Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors

Journal of the American Chemical Society

Volumn 135, Issue 10, 2013, Pages 3776-3779

  Gampe, Christian M ^a   Tsukamoto, Hirokazu ^a   Doud, Emma H ^b   Walker, Suzanne ^b   Kahne, Daniel ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC DRUGS; BACTERIAL PATHOGENS; BACTERIAL PEPTIDOGLYCAN; CELL WALL BIOSYNTHESIS; CHEMO-ENZYMATIC SYNTHESIS; DISPLACEMENT ASSAY; GLYCOSYLTRANSFERASES; NATURAL ANTIBIOTICS;

ASSAYS; BINDING ENERGY; BIOCHEMISTRY; CELL MEMBRANES; ENZYMES; ESCHERICHIA COLI; LEAD COMPOUNDS; PHARMACODYNAMICS;

ANTIBIOTICS;

FLUORESCENT DYE; MOENOMYCIN A; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE;

ARTICLE; BACTERIAL CELL WALL; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; MOLECULAR PROBE; NONHUMAN; PHARMACOPHORE; STAPHYLOCOCCUS AUREUS; TUNING CURVE;

ANTI-BACTERIAL AGENTS; BAMBERMYCINS; CELL WALL; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; STAPHYLOCOCCUS AUREUS;

EID: 84874973420     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4000933     Document Type: Article

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