Novel multiple agents loaded PLGA nanoparticles for brain delivery via inner ear administration: In vitro and in vivo evaluation

European Journal of Pharmaceutical Sciences

Volumn 48, Issue 4-5, 2013, Pages 595-603

  Zhang, Xiao ^a   Chen, Gang ^a   Wen, Lu ^a   Yang, Fan ^a   Shao, A Li ^a   Li, Xia ^a   Long, Wei ^a   Mu, Lei ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Brain delivery; Inner ear administration; Nanoparticles; PLGA

Indexed keywords

MALONALDEHYDE; NANOPARTICLE; NITRIC OXIDE SYNTHASE; POLYGLACTIN; SALVIANOLIC ACID B; SUPEROXIDE DISMUTASE; TANSHINONE IIA;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BRAIN TISSUE; CEREBROSPINAL FLUID; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; DRUG SCREENING; DRUG SOLUBILITY; ENZYME ACTIVITY; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MAXIMUM PLASMA CONCENTRATION; NANOENCAPSULATION; NEUROPROTECTION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; REPERFUSION INJURY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BENZOFURANS; BRAIN; CAROTID ARTERIES; DITERPENES, ABIETANE; DRUG ADMINISTRATION ROUTES; DRUG CARRIERS; EAR, INNER; GINSENOSIDES; GUINEA PIGS; LACTIC ACID; MALE; NANOPARTICLES; NEUROPROTECTIVE AGENTS; PANAX NOTOGINSENG; PARTICLE SIZE; POLYGLYCOLIC ACID; REPERFUSION INJURY;

EID: 84875190852     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.01.007     Document Type: Article

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