Loxoscelism

Clinics in Dermatology

Volumn 24, Issue 3, 2006, Pages 213-221

  Swanson, David L ^a   Vetter, Richard S ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; CYPROHEPTADINE; DAPSONE; DEXTRAN; DIPHENHYDRAMINE; GLUCOCORTICOID; GLYCERYL TRINITRATE; HEPARIN; METRONIDAZOLE; PHENTOLAMINE; SERINE PROTEINASE; SPHINGOMYELIN PHOSPHODIESTERASE; SPIDER VENOM; TRYPSIN; VASODILATOR AGENT; VENOM ANTISERUM;

AGRANULOCYTOSIS; ARTICLE; CURETTAGE; DRUG INHIBITION; ELECTRIC SHOCK; EXFOLIATIVE DERMATITIS; GASTROINTESTINAL SYMPTOM; HEADACHE; HEMOLYSIS; HEPATITIS; HISTOPATHOLOGY; HUMAN; HYPERBARIC OXYGEN; LABORATORY DIAGNOSIS; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; SKIN NECROSIS; SKIN ULCER; SOUTH AMERICA; SPIDER; SPIDER BITE; WESTERN HEMISPHERE;

ARACHNIDISM; HUMANS;

EID: 33646563390     PISSN: 0738081X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clindermatol.2005.11.006     Document Type: Article

References (94)

1. Binford G.J., and Wells M.A. The phylogenetic distribution of sphingomyelinase D activity in venoms of haplogyne spiders. Comp Biochem Physiol B Biochem Mol Biol 135 (2003) 25-33
2. Caveness W.A. Insect bite, complicated with fever. Nashville J Med Surg 10 (1872) 333-337
3. Macchiavello A. Cutaneous arachnidism or gangrenous spot of Chile. P R J Public Health Trop Med 22 (1947) 425-466
4. Schmaus L.F. Case of arachnidism (spider bite). JAMA 92 (1929) 1265-1266
5. Atkins J.A., Curtis W.W., and Sodeman W.A. Probable cause of necrotic spider bite in the Midwest. Science 126 (1957) 73
6. Platnick N.I. The World Spider Catalogue, Version 6.0 (2005). http://research.amnh.org/entomology/spiders/catalog/INTRO1.html
7. Gertsch W.J., and Ennik F. The spider genus Loxosceles in North America, Central America and the West Indies (Araneae Loxoscelidae). Bull Am Mus Nat Hist 175 (1983) 264-360
8. Vetter R.S. Arachnids submitted as suspected brown recluse spiders (Araneae: Sicariidae): Loxosceles spiders are virtually restricted to their known distributions but are perceived to exist throughout the United States. J Med Entomol 42 (2005) 512-521
9. Vetter R.S., Edwards G.B., and James L.F. Reports of envenomation by brown recluse spiders (Araneae: Sicariidae) outnumber verifications of Loxosceles spiders in Florida. J Med Entomol 41 (2004) 593-597
10. White J., Cardoso J.L., and Fan H.W. Clinical toxicology of spider bites. Ch. 20. In: Meier J., and White J. (Eds). Handbook of clinical toxicology of animal venoms and poisons (1995), CRC Press, Boca Raton (Fla) 261-329
11. Gertsch W.J. The spider genus Loxosceles in South America (Araneae Scytodidae). Bull Am Mus Nat Hist 136 (1967) 117-174
12. Van Den Berg C.W., De Andrade R.M., Magnoli F.C., Marchbank K.J., and Tambourgi D.V. Loxosceles spider venom induces metalloproteinase mediated cleavage of MCP/CD46 and MHCI and induces protection against C-mediated lysis. Immunology 107 (2002) 102-110
13. Futrell J.M. Loxoscelism. Am J Med Sci 304 (1992) 261-267
14. Southcott R.V. Spiders of the genus Loxosceles in Australia. Med J Aust 1 (1976) 406-408
15. Fischer M.L., and Vasconcellos-Neto J. Microhabitats occupied by Loxosceles intermedia and Loxosceles laeta (Araneae:Sicariidae) in Curitiba, Parana, Brazil. J Med Entomol 42 (2005) 756-765
16. Schenone H., Rojas A., Reyes H., Villarroel F., and Suarez G. Prevalence of Loxosceles laeta in houses in central Chile. Am J Trop Med Hyg 19 (1970) 564-567
17. Vetter R. Identifying and misidentifying the brown recluse spider. http://dermatology.cdlib.org/DOJvol5num2/special/recluse.html [Last accessed 9/28/05]
18. Brescovit A.D., and Rheims C.A. On the synanthropic species of the genus Scytodes Latreille (Araneae, Scytodidae) of Brazil, with synonymies and records of these species in other neotropical countries. Bull Br Arachnol Soc 11 (2000) 320-330
19. Isbister G.K., and Gray M.R. White-tail spider bite: a prospective study of 130 definite bites by Lampona species. Med J Aust 179 (2003) 199-202
20. Ribeiro L.A., Jorge M.T., Piesco R.V., and Nishioka S de A. Wolf spider bites in Sao Paulo, Brazil: a clinical and epidemiological study of 515 cases. Toxicon 28 (1990) 715-717
21. Isbister G.K., and Framenau V.W. Australian wolf spider bites (Lycosidae): clinical effects and influence of species on bite circumstances. J Toxicol Clin Toxicol 42 (2004) 153-161
22. Isbister G.K., and Gray M.R. Black house spiders are unlikely culprits in necrotic arachnidism: a prospective study. Intern Med J 34 (2004) 287-289
23. Vetter R.S., and Isbister G.K. Do hobo spider bites cause dermonecrotic injuries?. Ann Emerg Med 44 (2004) 605-607
24. Young A.R., and Pincus S.J. Comparison of enzymatic activity from three species of necrotising arachnids in Australia: Loxosceles rufescens, Badumna insignis and Lampona cylindrata. Toxicon 39 (2000) 391-400
25. Foradori M.J., Smith S.C., Smith E., and Wells R.E. Survey for potentially necrotizing spider venoms, with special emphasis on Cheiracanthium mildei. Comp Biochem Physiol C Toxicol Pharmacol 141 (2005) 32-39
26. Isbister G.K. Letter to the editor. Toxicon 39 (2001) 1941-1942
27. Bodner M.R., Callahan M., and Binford G.J. Evolutionary origin and loss of sphingomyelinase D in the Sicarius and Loxosceles lineages. 29th Annual meeting of Amer. Arachnol. Soc. Akron OH, 29 Jun (2005)
28. Macchiavello A. Cutaneous arachnidism experimentally produced with the glandular poison of Loxosceles laeta. P R J Public Health Trop Med 23 (1948) 266
29. da Silva P.H., da Silveira R.B., Appel M.H., et al. Brown spiders and loxoscelism. Toxicon 44 (2004) 693-709
30. de Oliveira K.C., Goncalves de Andrade R.M., Piazza R.M., et al. Variations in Loxosceles spider venom composition and toxicity contribute to the severity of envenomation. Toxicon 45 (2005) 421-429
31. Morgan P.N. Preliminary studies on venom from brown recluse spider, Loxosceles reclusa. Toxicon 6 (1969) 161-165
32. Wigger E., Kuhn-Nentwig L., and Nentwig W. The venom optimisation hypothesis: a spider injects large venom quantities only into difficult prey types. Toxicon 40 (2002) 749-752
33. da Silveira R.B., dos Santos Filho J.F., Mangili O.C., et al. Identification of proteases in the extract of venom glands from brown spiders. Toxicon 40 (2002) 815-822
34. Fernandes P.M.F., Junqueira de Azevedo I.L., Goncalves de Andrade R.M., et al. Molecular cloning and expression of a functional dermonecrotic and haemolytic factor from Loxosceles laeta venom. Biochem Biophys Res Commun 298 (2002) 638-645
35. Kalapothakis E., Araujo S.C., de Castro C.S., et al. Molecular cloning, expression and immunological properties of LiD1, a protein from the dermonecrotic family of Loxosceles intermedia spider venom. Toxicon 40 (2002) 1691-1699
36. Guilherme P., Fernandes I., and Barbaro K.C. Neutralization of dermonecrotic and lethal activities and differences among 32-35 kDa toxins of medically important Loxosceles spider venoms in Brazil revealed by monoclonal antibodies. Toxicon 39 (2001) 1333-1342
37. Norment B.R., Jong Y.S., and Heitz J.R. Separation and characterization of venom components in Loxosceles reclusa-III. Hydrolytic enzyme activity. Toxicon 17 (1979) 539-548
38. Schenone H., and Suarez G. Venoms of Scytodidae. Genus Loxosceles. In: Bettini S. (Ed). Handbook of experimental pharmacology. Arthropod venoms vol. 48 (1978), Springer-Verlag, New York 247-275
39. Forrester L.J., Barrett J.T., and Campbell B.J. Red blood cell lysis induced by the venom of the brown recluse spider: The role of sphingomyelinase D. Arch Biochem Biophys 187 (1978) 355-365
40. Russell F.E. Phosphodiesterase of some snake and arthropod venoms. Toxicon 4 (1966) 153-154
41. Jong Y.S., Norment B.R., and Heitz J.R. Separation and characterization of venom components in Loxosceles reclusa-II. Protease enzyme activity. Toxicon 17 (1979) 529-537
42. Feitosa L., Gremski W., Veiga S.S., et al. Detection and characterization of metalloproteinases with gelatinolytic, fibronectinolytic and fibrinogenolytic activities in brown spider (Loxosceles intermedia) venom. Toxicon 36 (1998) 1039-1051
43. Veiga S.S., Feitosa L., dos Santos V.L., et al. Effect of brown spider venom on basement membrane structures. Histochem J 32 (2000) 397-408
44. Rekow M.A., Civello D.J., and Geren C.R. Enzymatic and hemolytic properties of brown recluse spider (Loxosceles reclusa) toxin and extracts of venom apparatus, cephalothorax and abdomen. Toxicon 29 (1983) 1225-1233
45. Veiga S.S., da Silveira R.B., Dreyfus J.L., et al. Identification of high molecular weight serine-proteases in Loxosceles intermedia (brown spider) venom. Toxicon 38 (2000) 825-839
46. Tambourgi D.V., Morgan B.P., de Andrade R.M., Magnoli F.C., and van Den Berg C.W. Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis. Blood 95 (2000) 683-691
47. Tambourgi D.V., Magnoli F.C., Von Eickstedt V.R., et al. Incorporation of a 35-kilodalton purified protein from Loxosceles intermedia spider venom transforms human erythrocytes into activators of autologous complement alternative pathway. J Immunol 155 (1995) 4459-4466
48. Foradori M.J., Keil L.M., Wells R.E., Diem M., and Tillinghast E.K. An examination of the potential role of spider digestive proteases as a causative factor in spider bite necrosis. Comp Biochem Physiol C 130 (2001) 209-218
49. Monteiro C.L., Rubel R., Cogo L.L., et al. Isolation and identification of Clostridium perfringens in the venom and fangs of Loxosceles intermedia (brown spider): enhancement of the dermonecrotic lesion in loxoscelism. Toxicon 40 (2002) 409-418
50. Vetter R.S., and Barger D.K. An infestation of 2055 brown recluse spiders (Araneae: Sicariidae) and no envenomations in a Kansas home: implications for bite diagnoses in nonendemic areas. J Med Entomol 39 (2002) 948-951
51. Berger R.S. The unremarkable brown recluse spider bite. JAMA 225 (1973) 1109-1110
52. Gomez H.F., Krywko D.M., and Stoecker W.V. A new assay for the detection of Loxosceles species (brown recluse) spider venom. Ann Emerg Med 39 (2002) 469-474
53. Anderson P.C. Loxoscelism threatening pregnancy: five cases. Am J Obstet Gynecol 165 (1991) 1454-1456
54. Franca F.O., Barbaro K.C., and Abdulkader R.C. Rhabdomyolysis in presumed viscero-cutaneous loxoscelism: report of two cases. Trans R Soc Trop Med Hyg 96 (2002) 287-290
55. Anderson P.C. Missouri brown recluse spider: a review and update. Mo Med 95 (1998) 318-322
56. Veiga S.S., Zanetti V.C., Franco C.R., et al. In vivo and in vitro cytotoxicity of brown spider venom for blood vessel endothelial cells. Thromb Res 102 (2001) 229-237
57. Ospedal K.Z., Appel M.H., Fillus Neto J., et al. Histopathological findings in rabbits after experimental acute exposure to the Loxosceles intermedia (brown spider) venom. Int J Exp Pathol 83 (2002) 287-294
58. Smith C.W., and Micks D.W. The role of polymorphonuclear leukocytes in the lesion caused by the venom of the brown spider, Loxosceles reclusa. Lab Invest 22 (1970) 90-93
59. Tambourgi D.V., Paixao-Cavalcante D., Goncalves de Andrade R.M., et al. Loxosceles sphingomyelinase induces complement-dependent dermonecrosis, neutrophil infiltration, and endogenous gelatinase expression. J Invest Dermatol 124 (2005) 725-731
60. Ward P.A., and Cochrane C.G. Bound complement and immunologic injury of blood vessels. J Exp Med 121 (1965) 215-234
61. Gates C.A., and Rees R.S. Serum amyloid P component: its role in platelet activation stimulated by sphingomyelinase D purified from the venom of the brown recluse spider (Loxosceles reclusa). Toxicon 28 (1990) 1303-1315
62. Rees R.S. Platelet activation stimulated by the toxin of the brown recluse spider requires serum amyloid P component, not C-reactive protein. Toxicon 27 (1989) 953-954
63. Veiga S.S., Zanetti V.C., Braz A., Mangili O.C., and Gremski W. Extracellular matrix molecules as targets for brown spider venom toxins. Braz J Med Biol Res 34 (2001) 843-850
64. Sutherland S.K. Venoms of Dipluridae. In: Bettini S. (Ed). Handbook of experimental pharmacology. Arthropod venoms vol. 48 (1978), Springer-Verlag, New York 121-148
65. Swanson D.L., and Vetter R.S. Bites of brown recluse spiders and suspected necrotic arachnidism. N Engl J Med 352 (2005) 700-707
66. Vetter R.S., Cushing P.E., Crawford R.L., and Royce L.A. Diagnoses of brown recluse spider bites (loxoscelism) greatly outnumber actual verifications of the spider in four western American states. Toxicon 42 (2003) 413-418
67. Russell F.E., and Gertsch W.J. Letter to the editor. Toxicon 21 (1983) 337-339
68. Moaven L.D., Alten S.A., and Newnham A.R. Sporotrichosis mimicking necrotising arachnidism. Med J Aust 171 (1999) 685-686
69. Osterhoudt K.C., Zaoutis T., and Zorc J.J. Lyme disease masquerading as brown recluse spider bite. Ann Emerg Med 39 (2002) 558-561
70. Roche K.J., Chang M.W., and Lazarus H. Cutaneous anthrax infection. N Engl J Med 345 (2001) 1611
71. Dominguez T.J. It's not a spider bite, it's community-acquired methicillin-resistant Staphylococcus aureus. J Am Board Fam Pract 17 (2004) 220-226
72. Beilman G.J., Sandifer G., Skarda D., et al. Emerging infections with community-associated methicillin-resistant Staphylococcus aureus in outpatients at an Army Community Hospital. Surg Infect (Larchmt) 6 (2005) 87-92
73. Auer A.I., and Hershey F.B. Surgery for necrotic bites of the brown spider. Arch Surg 108 (1974) 612-618
74. Fardon D.W., Wingo C.W., Robinson D.W., and Masters F.W. The treatment of brown spider bite. Plast Reconstr Surg 40 (1967) 482-488
75. Paniker U., and Levine N. Dapsone and sulfapyridine. Dermatol Clin 19 (2001) 79-86
76. King L.E., and Rees R.S. Dapsone treatment of a brown recluse bite. JAMA 250 (1983) 648
77. Barrett S.M., Romine-Jenkins M., and Fisher D.E. Dapsone or electric shock therapy of brown recluse spider envenomation?. Ann Emerg Med 24 (1994) 21-25
78. Phillips S., Kohn M., Baker D., et al. Therapy of brown spider envenomation: a controlled trial of hyperbaric oxygen, dapsone, and cyproheptadine. Ann Emerg Med 25 (1995) 363-368
79. Elston D.M., Miller S.D., Young III R.J., et al. Comparison of colchicine, dapsone, triamcinolone, and diphenhydramine therapy for the treatment of brown recluse spider envenomation: a double-blind, controlled study in a rabbit model. Arch Dermatol 141 (2005) 595-597
80. Bryant S.M., and Pittman L.M. Dapsone use in Loxosceles reclusa envenomation: is there an indication?. Am J Emerg Med 21 (2003) 89-90
81. Gleid R., and Rico J. Treatment of autoimmune blistering diseases. Dermatol Clin 17 (1999) 431-440
82. Dillaha C.J., Jansen G.T., Honeycutt W.M., and Hayden C.R. The gangrenous bite of the brown spider in Arkansas. J Ark Med Soc 60 (1963) 91
83. Jansen G.T., Morgan P.N., McQueen J.N., and Bennett W.E. The brown recluse spider bite: controlled evaluation of treatment using the white rabbit as an animal model. South Med J 62 (1971) 1194-1202
84. Maynor M.L., Moon R.E., Klitzman B., Fracica P.J., and Canada A. Brown recluse spider bites: beneficial effects of hyperbaric oxygen. J Hyperb Med 7 (1992) 89-102
85. Svendsen F.J. Treatment of clinically diagnosed brown recluse spider bites with hyperbaric oxygen: a clinical observation. J Ark Med Soc 83 (1986) 199-204
86. Hobbs G.D., Anderson A.R., Greene T.J., and Yealy D.M. Comparison of hyperbaric oxygen and dapsone therapy for Loxosceles envenomation. Acad Emerg Med 3 (1996) 758-761
87. Guderian R.H., Mackenzie C.D., and Williams J.F. High voltage shock treatment for snake bite. Lancet 2 (1986) 229
88. Osborn C.D. Treatment of spider bites by high voltage direct current. J Okla State Med Assoc 84 (1991) 257-260
89. Rees R.S., Altenbern D.P., Lynch J.B., and King Jr. L.E. Brown recluse spider bites. A comparison of early surgical excision versus dapsone and delayed surgical excision. Ann Surg 202 (1985) 659-663
90. Malaque C.M., Castro-Valencia J.E., Cardoso J.L., et al. Clinical and epidemiological features of definitive and presumed loxoscelism in Sao Paulo, Brazil. Rev Inst Med Trop Sao Paulo 44 (2002) 139-143
91. de Roodt A.R., Litwin S., Dokmetjian J.C., and Vidal J.C. A reduced immunization scheme to obtain an experimental anti-Loxosceles laeta ("violinist spider") venom. J Nat Toxins 11 (2002) 193-203
92. Barbaro K.C., Knysak I., Martins R., Hogan C., and Winkel K. Enzymatic characterization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas. Toxicon 45 (2005) 489-499
93. Rees R., Campbell D., Rieger E., and King L.E. The diagnosis and treatment of brown recluse spider bites. Ann Emerg Med 16 (1987) 945-949
94. Araujo S.C., Castanheira P., Alvarenga L.M., et al. Protection against dermonecrotic and lethal activities of Loxosceles intermedia spider venom by immunization with a fused recombinant protein. Toxicon 41 (2003) 261-267