Delivery of a granzyme B inhibitor gene using carbamate-mannose modified PEI protects against cytotoxic lymphocyte killing

Biomaterials

Volumn 34, Issue 14, 2013, Pages 3697-3705

  Cheng, Wei ^a,b   Yang, Chuan ^b   Hedrick, James L ^c   Williams, David F ^d   Yang, Yi Yan ^b   Ashton Rickardt, Philip G ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^c IBM ALMADEN RESEARCH CENTER   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Carbamate mannose; Cytotoxicity; Gene transfer; Immunorejection; PEI; PI 9 gene

Indexed keywords

CARBAMATE-MANNOSE; CYTOTOXIC T LYMPHOCYTES; HUMAN EMBRYONIC KIDNEY CELLS; IMMUNOREJECTION; NATURAL KILLER CELLS; NUCLEOPHILIC ADDITIONS; TRANSFECTION EFFICIENCY; TRANSPLANT REJECTION;

ADDITION REACTIONS; CARBOHYDRATES; CELL CULTURE; CELL DEATH; CYTOTOXICITY; DISEASES; DNA; ENCODING (SYMBOLS); GENE TRANSFER; GENES; LYMPHOCYTES; POLYETHERIMIDES; POLYMERS;

MOLECULAR BIOLOGY;

AMINE; CARBAMIC ACID; CARBOHYDRATE; CARBONIC ACID; GRANZYME B; GREEN FLUORESCENT PROTEIN; MANNOSE; POLYETHYLENEIMINE; POLYMER; PROTEINASE INHIBITOR;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; CYTOTOXICITY; GENE TARGETING; GENETIC TRANSFECTION; GRAFT REJECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RING OPENING;

CARBAMATES; CELL LINE; DNA; GRANZYMES; GREEN FLUORESCENT PROTEINS; HUMANS; MANNOSE; PLASMIDS; POLYETHYLENEIMINE; POLYMERS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

VERTEBRATA;

EID: 84875259286     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.090     Document Type: Article

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