Preliminary study on brain-targeted drug delivery via inner ear

Yaoxue Xuebao

Volumn 42, Issue 10, 2007, Pages 1102-1106

  Chen, Gang ^a   Hou, Shi Xiang ^b   Hu, Ping ^b   Jin, Miao Zhen ^a   Liu, Jun ^c  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c Chengdu Hospital of Chinese People Armed Police Forces   (China)

Author keywords

Brain targeted drug delivery; Dexamethasone; Intratympanic administration; Perilymph; Solid lipid nanoparticle

Indexed keywords

ANTIINFLAMMATORY AGENT; DEXAMETHASONE; DEXAMETHASONE 21-PHOSPHATE; DEXAMETHASONE ACETATE; DEXAMETHASONE SODIUM PHOSPHATE; DRUG DERIVATIVE; FATTY ACID; GLYCEROL BEHENATE; NANOPARTICLE; PHOSPHATIDYLCHOLINE; SURFACTANT;

ANIMAL; ARTICLE; BRAIN; CEREBROSPINAL FLUID; CHEMISTRY; DRUG DELIVERY SYSTEM; FEMALE; GUINEA PIG; INNER EAR; MALE; METABOLISM; PARTICLE SIZE; PERILYMPH; RANDOMIZATION; TISSUE DISTRIBUTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CEREBROSPINAL FLUID; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; EAR, INNER; FATTY ACIDS; FEMALE; GUINEA PIGS; LECITHINS; MALE; NANOPARTICLES; PARTICLE SIZE; PERILYMPH; RANDOM ALLOCATION; SURFACE-ACTIVE AGENTS; TISSUE DISTRIBUTION;

EID: 42149162282     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Pardridge WM. Drug and gene targeting to the brain with molecular Trojan horses [J]. Nat Rev Drug Discov, 2002,1:131-139.
2. Zhang QZ, Jiang XG, Shi ZQ, et al. Effects of intranasal administration of nimodipine on cerebral hemodynamics of dogs [J]. Acta Pharm Sin, 2005,40:466-469.
3. Shi ZQ, Zhang QZ, Jiang XG. Enhancement of systemic and CNS delivery of meptazinol hydrochloride by intranasal administration to rats [J]. Acta Pharm Sin, 2005,40:754-757.
4. Sterkers O, Ferrary E, Amiel C. Production of inner ear fluids [J]. Physiol Rev, 1988,68:1083-1128.
5. Li SL, Zhu HL, Wang XX, et al. Methods of gene therapy for inner ear diseases [J]. J Clin Otorhinolaryngol, 2002, 16:546-549.
6. Li YT, Dong P, Li KY. Recent advances in gene transferring into the inner ear [J]. J Preclin Med Coll Shandong Univ, 2003, 17:180-183.
7. Goycoolea MV, Muchow D, Schachern P. Experimental studies on round window structure: function and permeability [J]. Laryngoscope, 1988,98(6 Pt 2 Suppl 44):1-20.
8. Hu LD, Tang X, Cui FD. Preparation of solid lipid nanoparticles loaded with all-trans retinoic acid and their evaluation in vitro and in vivo [J]. Acta Pharm Sin, 2005,40:71-75.
9. Himeno C, Komeda M, Izumikawa M, et al. Intracochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig [J]. Hear Res, 2002,167:61-70.
10. Liu HJ, Dong MM, Chi FL. Structure and function influence of cochlear after dexamethasone in tratympanic application [J]. Chin J Otorhinolaryngol Head Neck Surg, 2005,40:440-443.
11. Parnes LS, Sun AH, Freeman DJ. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application [J]. Laryngoscope, 1999,109(7, Pt 2):1-17.
12. Li S, Gong SS, Chen JG, et al. Pharmacokinetics of the methlprednisolone, dexamethasone and hydrocortisone in the inner ear after administered via round window [J]. J Clin Otorhinolaryngol, 24-26.