Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom

Toxicon

Volumn 67, Issue , 2013, Pages 17-30

  Wille, Ana Carolina Martins ^a,b   Chaves Moreira, Daniele ^a   Trevisan Silva, Dilza ^a   Magnoni, Mariana Gabriel ^a   Boia Ferreira, Marianna ^a   Gremski, Luiza Helena ^a   Gremski, Waldemiro ^a,c   Chaim, Olga Meiri ^a   Senff Ribeiro, Andrea ^a   Veiga, Silvio Sanches ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Brown spider venom; Cell proliferation; Cytosolic calcium influx; Membrane phospholipid modulation; Recombinant phospholipase D

Indexed keywords

CERAMIDE 1 PHOSPHATE; CHEMICAL COMPOUND; CHOLINE; FLUO 4; FLUOROPHORE; GREEN FLUORESCENT PROTEIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; RECOMBINANT ENZYME; RECOMBINANT PHOSPHOLIPASE D; SPHINGOMYELIN; SPIDER VENOM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CANCER CELL CULTURE; CELL DAMAGE; CELL PROLIFERATION; CELL SURFACE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS REACTION; CYTOPLASM; CYTOSOL; DRUG ACTIVITY; DRUG PROTEIN BINDING; ENZYME DEGRADATION; ENZYME KINETICS; HYDROLYSIS; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LOXOSCELES; LOXOSCELES INTERMEDIA; MELANOMA B16; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS; BROWN RECLUSE SPIDER; CALCIUM SIGNALING; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CHOLINE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MELANOMA, EXPERIMENTAL; PHOSPHOLIPASE D; PHOSPHOLIPIDS; PHOSPHORIC DIESTER HYDROLASES; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SPHINGOMYELINS; SPIDER VENOMS;

EID: 84875238193     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.01.027     Document Type: Article

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