Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists

European Journal of Pharmacology

Volumn 560, Issue 2-3, 2007, Pages 132-141

  McNaull, Benjamin ^a   Trang, Tuan ^a   Sutak, Maaja ^a   Jhamandas, Khem ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Adenosine; Opioid receptor antagonist; Opioid tolerance; Ultra low dose

Indexed keywords

DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; MORPHINE SULFATE; NALTREXONE; NALTRINDOLE; NORBINALTORPHIMINE; OPIATE ANTAGONIST;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG TOLERABILITY; HYPERALGESIA; LOW DRUG DOSE; MALE; MORPHINE TOLERANCE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TAIL FLICK TEST;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; THEOPHYLLINE;

EID: 33847414392     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.12.013     Document Type: Article

References (39)

1. Abul-Husn N., Powell K.J., Sutak M., Hong M., and Jhamandas K. Ultra-low doses of mu and delta opioid receptor antagonists augment spinal morphine antinociception and inhibit the development of tolerance. Soc. Neurosci. 27 (2001) 1614
2. Cahill C.M., White T.D., and Sawynok J. Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of opioid subtypes. J. Pharmacol. Exp. Ther. 275 (1995) 84-93
3. Chen L., and Huang L.Y. Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid. Neuron 7 (1991) 319-326
4. Cheng P.Y., Liu-Chen L.Y., and Pickel V.M. Dual ultrastructural immunocytochemical labeling of mu and delta opioid receptors in the superficial layers of the rat cervical spinal cord. Brain Res. 778 (1997) 367-380
5. Crain S.M., and Shen K.F. Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons. Trends Pharmacol. Sci. 11 (1990) 77-81
6. Crain S.M., and Shen K.F. Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 10540-10544
7. Crain S.M., and Shen K.F. Antagonists of excitatory opioid receptor functions enhance morphine′s analgesic potency and attenuate opioid tolerance/dependence liability. Pain 84 (2000) 121-131
8. Crain S.M., and Shen K.F. Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid antinociception. Brain Res. 888 (2001) 75-82
9. D'Amour F.E., and Smith D.D. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72 (1941) 74-79
10. De Lander G.E., and Keil G.J. Antinociception induced by intrathecal coadministration of selective adenosine receptor and selective opioid receptor agonists in mice. J. Pharmacol. Exp. Ther. 268 (1994) 943-951
11. Dickenson A.H., and Sullivan A.F. Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn. Pain 24 (1986) 211-222
12. Dunbar S., and Yaksh T.L. Concurrent spinal infusion of MK801 blocks spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Anesthesiology 84 (1996) 1177-1188
13. Fairbanks C.A., and Wilcox G.L. Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance. J. Pharmacol. Exp. Ther. 282 (1997) 1408-1417
14. Fairbanks C.A., and Wilcox G.L. Spinal plasticity of acute opioid tolerance. J. Biomed. Sci. 7 (2000) 200-212
15. Gardell L.R., Wang R., Burgess S.E., Ossipov M.H., Vanderah T.W., Malan Jr. T.P., Lai J., and Porreca F. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J. Neurosci. 22 (2002) 6747-6755
16. George S.R., Fan T., Xie Z., Tse R., Tam V., Varghese G., and O'Dowd B.F. Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J. Biol. Chem. 275 (2000) 26128-26135
17. Gomes I., Jordan B.A., Gupta A., Trapaidze N., Nagy V., and Devi L.A. Heterodimerization of mu and delta opioid receptors: a role in opiate synergy. J. Neurosci. 20 (2000) RC110
18. Gouarderes C., Sutak M., Zajac J.M., and Jhamandas K. Role of adenosine in the spinal antinociceptive and morphine modulatory actions of neuropeptide FF analogs. Eur. J. Pharmacol. 406 (2000) 391-401
19. Hamann S.R., Malik H., Sloan J.W., and Wala E.P. Interactions of "ultra-low" doses of naltrexone and morphine in mature and young male and female rats. Recept. Channels 10 (2004) 73-81
20. Jordan B.A., and Devi L.A. G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399 (1999) 697-700
21. Kissin I., Bright C.A., and Bradley Jr. E.L. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 91 (2000) 110-116
22. Knox R.J., and Dickenson A.H. Effects of selective and non-selective kappa-opioid receptor agonists on cutaneous C-fibre-evoked responses of rat dorsal horn neurons. Brain Res. 415 (1987) 21-29
23. Laulin J.P., Celerier E., Larcher A., Le Moal M., and Simonnet G. Opiate tolerance to daily heroin administration: an apparent phenomenon associated with enhanced pain sensitivity. Neuroscience 89 (1999) 631-636
24. Loomis C., Cervenko F., Jhamandas K., Sutak M., and Milne B. Analgesia and autonomic function following intrathecal administration of morphine and norepinephrine to the rat. Can. J. Physiol. Pharm. 63 (1985) 656-662
25. Loomis C.W., Milne B., and Cervenko F.W. Determination of cross tolerance in rat spinal cord using intrathecal infusion via sequential mini-osmotic pumps. Pharmacol. Biochem. Behav. 26 (1987) 131-139
26. Mao J., Price D.D., and Mayer D.J. Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C. J. Neurosci. 14 (1994) 2301-2312
27. Mao J., Price D.D., and Mayer D.J. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 62 (1995) 259-274
28. McNally G.P. Pain facilitatory circuits in the mammalian central nervous system: their behavioral significance and role in morphine analgesic tolerance. Neurosci. Biobehav. Rev. 23 (1999) 1059-1078
29. Owen J.A., Milne B., Jhamandas K., and Nakatsu K. Assembly of an inexpensive tail flick antinociception meter. J. Pharmacol. Methods 6 (1981) 33-37
30. Powell K.J., Ma W., Sutak M., Doods H., Quirion R., and Jhamandas K. Blockade and reversal of spinal morphine tolerance by peptide and non-peptide calcitonin gene-related peptide receptor antagonists. Br. J. Pharmacol. 131 (2000) 875-884
31. Powell K.J., Abul-Husn N.S., Jhamandas A., Olmstead M.C., Beninger R.J., and Jhamandas K. Paradoxical effects of the opioid antagonist naltrexone on morphine antinociception, tolerance, and reward in rats. J. Pharmacol. Exp. Ther. 300 (2002) 588-596
32. Powell K.J., Quirion R., and Jhamandas K. Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine induced increase in CGRP expression in cultured dorsal root ganglion neurons. Eur. J. Neurosci. 18 (2003) 1572-1583
33. Sandner-Kiesling A., Li X., and Eisenach J.C. Morphine-induced spinal release of adenosine is reduced in neuropathic rats. Anesthesiology 95 (2001) 1455-1459
34. Sawynok J., Sweeney M.I., and White T.D. Classification of adenosine receptors mediating antinociception in the rat spinal cord. Br. J. Pharmacol. 88 (1986) 923-930
35. Shen K.F., and Crain S.M. Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture. Brain Res. 491 (1989) 227-242
36. Sweeney M.I., White T.D., and Sawynok J. Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline. J. Pharmacol. Exp. Ther. 243 (1987) 657-665
37. Terner J.M., Barrett A.C., Lomas L.M., Negus S.S., and Picker M.J. Influence of low doses of naltrexone on morphine antinociception and morphine tolerance in male and female rats of four strains. Pain 122 (2006) 90-101
38. Wang H.Y., Friedman E., Olmstead M.C., and Burns L.H. Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor-G protein coupling and Gbetagamma signaling. Neuroscience 135 (2005) 247-261
39. Yaksh T.L., and Rudy T.A. Chronic catheterization of the spinal subarachnoid space. Physiol. Behav. 17 (1976) 1031-1036