Expression and clinical significance of GRIM-19 in lung cancer

Medical Oncology

Volumn 29, Issue 5, 2012, Pages 3183-3189

  Fan, Xiao Yun ^a   Jiang, Zi Feng ^a   Cai, Li ^a,b   Liu, Rong Yu ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Apoptosis regulated gene; GRIM 19; Immunohistochemistry; Laser scanning confocal microscopy; Lung cancer

Indexed keywords

ADULT; APOPTOSIS; ARTICLE; BRONCHUS BIOPSY; CANCER GRADING; CANCER STAGING; CELL PROLIFERATION; CLINICAL EVALUATION; COLORECTAL CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; ESOPHAGUS TUMOR; FEMALE; GENE LOCATION; GENE OVEREXPRESSION; GRIM 19 GENE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; LUNG CANCER; LUNG SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; SQUAMOUS CELL CARCINOMA; THYROID CARCINOMA; UPREGULATION; AGED; BIOSYNTHESIS; CARCINOMA; CONFOCAL MICROSCOPY; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY;

APOPTOSIS REGULATORY PROTEIN; GRIM19 PROTEIN, HUMAN; OXIDOREDUCTASE; TUMOR MARKER;

AGED; APOPTOSIS REGULATORY PROTEINS; CARCINOMA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; NADH, NADPH OXIDOREDUCTASES; NEOPLASM STAGING; TUMOR MARKERS, BIOLOGICAL;

EID: 84880281498     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-012-0249-1     Document Type: Article

References (26)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74-108.
2. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin. 2007;57:43-66.
3. Brundage MD, Davies D, Mackillop WJ. Prognostic factors in non-small cell lung cancer: a decade of progress. Chest. 2002;122:1037-57.
4. Ayabe T, Matsuzaki Y, Edagawa M, Shimizu T, Hara M, Tomita M, Ninomiya H, Onitsuka T. Primary lung cancer; assessment of the disclosed 5-year survival rate by the Internet website. Kyobu geka. 2005;58:451-9.
5. Angell JE, Lindner DJ, Shapiro PS, Hofmann ER, Kalvakolanu DV. Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach. J Biol Chem. 2000;275:33416-26.
6. Kalvakolanu DV. The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression. Cytokine Growth Factor Rev. 2004;15:169-94.
7. Maximo V, Botelho T, Capela J, Soares P, Lima J, Taveira A, Amaro T, Barbosa AP, Preto A, Harach HR, Williams D, Sobrinho-Simoes M. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer. 2005;92:1892-8.
8. He X, Cao X. Identification of alternatively spliced GRIM-19 mRNA in kidney cancer tissues. J Human Genetics. 2010;55:507-11.
9. Wang T, Yan XB, Zhao JJ, Ye J, Jiang ZF, Wu DR, Xiao WH, Liu RY. Gene associated with retinoid-interferon-induced mortality-19 suppresses growth of lung adenocarcinoma tumor in vitro and in vivo. Lung Cancer. 2011;72:287-93.
10. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
11. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411:342-8.
12. Huang G, Lu H, Hao A, Ng DC, Ponniah S, Guo K, Lufei C, Zeng Q, Cao X. GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I. Mol Cell Biol. 2004;24:8447-56.
13. Gong LB, Luo XL, Liu SY, Tao DD, Gong JP, Hu JB. Correlations of GRIM-19 and its target gene product STAT3 to malignancy of human colorectal carcinoma. Ai Zheng. 2007;26:683-7.
14. Alchanati I, Nallar SC, Sun P, Gao L, Hu J, Stein A, Yakirevich E, Konforty D, Alroy I, Zhao X, Reddy SP, Resnick MB, Kalvakolau DV. A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Oncogene. 2006;25:7138-47.
15. Zhang X, Huang Q, Yang Z, Li Y, Li CY. GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res. 2004;64:2474-81.
16. Lufei C, Ma J, Huang G, Zhang T, Novotny-Diermayr V, Ong CT, Cao X. GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. EMBO J. 2003;22:1325-35.
17. Huang Y, Yang M, Yang H, Zeng Z. Upregulation of the GRIM-19 gene suppresses invasion and metastasis of human gastric cancer SGC-7901 cell line. Exp Cell Res. 2010;316:2061-70.
18. Huang G, Chen Y, Lu H, Cao X. Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death. Cell Death Differ. 2007;14:327-37.
19. Tripathy MK, Ahmed Z, Ladha JS, Mitra D. The cell death regulator GRIM-19 is involved in HIV-1 induced T-cell apoptosis. Apoptosis. 2010;15:1453-60.
20. Maximo V, Lima J, Soares P, Silva A, Bento I, Sobrinho-Simoes M. GRIM-19 in health and disease. Adv Anat Pathol. 2008;15:46-53.
21. Squazzo SL, O'Geen H, Komashko VM, Krig SR, Jin VX, Jang SW, Margueron R, Reinberg D, Green R, Farnham PJ. Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res. 2006;16:890-900.
22. Burysek L, Pitha PM. Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase. J Virol. 2001;75:2345-52.
23. Kalvakolanu DV, Nallar SC, Kalakonda S. Cytokine-induced tumor suppressors: a GRIM story. Cytokine. 2010;52:128-42.
24. Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, Poli V, Stark GR, Kalvakolanu DV. The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci USA. 2003;100:9342-7.
25. Reeves MB, Davies AA, McSharry BP, Wilkinson GW, Sinclair JH. Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. Science. 2007;316:1345-8.
26. Kalakonda S, Nallar SC, Gong P, Lindner DJ, Goldblum SE, Reddy SP, Kalvakolanu DV. Tumor suppressive protein gene associated with retinoid-interferon-induced mortality (GRIM)-19 inhibits src-induced oncogenic transformation at multiple levels. Am J Pathol. 2007;171:1352-68.