In silico modelling of drug-polymer interactions for pharmaceutical formulations

Journal of the Royal Society Interface

Volumn 7, Issue SUPPL. 4, 2010, Pages

  Ahmad, Samina ^a   Johnston, Blair F ^a   Mackay, Simon P ^a   Schatzlein, Andreas G ^b   Gellert, Paul ^c   Sengupta, Durba ^d   Uchegbu, Ijeoma F ^b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Chitosan amphiphile; Coarse grained; Mesoscale; Poly(lactic acid)

Indexed keywords

AMMONIUM COMPOUNDS; AMPHIPHILES; BIOCHEMISTRY; BODY FLUIDS; CHITIN; CHITOSAN; COMPUTER CONTROL SYSTEMS; COMPUTER SIMULATION; DRUG PRODUCTS; ENCAPSULATION; EXPERIMENTS; GLYCOLS; HYDRAZINE; HYDROPHILICITY; HYDROPHOBICITY; LACTIC ACID; MICELLES; MICROSPHERES; MOLECULAR DYNAMICS; ORGANIC ACIDS; POLYMERS;

COARSE-GRAINED; COARSE-GRAINED MOLECULAR DYNAMICS; CONTROLLED RELEASE; DISSIPATIVE PARTICLE DYNAMICS; DRUG ENCAPSULATION; DRUG-POLYMER INTERACTION; EXPERIMENTAL DATA; FORCE FIELDS; GLYCOL CHITOSAN; GOOD CORRELATIONS; HETEROGENEOUS DISTRIBUTIONS; HYDROPHILIC DRUGS; HYDROPHOBIC AND HYDROPHILIC; HYDROPHOBIC DRUG; IN-SILICO; MESOSCALE; MOLECULAR DYNAMICS SIMULATIONS; PARACETAMOL; PHARMACEUTICAL FORMULATION; POLY(L-LACTIC ACID); POLY(LACTIC ACID); PREDNISOLONE; PROPOFOL; QUATERNARY AMMONIUM; SPEED-UPS; TRIAL AND ERROR;

DRUG INTERACTIONS;

CHITOSAN DERIVATIVE; ISONIAZID; MICROSPHERE; PARACETAMOL; POLYLACTIC ACID; POLYMER; PREDNISOLONE; PROPOFOL; QUATERNARY AMMONIUM DERIVATIVE;

ARTICLE; BIOAVAILABILITY; COMPUTER SIMULATION; CONTROLLED RELEASE FORMULATION; DRUG FORMULATION; ENCAPSULATION; HYDROPHILICITY; HYDROPHOBICITY; MICELLE; MODEL; MOLECULAR DYNAMICS; SIMULATION;

EID: 77955762171     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2010.0190.focus     Document Type: Article

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