Small molecule antivirulents targeting the iron-regulated heme oxygenase (HemO) of P. aeruginosa

Journal of Medicinal Chemistry

Volumn 56, Issue 5, 2013, Pages 2097-2109

  Hom, Kellie ^a   Heinzl, Geoffrey A ^a   Eakanunkul, Suntara ^a   Lopes, Pedro E M ^a   Xue, Fengtian ^a   MacKerell, Alexander D ^a   Wilks, Angela ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(E) 3 (4 (PHENYLAMINO)PHENYLCARBAMOYL)ACRYLIC ACID; (E) N' (4 (DIMETHYLAMINO)BENZYLIDENE) DIAZENECARBOXIMIDHYDRAZIDE; ANTIINFECTIVE AGENT; HEME OXYGENASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG TARGETING; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA;

ANIMALS; APOENZYMES; CAENORHABDITIS ELEGANS; DIPHENYLAMINE; ENZYME INHIBITORS; FUMARATES; GUANIDINES; HEME OXYGENASE (DECYCLIZING); HYDRAZONES; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PSEUDOMONAS AERUGINOSA; VIRULENCE;

EID: 84875168081     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301819k     Document Type: Article

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