A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Apicella, Alessandra ^a,b   Soncini, Monica ^a   Deriu, Marco Agostino ^c   Natalello, Antonino ^d   Bonanomi, Marcella ^d   Dellasega, David ^a   Tortora, Paolo ^d   Regonesi, Maria Elena ^d   Casari, Carlo Spartaco ^a,e  

^a POLITECNICO DI MILANO   (Italy)

^b LABORATOIRE DE TECHNOLOGIE DES COMPOSITES ET POLYMÈRES LTC   (Switzerland)

^c POLITECNICO DI TORINO   (Italy)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

^e ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; GOLD; JOSEPHIN DOMAIN PROTEIN; MONOMER; OLIGOMER; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; ATOMIC FORCE MICROSCOPY; BETA SHEET; CELL SURFACE; CONFORMATIONAL TRANSITION; HYDROPHILICITY; HYDROPHOBICITY; INFRARED SPECTROSCOPY; MOLECULAR DYNAMICS; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MISFOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ABSORPTION; ALUMINUM SILICATES; GOLD; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEINS; SOLUTIONS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES;

EID: 84875107285     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058794     Document Type: Article

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