Aeromonas spp. whole genomes and virulence factors implicated in fish disease

Journal of Fish Diseases

Volumn 36, Issue 4, 2013, Pages 371-388

  Beaz Hidalgo, R ^a   Figueras, M J ^a  

^a FACULTAT DE MEDICINA I CIÈNCIES DE LA SALUT   (Spain)

Author keywords

Aeromonas; Fish; Genome; Virulence

Indexed keywords

BACTERIAL PROTEIN; VIRULENCE FACTOR;

AEROMONAS; BACTERIAL GENOME; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; REVIEW;

AEROMONAS; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENOME, BACTERIAL; VIRULENCE FACTORS;

AEROMONAS; BACTERIA (MICROORGANISMS);

EID: 84874957055     PISSN: 01407775     EISSN: 13652761     Source Type: Journal    
DOI: 10.1111/jfd.12025     Document Type: Review

References (109)

1. Abbott S.L., Cheung W.K. & Janda J.M. (2003) The genus Aeromonas: biochemical characteristics, atypical reactions, and phenotypic identification schemes. Journal of Clinical Microbiology 41, 2348-2357.
2. Abolghait S.K., Akeda Y., Kodama T., Cantarelli V.V., Iida T. & Honda T. (2010) Aeromonas hydrophila PepO outer membrane endopeptidase activates human big endothelin-3 in vitro and induces skin ulcer in goldfish (Carassius auratus). Veterinary Microbiology 145, 113-121.
3. Aravena-Román M., Harnett G.B., Riley T.V., Inglis T.J. & Chang B.J. (2011) Aeromonas aquariorum is widely distributed in clinical and environmental specimens and can be misidentified as Aeromonas hydrophila. Journal of Clinical Microbiology 49, 3006-3008.
4. Arnadottir H., Hvanndal I., Andresdottir V., Burr S.E., Frey J. & Gudmundsdottir B.K. (2009) The AsaP1 peptidase of Aeromonas salmonicida subsp. achromogenes is a highly conserved deuterolysin metalloprotease (family M35) and a major virulence factor. Journal of Bacteriology 191, 403-410.
5. Austin B. & Austin D.A. (2007) Bacterial Fish Pathogens, Disease of Farmed and Wild Fish, 4th edn. Springer-Praxis, Chichester.
6. Beatson S.A., das Graças de Luna M., Bachmann N.L., Alikhan N.F., Hanks K.R., Sullivan M.J., Wee B.A., Freitas-Almeida A.C., Dos Santos P.A., de Melo J.T., Squire D.J., Cunningham A.F., Fitzgerald J.R. & Henderson I.R. (2011) Genome sequence of the emerging pathogen Aeromonas caviae. Journal of Bacteriology 193, 1286-1287.
7. Beaz-Hidalgo R. & Figueras M.J. (2012) Molecular detection and characterization of furunculosis and other Aeromonas fish infections. In: Health and Environment in Aquaculture (ed. by E. Carvalho), pp. 97-132. InTech, Brazil. http://cdn.intechopen.com/pdfs/35139/InTech-Molecular_detection_and_characterization_of_furunculosis_and_other_aeromonas_fish_infections.pdf. Accessed on 19 October 2012.
8. Beaz-Hidalgo R., Alperi A., Figueras M.J. & Romalde J.L. (2009) Aeromonas piscicola sp. nov., isolated from diseased fish. Systematic Applied Microbiology 32, 471-479.
9. Beaz-Hidalgo R., Alperi A., Buján N., Romalde J.L. & Figueras M.J. (2010) Comparison of phenotypical and genetic identification of Aeromonas strains isolated from diseased fish. Systematic Applied Microbiology 33, 149-153.
10. Bernoth E. (1990) Autoagglutination, growth on tryptone-soy-Coomassie agar, outer membrane protein patterns and virulence of Aeromonas salmonicida strain. Journal of Fish Diseases 13, 145-155.
11. Bernoth E.M., Ellis A., Midtlyng P., Olivier G. & Smith P. (1997) Furunculosis Multidisciplinary Fish Disease Research, 1st edn. Academic Press, San Diego, CA.
12. Bi Z.X., Liu Y.J. & Lu C.P. (2007) Contribution of AhyR to virulence of Aeromonas hydrophila J-1. Research in Veterinary Science 83, 150-156.
13. Boyd J.M., Dacanay A., Knickle L.C., Touhami A., Brown L.L., Jericho M.H., Johnson S.C. & Reith M. (2008) Contribution of type IV pili to the virulence of Aeromonas salmonicida subsp. salmonicida in Atlantic salmon (Salmo salar L.). Infection and Immunity 76, 1445-1455.
14. Bruhn J.B., Dalsgaard I., Nielsen K.F., Buchholtz C., Larsen J.L. & Gram L. (2005) Quorum sensing signal molecules (acylated homoserine lactones) in Gram-negative fish pathogenic bacteria. Diseases of Aquatic Organisms 65, 43-52.
15. Canals R., Vilches S., Wilhelms M., Shaw J.G., Merino S. & Tomás J.M. (2007) Non structural flagella genes affecting both polar and lateral flagella-mediated motility in Aeromonas hydrophila. Microbiology 153, 1165-1175.
16. Cao Y., He S., Zhou Z., Zhang M., Mao W., Zhang H. & Yao B. (2012) Orally administered thermostable N-acyl homoserine lactonase from Bacillus sp. strain AI96 attenuates Aeromonas hydrophila infection in zebrafish. Applied and Environmental Microbiology 78, 1899-1908.
17. Castro-Escarpulli G., Figueras M.J., Aguilera-Arreola G., Soler L., Fernández-Rendón E., Aparicio G.O., Guarro J. & Chacón M.R. (2003) Characterisation of Aeromonas spp. isolated from frozen fish intended for human consumption in Mexico. International Journal of Food Microbiology 84, 41-49.
18. Chacón M.R., Castro-Escarpulli G., Soler L., Guarro J. & Figueras M.J. (2002) A DNA probe specific for Aeromonas colonies. Diagnostic Microbiology and Infectious Disease 44, 221-225.
19. Chacón M.R., Figueras M.J., Castro-Escarpulli G., Soler L. & Guarro J. (2003) Distribution of virulence genes in clinical and environmental isolates of Aeromonas spp. Antonie van Leeuwenhoek 84, 269-278.
20. Charette S.J., Brochu F., Boyle B., Filion G., Tanaka K.H. & Derome N. (2012) Draft genome sequence of the virulent strain 01-B526 of the fish pathogen Aeromonas salmonicida. Journal of Bacteriology 194, 722-723.
21. Chen R., Zhou Z., Cao Y., Bai Y. & Yao B. (2010) High yield expression of an AHL-lactonase from Bacillus sp. B546 in Pichia pastoris and its application to reduce Aeromonas hydrophila mortality in aquaculture. Microbial Cell factories 9, 39.
22. Chhabra G., Upadhyaya T. & Dixit A. (2012) Molecular cloning, sequence analysis and structure modeling of OmpR, the response regulator of Aeromonas hydrophila. Molecular Biology Reports 39, 41-50.
23. Chopra A.K., Graf J., Horneman A.J. & Johnson J.A. (2009) Virulence factor-activity relationships (VFAR) with specific emphasis on Aeromonas species. Journal of Water and Health 7(Suppl 1), S29-S54.
24. Chu W., Lu F., Zhu W. & Kang C. (2011) Isolation and characterization of new potential probiotic bacteria based on quorum-sensing system. Journal of Applied Microbiology 110, 202-208.
25. Dacanay A., Knickle L., Solanky K.S., Boyd J.M., Walter J.A., Brown L.L., Johnson S.C. & Reith M. (2006) Contribution of the type III secretion system (TTSS) to virulence of Aeromonas salmonicida subsp. salmonicida. Microbiology 152, 1847-1856.
26. Dacanay A., Boyd J.M., Fast M.D., Knickle L.C. & Reith M.E. (2010) Aeromonas salmonicida Type I pilus system contributes to host colonization but not invasion. Diseases of Aquatic Organisms 88, 199-206.
27. Daher R.K., Filion G., Tan S.G., Dallaire-Dufresne S., Paquet V.E. & Charette S.J. (2011) Alteration of virulence factors and rearrangement of pAsa5 plasmid caused by the growth of Aeromonas salmonicida in stressful conditions. Veterinary Microbiology 152, 352-360.
28. Dautremepuits C., Fortier M., Croisetiere S., Belhumeur P. & Fournier M. (2006) Modulation of juvenile brook trout (Salvelinus fontinalis) cellular immune system after Aeromonas salmonicida challenge. Veterinary Immunology and Immunopathology 110, 27-36.
29. Del Corral F., Shotts E.B. & Brown J. (1990) Adherence, haemagglutination and cell surface characteristics of motile aeromonads virulent for fish. Journal of Fish Diseases 13, 255-268.
30. Ebanks R.O., Dacanay A., Goguen M., Pinto D.M. & Ross N.W. (2004) Differential proteomic analysis of Aeromonas salmonicida outer membrane proteins in response to low iron and in vivo growth conditions. Proteomics 4, 1074-1085.
31. Ebanks R.O., Goguen M., McKinnon S., Pinto D.M. & Ross N.W. (2005) Identification of the major outer membrane proteins of Aeromonas salmonicida. Diseases of Aquatic Organisms 68, 29-38.
32. Ellis A.E. (1991) An appraisal of the extracellular toxins of Aeromonas salmonicida ssp. salmonicida. Journal of Fish Diseases 14, 265-277.
33. Ellis A.E., Burrows A.S. & Stapleton K.J. (1988) Lack of relationship between virulence of Aeromonas salmonicida and the putative virulence factors, A-layer, extracellular proteases and extracellular haemolysins. Journal of Fish Diseases 11, 309-323.
34. Esteve C., Alcaide E. & Blasco M.D. (in press) Aeromonas hydrophila subsp. dhakensis isolated from feces, water and fish in Mediterranean Spain. Microbes Environment doi: http://dx.doi.org/10.1264/jsme2.ME12009.
35. Fast M.D., Tse B., Boyd J.M. & Johnson S.C. (2009) Mutations in the Aeromonas salmonicida subsp. salmonicida type III secretion system affect Atlantic salmon leucocyte activation and downstream immune responses. Fish and Shellfish Immunology 27, 721-728.
36. Figueras M.J. (2005) Clinical relevance of Aeromonas. Reviews in Medical Microbiology 16, 145-153.
37. Figueras M.J., Alperi A., Saavedra M.J., Ko W.C., Gonzalo N., Navarro M. & Martínez-Murcia A. (2009) Clinical relevance of the recently described Aeromonas aquariorum. Journal of Clinical Microbiology 47, 3742-3746.
38. Figueras M.J., Beaz-Hidalgo R., Collado L. & Martínez-Murcia A.J. (2011a) Point of view on the recommendations for new bacterial species description and their impact on the genus Aeromonas and Arcobacter. The Bulletin of Bergey′s International Society for Microbial Systematics 2(Pt 1), 1-16.
39. Figueras M.J., Beaz-Hidalgo R. & Paredes K. (2011b) Furunculosis y otras infecciones producidas por Aeromonas. In: Enfermedades infecciosas del cultivo de Salmónidos en Chile y el Mundo (ed. by R. Avendaño-Herrera), pp. 285-374. Niva Chile S.A., Puerto Varas, Chile.
40. Gudmundsdóttir B.K. & Björnsdóttir B. (2007) Vaccination against atypical furunculosis and winter ulcer disease of fish. Vaccine 25, 5512-5523.
41. Hadi N., Yang Q., Barnett T.C., Tabei S.M., Kirov S.M. & Shaw J.G. (2012) Bundle-forming pilus locus of Aeromonas veronii bv. sobria. Infection and Immunology 80, 1351-1360.
42. Han H.J., Kim D.Y., Kim W.S., Kim C.S., Jung S.J., Oh M.J. & Kim D.H. (2011) Atypical Aeromonas salmonicida infection in the black rockfish, Sebastes schlegeli Hilgendorf, in Korea. Journal of Fish Diseases 34, 47-55.
43. Hastein T., Saltveit S.J. & Roberts R.J. (1978) Mass mortality among minnows Phoxinus phoxinus (L.) in Lake Tveivatn, Norway due to an aberrant strain of Aeromonas salmonicida. Journal of Fish Diseases 1, 241-249.
44. Hirst I.D., Hastings T.S. & Ellis A.E. (1994) Utilization of haem compounds by Aeromonas salmonicida. Journal of Fish Diseases 17, 365-373.
45. Janda J.M. (2001) Aeromonas and Plesiomonas. In: Molecular Medical Microbiology (ed. by M. Sussman), pp. 1237-1270. Academic Press, San Diego, CA.
46. Janda J.M. & Abbott S.L. (2010) The genus Aeromonas, taxonomy, pathogenicity, and infection. Clinical Microbiology Reviews 23, 35-73.
47. Jangid K., Kong R., Patole M. & Shouche Y.S. (2007) luxRI homologs are universally present in the genus Aeromonas. BMC Microbiology 7, 93.
48. Jiménez N., Lacasta A., Vilches S., Reyes M., Vázquez J., Aquillini E., Merino S., Regué M. & Tomás J.M. (2009) Genetics and proteomics of Aeromonas salmonicida lipopolysaccharide core biosynthesis. Journal of Bacteriology 191, 2228-22236.
49. Joseph S.W. & Carnahan A. (1994) The isolation, identification and systematics of the motile Aeromonas species. Annual Review of Fish Diseases 4, 315-343.
50. Jutfelt F., Sundh H., Glette J., Mellander L., Thrandur Björnsson B. & Sundell K. (2008) The involvement of Aeromonas salmonicida virulence factors in bacterial translocation across the rainbow trout, Oncorhynchus mykiss (Walbaum) intestine. Journal of Fish Diseases 31, 141-151.
51. Khajanchi B.K., Sha J., Kozlova E.V., Erova T.E., Suárez G., Sierra J.C., Popov V.L., Horneman A.J. & Chopra A.K. (2009) N-acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila. Microbiology 155, 3518-3531.
52. Khushiramani R.M., Maiti B., Shekar M., Girisha S.K., Akash N., Deepanjali A., Karunasagar I. & Karunasagar I. (2012) Recombinant Aeromonas hydrophila outer membrane protein 48 (Omp48) induces a protective immune response against Aeromonas hydrophila and Edwardsiella tarda. Research in Microbiology 163, 286-291.
53. Kozińska A. (2007) Dominant pathogenic species of mesophilic aeromonads isolated from diseased and healthy fish cultured in Poland. Journal of Fish Diseases 30, 293-301.
54. Kozińska A. & Pekala A. (2012) Characteristics of disease spectrum in relation to species, serogroups, and adhesion ability of motile aeromonads in fish. Scientific World Journal 2012, 949358. doi: 10.1100/2012/949358.
55. Kozlova E.V., Khajanchi B.K., Sha J. & Chopra A.K. (2011) Quorum sensing and c-di-GMP-dependent alterations in gene transcripts and virulence-associated phenotypes in a clinical isolate of Aeromonas hydrophila. Microbial Pathogenesis 50, 213-223.
56. Lee K.K. & Ellis A.E. (1990) Glycerophospholipid:cholesterol acyltransferase complexed with lipopolysaccharide (LPS) is a major lethal exotoxin and cytolysin of Aeromonas salmonicida: LPS stabilizes and enhances toxicity of the enzyme. Journal of Bacteriology 172, 5382-5393.
57. Lee K.K. & Ellis A.E. (1991) The role of the lethal extracellular cytolysin of Aeromonas salmonicida in the pathology of furunculosis. Journal of Fish Diseases 14, 453-460.
58. Li Y. & Cai S.H. (2011) Identification and pathogenicity of Aeromonas sobria on tail-rot disease in juvenile tilapia Oreochromis niloticus. Current Microbiology 62, 623-627.
59. Li Y., Liu Y., Zou Z., Huang H., Ren Y., Zhang Y., Li G., Zou Z. & Wang L. (2011a) Complete genome sequence of Aeromonas veronii strain B565. Journal of Bacteriology 193, 3389-3390.
60. Li G., Miller A., Bull H. & Howard S.P. (2011b) Assembly of the type II secretion system, identification of ExeA residues critical for peptidoglycan binding and secretin multimerization. Journal of Bacteriology 193, 197-204.
61. Liu P.C., Chuang W.H., Tu C.C. & Lee K.K. (2010) Purification of a toxic cysteine protease produced by pathogenic Aeromonas hydrophila isolated from rainbow trout. Journal of Bacteriology 50, 538-547.
62. Magnadottir B. (2010) Immunological control of fish diseases. Marine Biotechnology 12, 361-379.
63. Martin-Carnahan A. & Joseph S.W. (2005) Family I. Aeromonadaceae Colwell, MacDonell and DeLey 1986. In: Bergey's Manual of Systematic Bacteriology, 2nd edn, Vol. 2 (ed. by D.J. Brennan, N.R. Krieg, J.T. Staley & G.N. Garrity), pp. 556-578. Springer-Verlag, New York.
64. Masada C.L., LaPatra S.E., Morton A.W. & Strom M.S. (2002) An Aeromonas salmonicida type IV pilin is required for virulence in rainbow trout Oncorhynchus mykiss. Diseases of Aquatic Organisms 51, 13-25.
65. Merino S., Camprubí S. & Tomás J.M. (1991) The role of lipopolysaccharide in complement-killing of Aeromonas hydrophila strains of serotype O:34. Journal of General Microbiology 137, 1583-1590.
66. Merino S., Rubirés X., Aguilar A. & Tomás J.M. (1997) The role of flagella and motility in the adherence and invasion to fish cell lines by Aeromonas hydrophila serogroup O:34 strains. FEMS Microbiology Letters 151, 213-217.
67. Merino S., Aguilar A., Nogueras M.M., Regue M., Swift S. & Tomás J.M. (1999) Cloning, sequencing, and role in virulence of two phospholipases (A1 and C) from mesophilic Aeromonas sp. serogroup O:34. Infection and Immunology 67, 4008-40013.
68. Merino S., Gavin R., Vilches S., Shaw J.G. & Tomás J.M. (2003) A colonization factor (production of lateral flagella) of mesophilic Aeromonas spp. is inactive in Aeromonas salmonicida strains. Applied and Environmental Microbiology 69, 663-667.
69. Merino S., Vilches S., Canals R., Ramirez S. & Tomás J.M. (2005) C1q-binding 40 kDa porin from Aeromonas salmonicida, cloning, sequencing, role in serum susceptibility and fish immunoprotection. Microbial Pathogenesis 38, 227-237.
70. Molero R., Wilhelms M., Infanzon B., Tomás J.M. & Merino S. (2011) Aeromonas hydrophila motY is essential for polar flagellum function, requires coordinate expression of motX and Pom proteins. Microbiology 157, 2772-2784.
71. Naharro G., Riaño J., de Castro L., Álvarez S. & Luengo J.M. (2010) Aeromonas. In: Molecular Detection of Foodborne Pathogens (ed. by L. Dongyou), pp. 273-287. CRC Press, Boca Ratón, FL.
72. Najimi M., Lemos M.L. & Osorio C.R. (2008) Identification of heme uptake genes in the fish pathogen Aeromonas salmonicida subsp. salmonicida. Archives of Microbiology 190, 439-449.
73. Najimi M., Lemos M.L. & Osorio C.R. (2009) Identification of iron regulated genes in the fish pathogen Aeromonas salmonicida subsp. salmonicida, Genetic diversity and evidence of conserved iron uptake systems. Veterinary Microbiology 133, 377-382.
74. Nawaz M., Sung K., Khan S.A., Khan A.A. & Steele R. (2006) Biochemical and molecular characterization of tetracycline-resistant Aeromonas veronii isolates from catfish. Applied and Environmental Microbiology 27, 6461-6466.
75. Nawaz M., Khan S.A., Sung K., Tran Q., Kerdahi K. & Steel R. (2010) Detection and characterization of virulence genes and integrons in Aeromonas veronii isolated from catfish. Food Microbiology 27, 327-331.
76. Ni X.D., Wang N., Liu Y.J. & Lu C.P. (2010) Immunoproteomics of extracellular proteins of the Aeromonas hydrophila China vaccine strain J-1 reveal a highly immunoreactive outer membrane protein. FEMS Immunology and Medical Microbiology 58, 363-373.
77. Noga E.J. (2010) Fish Diseases: Diagnosis and Treatment, 2nd edn. Willey-Blackwell, Singapore.
78. Noonin C., Jiravanichpaisal P., Soöderhäll I., Merino S., Tomás J.M. & Soöderhäll K. (2010) Melanization and pathogenicity in the insect, Tenebrio molitor, and the crustacean, Pacifastacus leniusculus, by Aeromonas hydrophila AH-3. PLoS ONE 5, e15728.
79. Puthucheary S.D., Puah S.M. & Chua K.H. (2012) Molecular characterization of clinical isolates of Aeromonas species from Malaysia. PLoS ONE 7, e30205.
80. Rangrez A.Y., Dayananda K.M., Atanur S., Joshi R., Patole M.S. & Shouche Y.S. (2006) Detection of conjugation related type four secretion machinery in Aeromonas culicicola. PLoS ONE 1, e115.
81. Rasch M., Kastbjerg V.G., Bruhn J.B., Dalsgaard I., Givskov M. & Gram L. (2007) Quorum sensing signals are produced by Aeromonas salmonicida and quorum sensing inhibitors can reduce production of a potential virulence factors. Diseases of Aquatic Organisms 78, 105-113.
82. Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C. & Brown L.L. (2008) The genome of Aeromonas salmonicida subsp. salmonicida A449, insights into the evolution of a fish pathogen. BMC Genomics 9, 427.
83. Rhodes G., Parkhill J., Bird C., Ambrose K., Jones M.C., Huys G., Swins J. & Pickup R.W. (2004) Complete nucleotide sequence of the conjugative tetracycline resistance plasmid pFBAOT6, a member of a group of IncU plasmids with global ubiquity. Applied and Environmental Microbiology 70, 7497-7510.
84. Schwenteit J., Gram L., Nielsen K.F., Fridjonsson O.H., Bornscheuer U.T., Givskov M. & Gudmundsdóttir B.K. (2011) Quorum sensing in Aeromonas salmonicida subsp. achromogenes and the effect of the auto inducer synthetase AsaI on bacterial virulence. Veterinary Microbiology 147, 389-397.
85. T, jack of all trades. Journal of Bacteriology 188, 8272-8282.
86. Sha J., Pillai L., Fadl A.A., Galindo C.L., Erova T.E. & Chopra A.K. (2005) The type III secretion system and cytotoxic enterotoxin alter the virulence of Aeromonas hydrophila. Infection and Immunity 73, 6446-6457.
87. Sierra J.C., Suárez G., Sha J., Baze W.B., Foltz S.M. & Chopra A.K. (2010) Unravelling the mechanism of action of a new type III secretion system effector AexU from Aeromonas hydrophila. Microbial Pathogenesis 49, 122-134.
88. Singh V., Somvanshi P., Rathore G., Kapoor D. & Mishra B.N. (2009) Gene cloning, expression and homology modelling of hemolysin gene from Aeromonas hydrophila. Protein Expression and Purification 65, 1-7.
89. Soler L., Figueras M.J., Chacón M.R., Guarro J. & Martínez-Murcia A.J. (2003) Comparison of three molecular methods for typing Aeromonas popoffii isolates. Antonie van Leeuwenhoek 83, 341-349.
90. Soler L., Yañez M.A., Chacón M.R., Aguilera-Arreola M.G., Catalán V., Figueras M.J. & Martínez-Murcia A.J. (2004) Phylogenetic analysis of the genus Aeromonas based on two housekeeping genes. International Journal of Systematic and Evolutionary Microbiology 54, 1511-1519.
91. Soriano-Vargas E., Castro-Escarpulli G., Aguilera-Arreola M.G., Vega-Castillo F. & Salgado-Miranda C. (2010) Aislamiento e identificación de Aeromonas bestiarum a partir de carpa común de cultivo (Cyprinus carpió L.) procedentes de Santa María Chapa de Mota, Estado de México, México. Veterinaria México 41, 111-115.
92. Suárez G., Sierra J.C., Sha J., Wang S., Erova T.E., Fadl A.A., Foltz S.M., Horneman A.J. & Chopra A.K. (2008) Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila. Microbial Pathogenesis 44, 344-361.
93. Suárez G., Sierra J.C., Erova T.E., Sha J., Horneman A.J. & Chopra A.K. (2010) A type VI secretion system effector protein, VgrG1, from Aeromonas hydrophila that induces host cell toxicity by ADP ribosylation of actin. Journal of Bacteriology 192, 155-168.
94. Swift S., Karlyshev A.V., Fish L., Durant E.L., Winson M.K., Chhabra S.R., Williams P., Macintyre S. & Stewart G.S. (1997) Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida, identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules. Journal of Bacteriology 179, 5271-5281.
95. Tanaka K.H., Dallaire-Dufresne S., Daher R.K., Frenette M. & Charette S.J. (2012) An insertion sequence-dependent plasmid rearrangement in Aeromonas salmonicida causes the loss of the type three secretion system. PLoS ONE 7, e33725.
96. Turska-Szewczuk A., Kozińska A., Russa R. & Holst O. (2010) The structure of the O-specific polysaccharide from the lipopolysaccharide of Aeromonas bestiarum strain 207. Carbohydrate Research 345, 680-684.
97. Vázquez-Juarez R.C., Gomez-Chiarri M., Barrera-Saldaña H., Hernández-Saavedra N., Dumas S. & Ascensio F. (2005) Evaluation of DNA vaccination of spotted sand bass (Paralabrax maculatofasciatus) with two major outer-membrane protein-encoding genes from Aeromonas veronii. Fish and Shellfish Immunology 19, 153-163.
98. Vilches S., Urgell C., Merino S., Chacón M.R., Soler L., Castro-Escarpulli G., Figueras M.J. & Tomas J.M. (2004) Complete type III secretion system of a mesophilic Aeromonas hydrophila strain. Applied and Environmental Microbiology 70, 6914-6919.
99. Vilches S., Wilhelms M., Yu H.B., Leung K.Y., Tomás J.M. & Merino S. (2008) Aeromonas hydrophila AH-3 AexT is an ADP-ribosylating toxin secreted through the type III secretion system. Microbial Pathogenesis 44, 1-12.
100. Vilches S., Jiménez N., Tomás J.M. & Merino S. (2009) Aeromonas hydrophila AH-3 type III secretion system expression and regulatory network. Applied and Environmental Microbiology 75, 6382-6392.
101. Vipond R., Bricknell I.R., Durant E., Bowden T.J., Ellis A.E., Smith M. & MacIntyre S. (1998) Defined deletion mutants demonstrate that the major secreted toxins are not essential for the virulence of Aeromonas salmonicida. Infection and Immunity 66, 1990-1998.
102. Wang Z., Liu X., Dacanay A., Harrison B.A., Fast M., Colquhoun D.J., Lund V., Brown L.L., Li J. & Altman E. (2007) Carbohydrate analysis and serological classification of typical and atypical isolates of Aeromonas salmonicida, A rationale for the lipopolysaccharide-based classification of A. salmonicida. Fish and Shellfish Immunology 23, 1095-1106.
103. Whittington R.J., Gudkovs N., Carrigan M.J., Ashburner L.D. & Thurstan S.J. (1987) Clinical, microbiological and epidemiological findings in recent outbreaks of goldfish ulcer disease due to atypical Aeromonas salmonicida in south-eastern Australia. Journal of Fish Diseases 10, 353-362.
104. Wihelms M., Vilches S., Reyes M., Moler R., Shaw J.G., Tomás J.M. & Merino S. (2009) Two redundant sodium-driven stator motor proteins are involved in Aeromonas hydrophila polar flagellum rotation. Journal of Bacteriology 191, 2206-2217.
105. Wu C.J., Wang H.C., Chen C.S., Shu H.Y., Kao A.W., Chen P.L. & Ko W.C. (2012) Genome sequence of a novel human pathogen, Aeromonas aquariorum. Journal of Bacteriology 194, 4114.
106. Yeh H.Y. & Klesius P.H. (2011) Over-expression, purification and immune responses to Aeromonas hydrophila AL09-73 flagellar proteins. Fish and Shellfish Immunology 31, 1278-1283.
107. Yu H.B., Zhang Y.L., Lau Y.L., Yao F., Vilches S., Merino S., Tomás J.M., Howard S.P. & Leung K.Y. (2005) Identification and characterization of putative virulence genes and gene clusters in Aeromonas hydrophila PPD134/91. Applied and Environmental Microbiology 71, 4469-4477.
108. Zhang Y.L., Arakawa E. & Leung K.Y. (2002) Novel Aeromonas hydrophila PPD134/91 genes involved in O-antigen and capsule biosynthesis. Infection and Immunology 70, 2326-2335.
109. Zhang Y.L., Lau Y.L., Arakawa E. & Leung K.Y. (2003) Detection and genetic analysis of group II capsules in Aeromonas hydrophila. Microbiology 149, 1051-1060.