-
1
-
-
33947635198
-
The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes
-
Alam, S. M., et al. 2007. The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes. J. Immunol. 178:4424-4435.
-
(2007)
J. Immunol.
, vol.178
, pp. 4424-4435
-
-
Alam, S.M.1
-
2
-
-
73949133588
-
Role of HIV membrane in neutralization by two broadly neutralizing antibodies
-
Alam, S. M., et al. 2009. Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc. Natl. Acad. Sci. U. S. A. 106:20234-20239.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 20234-20239
-
-
Alam, S.M.1
-
3
-
-
37349057483
-
Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection
-
Alam, S. M., et al. 2008. Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection. J. Virol. 82:115-125.
-
(2008)
J. Virol.
, vol.82
, pp. 115-125
-
-
Alam, S.M.1
-
4
-
-
0025583832
-
Human heavy chain variable region gene diversity, organization, and expression
-
Berman, J. E., and F. W. Alt. 1990. Human heavy chain variable region gene diversity, organization, and expression. Int. Rev. Immunol. 5:203-214.
-
(1990)
Int. Rev. Immunol.
, vol.5
, pp. 203-214
-
-
Berman, J.E.1
Alt, F.W.2
-
5
-
-
13844255333
-
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41
-
Cardoso, R. M., et al. 2005. Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Immunity 22:163-173.
-
(2005)
Immunity
, vol.22
, pp. 163-173
-
-
Cardoso, R.M.1
-
6
-
-
0021855144
-
Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin
-
Clarke, S. H., et al. 1985. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J. Exp. Med. 161:687-704.
-
(1985)
J. Exp. Med.
, vol.161
, pp. 687-704
-
-
Clarke, S.H.1
-
7
-
-
0028986982
-
The human immunoglobulin VH repertoire
-
Today
-
Cook, G. P., and I. M. Tomlinson. 1995. The human immunoglobulin VH repertoire. Immunol. Today 16:237-242.
-
(1995)
Immunol
, vol.16
, pp. 237-242
-
-
Cook, G.P.1
Tomlinson, I.M.2
-
8
-
-
0028235295
-
A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
-
Cook, G. P., et al. 1994. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nat. Genet. 7:162-168.
-
(1994)
Nat. Genet.
, vol.7
, pp. 162-168
-
-
Cook, G.P.1
-
9
-
-
0037029607
-
Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced
-
Dal Porto, J. M., A. M. Haberman, G. Kelsoe, and M. J. Shlomchik. 2002. Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. J. Exp. Med. 195:1215-1221.
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1215-1221
-
-
Dal Porto, J.M.1
Haberman, A.M.2
Kelsoe, G.3
Shlomchik, M.J.4
-
10
-
-
78651388412
-
Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens
-
Dennison, S. M., et al. 2011. Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens. J. Virol. 85:1340-1347.
-
(2011)
J. Virol.
, vol.85
, pp. 1340-1347
-
-
Dennison, S.M.1
-
11
-
-
70349272203
-
Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions
-
Dennison, S. M., et al. 2009. Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions. J. Virol. 83:10211-10223.
-
(2009)
J. Virol.
, vol.83
, pp. 10211-10223
-
-
Dennison, S.M.1
-
12
-
-
78649861760
-
Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies
-
Frey, G., et al. 2010. Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies. Nat. Struct. Mol. Biol. 17:1486-1491.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1486-1491
-
-
Frey, G.1
-
13
-
-
41649090223
-
A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
-
Frey, G., et al. 2008. A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proc. Natl. Acad. Sci. U. S. A. 105:3739-3744.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 3739-3744
-
-
Frey, G.1
-
15
-
-
69249208675
-
Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype Cinfected blood donors
-
Gray, E. S., et al. 2009. Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype Cinfected blood donors. J. Virol. 83:8925-8937.
-
(2009)
J. Virol.
, vol.83
, pp. 8925-8937
-
-
Gray, E.S.1
-
16
-
-
21344434534
-
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
-
Haynes, B. F., et al. 2005. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 308:1906-1908.
-
(2005)
Science
, vol.308
, pp. 1906-1908
-
-
Haynes, B.F.1
-
17
-
-
33646780263
-
Antibody polyspecificity and neutralization of HIV-1: a hypothesis
-
Haynes, B. F., M. A. Moody, L. Verkoczy, G. Kelsoe, and S. M. Alam. 2005. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum. Antibodies 14:59-67.
-
(2005)
Hum. Antibodies
, vol.14
, pp. 59-67
-
-
Haynes, B.F.1
Moody, M.A.2
Verkoczy, L.3
Kelsoe, G.4
Alam, S.M.5
-
18
-
-
77950803157
-
Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding
-
Julien, J. P., et al. 2010. Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding. J. Virol. 84:4136-4147.
-
(2010)
J. Virol.
, vol.84
, pp. 4136-4147
-
-
Julien, J.P.1
-
19
-
-
0030479971
-
The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation
-
Kohsaka, H., et al. 1996. The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation. J. Clin. Invest. 98:2794-2800.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 2794-2800
-
-
Kohsaka, H.1
-
20
-
-
0029029375
-
Evidence for the overexpression of the VH4-34 (VH4 21) Ig gene segment in the normal adult human peripheral blood B cell repertoire
-
Kraj, P., D. F. Friedman, F. Stevenson, and L. E. Silberstein. 1995. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J. Immunol. 154:6406-6420.
-
(1995)
J. Immunol.
, vol.154
, pp. 6406-6420
-
-
Kraj, P.1
Friedman, D.F.2
Stevenson, F.3
Silberstein, L.E.4
-
21
-
-
0037069682
-
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
-
Kwong, P. D., et al. 2002. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature 420:678-682.
-
(2002)
Nature
, vol.420
, pp. 678-682
-
-
Kwong, P.D.1
-
22
-
-
0036954986
-
Genetic diversity of the human immunoglobulin heavy chain VH region
-
Li, H., X. Cui, S. Pramanik, and N. O. Chimge. 2002. Genetic diversity of the human immunoglobulin heavy chain VH region. Immunol. Rev. 190:53-68.
-
(2002)
Immunol. Rev.
, vol.190
, pp. 53-68
-
-
Li, H.1
Cui, X.2
Pramanik, S.3
Chimge, N.O.4
-
23
-
-
33746689169
-
A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
-
Liao, H. X., et al. 2006. A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. Virology 353:268-282.
-
(2006)
Virology
, vol.353
, pp. 268-282
-
-
Liao, H.X.1
-
24
-
-
0031775443
-
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
-
Matsuda, F., et al. 1998. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J. Exp. Med. 188:2151-2162.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2151-2162
-
-
Matsuda, F.1
-
25
-
-
0027378573
-
A conserved neutralizing epitope on gp41 of human deficiency virus type 1
-
Muster, T., et al. 1993. A conserved neutralizing epitope on gp41 of human deficiency virus type 1. J. Virol. 67:6642-6647.
-
(1993)
J. Virol.
, vol.67
, pp. 6642-6647
-
-
Muster, T.1
-
26
-
-
78649804618
-
Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region
-
Nicely, N. I., et al. 2010. Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region. Nat. Struct. Mol. Biol. 17:1492-1494.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1492-1494
-
-
Nicely, N.I.1
-
27
-
-
4544379899
-
Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope
-
Ofek, G., et al. 2004. Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope. J. Virol. 78:10724-10737.
-
(2004)
J. Virol.
, vol.78
, pp. 10724-10737
-
-
Ofek, G.1
-
28
-
-
77649132440
-
Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region
-
Ofek, G., et al. 2010. Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region. J. Virol. 84:2955-2962.
-
(2010)
J. Virol.
, vol.84
, pp. 2955-2962
-
-
Ofek, G.1
-
29
-
-
0028593629
-
A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1
-
Purtscher, M., et al. 1994. A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1. AIDS Res. Hum. Retroviruses 10:1651-1658.
-
(1994)
AIDS Res. Hum. Retroviruses
, vol.10
, pp. 1651-1658
-
-
Purtscher, M.1
-
30
-
-
0018894548
-
ontribution of immunoglobulin heavy-chain variable-region genes to antibody diversity
-
Rabbitts, T. H., G. Matthyssens, and P. H. Hamlyn. 1980. Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity. Nature 284:238-243.
-
(1980)
Nature
, vol.284
, pp. 238-243
-
-
Rabbitts, T.H.1
Matthyssens, G.2
Hamlyn, P.H.3
-
31
-
-
0037389643
-
Rapid evolution of the neutralizing antibody response to HIV type 1 infection
-
Richman, D. D., T. Wrin, S. J. Little, and C. J. Petropoulos. 2003. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. Proc. Natl. Acad. Sci. U. S. A. 100:4144-4149.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 4144-4149
-
-
Richman, D.D.1
Wrin, T.2
Little, S.J.3
Petropoulos, C.J.4
-
32
-
-
58149487645
-
Factors associated with the development of crossreactive neutralizing antibodies during human immunodeficiency virus type 1 infection
-
Sather, D. N., et al. 2009. Factors associated with the development of crossreactive neutralizing antibodies during human immunodeficiency virus type 1 infection. J. Virol. 83:757-769.
-
(2009)
J. Virol.
, vol.83
, pp. 757-769
-
-
Sather, D.N.1
-
33
-
-
77950537428
-
Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution
-
Shen, X., et al. 2010. Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. Proc. Natl. Acad. Sci. U. S. A. 107:5972-5977.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 5972-5977
-
-
Shen, X.1
-
34
-
-
64049092486
-
In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth
-
Shen, X., et al. 2009. In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth. J. Virol. 83:3617-3625.
-
(2009)
J. Virol.
, vol.83
, pp. 3617-3625
-
-
Shen, X.1
-
35
-
-
0036073140
-
Role of BCR affinity in T cell dependent antibody responses in vivo
-
Shih, T. A., E. Meffre, M. Roederer, and M. C. Nussenzweig. 2002. Role of BCR affinity in T cell dependent antibody responses in vivo. Nat. Immunol. 3:570-575.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 570-575
-
-
Shih, T.A.1
Meffre, E.2
Roederer, M.3
Nussenzweig, M.C.4
-
36
-
-
0036228846
-
Role of antigen receptor affinity in T cell-independent antibody responses in vivo
-
Shih, T. A., M. Roederer, and M. C. Nussenzweig. 2002. Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat. Immunol. 3:399-406.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 399-406
-
-
Shih, T.A.1
Roederer, M.2
Nussenzweig, M.C.3
-
37
-
-
67049156802
-
Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface
-
Song, L., et al. 2009. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. Proc. Natl. Acad. Sci. U. S. A. 106:9057-9062.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 9057-9062
-
-
Song, L.1
-
38
-
-
0027406481
-
Highfrequency representation of a single VH gene in the expressed human B cell repertoire
-
Stewart, A. K., C. Huang, B. D. Stollar, and R. S. Schwartz. 1993. Highfrequency representation of a single VH gene in the expressed human B cell repertoire. J. Exp. Med. 177:409-418.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 409-418
-
-
Stewart, A.K.1
Huang, C.2
Stollar, B.D.3
Schwartz, R.S.4
-
39
-
-
0029555715
-
A complete map of the human immunoglobulin VH locus
-
Tomlinson, I. M., et al. 1995. A complete map of the human immunoglobulin VH locus. Ann. N. Y. Acad. Sci. 764:43-46.
-
(1995)
Ann. N. Y. Acad. Sci.
, vol.764
, pp. 43-46
-
-
Tomlinson, I.M.1
-
40
-
-
0029791677
-
The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies
-
Veijola, R., et al. 1996. The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies. Am. J. Hum. Genet. 59:462-470.
-
(1996)
Am. J. Hum. Genet.
, vol.59
, pp. 462-470
-
-
Veijola, R.1
-
41
-
-
0029039727
-
Monozygotic rheumatoid arthritis twin pairs express similar levels of conserved immunoglobulin V gene in polyclonal rheumatoid factors irrespective of disease status
-
Vencovsky, J., R. A. Mageed, W. E. Ollier, and R. N. Maini. 1995. Monozygotic rheumatoid arthritis twin pairs express similar levels of conserved immunoglobulin V gene in polyclonal rheumatoid factors irrespective of disease status. Scand. J. Immunol. 42:147-157.
-
(1995)
Scand. J. Immunol.
, vol.42
, pp. 147-157
-
-
Vencovsky, J.1
Mageed, R.A.2
Ollier, W.E.3
Maini, R.N.4
-
42
-
-
76249083814
-
Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
-
Verkoczy, L., et al. 2010. Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proc. Natl. Acad. Sci. U. S. A. 107:181-186.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 181-186
-
-
Verkoczy, L.1
-
43
-
-
77958115264
-
A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals
-
Walker, L. W., et al. 2010. A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals. PLoS Pathog. 6:1-14.
-
(2010)
PLoS Pathog
, vol.6
, pp. 1-14
-
-
Walker, L.W.1
-
44
-
-
0037456827
-
Antibody neutralization and escape by HIV-1
-
Wei, X., et al. 2003. Antibody neutralization and escape by HIV-1. Nature 422:307-312.
-
(2003)
Nature
, vol.422
, pp. 307-312
-
-
Wei, X.1
-
45
-
-
0028808578
-
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region
-
Wood, N. W., et al. 1995. Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region. J. Neurol. 242:677-682.
-
(1995)
J. Neurol.
, vol.242
, pp. 677-682
-
-
Wood, N.W.1
-
46
-
-
70449701456
-
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens
-
Xiao, X., et al. 2009. Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens. Biochem. Biophys. Res. Commun. 390:404-409.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.390
, pp. 404-409
-
-
Xiao, X.1
-
47
-
-
0025186353
-
Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases
-
Yang, P. M., et al. 1990. Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases. Proc. Natl. Acad. Sci. U. S. A. 87:7907-7911.
-
(1990)
Proc. Natl. Acad. Sci. U. S. A.
, vol.87
, pp. 7907-7911
-
-
Yang, P.M.1
-
48
-
-
11144227042
-
Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1
-
Zwick, M. B., et al. 2005. Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1. J. Virol. 79:1252-1261.
-
(2005)
J. Virol.
, vol.79
, pp. 1252-1261
-
-
Zwick, M.B.1
|