SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 7, 2013, Pages 2145-2155

Small-molecule inhibition of the uPAR·uPA interaction: Synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis

(12) Mani, Timmy a Wang, Fang a Knabe, William Eric a Sinn, Anthony L a,b Khanna, May a Jo, Inha a Sandusky, George E b Sledge Jr , George W a,b,c Jones, David R b Khanna, Rajesh a Pollok, Karen E a,b Meroueh, Samy O a,b,c

a INDIANA UNIVERSITY SCHOOL OF MEDICINE (United States)

b INDIANA UNIVERSITY (United States)

c INDIANA UNIVERSITY SCHOOL OF MEDICINE (United States)

Author keywords

Breast cancer; Cancer; In vivo; Metastasis; Protein protein interaction inhibitors; Synthesis; Urokinase receptor; Virtual screening

Indexed keywords

3 [(3 (AZEPAN 1 YL) 6 OXO 6H ANTHRA[1,9 CD]ISOXAZOL 5 YL)AMINO]BENZOIC ACID; ANTINEOPLASTIC AGENT; IPR 803; MATRIX METALLOPROTEINASE; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER TISSUE; CELL ADHESION; CELL STRAIN MDA MB 231; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; ENZYME DEGRADATION; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FEMALE; HISTOPATHOLOGY; IMMUNOFLUORESCENCE MICROSCOPY; IN VIVO STUDY; LUNG METASTASIS; MAXIMUM PLASMA CONCENTRATION; METASTASIS INHIBITION; MIGRATION INHIBITION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PROTEIN INTERACTION; SATURATION TRANSFER DIFFERENCE NUCLEAR MAGNETIC RESONANCE; SCID MOUSE; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTEIN INTERACTION MAPS; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; SMALL MOLECULE LIBRARIES; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

MURINAE; MUS;

EID: 84875221885 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.12.047 Document Type: Article

Times cited : (49)

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