Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model

Molecular Therapy

Volumn 19, Issue 1, 2011, Pages 196-203

  Katsha, Ahmed M ^a   Ohkouchi, Shinya ^a   Xin, Hong ^a,b   Kanehira, Masahiko ^a   Sun, Ruowen ^a,c   Nukiwa, Toshihiro ^a   Saijo, Yasuo ^a,c  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Japan   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ELASTASE; EPIDERMAL GROWTH FACTOR; PHOSPHATE BUFFERED SALINE; SCATTER FACTOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CELL DIFFERENTIATION; CELL FUNCTION; COCULTURE; CONTROLLED STUDY; EMPHYSEMA; ENGRAFTMENT; EPITHELIUM CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PARACRINE SIGNALING; PROTEIN SYNTHESIS; STEM CELL TRANSPLANTATION; STROMA CELL;

MUS;

EID: 78650923962     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.192     Document Type: Article

References (49)

1. Siafakas, NM, Vermeire, P, Pride, NB, Paoletti, P, Gibson, J, Howard, P et al. (1995). Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. Eur Respir J 8: 1398-1420.
2. Tashkin, D P, Celli, B, Senn, S, Burkhart, D, Kesten, S, Menjoge, S et al. (2008). A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 359: 1543-1554.
3. Prockop, DJ (1997). Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276: 71-74.
4. Rojas, M, Xu, J, Woods, CR, Mora, AL, Spears, W, Roman, J et al. (2005). Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 33: 145-152.
5. Krause, DS, Theise, ND, Collector, MI, Henegariu, O, Hwang, S, Gardner, R et al. (2001). Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105: 369-377.
6. Yamada, M, Kubo, H, Kobayashi, S, Ishizawa, K, Numasaki, M, Ueda, S et al. (2004). Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J Immunol 172: 1266-1272.
7. Kotton, DN, Ma, BY, Cardoso, WV, Sanderson, EA, Summer, RS, Williams, MC et al. (2001). Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development 128: 5181-5188.
8. Ishizawa, K, Kubo, H, Yamada, M, Kobayashi, S, Numasaki, M, Ueda, S et al. (2004). Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema. FEBS Lett 556: 249-252.
9. Loebinger, MR, Sage, EK and Janes, SM (2008). Mesenchymal stem cells as vectors for lung disease. Proc Am Thorac Soc 5: 711-716.
10. Ortiz, LA, Gambelli, F, McBride, C, Gaupp, D, Baddoo, M, Kaminski, N et al. (2003). Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fbrotic effects. Proc Natl Acad Sci USA 100: 8407-8411.
11. Wong, A P, Dutly, AE, Sacher, A, Lee, H, Hwang, DM, Liu, M et al. (2007). Targeted cell replacement with bone marrow cells for airway epithelial regeneration. Am J Physiol Lung Cell Mol Physiol 293: L740-L752.
12. Spees, JL, Pociask, DA, Sullivan, DE, Whitney, MJ, Lasky, JA, Prockop, DJ et al. (2007). Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fbrosis. Am J Respir Crit Care Med 176: 385-394.
13. Crisostomo, PR, Wang, Y, Markel, TA, Wang, M, Lahm, T and Meldrum, DR (2008). Human mesenchymal stem cells stimulated by TNF-α, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism. Am J Physiol, Cell Physiol 294: C675-C682.
14. Chen, L, Tredget, EE, Wu, PY and Wu, Y (2008). Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE 3: e1886.
15. Block, GJ, Ohkouchi, S, Fung, F, Frenkel, J, Gregory, C, Pochampally, R et al. (2009). Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells 27: 670-681.
16. Lee, RH, Pulin, AA, Seo, MJ, Kota, DJ, Ylostalo, J, Larson, BL et al. (2009). Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-infammatory protein TSG-6. Cell Stem Cell 5: 54-63.
17. Phinney, DG and Prockop, DJ (2007). Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 25: 2896-2902.
18. Thurlbeck, WM (1976). Measurement of pulmonary emphysema. Am Rev Respir Dis 65: 752-764.
19. Saetta, M, Shiner, RJ, Angus, GE, Kim, WD, Wang, NS, King, M et al. (1985). Destructive index: a measurement of lung parenchymal destruction in smokers. Am Rev Respir Dis 131: 764-769.
20. McElroy, MC and Kasper, M (2004). The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair. Eur Respir J 24: 664-673.
21. Loi, R, Beckett, T, Goncz, KK, Suratt, BT and Weiss, DJ (2006). Limited restoration of cystic fbrosis lung epithelium in vivo with adult bone marrow-derived cells. Am J Respir Crit Care Med 173: 171-179.
22. Lappalainen, U, Whitsett, JA, Wert, SE, Tichelaar, JW and Bry, K (2005). Interleukin-1β causes pulmonary infammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol 32: 311-318.
23. Lucey, EC, Keane, J, Kuang, PP, Snider, GL and Goldstein, RH (2002). Severity of elastase-induced emphysema is decreased in tumor necrosis factor-α and interleukin-1β receptor-defcient mice. Lab Invest 82: 79-85.
24. Couillin, I, Vasseur, V, Charron, S, Gasse, P, Tavernier, M, Guillet, J et al. (2009). IL-1R1/MyD88 signaling is critical for elastase-induced lung infammation and emphysema. J Immunol 183: 8195-8202.
25. Tögel, F, Hu, Z, Weiss, K, Isaac, J, Lange, C and Westenfelder, C (2005). Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 289: F31-F42. (Pubitemid 40863570)
26. Hegab, AE, Kubo, H, Yamaya, M, Asada, M, He, M, Fujino, N et al. (2008). Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema. Mol Ther 16: 1417-1426.
27. Shigemura, N, Sawa, Y, Mizuno, S, Ono, M, Ohta, M, Nakamura, T et al. (2005). Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats. Circulation 111: 1407-1414.
28. Chung, KF (2001). Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl 34: 50s-59s.
29. Velarde, MC, Parisek, SI, Eason, RR, Simmen, FA and Simmen, RC (2005). The secretory leukocyte protease inhibitor gene is a target of epidermal growth factor receptor action in endometrial epithelial cells. J Endocrinol 184: 141-151.
30. Nakamura, A, Mori, Y, Hagiwara, K, Suzuki, T, Sakakibara, T, Kikuchi, T et al. (2003). Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-defcient mice. J Exp Med 197: 669-674.
31. Ayad, MS, Knight, KR, Burdon, JG and Brenton, S (2003). Secretory leukocyte proteinase inhibitor, α-1-antitrypsin defciency and emphysema: Preliminary study, speculation and an hypothesis. Respirology 8: 175-180.
32. Plantier, L, Marchand-Adam, S, Antico, VG, Boyer, L, De Coster, C, Marchal, J et al. (2007). Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol 293: L1230-L1239.
33. Ortiz, LA, Dutreil, M, Fattman, C, Pandey, AC, Torres, G, Go, K et al. (2007). Interleukin 1 receptor antagonist mediates the antiinfammatory and antifbrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 104: 11002-11007.
34. Aslam, M, Baveja, R, Liang, OD, Fernandez-Gonzalez, A, Lee, C, Mitsialis, SA et al. (2009). Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med 180: 1122-1130.
35. Van Haffen, T, Byrne, R, Bonnet, S, Rochefort, GY, Akabutu, J, Bouchentouf, M et al. (2009). Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med 180: 1131-1142.
36. Németh, K, Leelahavanichkul, A, Yuen, PS, Mayer, B, Parmelee, A, Doi, K et al. (2009). Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15: 42-49.
37. Gupta, N, Su, X, Popov, B, Lee, JW, Serikov, V and Matthay, MA (2007). Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 179: 1855-1863.
38. Lee, JW, Fang, X, Gupta, N, Serikov, V and Matthay, MA (2009). Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA 106: 16357-16362.
39. Xu, J, Woods, CR, Mora, AL, Joodi, R, Brigham, KL, Iyer, S et al. (2007). Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol 293: L131-L141.
40. Chang, YS, Oh, W, Choi, SJ, Sung, DK, Kim, SY, Choi, EY et al. (2009). Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. Cell Transplant 18: 869-886.
41. Bingle, L and Tetley, TD (1996). Secretory leukoprotease inhibitor: partnering α1-proteinase inhibitor to combat pulmonary infammation. Thorax 51: 1273-1274.
42. Nukiwa, T, Suzuki, T, Fukuhara, T and Kikuchi, T (2008). Secretory leukocyte peptidase inhibitor and lung cancer. Cancer Sci 99: 849-855.
43. Uccelli, A, Moretta, L and Pistoia, V (2008). Mesenchymal stem cells in health and disease. Nat Rev Immunol 8: 726-736.
44. Wei, X, Du, Z, Zhao, L, Feng, D, Wei, G, He, Y et al. (2009). IFATS collection: The conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells 27: 478-488.
45. Mei, SH, McCarter, SD, Deng, Y, Parker, CH, Liles, WC and Stewart, DJ (2007). Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med 4: e269.
46. Xu, J, Qu, J, Cao, L, Sai, Y, Chen, C, He, L et al. (2008). Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice. J Pathol 214: 472-481.
47. Xin, H, Kanehira, M, Mizuguchi, H, Hayakawa, T, Kikuchi, T, Nukiwa, T et al. (2007). Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells. Stem Cells 25: 1618-1626. (Pubitemid 47121838)
48. Kanehira, M, Xin, H, Hoshino, K, Maemondo, M, Mizuguchi, H, Hayakawa, T et al. (2007). Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells. Cancer Gene Ther 14: 894-903. (Pubitemid 47557220)
49. Massaro, GD and Massaro, D (1997). Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 3: 675-677. (Pubitemid 27264979)