Rational design of biodegradable cationic polycarbonates for gene delivery

Journal of Controlled Release

Volumn 152, Issue 1, 2011, Pages 120-126

  Ong, Zhan Yuin ^a,b   Fukushima, Kazuki ^c   Coady, Daniel J ^c   Yang, Yi Yan ^a   Ee, Pui Lai Rachel ^b   Hedrick, James L ^c  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c IBM ALMADEN RESEARCH CENTER   (United States)

Author keywords

Cationic polymer; Gene transfection; Organocatalysis; Polycarbonate; Ring opening polymerization

Indexed keywords

ALKYL HALIDES; CATIONIC POLYMERS; CELL LINES; CONDENSED DNA; CYCLIC CARBONATES; EXPRESSION EFFICIENCY; FUNCTIONAL MOIETIES; FUNCTIONALIZATIONS; GENE DELIVERY; GENE DELIVERY VECTORS; GENE TRANSFECTION; HEK-293; NONVIRAL VECTORS; ORGANOCATALYSIS; ORGANOCATALYTIC; RATIONAL DESIGN; REPORTER-GENE EXPRESSION; SIDE-CHAINS;

BIOCOMPATIBILITY; BIODEGRADABLE POLYMERS; CARBONATES; CATIONIC POLYMERIZATION; CELL CULTURE; FUNCTIONAL POLYMERS; GENE THERAPY; GENE TRANSFER; POLYCARBONATES; POLYDISPERSITY; REACTION KINETICS; RING OPENING POLYMERIZATION; ZETA POTENTIAL;

GENE EXPRESSION;

NANOPARTICLE; POLYCARBONATE; POLYMER;

ANIMAL CELL; ARTICLE; BIODEGRADABILITY; CYTOTOXICITY; GENE TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; REPORTER GENE; ZETA POTENTIAL;

CATIONS; DNA; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEK293 CELLS; HEP G2 CELLS; HUMANS; POLYCARBOXYLATE CEMENT;

EID: 79958139935     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.01.020     Document Type: Article

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