메뉴 건너뛰기




Volumn 253, Issue 3, 1998, Pages 817-826

A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis

Author keywords

Amino terminal fragment; Bikunin; Hybrid protein; Urinary trypsin inhibitor; Urokinase type plasminogen activator

Indexed keywords

MATRIGEL; ULINASTATIN; UROKINASE;

EID: 0032079489     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2530817.x     Document Type: Article
Times cited : (68)

References (52)
  • 3
    • 0023223148 scopus 로고
    • The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases
    • Appella, E., Robinson, E. A., Ullrich, S. J., Stoppelli, M. P., Corti, A., Cassani, G. & Blasi, F. (1987) The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases, J. Biol. Chem. 262, 4437-4440.
    • (1987) J. Biol. Chem. , vol.262 , pp. 4437-4440
    • Appella, E.1    Robinson, E.A.2    Ullrich, S.J.3    Stoppelli, M.P.4    Corti, A.5    Cassani, G.6    Blasi, F.7
  • 5
    • 0028049507 scopus 로고
    • Cytokine-specific regulation of urokinase receptor (CD87) expression by U937 mononuclear phagocytes
    • Sitrin, R. G., Todd, R. F. III, Mizukami, I. F, Gross, T. J., Shollenberger, S. B. & Gyetko, M. R. (1994) Cytokine-specific regulation of urokinase receptor (CD87) expression by U937 mononuclear phagocytes, Blood 84, 1268-1275.
    • (1994) Blood , vol.84 , pp. 1268-1275
    • Sitrin, R.G.1    Todd III, R.F.2    Mizukami, I.F.3    Gross, T.J.4    Shollenberger, S.B.5    Gyetko, M.R.6
  • 6
    • 0026641093 scopus 로고
    • Urokinase-catalyzed plasminogen activation at the monocyte/macrrophage cell surface: A localized and regulated proteolytic system
    • Vassalli, J.-D., Wohlwend, A. & Belin, D. (1992) Urokinase-catalyzed plasminogen activation at the monocyte/macrrophage cell surface: a localized and regulated proteolytic system, Curr. Top. Microbiol. Immunol. 181, 65-86.
    • (1992) Curr. Top. Microbiol. Immunol. , vol.181 , pp. 65-86
    • Vassalli, J.-D.1    Wohlwend, A.2    Belin, D.3
  • 7
    • 0024435761 scopus 로고
    • Functional characteristics of receptor-bound urokinase on human monocytes: Catalytic efficiency and susceptibility to inactivation by plasminogen activator inhibitors
    • Kirchheimer, J. C. & Remold, H. G. (1989) Functional characteristics of receptor-bound urokinase on human monocytes: catalytic efficiency and susceptibility to inactivation by plasminogen activator inhibitors, Blood 74, 1396-1402.
    • (1989) Blood , vol.74 , pp. 1396-1402
    • Kirchheimer, J.C.1    Remold, H.G.2
  • 8
    • 0024420806 scopus 로고
    • Endogenous receptor-bound urokinase mediates tissue invasion of human monocytes
    • Kirchheimer, J. C. & Remold, H. G. (1989) Endogenous receptor-bound urokinase mediates tissue invasion of human monocytes, J. Immunol. 143, 2634-2639.
    • (1989) J. Immunol. , vol.143 , pp. 2634-2639
    • Kirchheimer, J.C.1    Remold, H.G.2
  • 9
    • 0026063532 scopus 로고
    • Cellular receptor for urokinase plasminogen activator: Carboxyl-terminal processing and membrane anchoring by glycosylphosphatidylinositol
    • Ploug, M., Rønne, E., Behrend, N., Jensen, A. L., Blasi, F & Dano, K. (1991) Cellular receptor for urokinase plasminogen activator: carboxyl-terminal processing and membrane anchoring by glycosylphosphatidylinositol, J. Biol. Chem. 266, 1926-1933.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1926-1933
    • Ploug, M.1    Rønne, E.2    Behrend, N.3    Jensen, A.L.4    Blasi, F.5    Dano, K.6
  • 10
    • 0029294650 scopus 로고
    • The structure and function of the urokinase receptor, a membrane protein govering plasminogen activation on the cell surface
    • Behrendt, N., Ronne, E. & Dano, K. (1995) The structure and function of the urokinase receptor, a membrane protein govering plasminogen activation on the cell surface, Biol. Chem. Hoppe-Seyler 376, 269-279.
    • (1995) Biol. Chem. Hoppe-Seyler , vol.376 , pp. 269-279
    • Behrendt, N.1    Ronne, E.2    Dano, K.3
  • 13
    • 0027408254 scopus 로고
    • Saturation of tumour cell surface receptors for urokinase-type plasminogen activator by amino-terminal fragment and subsequent effect on reconstituted basement membranes invasion
    • Kobayashi, H., Ohi, H., Shinohara, H., Sugimura, M., Fujii, T., Terao, T., Schmitt, M., Goretzki, L., Chucholowski, N., Jänicke, F. & Graeff, H. (1993) Saturation of tumour cell surface receptors for urokinase-type plasminogen activator by amino-terminal fragment and subsequent effect on reconstituted basement membranes invasion, Br. J. Cancer 67, 537-544.
    • (1993) Br. J. Cancer , vol.67 , pp. 537-544
    • Kobayashi, H.1    Ohi, H.2    Shinohara, H.3    Sugimura, M.4    Fujii, T.5    Terao, T.6    Schmitt, M.7    Goretzki, L.8    Chucholowski, N.9    Jänicke, F.10    Graeff, H.11
  • 14
    • 0028287392 scopus 로고
    • Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within growth factor-like domain of urokinase in the experimental and spontaneous metastasis model
    • Kobayashi, H., Gotoh, J., Fujie, M., Shinohara, H., Moniwa, N. & Terao, T. (1994) Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within growth factor-like domain of urokinase in the experimental and spontaneous metastasis model, Int. J. Cancer 57, 727-733.
    • (1994) Int. J. Cancer , vol.57 , pp. 727-733
    • Kobayashi, H.1    Gotoh, J.2    Fujie, M.3    Shinohara, H.4    Moniwa, N.5    Terao, T.6
  • 15
    • 0028006420 scopus 로고
    • Recombinant soluble urokinase receptor as a scavenger for urokinase-type plasminogen activator (uPA). Inhibition of proliferation and invasion of human ovarian cancer cells
    • Wilhelm, O., Werdle, U., Hohl, S., Rettenberger, P., Schmitt, M. & Graeff, H. (1994) Recombinant soluble urokinase receptor as a scavenger for urokinase-type plasminogen activator (uPA). Inhibition of proliferation and invasion of human ovarian cancer cells, FEBS Lett. 337, 131-134.
    • (1994) FEBS Lett. , vol.337 , pp. 131-134
    • Wilhelm, O.1    Werdle, U.2    Hohl, S.3    Rettenberger, P.4    Schmitt, M.5    Graeff, H.6
  • 16
    • 0028239335 scopus 로고
    • Effects of urinary trypsin inhibitor on the invasion of reconstituted basement membranes by ovarian cancer cells
    • Kobayashi, H., Fujie, M., Shinohara, H., Ohi, H., Sugimura, M. & Terao, T. (1994) Effects of urinary trypsin inhibitor on the invasion of reconstituted basement membranes by ovarian cancer cells, Int. J. Cancer 57, 378-384.
    • (1994) Int. J. Cancer , vol.57 , pp. 378-384
    • Kobayashi, H.1    Fujie, M.2    Shinohara, H.3    Ohi, H.4    Sugimura, M.5    Terao, T.6
  • 17
    • 0028091273 scopus 로고
    • Inhibition of the soluble and the tumor cell receptor-bound plasmin by urinary trypsin inhibitor and subsequent effects on tumor cell invasion and metastasis
    • Kobayashi, H., Shinohara, H., Takeuchi, K., Itoh, M., Fujie, M., Saitoh, M. & Terao, T. (1994) Inhibition of the soluble and the tumor cell receptor-bound plasmin by urinary trypsin inhibitor and subsequent effects on tumor cell invasion and metastasis, Cancer Res. 54, 844-849.
    • (1994) Cancer Res. , vol.54 , pp. 844-849
    • Kobayashi, H.1    Shinohara, H.2    Takeuchi, K.3    Itoh, M.4    Fujie, M.5    Saitoh, M.6    Terao, T.7
  • 18
    • 0028269717 scopus 로고
    • Urinary trypsin inhibitor (UTI) and fragments derived from UTI by limited proteolysis efficiently inhibit tumor cell invasion
    • Kobayashi, H., Shinohara, H., Ohi, H., Sugimura, M. Terao, T. & Fujie, M (1994) Urinary trypsin inhibitor (UTI) and fragments derived from UTI by limited proteolysis efficiently inhibit tumor cell invasion, Clin. Exp. Metastasis 12, 117-128.
    • (1994) Clin. Exp. Metastasis , vol.12 , pp. 117-128
    • Kobayashi, H.1    Shinohara, H.2    Ohi, H.3    Sugimura, M.4    Terao, T.5    Fujie, M.6
  • 19
    • 0028828751 scopus 로고
    • Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agent
    • Kobayashi, H., Shinohara, H., Gotoh, J., Fujie, M., Fujishiro, S. & Terao, T. (1995) Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agent, Br. J. Cancer 72, 1131-1137.
    • (1995) Br. J. Cancer , vol.72 , pp. 1131-1137
    • Kobayashi, H.1    Shinohara, H.2    Gotoh, J.3    Fujie, M.4    Fujishiro, S.5    Terao, T.6
  • 20
    • 0028910195 scopus 로고
    • Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro
    • Kobayashi, H., Gotoh, J., Hirashima, Y., Fujie, M., Sugino, D. & Terao, T. (1995) Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro, J. Biol. Chem. 270, 8361-8366.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8361-8366
    • Kobayashi, H.1    Gotoh, J.2    Hirashima, Y.3    Fujie, M.4    Sugino, D.5    Terao, T.6
  • 21
    • 0028960002 scopus 로고
    • Inhibition of tumor cell invasion through Matrigel by a peptide derived from the domain II region in urinary trypsin inhibitor
    • Kobayashi, H., Gotoh, J., Kanayama, N., Hirashima, Y., Terao, T. & Sugino, D. (1995) Inhibition of tumor cell invasion through Matrigel by a peptide derived from the domain II region in urinary trypsin inhibitor, Cancer Res. 55, 1847-1852.
    • (1995) Cancer Res. , vol.55 , pp. 1847-1852
    • Kobayashi, H.1    Gotoh, J.2    Kanayama, N.3    Hirashima, Y.4    Terao, T.5    Sugino, D.6
  • 22
    • 0028202550 scopus 로고
    • Inhibition of the metastasis of Lewis lung carcinoma by antibody against urokinase-type plasminogen activator in the experimental and spontaneous metastasis model
    • Kobayashi, H., Gotoh, J., Shinohara, H., Moniwa, N. & Terao, T. (1994) Inhibition of the metastasis of Lewis lung carcinoma by antibody against urokinase-type plasminogen activator in the experimental and spontaneous metastasis model, Thromb. Haemost. 71, 474-480.
    • (1994) Thromb. Haemost. , vol.71 , pp. 474-480
    • Kobayashi, H.1    Gotoh, J.2    Shinohara, H.3    Moniwa, N.4    Terao, T.5
  • 23
    • 0029944630 scopus 로고    scopus 로고
    • Expression of urokinase and urinary trypsin inhibitor in metastatic and non-metastatic murine Lewis lung carcinoma cells
    • Kobayashi, H., Gotoh, J., Hirashima, Y. & Terao, T. (1996) Expression of urokinase and urinary trypsin inhibitor in metastatic and non-metastatic murine Lewis lung carcinoma cells, Int. J. Oncol. 8, 757-763.
    • (1996) Int. J. Oncol. , vol.8 , pp. 757-763
    • Kobayashi, H.1    Gotoh, J.2    Hirashima, Y.3    Terao, T.4
  • 24
    • 0025908960 scopus 로고
    • Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer
    • Hollas, W., Blasi, F. & Boyd, D. (1991) Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer, Cancer Res. 51, 3690-3695.
    • (1991) Cancer Res. , vol.51 , pp. 3690-3695
    • Hollas, W.1    Blasi, F.2    Boyd, D.3
  • 25
    • 0018307692 scopus 로고
    • The use of avidin-biotin interaction in immunoenzymatic techniques
    • Guesdon, J. L., Ternynck, T. & Avrameas, S. (1979) The use of avidin-biotin interaction in immunoenzymatic techniques, J. Histochem. Cytochem. 27, 1131-1139.
    • (1979) J. Histochem. Cytochem. , vol.27 , pp. 1131-1139
    • Guesdon, J.L.1    Ternynck, T.2    Avrameas, S.3
  • 26
    • 0025845425 scopus 로고
    • Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (pro-uPA)
    • Kobayashi, H., Schmitt, M., Goretzki, L., Chucholowski, N., Calvete, J., Kramer, M., Günzler, W. A., Jänicke, F. & Graeff, H. (1991) Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (pro-uPA), J. Biol. Chem. 266, 5147-5152.
    • (1991) J. Biol. Chem. , vol.266 , pp. 5147-5152
    • Kobayashi, H.1    Schmitt, M.2    Goretzki, L.3    Chucholowski, N.4    Calvete, J.5    Kramer, M.6    Günzler, W.A.7    Jänicke, F.8    Graeff, H.9
  • 27
    • 0027179188 scopus 로고
    • Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes
    • Kobayashi, H., Moniwa, N., Sugimura, M., Shinohara, H., Ohi, H. & Terao, T. (1993) Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes, Biochim. Biophys. Acta 1178, 55-62.
    • (1993) Biochim. Biophys. Acta , vol.1178 , pp. 55-62
    • Kobayashi, H.1    Moniwa, N.2    Sugimura, M.3    Shinohara, H.4    Ohi, H.5    Terao, T.6
  • 28
    • 0028067301 scopus 로고
    • Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-pseudomonas exotoxin chimeric protein
    • Puri, R. K., Leland, P., Kreitman, R. J. & Pastan, I. (1994) Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-pseudomonas exotoxin chimeric protein, Int. J. Cancer 58, 574-581.
    • (1994) Int. J. Cancer , vol.58 , pp. 574-581
    • Puri, R.K.1    Leland, P.2    Kreitman, R.J.3    Pastan, I.4
  • 29
    • 0027202040 scopus 로고
    • Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line
    • Kariko, K., Kuo, A., Boyd, D., Okada, S. S., Cines, D. B. & Barnathan, E. S. (1993) Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line, Cancer Res. 53, 3109-3117.
    • (1993) Cancer Res. , vol.53 , pp. 3109-3117
    • Kariko, K.1    Kuo, A.2    Boyd, D.3    Okada, S.S.4    Cines, D.B.5    Barnathan, E.S.6
  • 30
    • 0019631514 scopus 로고
    • Kunitz-type protease inhibitors derived by limited proteolysis of inter-α-trypsin inhibitor, V
    • Hochstrasser, K., Schonberger, O. L., Rossmanith, I. & Wachter, E. (1981) Kunitz-type protease inhibitors derived by limited proteolysis of inter-α-trypsin inhibitor, V, Hoppe-Seyler Z. Physiol. Chem. 362, 1357-1362.
    • (1981) Hoppe-Seyler Z. Physiol. Chem. , vol.362 , pp. 1357-1362
    • Hochstrasser, K.1    Schonberger, O.L.2    Rossmanith, I.3    Wachter, E.4
  • 31
    • 0019630942 scopus 로고
    • Kunitz-type protease inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, IV
    • Wachter, E. & Hochstrasser, K. (1981) Kunitz-type protease inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, IV, Hoppe-Seyler's Z. Physiol. Chem. 362, 1351-1355.
    • (1981) Hoppe-Seyler's Z. Physiol. Chem. , vol.362 , pp. 1351-1355
    • Wachter, E.1    Hochstrasser, K.2
  • 32
    • 0021045073 scopus 로고
    • Kunitz-type protease inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, IX
    • Albrecht, G. J., Hochstraser, K. & Salier, J.-P. (1983) Kunitz-type protease inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, IX, Hoppe-Seyler's Z. Physiol. Chem. 364, 1703-1708.
    • (1983) Hoppe-Seyler's Z. Physiol. Chem. , vol.364 , pp. 1703-1708
    • Albrecht, G.J.1    Hochstraser, K.2    Salier, J.-P.3
  • 33
    • 0021809315 scopus 로고
    • Human inter-alpha-trypsin inhibitor: Localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinases
    • Reisinger, P., Hochstrasser, K., Albrecht, G. J., Lempart, K. & Salier, J.-P. (1985) Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinases, Biol. Chem. Hoppe-Seyler 366, 479-483.
    • (1985) Biol. Chem. Hoppe-Seyler , vol.366 , pp. 479-483
    • Reisinger, P.1    Hochstrasser, K.2    Albrecht, G.J.3    Lempart, K.4    Salier, J.-P.5
  • 34
    • 0024551443 scopus 로고
    • A proteoglycan related to the urinary teypsin inhibitor (UTI) links the two heavy chains of inter-alpha-trypsin inhibitor
    • Balduyck, M., Laroui, S., Mizon, C. & Mizon, J. A. (1989) A proteoglycan related to the urinary teypsin inhibitor (UTI) links the two heavy chains of inter-alpha-trypsin inhibitor, Biol. Chem. Hoppe-Seyler 370, 329-336.
    • (1989) Biol. Chem. Hoppe-Seyler , vol.370 , pp. 329-336
    • Balduyck, M.1    Laroui, S.2    Mizon, C.3    Mizon, J.A.4
  • 35
    • 0010627039 scopus 로고
    • Kunitz-type protease inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, VIII
    • Hochstrasser, K., Albrecht, G. J., Schonberger, O. L. & Wachter, E. (1989) Kunitz-type protease inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, VIII, Hoppe-Seyler's Z., Physiol. Chem. 370, 1689-1696.
    • (1989) Hoppe-Seyler's Z., Physiol. Chem. , vol.370 , pp. 1689-1696
    • Hochstrasser, K.1    Albrecht, G.J.2    Schonberger, O.L.3    Wachter, E.4
  • 36
    • 0028148073 scopus 로고
    • Characterization of the cellular binding site for the urinary trypsin inhibitor
    • Kobayashi, H., Gotoh, J., Fujie, M. & Terao, T. (1994) Characterization of the cellular binding site for the urinary trypsin inhibitor, J. Biol. Chem. 269, 20642-20647.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20642-20647
    • Kobayashi, H.1    Gotoh, J.2    Fujie, M.3    Terao, T.4
  • 37
    • 15844370973 scopus 로고    scopus 로고
    • Inter-α-trypsin inhibitor bound to tumor cells is cleaved into the heavy chains and the light chain on the cell surface
    • Kobayashi, H. Gotoh, J., Hirashima, Y. & Terao, T. (1996) Inter-α-trypsin inhibitor bound to tumor cells is cleaved into the heavy chains and the light chain on the cell surface, J. Biol. Chem. 271, 11 362-11 367.
    • (1996) J. Biol. Chem. , vol.271 , pp. 11362-11367
    • Kobayashi, H.1    Gotoh, J.2    Hirashima, Y.3    Terao, T.4
  • 38
    • 0026741960 scopus 로고
    • A hybrid protein of urokinase growth-factor domain and plasminogen activator inhibitor type 2 inhibits urokinase activity and hinds to the urokinase receptor
    • Ballance, D. J., Marshall, J. M., Cottingham, I. R., Steven, J., Berry, S., Cederholm-Williams, S. A., Goodey, A. R. & Courtney, M. (1992) A hybrid protein of urokinase growth-factor domain and plasminogen activator inhibitor type 2 inhibits urokinase activity and hinds to the urokinase receptor, Eur. J. Biochem. 207, 177-183.
    • (1992) Eur. J. Biochem. , vol.207 , pp. 177-183
    • Ballance, D.J.1    Marshall, J.M.2    Cottingham, I.R.3    Steven, J.4    Berry, S.5    Cederholm-Williams, S.A.6    Goodey, A.R.7    Courtney, M.8
  • 39
    • 0027371837 scopus 로고
    • A conjugate between human urokinase and saporin, a type-1 ribosome-inactivating protein, is selectively cytotoxic to urokinase receptor-expressing cells
    • Cavallaro, U., delVecchio, A., Lappi, D. A. & Soria, M. R. (1943) A conjugate between human urokinase and saporin, a type-1 ribosome-inactivating protein, is selectively cytotoxic to urokinase receptor-expressing cells, J. Biol Chem. 268, 23 186-23 190.
    • (1943) J. Biol Chem. , vol.268 , pp. 23186-23190
    • Cavallaro, U.1    DelVecchio, A.2    Lappi, D.A.3    Soria, M.R.4
  • 40
    • 0027476674 scopus 로고
    • Production of a bifunctional hybrid molecule B72.3/metallothionein-1 by protein engineering
    • Xiang, J., Koropatnick, J., Qi, Y., Luo, X., Moyana, T., Li, K. & Chen, Y. (1993) Production of a bifunctional hybrid molecule B72.3/metallothionein-1 by protein engineering, Immunology 78, 574-581.
    • (1993) Immunology , vol.78 , pp. 574-581
    • Xiang, J.1    Koropatnick, J.2    Qi, Y.3    Luo, X.4    Moyana, T.5    Li, K.6    Chen, Y.7
  • 41
    • 0027766244 scopus 로고
    • In vitro sensitivity of human bladder cancers and cell lines to TP-40, a hybrid protein with selective targeting and cytotoxicity
    • Sarosdy, M. F., Hutzler, D. H., Yee, D. & von Hoff, D. D. (1993) In vitro sensitivity of human bladder cancers and cell lines to TP-40, a hybrid protein with selective targeting and cytotoxicity, J. Urol. 150, 1950-1955.
    • (1993) J. Urol. , vol.150 , pp. 1950-1955
    • Sarosdy, M.F.1    Hutzler, D.H.2    Yee, D.3    Von Hoff, D.D.4
  • 43
    • 0027280263 scopus 로고
    • Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator
    • Niedbala, M. J. & Stein-Picarella, M. (1993) Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator, Blood 81, 2608-2607.
    • (1993) Blood , vol.81 , pp. 2608-12607
    • Niedbala, M.J.1    Stein-Picarella, M.2
  • 44
    • 0028334672 scopus 로고
    • Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy
    • Waltz, D. A. & Chapman, H. A. (1994) Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy, J. Biol. Chem. 269, 14746-14750.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14746-14750
    • Waltz, D.A.1    Chapman, H.A.2
  • 47
    • 0028244045 scopus 로고
    • Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor
    • Li, H., Kuo, A., Kochan, J., Strickland, D., Kariko, K., Barnathan, H. S. & Cines, D. B. (1994) Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor, J Biol. Chem. 269, 8153-8158.
    • (1994) J Biol. Chem. , vol.269 , pp. 8153-8158
    • Li, H.1    Kuo, A.2    Kochan, J.3    Strickland, D.4    Kariko, K.5    Barnathan, H.S.6    Cines, D.B.7
  • 51
    • 0026643491 scopus 로고
    • Structural requirments for the growth factor activity of the amino-terminal domain of urokinase
    • Rabbani, S. A., Mazar, A. P., Bernier, S. M., Haq, M., Bolivar, I., Henkin, J. & Geltzman, D. (1991) Structural requirments for the growth factor activity of the amino-terminal domain of urokinase, J. Biol. Chem. 267, 14 151-14 156.
    • (1991) J. Biol. Chem. , vol.267 , pp. 14151-14156
    • Rabbani, S.A.1    Mazar, A.P.2    Bernier, S.M.3    Haq, M.4    Bolivar, I.5    Henkin, J.6    Geltzman, D.7
  • 52
    • 0028857650 scopus 로고
    • Urokinase receptor in human malignant mesothelioma cells: Role in tumor cell mitogenesis and proteolysis
    • Sreerama, S., Kumar, A., Johnson, A., Purblitz, S. & Idell, S. (1995) Urokinase receptor in human malignant mesothelioma cells: role in tumor cell mitogenesis and proteolysis, Am. J. Physiol. 268, L972-L982.
    • (1995) Am. J. Physiol. , vol.268
    • Sreerama, S.1    Kumar, A.2    Johnson, A.3    Purblitz, S.4    Idell, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.