Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity

Biochimie

Volumn 90, Issue 11-12, 2008, Pages 1722-1736

  Kusma, J ^a   Chaim, O M ^a,b   Wille, A C M ^c   Ferrer, V P ^a   Sade, Y B ^a   Donatti, L ^a   Gremski, W ^a,d   Mangili, O C ^a   Veiga, S S ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

^d PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Brown spider; Nephrotoxicity; Phospholipase D; Venom

Indexed keywords

CHOLINE; PHOSPHOLIPASE D; PHOSPHOLIPID; SPIDER VENOM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; CATALYSIS; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GLOMERULONEPHRITIS; HEMATURIA; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; KIDNEY BIOPSY; MOUSE; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; SPIDER BITE; UREA NITROGEN BLOOD LEVEL; URINALYSIS;

ANIMALS; CATALYTIC DOMAIN; EPITHELIAL CELLS; KIDNEY FAILURE; KIDNEY TUBULES; MICE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; PHOSPHOLIPASE D; PHOSPHORIC DIESTER HYDROLASES; PROTEIN ISOFORMS; PROTEINURIA; RABBITS; RECOMBINANT PROTEINS; SPIDER VENOMS;

ANIMALIA; ARANEAE; LOXOSCELES; MUS;

EID: 55349126717     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2008.07.011     Document Type: Article

References (50)

1. Futrell J. Loxoscelism. Am. J. Med. Sci. 304 (1992) 261-267
2. da Silva P.H., da Silveira R.B., Appel M.H., Mangili O.C., Gremski W., and Veiga S.S. Brown spider and loxoscelism. Toxicon 44 (2004) 693-709
3. Hogan C.J., Barbaro K.C., and Winkel K. Loxoscelism: old obstacles, new directions. Ann. Emerg. Med. 44 (2004) 608-624
4. Swanson D.L., and Vetter R.S. Loxoscelism. Clin. Dermatol. 24 (2006) 213-221
5. Sams H.H., Dunnick C.A., Smith M.L., and King L.E. Necrotic arachnidism. J. Am. Acad. Dermatol. 44 (2001) 561-573
6. Feitosa L., Gremski W., Veiga S.S., Elias M.C.Q.B., Graner E., Mangili O.C., and Brentani R.R. Detection and characterization of metalloproteinases with gelatinolytic, fibronectinolytic and fibrinogenolytic activities in brown spider (Loxosceles intermedia) venom. Toxicon 36 (1998) 1039-1051
7. de Castro C.S., Silvestre F.G., Araújo S.C., Gabriel M.Y., Mangili O.C., Cruz I., Chavez-Olortegui C., and Kalapothakis E. Identification and molecular cloning of insecticidal toxins from the venom of the brown spider Loxosceles intermedia. Toxicon 44 (2004) 273-280
8. Barbaro K.C., Knysak I., Martins R., Hogan C., and Winkel K. Enzymatic charactarization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas. Toxicon 45 (2005) 489-499
9. da Silveira R.B., Pigozzo R.B., Chaim O.M., Appel M.H., Dreyfuss J.L., Toma L., Mangili O.C., Gremski W., Dietrich C.P., Nader H.B., and Veiga S.S. Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (Brown spider) venom gland. Biochimie 88 (2006) 1241-1253
10. da Silveira R.B., Chaim O.M., Mangili O.C., Gremski W., Dietrich C.P., Nader H.B., and Veiga S.S. Hyaluronidases in Loxosceles intermedia (Brown spider) venom are endo-β-N-acetylhexosaminidases hydrolases. Toxicon 49 (2007) 758-768
11. da Silveira R.B., Pigozzo R.B., Chaim O.M., Appel M.H., Silva D.T., Dreyfuss J.L., Toma L., Dietrich C.P., Nader H.B., Veiga S.S., and Gremski W. Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from Brown spider (Loxosceles intermedia) venom: from cloning to functional characterization. Biochimie 89 (2007) 289-300
12. da Silveira R.B., Wille A.C.M., Chaim O.M., Appel M.H., Silva D.T., Franco C.R.C., Toma L., Mangili O.C., Gremski W., Dietrich C.P., Nader H.B., and Veiga S.S. Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom. Biochem. J. 406 (2007) 355-363
13. Lee S., and Lynch K.R. Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). Biochem. J. 391 (2005) 317-323
14. Moolenaar W.H., van Meeteren L.A., and Giepmans B.N. The ins and outs of lysophosphatidic acid signaling. BioEssays 26 (2004) 870-881
15. Anliker B., and Chun J. Lysophospholipid G protein-coupled receptors. J. Biol. Chem. 279 (2004) 20555-20558
16. Barbaro K.C., Sousa M.V., Morhy L., Eickstedt V.R., and Mota I. Compared chemical properties of dermonecrotic and lethal toxins from spiders of the genus Loxosceles (Araneae). J. Protein Chem. 15 (1996) 337-343
17. Gomez H.F., Miller M.J., Waggener M.W., Lankford H.A., and Warren J.S. Antigenic cross-reactivity of venoms from medically important North American Loxosceles spider species. Toxicon 39 (2001) 817-824
18. Cunha R.B., Barbaro K.C., Muramatsu D., Portaro F.C.V., Fontes W., and Sousa M.V. Purification and characterization of Loxnecrogin, a dermonecrotic toxin from Loxosceles gaucho brown spider venom. J. Protein Chem. 22 (2003) 135-146
19. Ramos-Cerrillo B., Olvera A., Odell G.V., Paniagua-Solis J., Alagón A., and Stock R.P. Genetic and enzymatic characterization of sphingomyelinase D isoforms from the North American fiddleback spiders Loxosceles boneti and Loxosceles recluse. Toxicon 44 (2004) 507-514
20. Machado L.F., Laugesen S., Botelho E.D., Ricart C.A., Fontes W., Barbaro K.C., Roepstorff P., and Sousa M.V. Proteome analysis of brown spider venom: identification of loxnecrogin isoforms in Loxosceles gaucho venom. Proteomics 5 (2005) 2167-2176
21. Binford G.J., Cordes M.H.J., and Wells M.A. Sphingomyelinase D from venoms of Loxosceles spiders: evolutionary insights from cDNA sequences and gene structure. Toxicon 45 (2005) 547-560
22. Chaim O.M., Sade Y.B., da Silveira R.B., Toma L., Kalapothakis E., Chávez-Olórtegui C., Mangili O.C., Gremski W., Dietrich C.P., Nader H.B., and Veiga S.S. Brown spider dermonecrotic toxin directly induces nephrotoxicity. Toxicol. Appl. Pharmacol. 211 (2006) 64-77
23. Appel M.H., da Silveira R.B., Chaim O.M., Paludo K.S., Silva D.T., Chaves D.M., Silva P.H., Mangili O.C., Senff-Ribeiro A., Gremski W., Nader H.B., and Veiga S.S. Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase-D) from brown spider (Loxosceles intermedia) venom. Biochim. Biophys. Acta 1780 (2008) 167-178
24. Kalapothakis E., Chatzaki M., Dornelas H.G., de Castro C.S., Silvestre F.G., Laborne F.V., de Moura J.F., Veiga S.S., Chávez-Olórtegui C., Granier C., and Barbaro K.C. The LoxTox protein family in Loxosceles intermedia (Mello-Leitão) venom. Toxicon 50 (2007) 938-946
25. Luciano M.N., Silva P.H., Chaim O.M., Santos V.P., Franco C.R.C., Soares M.F.S., Zanata S.M., Mangili O.C., Gremski W., and Veiga S.S. Experimental evidence for a direct cytotoxicity of Loxosceles intermedia (brown spider) venom on renal tissue. J. Histochem. Cytochem. 52 (2004) 455-467
26. Sambrook J., and Russel D.W. Molecular Cloning: a Laboratory Manual. third ed. (2001), Cold Spring Harbor Lab. Press, Cold Spring Harbor, NY
27. Culling C.F.A., Allison R.T., and Barr W.T. Cellular Pathology Technique (1985), Butterworth & Co Ltd, London, England
28. Karnovsky M.J. A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. J. Cell Biol. 27 (1965) 137A
29. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
30. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
31. Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc. Natl. Acad. Sci. U.S.A. 76 (1979) 4350-4354
32. Henry J.H. Clinical Diagnosis and Management by Laboratory Methods (2001), Saunders, United States
33. Freshney R.I. Culture of Animal Cells: a Manual of Basic Techniques. third ed. (2000), Wiley-Liss, Inc., New York, USA
34. Williams S.T., Khare V.K., Johnston G.A., and Blackall D.P. Severe intravascular hemolysis associated with brown recluse spider envenomation. Am. J. Clin. Pathol. 104 (1995) 463-467
35. Bey T.A., Walter F.G., Lober W., Schmidt J., Spark R., and Schlievert P.M. Loxosceles arizonica bite associated with shock. Ann. Emerg. Med. 30 (1997) 701-703
36. Lung J.M., and Mallory S.B. A child with spider bite and glomerulonephritis: a diagnostic challenge. Int. J. Dermatol. 39 (2000) 287-289
37. França F.O.S., Barbaro K.C., and Abdulkader C.R.M. Rhabdomyolisis in presumed viscero-cutaneous loxoscelism: report of two cases. Trans. R. Soc. Trop. Med. Hyg. 96 (2002) 287-290
38. Chioato L., and Ward R.J. Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis. Toxicon 42 (2003) 869-883
39. Sakamoto H., Bellalou J., Sebo P., and Ladant D. Bordetella pertussis adenylate cyclase toxin. Structural and functional independence of the catalytic and hemolytic activities. J. Biol. Chem. 267 (1992) 13598-13602
40. Murakami M.T., Fernandes-Pedrosa M.F., Tambourgi D.V., and Arni R.K. Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D. J. Biol. Chem. 280 (2005) 13658-13664
41. Cotran R.S., Kumar V., and Robbins S.L. Pathologic Basis of Disease (1999), Elsevier, Boston
42. Sousa Alves R., do Nascimento N.R., Barbosa P.S., Kerntopf M.R., Lessa L.M., de Sousa C.M., Martins R.D., Sousa D.F., de Queiroz M.G., Toyama M.H., Fonteles M.C., Martins A.M., and Monteiro H.S. Renal effects and vascular reactivity induced by Tityus serrulatus venom. Toxicon 46 (2005) 271-276
43. Pipelzadeh M.H., Dezfulian A.R., Jalali M.T., and Mansouri A.K. In vitro and in vivo studies on some toxic effects of the venom from Hemiscorpious lepturus scorpion. Toxicon 48 (2006) 93-103
44. Huwiler A., Kolter T., Pfeilschifer J., and Sandhoff K. Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim. Biophys. Acta 1485 (2000) 63-99
45. Faquhar M.G. The glomerular basement membrane: a selective macromolecular filter. In: Hay E.D. (Ed). Cell Biology of Extracellular Matrix (1991), Pleun Press, New York
46. Elston D.M., Eggers J.S., Schmidt W.E., Storrow A.B., Doe R.H., McGlasson D., and Fischer J.R. Histological findings after brown recluse spider envenomation. Am. J. Dermatopathol 22 (2000) 242-246
47. Ospedal K.Z., Appel M.H., Neto J.F., Mangili O.C., Veiga S.S., and Gremski W. Histopathological findings in rabbits after experimental acute exposure to the Loxosceles intermedia (brown spider) venom. Int. J. Exp. Pathol. 83 (2002) 287-294
48. Zager R.A., Conrad S.L., Sweeney E.A., Igarashi Y., and Burkhart K.M. Altered sphingomyelinase and ceramide expression in the setting of ischemic and nephrotoxic acute renal failure. Kidney Int. 53 (1998) 573-582
49. Shayman J.A. Sphingolipids: their role in intracellular signalling and renal growth. J. Am. Soc. Nephrol. 7 (1996) 171-182
50. Shayman J.A. Sphingolypids. Kidney Int. 58 (2000) 11-26