Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers

Journal of Interferon and Cytokine Research

Volumn 29, Issue 10, 2009, Pages 695-703

  Zhou, Ying ^a   Li, Min ^a   Wei, Ying ^a   Feng, Dingqing ^a   Peng, Cheng ^a   Weng, Haiyan ^b   Ma, Yang ^c   Bao, Liang ^c   Nallar, Shreeram ^d   Kalakonda, Sudhakar ^d   Xiao, Weihua ^c   Kalvakolanu, Dhananjaya V ^d   Ling, Bin ^a  

^a Anhui Province Key Laboratory of Molecular Medicine   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE ASSOCIATED WITH RETINOID INTERFERON INDUCED MORTALITY 19 PROTEIN; STAT3 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; UTERINE CERVIX CANCER; WART VIRUS;

ADULT; ALPHAPAPILLOMAVIRUS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CERVIX UTERI; DNA, VIRAL; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; MIDDLE AGED; NADH, NADPH OXIDOREDUCTASES; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; PAPILLOMAVIRUS INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN; UTERINE CERVICAL NEOPLASMS;

HUMAN PAPILLOMAVIRUS;

EID: 70349675337     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2009.0003     Document Type: Article

References (47)

1. Alchanati I, Nallar SC, Sun P, Gao L, Hu J, Stein A, Yakirevich E, Konforty D, Alroy I, Zhao X, Reddy SP, Resnick MB, Kalvakolanu DV. 2006. A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Oncogene 25(54):7138-7147
2. Braun K, Ehemann V, Waldeck W, Pipkorn R, Corban-Wilhelm H, Jenne J, Gissmann L, Debus J. 2004. HPV18 E6 and E7 genes affect cell cycle, pRB and p53 of cervical tumor cells and represent prominent candidates for intervention by use peptide nucleic acids (PNAs). Cancer Lett 209(1):37-49
3. Bromberg JF, Horvath CM, Besser D, Lathem WW, Darnell JE, Jr. 1998. Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol 18(5):2553-2558
4. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE, Jr. 1999. Stat3 as an oncogene. Cell 98(3):295-303
5. Buettner R, Mora LB, Jove R. 2002. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8(4):945-954
6. Castellsague X. 2008. Natural history and epidemiology of HPV infection and cervical cancer. Gynecol Oncol 110(3 Suppl 2): S4-S7
7. Charpin C, Dales JP, Garcia S, Carpentier S, Djemli A, Andrac L, Lavaut MN, Allasia C, Bonnier P. 2004. Tumor neoangiogenesis by CD31 and CD105 expression evaluation in breast carcinoma tissue microarrays. Clin Cancer Res 10(17):5815-5819
8. Chen CL, Hsieh FC, Lieblein JC, Brown J, Chan C, Wallace JA, Cheng G, Hall BM, Lin J. 2007. Stat3 activation in human endometrial and cervical cancers. Br J Cancer 96(4):591-599
9. Dechow TN, Pedranzini L, Leitch A, Leslie K, Gerald WL, Linkov I, Bromberg JF. 2004. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc Natl Acad Sci USA 101(29):10602-10607
10. Dvorak HF, Gresser I. 1989. Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumors in mice. J Natl Cancer Inst 81(7):497-502
11. Fearnley IM, Carroll J, Shannon RJ, Runswick MJ, Walker JE, Hirst J. 2001. GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I). J Biol Chem 276(42):38345-38348
12. Frank DA. 2007. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 251(2):199-210
13. Hu J, Angell JE, Zhang J, Ma X, Seo T, Raha A, Hayashi J, Choe J, Kalvakolanu DV. 2002. Characterization of monoclonal antibodies against GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death. J Interferon Cytokine Res 22(10):1017-1026
14. Huibregtse JM, Scheffner M, Howley PM. 1991. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J 10(13):4129-4135
15. Inghirami G, Chiarle R, Simmons WJ, Piva R, Schlessinger K, Levy DE. 2005. New and old functions of STAT3: a pivotal target for individualized treatment of cancer. Cell Cycle 4(9):1131-1133
16. Kalakonda S, Nallar SC, Lindner DJ, Hu J, Reddy SP, Kalvakolanu DV. 2007. Tumor-suppressive activity of the cell death activator GRIM-19 on a constitutively active signal transducer and activator of transcription 3. Cancer Res 67(13):6212-6220
17. Kalvakolanu DV. 2004. The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression. Cytokine Growth Factor Rev 15(2-3):169-194
18. Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH. 2003. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J 22(12):2934-2947
19. Lippman SM, Kavanagh JJ, Paredes-Espinoza M, Delgadillo-Madrueno F, Paredes-Casillas P, Hong WK, Holdener E, Krakoff IH. 1992. 13-cis-retinoic acid plus interferon alpha-2a: highly active systemic therapy for squamous cell carcinoma of the cervix. J Natl Cancer Inst 84(4):241-245
20. Lowy DR, Solomon D, Hildesheim A, Schiller JT, Schiffman M. 2008. Human papillomavirus infection and the primary and secondary prevention of cervical cancer. Cancer 113(7 Suppl):1980-1993
21. Lu H, Cao X. 2008. GRIM-19 is essential for maintenance of mitochondrial membrane potential. Mol Biol Cell 19(5):1893-1902
22. Lufei C, Ma J, Huang G, Zhang T, Novotny-Diermayr V, Ong CT, Cao X. 2003. GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. EMBO J 22(6):1325-1335
23. Majewski S, Szmurlo A, Marczak M, Jablonska S, Bollag W. 1994. Synergistic effect of retinoids and interferon alpha on tumorinduced angiogenesis: anti-angiogenic effect on HPV-harboring tumor-cell lines. Int J Cancer 57(1):81-85
24. Martin CM, Kehoe L, Spillane CO, O'Leary JJ. 2007. Gene discovery in cervical cancer: towards diagnostic and therapeutic biomarkers. Mol Diagn Ther 11(5):277-290
25. Mita AC, Mita MM, Nawrocki ST, Giles FJ. 2008. Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res 14(16):5000-5005
26. Ochsenbein AF, Sierro S, Odermatt B, Pericin M, Karrer U, Hermans J, Hemmi S, Hengartner H, Zinkernagel RM. 2001. Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature 411(6841):1058-1064
27. Papa F, Delia M, Trentadue R, Panelli D, Bellomo F, Serpico R, Petruzzi M, De Benedittis M, Scacco S. 2007. Differential effects of all-trans retinoic acid on the growth of human keratinocytes and mouth carcinoma epidermoid cultures. Involvement of GRIM-19 and complex I of the respiratory chain. Int J Immunopathol Pharmacol 20(4):719-729
28. Reeves MB, Davies AA, McSharry BP, Wilkinson GW, Sinclair JH. 2007. Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. Science 316(5829):1345-1348
29. Reuter S, Delius H, Kahn T, Hofmann B, zur Hausen H, Schwarz E. 1991. Characterization of a novel human papillomavirus DNA in the cervical carcinoma cell line ME180. J Virol 65(10): 5564-5568
30. Santin AD, Zhan F, Bignotti E, Siegel ER, Cane S, Bellone S, Palmieri M, Anfossi S, Thomas M, Burnett A, Kay HH, Roman JJ, O'Brien TJ, Tian E, Cannon MJ, Shaughnessy J, Jr., Pecorelli S. 2005. Gene expression profi les of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identifi cation of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology 331(2):269-291
31. Schaefer LK, Ren Z, Fuller GN, Schaefer TS. 2002. Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2). Oncogene 21(13):2058-2065
32. Scheffner M, Munger K, Huibregtse JM, Howley PM. 1992. Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins. EMBO J 11(7):2425-2431
33. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63(6):1129-1136
34. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. 2007. Human papillomavirus and cervical cancer. Lancet 370(9590):890-907
35. Seo T, Lee D, Shim YS, Angell JE, Chidambaram NV, Kalvakolanu DV, Choe J. 2002. Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death. J Virol 76(17):8797-8807
36. Sidky YA, Borden EC. 1987. Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses. Cancer Res 47(19):5155-5161
37. Speliotes EK, Uren A, Vaux D, Horvitz HR. 2000. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. Mol Cell 6(2):211-223
38. Terenzi F, Saikia P, Sen GC. 2008. Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J 27(24):3311-3321
39. Wang L, Luo J, He S. 2007. Induction of MMP-9 release from human dermal fi broblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 release. BMC Cell Biol 8:14
40. Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. 2003. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22(3):319-329
41. Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC. 2001. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol 11(11):886-890
42. Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S. 2006. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res 66(6):3188-3196
43. Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. 2004. Stat3 activation regulates the expression of matrix metalloproteinase- 2 and tumor invasion and metastasis. Oncogene 23(20):3550-3560
44. Xu Q, Briggs J, Park S, Niu G, Kortylewski M, Zhang S, Gritsko T, Turkson J, Kay H, Semenza GL, Cheng JQ, Jove R, Yu H. 2005. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 24(36):5552-5560
45. Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, Poli V, Stark GR, Kalvakolanu DV. 2003. The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci USA 100(16):9342-9347
46. Zhang L, Gao L, Li Y, Lin G, Shao Y, Ji K, Yu H, Hu J, Kalvakolanu DV, Kopecko DJ, Zhao X, Xu DQ. 2008. Effects of plasmid-based Stat3-specifi c short hairpin RNA and GRIM-19 on PC-3M tumor cell growth. Clin Cancer Res 14(2):559-568
47. Zhang X, Huang Q, Yang Z, Li Y, Li CY. 2004. GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res 64(7):2474-2481