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Volumn 34, Issue 3, 2013, Pages 120-128

Drug targets in the cytokine universe for autoimmune disease

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CANAKINUMAB; CLAZAKIZUMAB; DACLIZUMAB; GAMMA INTERFERON; GEVOKIZUMAB; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 11; RILONACEPT; SARILUMAB; SIRUKUMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 84875252254     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2012.10.003     Document Type: Review
Times cited : (31)

References (71)
  • 1
    • 34247551647 scopus 로고    scopus 로고
    • Cytokines and T-cell homeostasis
    • Boyman O., et al. Cytokines and T-cell homeostasis. Curr. Opin. Immunol. 2007, 19:320-326.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 320-326
    • Boyman, O.1
  • 2
    • 33644519308 scopus 로고    scopus 로고
    • Self-limitation of Th1-mediated inflammation by IFN-gamma
    • Feuerer M., et al. Self-limitation of Th1-mediated inflammation by IFN-gamma. J. Immunol. 2006, 176:2857-2863.
    • (2006) J. Immunol. , vol.176 , pp. 2857-2863
    • Feuerer, M.1
  • 3
    • 80054699918 scopus 로고    scopus 로고
    • Cytokines in autoimmunity: role in induction, regulation, and treatment
    • Moudgil K.D., Choubey D. Cytokines in autoimmunity: role in induction, regulation, and treatment. J. Interferon Cytokine Res. 2011, 31:695-703.
    • (2011) J. Interferon Cytokine Res. , vol.31 , pp. 695-703
    • Moudgil, K.D.1    Choubey, D.2
  • 4
    • 79954557114 scopus 로고    scopus 로고
    • Immune tolerance in multiple sclerosis
    • Goverman J.M. Immune tolerance in multiple sclerosis. Immunol. Rev. 2011, 241:228-240.
    • (2011) Immunol. Rev. , vol.241 , pp. 228-240
    • Goverman, J.M.1
  • 5
    • 77956326466 scopus 로고    scopus 로고
    • Averting inflammation by targeting the cytokine environment
    • Kopf M., et al. Averting inflammation by targeting the cytokine environment. Nat. Rev. Drug Discov. 2010, 9:703-718.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 703-718
    • Kopf, M.1
  • 7
    • 80052414102 scopus 로고    scopus 로고
    • Biologic therapies in non-rheumatic diseases: lessons for rheumatologists?
    • Bell G.M., et al. Biologic therapies in non-rheumatic diseases: lessons for rheumatologists?. Nat. Rev. Rheumatol. 2011, 7:507-516.
    • (2011) Nat. Rev. Rheumatol. , vol.7 , pp. 507-516
    • Bell, G.M.1
  • 8
    • 79954545784 scopus 로고    scopus 로고
    • Genome-wide association studies in multiple sclerosis: lessons and future prospects
    • Kemppinen A., et al. Genome-wide association studies in multiple sclerosis: lessons and future prospects. Brief. Funct. Genomics 2011, 10:61-70.
    • (2011) Brief. Funct. Genomics , vol.10 , pp. 61-70
    • Kemppinen, A.1
  • 9
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S., et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476:214-219.
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1
  • 10
    • 58149333555 scopus 로고    scopus 로고
    • Autoimmune diseases: insights from genome-wide association studies
    • Lettre G., Rioux J.D. Autoimmune diseases: insights from genome-wide association studies. Hum. Mol. Genet. 2008, 17:R116-R121.
    • (2008) Hum. Mol. Genet. , vol.17
    • Lettre, G.1    Rioux, J.D.2
  • 12
    • 72649089874 scopus 로고    scopus 로고
    • Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
    • Brucklacher-Waldert V., et al. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009, 132:3329-3341.
    • (2009) Brain , vol.132 , pp. 3329-3341
    • Brucklacher-Waldert, V.1
  • 13
    • 34548661488 scopus 로고    scopus 로고
    • Interleukin-17 in inflammatory skin disorders
    • van Beelen A.J., et al. Interleukin-17 in inflammatory skin disorders. Curr. Opin. Allergy Clin. Immunol. 2007, 7:374-381.
    • (2007) Curr. Opin. Allergy Clin. Immunol. , vol.7 , pp. 374-381
    • van Beelen, A.J.1
  • 14
    • 35948937642 scopus 로고    scopus 로고
    • Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy
    • Singh R., et al. Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. J. Rheumatol. 2007, 34:2285-2290.
    • (2007) J. Rheumatol. , vol.34 , pp. 2285-2290
    • Singh, R.1
  • 15
    • 77955166892 scopus 로고    scopus 로고
    • The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time
    • Chatzigeorgiou A., et al. The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time. Ann. Med. 2010, 42:426-438.
    • (2010) Ann. Med. , vol.42 , pp. 426-438
    • Chatzigeorgiou, A.1
  • 16
    • 80052250727 scopus 로고    scopus 로고
    • Environmental triggers of multiple sclerosis
    • Kakalacheva K., Lunemann J.D. Environmental triggers of multiple sclerosis. FEBS Lett. 2011, 585:3724-3729.
    • (2011) FEBS Lett. , vol.585 , pp. 3724-3729
    • Kakalacheva, K.1    Lunemann, J.D.2
  • 17
    • 0034654320 scopus 로고    scopus 로고
    • Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints
    • Blankenhorn E.P., et al. Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints. J. Immunol. 2000, 164:3420-3425.
    • (2000) J. Immunol. , vol.164 , pp. 3420-3425
    • Blankenhorn, E.P.1
  • 18
    • 81155160952 scopus 로고    scopus 로고
    • Type 1 regulatory T cells (Tr1) in autoimmunity
    • Pot C., et al. Type 1 regulatory T cells (Tr1) in autoimmunity. Semin. Immunol. 2011, 23:202-208.
    • (2011) Semin. Immunol. , vol.23 , pp. 202-208
    • Pot, C.1
  • 19
    • 34648835408 scopus 로고    scopus 로고
    • Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse
    • Achiron A., et al. Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Ann. N. Y. Acad. Sci. 2007, 1107:155-167.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1107 , pp. 155-167
    • Achiron, A.1
  • 20
    • 62849096248 scopus 로고    scopus 로고
    • Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent
    • Pundt N., et al. Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent. Arthritis Res. Ther. 2009, 11:R16.
    • (2009) Arthritis Res. Ther. , vol.11
    • Pundt, N.1
  • 21
    • 58249136105 scopus 로고    scopus 로고
    • The role of nuclear factor-kappaB in the development of autoimmune diseases: a link between genes and environment
    • Kurylowicz A., Nauman J. The role of nuclear factor-kappaB in the development of autoimmune diseases: a link between genes and environment. Acta Biochim. Pol. 2008, 55:629-647.
    • (2008) Acta Biochim. Pol. , vol.55 , pp. 629-647
    • Kurylowicz, A.1    Nauman, J.2
  • 22
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S., et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155:1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1
  • 23
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett C.L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001, 27:20-21.
    • (2001) Nat. Genet. , vol.27 , pp. 20-21
    • Bennett, C.L.1
  • 24
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V., et al. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 2004, 199:971-979.
    • (2004) J. Exp. Med. , vol.199 , pp. 971-979
    • Viglietta, V.1
  • 25
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams L.M., Rudensky A.Y. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 2007, 8:277-284.
    • (2007) Nat. Immunol. , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 26
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
    • Tang Q., Bluestone J.A. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 2008, 9:239-244.
    • (2008) Nat. Immunol. , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 27
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatory T cells in mediating and restraining inflammation
    • Littman D.R., Rudensky A.Y. Th17 and regulatory T cells in mediating and restraining inflammation. Cell 2010, 140:845-858.
    • (2010) Cell , vol.140 , pp. 845-858
    • Littman, D.R.1    Rudensky, A.Y.2
  • 28
    • 33646370647 scopus 로고    scopus 로고
    • TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
    • Valencia X., et al. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 2006, 108:253-261.
    • (2006) Blood , vol.108 , pp. 253-261
    • Valencia, X.1
  • 29
    • 23244443617 scopus 로고    scopus 로고
    • Cutting edge: IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells
    • King I.L., Segal B.M. Cutting edge: IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells. J. Immunol. 2005, 175:641-645.
    • (2005) J. Immunol. , vol.175 , pp. 641-645
    • King, I.L.1    Segal, B.M.2
  • 30
    • 67449168109 scopus 로고    scopus 로고
    • IL-15 renders conventional lymphocytes resistant to suppressive functions of regulatory T cells through activation of the phosphatidylinositol 3-kinase pathway
    • Ben Ahmed M., et al. IL-15 renders conventional lymphocytes resistant to suppressive functions of regulatory T cells through activation of the phosphatidylinositol 3-kinase pathway. J. Immunol. 2009, 182:6763-6770.
    • (2009) J. Immunol. , vol.182 , pp. 6763-6770
    • Ben Ahmed, M.1
  • 31
    • 45949090105 scopus 로고    scopus 로고
    • Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21
    • Clough L.E., et al. Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21. J. Immunol. 2008, 180:5393-5401.
    • (2008) J. Immunol. , vol.180 , pp. 5393-5401
    • Clough, L.E.1
  • 32
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    • Korn T., et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat. Med. 2007, 13:423-431.
    • (2007) Nat. Med. , vol.13 , pp. 423-431
    • Korn, T.1
  • 33
    • 46049093364 scopus 로고    scopus 로고
    • Th17 Cells and autoimmune encephalomyelitis (EAE/MS)
    • Aranami T., Yamamura T. Th17 Cells and autoimmune encephalomyelitis (EAE/MS). Allergol. Int. 2008, 57:115-120.
    • (2008) Allergol. Int. , vol.57 , pp. 115-120
    • Aranami, T.1    Yamamura, T.2
  • 34
    • 77950534540 scopus 로고    scopus 로고
    • T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
    • Axtell R.C., et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat. Med. 2010, 16:406-412.
    • (2010) Nat. Med. , vol.16 , pp. 406-412
    • Axtell, R.C.1
  • 35
    • 76249117009 scopus 로고    scopus 로고
    • Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease
    • Liu X., et al. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat. Med. 2010, 16:191-197.
    • (2010) Nat. Med. , vol.16 , pp. 191-197
    • Liu, X.1
  • 36
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 2007, 8:967-974.
    • (2007) Nat. Immunol. , vol.8 , pp. 967-974
    • Zhou, L.1
  • 37
    • 0033971259 scopus 로고    scopus 로고
    • IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells
    • Tominaga K., et al. IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int. Immunol. 2000, 12:151-160.
    • (2000) Int. Immunol. , vol.12 , pp. 151-160
    • Tominaga, K.1
  • 38
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of CD4+ T cell lineage differentiation
    • Zhou L., et al. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009, 30:646-655.
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1
  • 39
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 40
    • 67049168780 scopus 로고    scopus 로고
    • Plasticity of CD4(+) FoxP3(+) T cells
    • Zhou X., et al. Plasticity of CD4(+) FoxP3(+) T cells. Curr. Opin. Immunol. 2009, 21:281-285.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 281-285
    • Zhou, X.1
  • 41
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17 cells
    • Annunziato F., et al. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007, 204:1849-1861.
    • (2007) J. Exp. Med. , vol.204 , pp. 1849-1861
    • Annunziato, F.1
  • 42
    • 34249079176 scopus 로고    scopus 로고
    • Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    • Acosta-Rodriguez E.V., et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 2007, 8:639-646.
    • (2007) Nat. Immunol. , vol.8 , pp. 639-646
    • Acosta-Rodriguez, E.V.1
  • 43
    • 79955958973 scopus 로고    scopus 로고
    • Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers
    • Sierra-Filardi E., et al. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood 2011, 117:5092-5101.
    • (2011) Blood , vol.117 , pp. 5092-5101
    • Sierra-Filardi, E.1
  • 44
    • 78650996588 scopus 로고    scopus 로고
    • Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
    • Mikita J., et al. Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration. Mult. Scler. 2011, 17:2-15.
    • (2011) Mult. Scler. , vol.17 , pp. 2-15
    • Mikita, J.1
  • 45
    • 33748288122 scopus 로고    scopus 로고
    • Lp-PLA2: a new kid on the block
    • Zalewski A., et al. Lp-PLA2: a new kid on the block. Clin. Chem. 2006, 52:1645-1650.
    • (2006) Clin. Chem. , vol.52 , pp. 1645-1650
    • Zalewski, A.1
  • 46
    • 84980052315 scopus 로고    scopus 로고
    • Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord: inhibition of inflammation by resolvin D1
    • Liu G., et al. Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord: inhibition of inflammation by resolvin D1. Am. J. Neurodegener. Dis. 2012, 1:60-74.
    • (2012) Am. J. Neurodegener. Dis. , vol.1 , pp. 60-74
    • Liu, G.1
  • 47
    • 0003380742 scopus 로고
    • The continuity of being: Chinese visions of nature
    • State University Press of New York, J.B. Callicott, R. Ames (Eds.)
    • Du W.M. The continuity of being: Chinese visions of nature. Nature in Asian Traditions of Thought 1989, 73-78. State University Press of New York. J.B. Callicott, R. Ames (Eds.).
    • (1989) Nature in Asian Traditions of Thought , pp. 73-78
    • Du, W.M.1
  • 48
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua D.J., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421:744-748.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1
  • 49
    • 34147130293 scopus 로고    scopus 로고
    • Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease
    • Zhang J. Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease. J. Clin. Invest. 2007, 117:871-873.
    • (2007) J. Clin. Invest. , vol.117 , pp. 871-873
    • Zhang, J.1
  • 50
    • 0036434844 scopus 로고    scopus 로고
    • Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity
    • Rosloniec E.F., et al. Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity. Arthritis Res. 2002, 4:333-336.
    • (2002) Arthritis Res. , vol.4 , pp. 333-336
    • Rosloniec, E.F.1
  • 51
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber I.A., et al. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 1996, 156:5-7.
    • (1996) J. Immunol. , vol.156 , pp. 5-7
    • Ferber, I.A.1
  • 52
    • 0031159108 scopus 로고    scopus 로고
    • High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors
    • Manoury-Schwartz B., et al. High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors. J. Immunol. 1997, 158:5501-5506.
    • (1997) J. Immunol. , vol.158 , pp. 5501-5506
    • Manoury-Schwartz, B.1
  • 53
    • 0034762869 scopus 로고    scopus 로고
    • Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain
    • Guedez Y.B., et al. Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. Arthritis Rheum. 2001, 44:2413-2424.
    • (2001) Arthritis Rheum. , vol.44 , pp. 2413-2424
    • Guedez, Y.B.1
  • 54
    • 40049103352 scopus 로고    scopus 로고
    • IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
    • Kreymborg K., et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 2007, 179:8098-8104.
    • (2007) J. Immunol. , vol.179 , pp. 8098-8104
    • Kreymborg, K.1
  • 55
    • 76849086881 scopus 로고    scopus 로고
    • Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers
    • Dorner T., et al. Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers. Pharmacol. Ther. 2010, 125:464-475.
    • (2010) Pharmacol. Ther. , vol.125 , pp. 464-475
    • Dorner, T.1
  • 56
    • 84856252354 scopus 로고    scopus 로고
    • Immune mechanisms of new therapeutic strategies in multiple sclerosis - a focus on alemtuzumab
    • Klotz L., et al. Immune mechanisms of new therapeutic strategies in multiple sclerosis - a focus on alemtuzumab. Clin. Immunol. 2012, 142:25-30.
    • (2012) Clin. Immunol. , vol.142 , pp. 25-30
    • Klotz, L.1
  • 57
    • 0037313086 scopus 로고    scopus 로고
    • CD3-specific antibody-induced active tolerance: from bench to bedside
    • Chatenoud L. CD3-specific antibody-induced active tolerance: from bench to bedside. Nat. Rev. Immunol. 2003, 3:123-132.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 123-132
    • Chatenoud, L.1
  • 58
    • 0031791241 scopus 로고    scopus 로고
    • Anti-CD4 therapy in treatment of rheumatoid arthritis - have the die been cast?
    • Keysser G., et al. Anti-CD4 therapy in treatment of rheumatoid arthritis - have the die been cast?. Z. Rheumatol. 1998, 57:320-325.
    • (1998) Z. Rheumatol. , vol.57 , pp. 320-325
    • Keysser, G.1
  • 59
    • 73349108470 scopus 로고    scopus 로고
    • Alemtuzumab
    • Bates D. Alemtuzumab. Int. MS J. 2009, 16:75-76.
    • (2009) Int. MS J. , vol.16 , pp. 75-76
    • Bates, D.1
  • 60
    • 78651355835 scopus 로고    scopus 로고
    • Therapy of steroid-refractory acute GVHD with CD52 antibody alemtuzumab is effective
    • Schub N., et al. Therapy of steroid-refractory acute GVHD with CD52 antibody alemtuzumab is effective. Bone Marrow Transplant. 2011, 46:143-147.
    • (2011) Bone Marrow Transplant. , vol.46 , pp. 143-147
    • Schub, N.1
  • 61
    • 0036022681 scopus 로고    scopus 로고
    • Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials
    • Wiendl H., Hohlfeld R. Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials. BioDrugs 2002, 16:183-200.
    • (2002) BioDrugs , vol.16 , pp. 183-200
    • Wiendl, H.1    Hohlfeld, R.2
  • 62
    • 2442504914 scopus 로고    scopus 로고
    • Characteristics of T-cell receptor repertoire and myelin-reactive T cells reconstituted from autologous haematopoietic stem-cell grafts in multiple sclerosis
    • Sun W., et al. Characteristics of T-cell receptor repertoire and myelin-reactive T cells reconstituted from autologous haematopoietic stem-cell grafts in multiple sclerosis. Brain 2004, 127:996-1008.
    • (2004) Brain , vol.127 , pp. 996-1008
    • Sun, W.1
  • 63
    • 1242272715 scopus 로고    scopus 로고
    • Induction of IL-10 in rat peritoneal macrophages and dendritic cells by glatiramer acetate
    • Jung S., et al. Induction of IL-10 in rat peritoneal macrophages and dendritic cells by glatiramer acetate. J. Neuroimmunol. 2004, 148:63-73.
    • (2004) J. Neuroimmunol. , vol.148 , pp. 63-73
    • Jung, S.1
  • 64
    • 18144387626 scopus 로고    scopus 로고
    • Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3
    • Hong J., et al. Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:6449-6454.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 6449-6454
    • Hong, J.1
  • 65
    • 68949144931 scopus 로고    scopus 로고
    • Regulatory properties of copolymer I in Th17 differentiation by altering STAT3 phosphorylation
    • Chen C., et al. Regulatory properties of copolymer I in Th17 differentiation by altering STAT3 phosphorylation. J. Immunol. 2009, 183:246-253.
    • (2009) J. Immunol. , vol.183 , pp. 246-253
    • Chen, C.1
  • 66
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi C., et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N. Engl. J. Med. 2012, 366:1190-1199.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1190-1199
    • Leonardi, C.1
  • 67
    • 84861801523 scopus 로고    scopus 로고
    • Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice
    • Pantelyushin S., et al. Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J. Clin. Invest. 2012, 122:2252-2256.
    • (2012) J. Clin. Invest. , vol.122 , pp. 2252-2256
    • Pantelyushin, S.1
  • 68
    • 34548351247 scopus 로고    scopus 로고
    • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    • Gregory S.G., et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat. Genet. 2007, 39:1083-1091.
    • (2007) Nat. Genet. , vol.39 , pp. 1083-1091
    • Gregory, S.G.1
  • 69
    • 56349109500 scopus 로고    scopus 로고
    • Role of Th1 and Th17 cells in organ-specific autoimmunity
    • Dardalhon V., et al. Role of Th1 and Th17 cells in organ-specific autoimmunity. J. Autoimmun. 2008, 31:252-256.
    • (2008) J. Autoimmun. , vol.31 , pp. 252-256
    • Dardalhon, V.1
  • 70
    • 0029751983 scopus 로고    scopus 로고
    • Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
    • van Oosten B.W., et al. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2. Neurology 1996, 47:1531-1534.
    • (1996) Neurology , vol.47 , pp. 1531-1534
    • van Oosten, B.W.1
  • 71
    • 33746822397 scopus 로고    scopus 로고
    • Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells
    • Wuthrich C., et al. Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. J. Neurovirol. 2006, 12:116-128.
    • (2006) J. Neurovirol. , vol.12 , pp. 116-128
    • Wuthrich, C.1


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