Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin

Journal of Structural Biology

Volumn 167, Issue 2, 2009, Pages 129-135

  Heaslet, Holly ^a   Shaw, Bailin ^a   Mistry, Anil ^a   Miller, Alita A ^a  

^a PFIZER INC   (United States)

Author keywords

Antibiotic discovery; Moenomycin; Staphylococcus aureus; Transglycosylase

Indexed keywords

BAMBERMYCIN; GLYCOSYLTRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM MUTANT; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; GENE MUTATION; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR INTERACTION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GLYCOSYLTRANSFERASES; MUTAGENESIS, SITE-DIRECTED; MUTATION; OLIGOSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID;

BACTERIA (MICROORGANISMS); MAMMALIA; STAPHYLOCOCCUS AUREUS;

EID: 67649804646     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2009.04.010     Document Type: Article

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