha) 1997, 42(2):105-112.
22. Mehra N.K., Kaur G. MHC-based vaccination approaches: progress and perspectives. Expert Rev Mol Med 2003, 5(7):1-17.
23. Abraham D., Grieve R.B., Holy J.M., Christensen B.M. Immunity to larval Brugia malayi in BALB/c mice: protective immunity and inhibition of larval development. Am J Trop Med Hyg 1989, 40:598-604.
24. Sim B.K., Kwa B.H., Mak J.W. Immune responses in human Brugia malayi infections: serum dependent cell-mediated destruction of infective larvae in vitro. Trans R Soc Trop Med Hyg 1982, 76(3):362-370.
25. Chandrashekar R., Rao U.R., Subrahmanyam D. Antibody-mediated cytotoxic effects in vitro and in vivo of rat cells on infective larvae of Brugia malayi. Int J Parasitol 1990, 20(6):725-730.
26. Helmy H., Weil J.G., Faris R., GAD A.M., Chandrasekar R., Ashour A., et al. Human antibody responses to Wuchereria bancrofti infective larvae. Parasite Immunol 2000, 22:89-96.
27. Gregory W.F., Atmadja A.K., Allen J.E., Maizels R.M. The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis. Infect Immun 2000, 68(7):4174-4179.
28. Sharmila S., Christiana I., Kiran P., Reddy M.V., Kaliraj P. The adjuvant-free immunoprotection of recombinant filarial protein Abundant Larval Transcript-2 (ALT-2) in mastomys coucha and the immunoprophylactic importance of its putative signal sequence. Exp Parasitol 2011, 129(3):247-253.
29. Haslbeck M., Franzmann T., Weinfurtner D., Buchner J. Some like it hot: the structure and function of small heat shock proteins. Nat Struct Mol Biol 2005, 12:842-846.
30. Suzue K., Zhou X., Eisen H.N., Young R.A. Heat shock protein fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc Natl Acad Sci USA 1997, 94:13146-13151.
31. Arizono N., Yamada M., Tegoshi T., Takaoka Y., Ohta M., Sakaeda T. Hsp12.6 expression is inducible by host immunity in adult worms of the parasitic nematode Nippostrongylus brasiliensis. PLoS One 2011, 6(March (3)):e18141.
32. Pearson M.S., Pickering D.A., McSorley H.J., Bethony J.M., Tribolet L., Dougall A.M., et al. Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2. PLoS Negl Trop Dis 2012, 6(3):e1564.
33. Kerepesi L.A., Keiser P.B., Nolan T.J., Schad G.A., Abraham D., Nutman T.B. DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice. Infect Immun 2005, 73(4):2298-2305.
34. Babu S., Ganley L.M., Klei T.R., Shultz L.D., Rajan T.V. Role of Gamma Interferon and Interleukin-4 in host defense against the human filarial parasite Brugia malayi. Infect Immun 2000, 68:3034-3035.