Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism

Toxicological Sciences

Volumn 107, Issue 1, 2009, Pages 156-164

  Zhao, Fang ^a   Cai, Tongjian ^a   Liu, Mingchao ^a   Zheng, Gang ^a   Luo, Wenjing ^a   Chen, Jingyuan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dopaminergic neuron; Inducible nitric oxide synthase; Interleukin 1 ; Manganese; Microglia; Tumor necrosis factor

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MANGANESE; MANGANESE CHLORIDE; MINOCYCLINE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; IMMUNOREACTIVITY; IN VIVO STUDY; INTOXICATION; MALE; MICROGLIA; NERVE DEGENERATION; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SUBSTANTIA NIGRA; UPREGULATION;

ANIMALS; CHLORIDES; DOPAMINE; GENE EXPRESSION; INTERLEUKIN-1BETA; MALE; MANGANESE COMPOUNDS; MICROGLIA; MINOCYCLINE; NERVE DEGENERATION; NEURONS; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE 3-MONOOXYGENASE;

ANIMALIA; RATTUS;

EID: 58049213897     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn213     Document Type: Article

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