Anti-Analgesic Effect of the Mu/Delta Opioid Receptor Heteromer Revealed by Ligand-Biased Antagonism

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Milan Lobo, Laura ^a   Enquist, Johan ^a   van Rijn, Richard M ^a   Whistler, Jennifer L ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; DELTA OPIATE RECEPTOR; LIGAND; METHADONE; MU OPIATE RECEPTOR; NALTRIBEN; NALTRINDOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING SITE; CELL SURFACE; CHRONIC DRUG ADMINISTRATION; CHRONIC PAIN; COMPLEX FORMATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG ANTAGONISM; DRUG DOSE ESCALATION; DRUG RECEPTOR BINDING; ENDOCYTOSIS; IN VITRO STUDY; INTERNALIZATION; LOW DRUG DOSE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UPREGULATION;

ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; PAIN; PAIN MANAGEMENT; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION;

EID: 84875009844     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058362     Document Type: Article

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